{"id":49876,"date":"2024-04-12T21:45:19","date_gmt":"2024-04-12T13:45:19","guid":{"rendered":"https:\/\/swarma.org\/?p=49876"},"modified":"2024-04-12T21:45:19","modified_gmt":"2024-04-12T13:45:19","slug":"nature%e8%af%84%e9%80%892024%e5%b9%b4%e5%80%bc%e5%be%97%e5%85%b3%e6%b3%a8%e7%9a%84%e4%b8%83%e5%a4%a7%e7%a7%91%e6%8a%80%ef%bc%9a%e8%9b%8b%e7%99%bd%e8%b4%a8%e8%ae%be%e8%ae%a1%e3%80%81%e8%84%91%e6%9c%ba","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=49876","title":{"rendered":"Nature\u8bc4\u90092024\u5e74\u503c\u5f97\u5173\u6ce8\u7684\u4e03\u5927\u79d1\u6280\uff1a\u86cb\u767d\u8d28\u8bbe\u8ba1\u3001\u8111\u673a\u63a5\u53e3\u3001\u7ec6\u80de\u56fe\u8c31\u7b49"},"content":{"rendered":"
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Nature <\/span><\/strong><\/em>\u6742\u5fd7\u5e74\u521d\u8bc4\u9009\u4e862024\u5e74\u503c\u5f97\u5173\u6ce8\u7684\u4e03\u5927\u79d1\u6280\uff0c\u5305\u62ec\uff1a\u7528\u4e8e\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u6df1\u5ea6\u5b66\u4e60\u3001\u6df1\u5ea6\u4f2a\u9020\u68c0\u6d4b\u3001\u5927\u7247\u6bb5DNA\u63d2\u5165\u3001\u8111\u673a\u63a5\u53e3\u3001\u8d85\u5206\u8fa8\u7387\u6210\u50cf\u6280\u672f\u3001\u7ec6\u80de\u56fe\u8c31\u30013D\u6253\u5370\u7eb3\u7c73\u6750\u6599\u3002\u4eca\u5e74\u6709\u8bb8\u591a\u79d1\u6280\u521b\u65b0\u4ee4\u4eba\u5174\u594b\uff0c\u800c\u4eba\u5de5\u667a\u80fd\u662f\u5f88\u591a\u9886\u57df\u7684\u6838\u5fc3\u6240\u5728\u3002<\/span><\/strong><\/span><\/strong><\/section>\n

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\u5173\u952e\u8bcd\uff1aAI for Biology\uff0c\u86cb\u767d\u8d28\u8bbe\u8ba1\uff0c\u8111\u673a\u63a5\u53e3\uff0c\u8d85\u5206\u8fa8\u7387\u6210\u50cf\u6280\u672f\uff0c\u7ec6\u80de\u56fe\u8c31\u30013D\u6253\u5370\u7eb3\u7c73\u6750\u6599<\/span><\/strong><\/span><\/strong><\/section>\n<\/section>\n
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Michael Eisenstein<\/span> | \u4f5c\u8005<\/span><\/strong><\/section>\n
\u822a\u6d77\u7684\u732a<\/span> <\/span>| \u8bd1\u8005<\/span><\/strong><\/strong><\/section>\n
Nevaeh<\/span> <\/span>| \u5ba1\u6821<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n
EON<\/span> <\/span>| \u7f16\u8f91<\/span><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n
\u795e\u7ecf\u73b0\u5b9e<\/span> <\/span>| \u6765\u6e90<\/span><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n
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\u7528\u4e8e\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u6df1\u5ea6\u5b66\u4e60<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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\u4e8c\u5341\u5e74\u524d\uff0c\u5728\u897f\u96c5\u56fe\u7684\u534e\u76db\u987f\u5927\u5b66\uff0c\u5927\u536b\u00b7\u8d1d\u514b<\/span>\uff08David Baker\uff09<\/span>\u548c\u4ed6\u7684\u540c\u4e8b\u53d6\u5f97\u4e86\u91cc\u7a0b\u7891\u5f0f\u7684\u79d1\u7814\u6210\u679c\uff1a\u4ed6\u4eec\u7528\u8ba1\u7b97\u673a\u5de5\u5177\u4ece\u5934\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u5168\u65b0\u7684\u86cb\u767d\u8d28\u2014\u2014Top7\u3002\u8fd9\u6761\u86cb\u767d\u8d28\u4ee5\u9884\u6d4b\u7684\u7ed3\u6784\u6298\u8fed\uff0c\u4f46\u5b83\u662f\u60f0\u6027\u7684\uff0c\u6ca1\u6709\u4efb\u4f55\u6709\u610f\u4e49\u7684\u751f\u7269\u5b66\u529f\u80fd\u3002\u5982\u4eca\u4ece\u5934\u86cb\u767d\u8d28\u8bbe\u8ba1<\/span>\uff08de novo protein design\uff09<\/span>\u5df2\u7ecf\u975e\u5e38\u6210\u719f\uff0c\u6210\u4e3a\u53ef\u4ee5\u7528\u4e8e\u5b9a\u5236\u9176\u548c\u5176\u4ed6\u86cb\u767d\u8d28\u7684\u5b9e\u7528\u5de5\u5177\u3002\u534e\u76db\u987f\u5927\u5b66\u7684\u751f\u7269\u5316\u5b66\u5bb6\u5c3c\u5c14\u00b7\u91d1<\/span>\uff08Neil King\uff09<\/span>\u8868\u793a\u201c\u8fd9\u4e2a\u6280\u672f\u592a\u5f3a\u5927\u4e86\u201d\uff0c\u4ed6\u548c\u8d1d\u514b\u7684\u79d1\u7814\u56e2\u961f\u5408\u4f5c\uff0c\u6b63\u5728\u8bbe\u8ba1\u57fa\u4e8e\u86cb\u767d\u7684\u75ab\u82d7\u548c\u836f\u7269\u9012\u9001\u8f7d\u4f53\u3002\u201c\u4e00\u5e74\u534a\u4ee5\u524d\u5f88\u591a\u4e0d\u53ef\u80fd\u5b9e\u73b0\u7684\u4e8b\u60c5\uff0c\u73b0\u5728\u5b8c\u5168\u4e0d\u662f\u4ec0\u4e48\u96be\u4e8b\u3002\u201d<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u201c\u57fa\u4e8e\u5e8f\u5217\u201d\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u4f7f\u7528\u4e86\u5927\u8bed\u8a00\u6a21\u578b\uff0c\u8fd9\u4e00\u6a21\u578b\u4e5f\u4f7f\u5f97\u804a\u5929\u673a\u5668\u4ebaChatGPT\u7b49\u5de5\u5177\u7684\u51fa\u73b0\u6210\u4e3a\u53ef\u80fd\u3002\u5982\u679c\u628a\u591a\u80bd\u770b\u4f5c\u201c\u6587\u5b57\u201d\uff0c\u800c\u86cb\u767d\u5e8f\u5217\u662f\u7531\u8fd9\u4e9b\u201c\u6587\u5b57\u201d\u7ec4\u6210\u7684\u6587\u4ef6\uff0c\u7b97\u6cd5\u901a\u8fc7\u5b66\u4e60\u771f\u5b9e\u4e16\u754c\u4e2d\u86cb\u767d\u8d28\u7684\u7ed3\u6784\uff0c\u53ef\u4ee5\u8bc6\u522b\u51fa\u5176\u4e2d\u8574\u542b\u7684\u6a21\u5f0f\u3002\u5df4\u585e\u7f57\u90a3\u5206\u5b50\u751f\u7269\u5b66\u7814\u7a76\u6240\u7684\u86cb\u767d\u8d28\u751f\u7269\u5316\u5b66\u5bb6\u8bfa\u57c3\u5229\u4e9a\u00b7\u8d39\u9c81\u5179<\/span>\uff08Noelia Ferruz\uff09<\/span>\u8868\u793a\uff1a\u201c\u5b83\u4eec\u771f\u7684\u5b66\u4f1a\u4e86\u80cc\u540e\u9690\u85cf\u7684\u8bed\u6cd5\u201d\u30022022\u5e74\uff0c\u5979\u7684\u56e2\u961f\u7814\u53d1\u4e86\u4e00\u4e2a\u88ab\u79f0\u4f5cProtGPT2\u7684\u7b97\u6cd5\uff0c\u8fd9\u4e00\u7b97\u6cd5\u80fd\u6301\u7eed\u8bbe\u8ba1\u8bb8\u591a\u5408\u6210\u86cb\u767d\uff0c\u7ecf\u8fc7\u8bd5\u9a8c\u9a8c\u8bc1\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u53ef\u4ee5\u7a33\u5b9a\u6298\u53e0[1]\u3002\u6b64\u5916\uff0c\u8d39\u62c9\u5179\u8fd8\u53c2\u4e0e\u7814\u53d1\u4e86\u53e6\u4e00\u4e2a\u53eb\u505aZymCTRL\u7684\u5de5\u5177\uff0c\u5b83\u80fd\u5b66\u4e60\u86cb\u767d\u5e8f\u5217\u548c\u529f\u80fd\u7684\u6570\u636e\uff0c\u8fdb\u800c\u57fa\u4e8e\u7814\u7a76\u9700\u6c42\u8bbe\u8ba1\u51fa\u4e0d\u540c\u4e8e\u5929\u7136\u9176\u7684\u4eba\u5de5\u9176[2]\u3002
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\u57fa\u4e8e\u5e8f\u5217\u7684\u65b9\u6cd5\u53ef\u4ee5\u57fa\u4e8e\u5df2\u6709\u86cb\u767d\u8d28\u7684\u7279\u5f81\uff0c\u8fdb\u884c\u6539\u9020\u5e76\u6784\u5efa\u65b0\u7684\u6846\u67b6\u3002\u4f46\u662f\uff0c\u5728\u5b9a\u5236\u86cb\u767d\u7684\u7ed3\u6784\u5143\u7d20\u6216\u7279\u5f81<\/span>\uff08\u5982\u4ee5\u53ef\u9884\u6d4b\u7684\u65b9\u5f0f\u4e0e\u7279\u5b9a\u9776\u6807\u7ed3\u5408\u7684\u80fd\u529b\uff09<\/span>\u65b9\u9762\uff0c\u5c31\u6ca1\u90a3\u4e48\u597d\u7528\u4e86\u3002\u5bf9\u4e8e\u8fd9\u7c7b\u60c5\u51b5\uff0c\u201c\u57fa\u4e8e\u7ed3\u6784\u201d<\/span>\uff08structure-based\uff09<\/span>\u7684\u8bbe\u8ba1\u65b9\u6cd5\u66f4\u52a0\u6709\u6548\uff0c\u57282023\u5e74\u8fd9\u4e00\u65b9\u6cd5\u4e5f\u53d6\u5f97\u4e86\u4ee4\u4eba\u77a9\u76ee\u7684\u8fdb\u5c55\u3002\u5176\u4e2d\u6700\u4e3a\u6210\u719f\u7684\u4e00\u4e9b\u65b9\u6cd5\u8fd0\u7528\u4e86\u201c\u6269\u6563\u201d<\/span>\uff08diffusion\uff09<\/span>\u6a21\u578b\uff0c\u8fd9\u7c7b\u6a21\u578b\u4e5f\u662fDALL-E\u7b49\u56fe\u5f62\u751f\u6210\u5de5\u5177\u7684\u57fa\u7840\u3002\u8fd9\u4e9b\u7b97\u6cd5\u5148\u662f\u88ab\u8bad\u7ec3\u4ece\u5927\u91cf\u771f\u5b9e\u86cb\u767d\u8d28\u7ed3\u6784\u4e2d\u53bb\u9664\u7531\u8ba1\u7b97\u673a\u751f\u6210\u7684\u566a\u97f3<\/span>\uff08noise\uff09<\/span>\uff0c\u5f53\u5b83\u4eec\u80fd\u6210\u529f\u5bf9\u771f\u5b9e\u7684\u7ed3\u6784\u5143\u7d20\u548c\u566a\u97f3\u8fdb\u884c\u5206\u8fa8\uff0c\u5b83\u4eec\u5c31\u53ef\u4ee5\u6784\u5efa\u51fa\u6ee1\u8db3\u7528\u6237\u9700\u6c42\u540c\u65f6\u53c8\u7b26\u5408\u751f\u7269\u5b66\u539f\u7406\u7684\u86cb\u767d\u7ed3\u6784\u3002<\/p>\n

\u8d1d\u514b\u5b9e\u9a8c\u5ba4\u7814\u53d1\u7684RFdiffusion\u8f6f\u4ef6[3]\u548c\u4f4d\u4e8e\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u8428\u9ed8\u7ef4\u5c14\u5e02\u7684Generate Biomedicines\u7814\u53d1\u7684Chroma[4]\u6b63\u662f\u8fd0\u7528\u8fd9\u79cd\u7b56\u7565\uff0c\u5e76\u53d6\u5f97\u4e86\u663e\u8457\u7684\u8fdb\u5c55\u3002\u4f8b\u5982\uff0c\u8d1d\u514b\u7684\u56e2\u961f\u6b63\u5728\u7528RFdiffusion\u8bbe\u8ba1\u5168\u65b0\u7684\u86cb\u767d\u8d28\uff0c\u8fd9\u79cd\u86cb\u767d\u80fd\u548c\u76ee\u6807\u9776\u70b9\u7d27\u5bc6\u7ed3\u5408\uff0c\u8d1d\u514b\u8bf4\uff0c\u90a3\u5c06\u662f\u201c\u80fd\u4e0e\u9776\u70b9\u8868\u9762\u5b8c\u7f8e\u543b\u5408\u201d\u7684\u8bbe\u8ba1\u3002\u800c\u65b0\u4e00\u4ee3\u7684\u201c\u5168\u539f\u5b50\u201d\u7248\u672cRFdiffusion[5]\uff0c\u8ba9\u7528\u6237\u53ef\u4ee5\u7528\u8ba1\u7b97\u673a\u8bbe\u8ba1\u51fa\u80fd\u591f\u7ed3\u5408DNA\u3001\u5c0f\u5206\u5b50\u751a\u81f3\u662f\u91d1\u5c5e\u79bb\u5b50\u7b49\u975e\u86cb\u767d\u9776\u70b9\u7684\u86cb\u767d\u8d28\u3002\u800c\u8fd9\u4e9b\u968f\u4e4b\u800c\u6765\u7684\u591a\u529f\u80fd\u6027\uff0c\u4e3a\u9176\u3001\u8f6c\u5f55\u8c03\u8282\u56e0\u5b50\u3001\u529f\u80fd\u6027\u751f\u7269\u6750\u6599\u548c\u5176\u4ed6\u7269\u8d28\u7684\u5de5\u7a0b\u8bbe\u8ba1\u5e26\u6765\u4e86\u5168\u65b0\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

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\u53ef\u516c\u5f00\u83b7\u53d6\u7684\u751f\u6210\u5f0fAI\u7b97\u6cd5\u6240\u53d6\u5f97\u7684\u7206\u53d1\u5f0f\u53d1\u5c55\uff0c\u8ba9\u6211\u4eec\u80fd\u8f7b\u677e\u5408\u6210\u8db3\u591f\u4ee5\u5047\u4e71\u771f\u7684\u56fe\u7247\u3001\u97f3\u9891\u548c\u89c6\u9891\u3002<\/span>\u5c3d\u7ba1\u751f\u6210\u7684\u5185\u5bb9\u53ef\u4ee5\u5a31\u4e50\u5927\u4f17\uff0c\u4f46\u662f\uff0c\u5728\u5730\u7f18\u653f\u6cbb\u51b2\u7a81\u9891\u53d1\u548c\u7f8e\u56fd\u603b\u7edf\u9009\u4e3e\u5373\u5c06\u6765\u4e34\u7684\u60c5\u51b5\u4e0b\uff0c\u901a\u8fc7\u64cd\u7eb5\u793e\u4ea4\u5a92\u4f53\uff0c\u5c06\u5176\u5f53\u4f5c\u6b66\u5668\u6765\u4e92\u76f8\u653b\u51fb\u7684\u4f8b\u5b50\u5c61\u89c1\u4e0d\u9c9c\u3002<\/span><\/section>\n<\/section>\n
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\u4e00\u79cd\u89e3\u51b3\u65b9\u6848\u662f\uff0c\u751f\u6210\u5f0fAI\u7814\u53d1\u4eba\u5458\u5728\u8fd9\u4e9b\u6a21\u578b\u8f93\u51fa\u7684\u7ed3\u679c\u4e2d\u5d4c\u5165\u9690\u85cf\u4fe1\u53f7\uff0c\u4e3aAI\u751f\u6210\u7684\u5185\u5bb9\u6253\u4e0a\u6c34\u5370\u3002\u5176\u4ed6\u65b9\u6848\u5219\u4fa7\u91cd\u4e8e\u5185\u5bb9\u672c\u8eab\u3002\u5415\u601d\u4f1f\u8868\u793a\uff0c\u4f8b\u5982\u4e00\u4e9b\u7ecf\u8fc7\u4f2a\u9020\u7684\u89c6\u9891\u5c06\u67d0\u516c\u4f17\u4eba\u7269\u7684\u9762\u90e8\u7279\u5f81\u66ff\u6362\u6210\u53e6\u4e00\u4e2a\u4eba\u7684\u9762\u90e8\u7279\u5f81\uff0c\u800c\u65b0\u7b97\u6cd5\u53ef\u4ee5\u5728\u6240\u66ff\u6362\u7279\u5f81\u7684\u8fb9\u7f18\u8bc6\u522b\u51fa\u4eba\u5de5\u7684\u75d5\u8ff9\u3002\u4e00\u4e2a\u4eba\u5916\u8033\u7684\u72ec\u7279\u8936\u76b1\u80fd\u63d0\u793a\u9762\u5bb9\u548c\u5934\u90e8\u5e76\u975e\u6765\u81ea\u540c\u4e00\u4e2a\u4eba\uff0c\u800c\u5728\u4e00\u4e9b\u5bf9\u53e3\u578b\u89c6\u9891\u4e2d\uff0c\u5f53\u4e8b\u4eba\u7684\u5634\u5df4\u88ab\u6570\u5b57\u5316\u5904\u7406\uff0c\u8bf4\u51fa\u4e00\u4e9b\u4ed6\u5e76\u672a\u8bf4\u8fc7\u7684\u8bdd\uff0c\u7259\u9f7f\u7684\u5f02\u5e38\u5c31\u53ef\u4ee5\u8d77\u5230\u63d0\u793a\u4f5c\u7528\u3002AI\u751f\u6210\u7684\u7167\u7247\u4e0d\u4ec5\u8bc6\u522b\u8d77\u4f86\u76f8\u5f53\u68d8\u624b\uff0c\u8fd8\u50cf\u201c\u6d3b\u9776\u201d\u4e00\u6837\u4e0d\u65ad\u53d8\u5316\u30022019 \u5e74\uff0c\u610f\u5927\u5229\u90a3\u4e0d\u52d2\u65af\u8d39\u5fb7\u91cc\u79d1\u4e8c\u4e16\u5927\u5b66\u7684\u5a92\u4f53\u53d6\u8bc1\u4e13\u5bb6\u8def\u6613\u838e\u00b7\u97e6\u5c14\u591a\u5229\u74e6<\/span>\uff08Luisa Verdoliva\uff09<\/span>\u534f\u52a9\u5f00\u53d1\u4e86FaceForensics++\uff0c\u53ef\u4ee5\u8bc6\u522b\u51e0\u6b3e\u5e38\u7528\u8f6f\u4ef6\u4f2a\u9020\u7684\u9762\u5b54[6]\u3002\u4f46\u56fe\u50cf\u53d6\u8bc1\u65b9\u6cd5\u5f80\u5f80\u9002\u7528\u4e8e\u7279\u5b9a\u5bf9\u8c61\u548c\u8f6f\u4ef6\uff0c\u5982\u4f55\u5c06\u5b83\u4eec\u901a\u7528\u5316\u662f\u4e2a\u6311\u6218\u3002\u97e6\u5c14\u591a\u5229\u74e6\u8bf4\uff0c\u201c\u4e0d\u5b58\u5728\u4e00\u4e2a\u901a\u7528\u7684\u68c0\u6d4b\u5668\u2014\u2014\u8fd9\u975e\u5e38\u56f0\u96be\u201d\u3002<\/p>\n

\u6b64\u5916\uff0c\u5982\u4f55\u5b9e\u65bd\u68c0\u6d4b\u4e5f\u662f\u4e2a\u6311\u6218\u3002\u7f8e\u56fd\u56fd\u9632\u90e8\u9ad8\u7ea7\u7814\u7a76\u8ba1\u5212\u5c40\u7684\u201c\u8bed\u4e49\u53d6\u8bc1\u201d<\/span>\uff08Semantic Forensics\uff09<\/span>\u8ba1\u5212\u5df2\u7ecf\u5f00\u53d1\u4e86\u4e00\u4e2a\u7528\u4e8e\u6df1\u5ea6\u4f2a\u9020\u5206\u6790\u7684\u5b9e\u7528\u5de5\u5177\u7bb1\uff0c\u4f46\u6b63\u5982\u300a\u81ea\u7136\u300b\u6742\u5fd7\u6240\u62a5\u9053\u7684\u90a3\u6837<\/span>\uff08\u89c1Nature 621, 676\u2013679; 2023\uff09<\/span>\uff0c\u5404\u5927\u793e\u4ea4\u5a92\u4f53\u7f51\u7ad9\u5e76\u6ca1\u6709\u5e38\u89c4\u4f7f\u7528\u8fd9\u4e00\u5de5\u5177\u3002\u800c\u6269\u5927\u4f7f\u7528\u8303\u56f4\u5c06\u4f1a\u6709\u52a9\u4e8e\u6293\u53d6\u66f4\u591a\u6570\u636e\uff0c\u4e3a\u6b64\uff0c\u5415\u601d\u4f1f\u56e2\u961f\u5f00\u53d1\u4e86DeepFake-O-Meter[7]\u3002\u8fd9\u662f\u4e00\u4e2a\u4e2d\u5fc3\u5316\u7684\u516c\u5171\u7b97\u6cd5\u5e93\uff0c\u53ef\u4ee5\u4ece\u4e0d\u540c\u89d2\u5ea6\u5206\u6790\u89c6\u9891\u5185\u5bb9\uff0c\u4ece\u800c\u8bc6\u522b\u51fa\u6df1\u5ea6\u4f2a\u9020\u7684\u5185\u5bb9\u3002\u8fd9\u4e9b\u8d44\u6e90\u5c06\u4f1a\u8d77\u5230\u5f88\u5927\u4f5c\u7528\uff0c\u4f46\u5728\u672a\u6765\u6570\u5e74\u5185\uff0c\u6211\u4eec\u5f88\u53ef\u80fd\u4ecd\u8981\u548cAI\u751f\u6210\u7684\u9519\u8bef\u4fe1\u606f\u7ee7\u7eed\u6597\u4e89\u3002<\/p>\n

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2023 \u5e74\u5e95\uff0c\u7f8e\u56fd\u548c\u82f1\u56fd\u7684\u76d1\u7ba1\u673a\u6784\u9996\u6b21\u6279\u51c6\u4e86\u57fa\u4e8e CRISPR \u7684\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\uff0c\u7528\u4e8e\u6cbb\u7597\u9570\u72b6\u7ec6\u80de\u75c5\u548c\u8f93\u8840\u4f9d\u8d56\u578b\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\uff0c\u8fd9\u662f\u57fa\u56e0\u7ec4\u7f16\u8f91\u4f5c\u4e3a\u4e34\u5e8a\u6cbb\u7597\u624b\u6bb5\u53d6\u5f97\u7684\u91cd\u5927\u80dc\u5229\u3002<\/span><\/section>\n<\/section>\n
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CRISPR \u53ca\u5176\u884d\u751f\u6280\u672f\u4f7f\u7528\u53ef\u7f16\u8f91\u7684\u77ed\u94feRNA\uff0c\u5c06Cas9\u7b49DNA\u5185\u5207\u9176\u5f15\u5bfc\u5230\u7279\u5b9a\u7684\u57fa\u56e0\u7ec4\u4f4d\u70b9\u3002\u5b83\u4eec\u662f\u5b9e\u9a8c\u5ba4\u7814\u7a76\u4e2d\u7684\u5e38\u89c4\u624b\u6bb5\uff0c\u7528\u4e8e\u5173\u95ed\u6709\u7f3a\u9677\u7684\u57fa\u56e0\u5e76\u5f15\u5165\u5fae\u5c0f\u7684\u5e8f\u5217\u53d8\u5316\u3002\u7cbe\u786e\u3001\u7a0b\u5e8f\u5316\u5730\u63d2\u5165\u8de8\u8d8a\u6570\u5343\u4e2a\u6838\u82f7\u9178\u7684\u8f83\u5927DNA\u5e8f\u5217\u975e\u5e38\u56f0\u96be\uff0c\u4f46\u65b0\u5174\u6280\u672f\u6216\u80fd\u8ba9\u79d1\u5b66\u5bb6\u66ff\u6362\u6709\u7f3a\u9677\u57fa\u56e0\u7684\u5173\u952e\u7247\u6bb5\u6216\u63d2\u5165\u529f\u80fd\u5b8c\u5168\u6b63\u5e38\u7684\u57fa\u56e0\u5e8f\u5217\u3002\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u65af\u5766\u798f\u5927\u5b66\u7684\u5206\u5b50\u9057\u4f20\u5b66\u5bb6\u4e1b\u4e50<\/span>\uff08Le Cong\uff09<\/span>\u548c\u540c\u4e8b\u4eec\u6b63\u5728\u7814\u7a76\u5355\u94fe\u9000\u706b\u86cb\u767d<\/span>\uff08SSAPs\uff09<\/span>\u2014\u2014\u4e00\u79cd\u75c5\u6bd2\u6765\u6e90\u7684\u5206\u5b50\uff0c\u53ef\u4ee5\u4ecb\u5bfc DNA \u91cd\u7ec4\u3002\u4e0e\u53bb\u9664\u4e86Cas9\u7684DNA\u526a\u5207\u529f\u80fd\u7684CRISPR-Cas\u7cfb\u7edf\u76f8\u7ed3\u5408\u65f6\uff0c\u8fd9\u4e9bSSAPs\u5c31\u80fd\u5c06\u957f\u8fbe2\u5343\u4e2a\u78b1\u57fa\u5bf9\u7684DNA\u7247\u6bb5\u7cbe\u51c6\u63d2\u5165\u4eba\u7c7b\u57fa\u56e0\u7ec4\u3002<\/p>\n

\u5176\u4ed6\u65b9\u6cd5\u5219\u501f\u52a9\u4e86\u5148\u5bfc\u7f16\u8f91<\/span>\uff08prime editing\uff09<\/span>\uff0c\u8fd9\u662f\u4e00\u79cd\u57fa\u4e8eCRISPR\u7684\u65b9\u6cd5\uff0c\u6765\u5f15\u5165\u5145\u5f53\u201c\u7740\u9646\u57ab\u201d\u7684\u77ed\u5e8f\u5217\u3002\u8fd9\u4e9b\u5e8f\u5217\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u62db\u52df\u9176\uff0c\u8fdb\u800c\u5c06\u5927\u7247\u6bb5DNA\u7cbe\u51c6\u62fc\u63a5\u5230\u57fa\u56e0\u7ec4\u4e2d\u3002\u4f8b\u5982\uff0c2022 \u5e74\uff0c\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u7684\u57fa\u56e0\u7ec4\u5de5\u7a0b\u5e08\u5965\u9a6c\u5c14\u00b7\u963f\u5e03\u8fbe\u8036<\/span>\uff08Omar Abudayyeh\uff09<\/span>\u3001\u4e54\u7eb3\u68ee\u00b7\u53e4\u817e\u4f2f\u683c<\/span>\uff08Jonathan Gootenberg\uff09<\/span>\u548c\u4ed6\u4eec\u7684\u540c\u4e8b\uff0c\u9996\u6b21\u63cf\u8ff0\u4e86\u901a\u8fc7\u7279\u5b9a\u4f4d\u70b9\u9776\u5411\u5143\u4ef6\u8fdb\u884c\u7f16\u8f91\u63d2\u5165\u7684\u65b9\u6cd5<\/span>\uff08PASTE\uff09<\/span>\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4ee5\u7cbe\u786e\u63d2\u5165\u957f\u8fbe3\u4e076\u5343\u4e2a\u78b1\u57fa\u5bf9\u7684 DNA\u5927\u7247\u6bb5[8]\u3002\u4e1b\u4e50\u8bf4\uff0cPASTE\u7279\u522b\u9002\u7528\u4e8e\u5bf9\u4f53\u5916\u57f9\u517b\u7684\u75c5\u4eba\u7ec6\u80de\u8fdb\u884c\u4fee\u9970\uff0c\u800c\u4e14\u4f5c\u4e3aPASTE\u57fa\u7840\u7684\u5148\u5bfc\u7f16\u8f91\u6280\u672f\u5df2\u7ecf\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\u3002\u4f46\u82e5\u662f\u5728\u4eba\u4f53\u5185\u8fdb\u884c\u7ec6\u80de\u4fee\u9970\uff0cSSAP\u4e5f\u8bb8\u80fd\u63d0\u4f9b\u4e00\u79cd\u66f4\u52a0\u7b80\u6d01\u7684\u65b9\u6848\uff1aPASTE\u9700\u8981\u4e09\u79cd\u4e0d\u540c\u7684\u75c5\u6bd2\u8f7d\u4f53\u6765\u9012\u9001\uff0c\u4e0e\u7531\u4e24\u90e8\u5206\u7ec4\u6210\u7684SSAP\u7cfb\u7edf\u76f8\u6bd4\uff0c\u662f\u4e2a\u8f83\u4e3a\u7b28\u91cd\u7684\u7cfb\u7edf\uff0c\u800c\u8fd9\u53ef\u80fd\u4f1a\u5f71\u54cd\u5176\u7f16\u8f91\u6548\u7387\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5373\u4fbf\u662f\u6548\u7387\u76f8\u5bf9\u8f83\u4f4e\u7684\u57fa\u56e0\u7f6e\u6362\u7b56\u7565\u4e5f\u8db3\u4ee5\u51cf\u8f7b\u8bb8\u591a\u9057\u4f20\u75c5\u7684\u75c7\u72b6\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5e76\u4e0d\u53ea\u662f\u5bf9\u4eba\u7c7b\u5065\u5eb7\u6709\u91cd\u5927\u610f\u4e49\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u7684\u9ad8\u5f69\u971e\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u51fa\u4e86PrimeRoot\uff0c\u8fd9\u79cd\u65b9\u6cd5\u4e5f\u501f\u52a9\u4e86\u5148\u5bfc\u7f16\u8f91\u5c06\u9176\u5f15\u5bfc\u81f3\u7279\u5b9a\u9776\u70b9\uff0c\u8fdb\u800c\u63d2\u5165\u957f\u8fbe2\u4e07\u4e2a\u78b1\u57fa\u5bf9\u7684DNA\u7247\u6bb5\uff0c\u8fd9\u5df2\u5728\u6c34\u7a3b\u548c\u7389\u7c73\u4e2d\u6210\u529f\u5e94\u7528[9]\u3002\u9ad8\u5f69\u971e\u8ba4\u4e3a\uff0c\u8fd9\u9879\u6280\u672f\u53ef\u5e7f\u6cdb\u5e94\u7528\u4e8e\u519c\u4f5c\u7269\uff0c\u8ba9\u5176\u5177\u6709\u6297\u75c5\u548c\u6297\u75c5\u539f\u4f53\u80fd\u529b\uff0c\u6301\u7eed\u63a8\u52a8\u57fa\u4e8eCRISPR\u7684\u690d\u7269\u57fa\u56e0\u7ec4\u7f16\u8f91\u7684\u521b\u65b0\u6d6a\u6f6e\u3002\u5979\u8bf4\uff0c\u201c\u6211\u76f8\u4fe1\u8fd9\u9879\u6280\u672f\u6700\u7ec8\u53ef\u4ee5\u5e94\u7528\u4e8e\u4efb\u4f55\u4e00\u79cd\u690d\u7269\u201d\u3002<\/p>\n

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\u5e15\u7279\u00b7\u8d1d\u5185\u7279<\/span>\uff08Pat Bennett\uff09<\/span>\u7684\u8bed\u901f\u6bd4\u4e00\u822c\u4eba\u6162\uff0c\u6709\u65f6\u8fd8\u4f1a\u7528\u8bcd\u4e0d\u5f53\u3002\u4f46\u8003\u8651\u5230\u8fd0\u52a8\u795e\u7ecf\u5143\u75be\u75c5*\u66fe\u4e00\u5ea6\u8ba9\u5979\u65e0\u6cd5\u7528\u8bf4\u8bdd\u6765\u8868\u8fbe\u81ea\u5df1\uff0c\u5982\u4eca\u8fd9\u6837\u5df2\u7ecf\u662f\u76f8\u5f53\u5927\u7684\u8fdb\u6b65\u3002<\/span><\/section>\n

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*\u8bd1\u6ce8\uff1a\u53c8\u79f0\u808c\u840e\u7f29\u6027\u5d74\u9ad3\u4fa7\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\uff0c\u5373\u5927\u4f17\u4fd7\u77e5\u7684\u6e10\u51bb\u75c7\uff0c\u521d\u59cb\u75c7\u72b6\u901a\u5e38\u5305\u62ec\u624b\u81c2\u6216\u817f\u90e8\u808c\u8089\u62bd\u6410\u548c\u65e0\u529b\u3001\u541e\u54bd\u56f0\u96be\u6216\u8a00\u8bed\u4e0d\u6e05\uff0c\u6700\u7ec8\u4f1a\u5bfc\u81f4\u65e0\u6cd5\u63a7\u5236\u79fb\u52a8\u3001\u8bf4\u8bdd\u3001\u8fdb\u98df\u548c\u547c\u5438\u6240\u9700\u7684\u808c\u8089\u3002<\/span><\/section>\n<\/section>\n<\/blockquote>\n<\/section>\n
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\u8d1d\u5185\u7279\u7684\u5eb7\u590d\u5f97\u76ca\u4e8e\u4e00\u6b3e\u5148\u8fdb\u7684\u8111\u673a\u63a5\u53e3\u8bbe\u5907\uff0c\u7531\u65af\u5766\u798f\u5927\u5b66\u7684\u795e\u7ecf\u79d1\u5b66\u5bb6\u5f17\u6717\u897f\u65af\u00b7\u5a01\u5229\u7279<\/span>\uff08Francis Willett\uff09<\/span>\u548c\u4ed6\u5728\u7f8e\u56fdBrainGate\u7814\u53d1\u96c6\u56e2\u7684\u540c\u4e8b\u6240\u5f00\u53d1[10]\u3002\u5a01\u5229\u7279\u548c\u540c\u4e8b\u5728\u8d1d\u5185\u7279\u7684\u5927\u8111\u4e2d\u690d\u5165\u7535\u6781\u4ee5\u8ffd\u8e2a\u795e\u7ecf\u5143\u6d3b\u52a8\uff0c\u7136\u540e\u8bad\u7ec3\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5\u5c06\u8fd9\u4e9b\u4fe1\u53f7\u8f6c\u5316\u4e3a\u8bed\u8a00\u3002\u7ecf\u8fc7\u51e0\u5468\u7684\u8bad\u7ec3\uff0c\u8d1d\u5185\u7279\u6bcf\u5206\u949f\u80fd\u8bf4\u51fa\u591a\u8fbe62\u4e2a\u5355\u8bcd\uff0c\u800c\u8fd9\u4e00\u8bbe\u5907\u7684\u8bcd\u6c47\u91cf\u9ad8\u8fbe12.5\u4e07\u2014\u2014\u662f\u4e00\u822c\u82f1\u8bed\u4f7f\u7528\u8005\u8bcd\u6c47\u91cf\u7684\u4e24\u500d\u591a\u3002\u751f\u7269\u5de5\u7a0b\u5e08\u8a79\u59ae\u5f17\u00b7\u79d1\u6797\u683c<\/span>\uff08Jennifer Collinger\uff09<\/span>\u5728\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5dde\u5339\u5179\u5821\u5927\u5b66\u8fdb\u884cBCI\u6280\u672f\u7814\u53d1\uff0c\u5979\u8bf4\uff1a\u201c\u4ed6\u4eec\u4ea4\u6d41\u7684\u901f\u5ea6\u5b9e\u5728\u662f\u592a\u60ca\u4eba\u4e86\u201d\u3002

\u8fc7\u53bb\u51e0\u5e74\u9664\u4e86BrainGate\u7684\u8bd5\u9a8c\uff0c\u8fd8\u6709\u5176\u4ed6\u51e0\u9879\u7814\u7a76\uff0c\u8fd9\u4e9b\u7814\u7a76\u8bc1\u660e\u4e86BCI\u6280\u672f\u53ef\u4ee5\u5e2e\u52a9\u6709\u4e25\u91cd\u795e\u7ecf\u635f\u4f24\u7684\u60a3\u8005\uff0c\u8ba9\u4ed6\u4eec\u91cd\u65b0\u83b7\u5f97\u5931\u53bb\u7684\u6280\u80fd\uff0c\u4ece\u800c\u51cf\u8f7b\u5bf9\u65c1\u4eba\u7684\u4f9d\u8d56\u3002\u5229\u00b7\u970d\u8d6b\u4f2f\u683c<\/span>\uff08Leigh Hochberg\uff09<\/span>\u662f\u5e03\u6717\u5927\u5b66\u7684\u795e\u7ecf\u5b66\u5bb6\uff0c\u540c\u65f6\u4e5f\u662fBrainGate\u7684\u8d1f\u8d23\u4eba\u3002\u4ed6\u8bf4\uff0c\u5176\u4e2d\u4e00\u4e9b\u8fdb\u5c55\u6e90\u4e8e\u6211\u4eec\u5bf9\u5404\u7c7b\u795e\u7ecf\u75be\u75c5\u60a3\u8005\u5927\u8111\u7684\u529f\u80fd\u795e\u7ecf\u89e3\u5256\u5b66\u77e5\u8bc6\u7684\u4e0d\u65ad\u79ef\u7d2f\u3002\u4ed6\u4e5f\u8865\u5145\u9053\uff0c\u673a\u5668\u5b66\u4e60\u6240\u9a71\u52a8\u7684\u5206\u6790\u65b9\u6cd5\u6781\u5927\u5730\u62d3\u5bbd\u4e86\u8fd9\u4e9b\u77e5\u8bc6\uff0c\u8fd9\u5c06\u6301\u7eed\u63ed\u793a\u5982\u4f55\u624d\u80fd\u66f4\u597d\u5730\u653e\u7f6e\u7535\u6781\uff0c\u4ee5\u53ca\u5982\u4f55\u66f4\u597d\u5730\u89e3\u7801\u7535\u6781\u6240\u91c7\u96c6\u5230\u7684\u4fe1\u53f7\u3002

\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u5728\u5e94\u7528\u57fa\u4e8e\u4eba\u5de5\u667a\u80fd\u7684\u8bed\u8a00\u6a21\u578b\u6765\u52a0\u5feb\u89e3\u8bfb\u60a3\u8005\u8bd5\u56fe\u8868\u8fbe\u7684\u5185\u5bb9\u2014\u2014\u672c\u8d28\u4e0a\u5c31\u662f\u5927\u8111\u7684\u201c\u81ea\u52a8\u8865\u5168\u201d\u3002\u8fd9\u662f\u5a01\u5229\u7279\u7814\u7a76\u7684\u6838\u5fc3\u5185\u5bb9\uff0c\u4e5f\u662f\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u795e\u7ecf\u5916\u79d1\u533b\u751f\u7231\u5fb7\u534e\u00b7\u5f20<\/span>\uff08Edward Chang\uff09<\/span>\u9886\u5bfc\u7684\u56e2\u961f\u7684\u53e6\u4e00\u9879\u7814\u7a76\u7684\u6838\u5fc3\u5185\u5bb9[11]\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0cBCI\u795e\u7ecf\u5047\u4f53\u8ba9\u4e00\u4f4d\u56e0\u4e2d\u98ce\u800c\u65e0\u6cd5\u8bf4\u8bdd\u7684\u5987\u5973\u4ee5\u6bcf\u5206\u949f78\u4e2a\u5355\u8bcd\u7684\u901f\u5ea6\u8fdb\u884c\u4ea4\u6d41\u2014\u2014\u5927\u7ea6\u662f\u82f1\u8bed\u4f7f\u7528\u8005\u5e73\u5747\u8bf4\u8bdd\u901f\u5ea6\u7684\u4e00\u534a\uff0c\u4f46\u6bd4\u5979\u4ee5\u524d\u4f7f\u7528\u7684\u8bed\u8a00\u8f85\u52a9\u8bbe\u5907\u5feb\u4e86\u4e94\u500d\u591a\u3002\u8be5\u9886\u57df\u5728\u5176\u4ed6\u65b9\u9762\u4e5f\u53d6\u5f97\u4e86\u8fdb\u5c55\u30022021 \u5e74\uff0c\u79d1\u6797\u683c\u548c\u7f8e\u56fd\u5339\u5179\u5821\u5927\u5b66\u7684\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5e08\u7f57\u4f2f\u7279\u00b7\u9ad8\u7279<\/span>\uff08Robert Gaunt\uff09<\/span>\u5c06\u7535\u6781\u690d\u5165\u4e00\u540d\u56db\u80a2\u762b\u75ea\u8005\u7684\u8fd0\u52a8\u548c\u8eaf\u4f53\u611f\u89c9\u76ae\u5c42\uff0c\u8ba9\u4ed6\u80fd\u591f\u5feb\u901f\u3001\u7cbe\u786e\u5730\u63a7\u5236\u5e26\u6709\u89e6\u89c9\u53cd\u9988\u7684\u673a\u68b0\u81c2[12]\u3002\u6b64\u5916\uff0cBrainGate\u548c\u8377\u5170\u4e4c\u5fb7\u52d2\u652f\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u6b63\u5728\u5404\u81ea\u5f00\u5c55\u72ec\u7acb\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u4f4d\u4e8e\u7ebd\u7ea6\u5e03\u9c81\u514b\u6797\u7684BCI\u516c\u53f8Synchron\u4e5f\u5728\u6d4b\u8bd5\u4e00\u4e2a\u80fd\u8ba9\u762b\u75ea\u8005\u63a7\u5236\u8ba1\u7b97\u673a\u7684\u7cfb\u7edf\u2014\u2014\u8fd9\u662f\u9996\u4e2a\u5de5\u4e1a\u754c\u51fa\u8d44\u7684BCI\u4eea\u5668\u4e34\u5e8a\u8bd5\u9a8c\u3002

\u4f5c\u4e3a\u4e00\u540d\u91cd\u75c7\u76d1\u62a4\u4e13\u5bb6\uff0c\u970d\u8d6b\u4f2f\u683c\u8feb\u5207\u5e0c\u671b\u5c06\u8fd9\u4e9b\u6280\u672f\u5e26\u7ed9\u6b8b\u969c\u60c5\u51b5\u6700\u4e3a\u4e25\u91cd\u7684\u75c5\u4eba\u3002\u968f\u7740BCI\u529f\u80fd\u4e0d\u65ad\u53d1\u5c55\uff0c\u4ed6\u770b\u5230\u4e86\u5b83\u5728\u6cbb\u7597\u4e2d\u5ea6\u8ba4\u77e5\u969c\u788d\u4ee5\u53ca\u60c5\u7eea\u969c\u788d\u7b49\u7cbe\u795e\u75be\u75c5\u4e2d\u7684\u6f5c\u529b\u3002\u4ed6\u8bf4\uff1a\u201c\u57fa\u4e8e\u8111\u673a\u63a5\u53e3\u7684\u95ed\u73af\u795e\u7ecf\u8c03\u8282\u7cfb\u7edf\u53ef\u4ee5\u4e3a\u5f88\u591a\u4eba\u63d0\u4f9b\u6781\u5927\u7684\u5e2e\u52a9\u201d\u3002<\/span><\/section>\n

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2014\u5e74\uff0c\u65af\u7279\u51e1\u00b7\u9ed1\u5c14<\/span>\uff08Stefan Hell\uff09<\/span>\u3001\u57c3\u91cc\u514b\u00b7\u8d1d\u9f50\u683c<\/span>\uff08Eric Betzig\uff09<\/span>\u548c\u5a01\u5ec9\u00b7\u83ab\u7eb3<\/span>\uff08William Moerner\uff09<\/span>\u56e0\u6253\u7834\u4e86\u9650\u5236\u5149\u5b66\u663e\u5fae\u955c\u7a7a\u95f4\u5206\u8fa8\u7387\u7684\u201c\u884d\u5c04\u6781\u9650\u201d<\/span>\uff08diffraction limit\uff09<\/span>\uff0c\u5171\u540c\u83b7\u5f97\u4e86\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u3002\u968f\u4e4b\u800c\u6765\u7684\u7eb3\u7c73\u7ea7\u7cbe\u786e\u89c6\u89d2\uff0c\u4e3a\u5206\u5b50\u5c3a\u5ea6\u6210\u50cf\u5b9e\u9a8c\u5f00\u8f9f\u4e86\u5e7f\u9614\u7684\u524d\u666f\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u4e00\u4e9b\u7814\u7a76\u4eba\u5458\u4ecd\u671f\u5f85\u83b7\u5f97\u66f4\u597d\u7684\u6210\u50cf\u6548\u679c\u2014\u2014\u5e76\u4e14\u4ed6\u4eec\u6b63\u53d6\u5f97\u98de\u901f\u8fdb\u5c55\u3002\u62c9\u5c14\u592b\u00b7\u5bb9\u66fc<\/span>\uff08Ralf Jungmann\uff09<\/span>\u662f\u5fb7\u56fd\u666e\u62c9\u5185\u683c\u9a6c\u514b\u65af\u00b7\u666e\u6717\u514b\u751f\u7269\u5316\u5b66\u7814\u7a76\u6240\u7eb3\u7c73\u6280\u672f\u7814\u7a76\u5458\uff0c\u5728\u8c08\u5230\u4e00\u79cd\u5728\u539f\u5b50\u7ea7\u5206\u8fa8\u7387\u4e4b\u4e0a\u91cd\u5efa\u86cb\u767d\u7684\u65b9\u6cd5\u65f6\uff0c\u4ed6\u8bf4\uff1a\u201c\u6211\u4eec\u6b63\u5728\u52aa\u529b\u7f29\u5c0f\u8d85\u5206\u8fa8\u7387\u663e\u5fae\u955c\u4e0e\u51b7\u51bb\u7535\u955c\u7b49\u7ed3\u6784\u751f\u7269\u5b66\u6280\u672f\u4e4b\u95f4\u7684\u5dee\u8ddd\u201d\u3002<\/span><\/section>\n<\/section>\n
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2022\u5e74\u5e95\uff0c\u9ed1\u5c14\u4ee5\u53ca\u4ed6\u5728\u54e5\u5ef7\u6839\u9a6c\u514b\u65af\u00b7\u666e\u6717\u514b\u591a\u5b66\u79d1\u79d1\u5b66\u7814\u7a76\u6240\u7684\u56e2\u961f\u9996\u6b21\u6d89\u8db3\u4e86\u8fd9\u4e00\u9886\u57df\u3002\u4ed6\u4eec\u91c7\u7528\u7684\u65b9\u6cd5\u540d\u4e3aMINSTED\uff0c\u5229\u7528\u4e13\u95e8\u7684\u5149\u5b66\u663e\u5fae\u955c\uff0c\u8fd9\u79cd\u65b9\u6cd5\u80fd\u4ee52.3\u57c3*<\/span>\uff08\u7ea6\u56db\u5206\u4e4b\u4e00\u7eb3\u7c73\uff09<\/span>\u7684\u7cbe\u5ea6\u5206\u8fa8\u5355\u4e2a\u8367\u5149\u6807\u7b7e[13]\u3002<\/p>\n

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*\u8bd1\u6ce8\uff1a\u57c3\u65af\u7279\u6717\uff0c\u7b80\u79f0\u57c3\uff0c\u7b26\u53f7\u00c5\uff0c\u662f\u4e00\u4e2a\u957f\u5ea6\u8ba1\u91cf\u5355\u4f4d\uff0c\u4e00\u57c3\u662f\u5341\u5206\u4e4b\u4e00\u7eb3\u7c73\uff08\u53731 \u00c5 = 10\u201310 m= 0.1 nm\uff09\u3002<\/span><\/section>\n<\/section>\n<\/blockquote>\n


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RESI\u4e28Max Iglesias, Max Planck Institute of Biochemistry<\/span><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5fb7\u56fd\u54e5\u5ef7\u6839\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u795e\u7ecf\u79d1\u5b66\u5bb6\u963f\u91cc\u00b7\u6c99\u4f0a\u5e03<\/span>\uff08Ali Shaib\uff09<\/span>\u548c\u897f\u5c14\u7ef4\u5965\u00b7\u91cc\u4f50\u5229<\/span>\uff08Silvio Rizzoli\uff09<\/span>\u9886\u5bfc\u7684\u56e2\u961f\u5f00\u53d1\u4e86\u201c\u4e00\u6b65\u7eb3\u7c73\u7ea7\u6269\u5c55\u201d<\/span>\uff08ONE\uff09<\/span>\u663e\u5fae\u955c\u6280\u672f\uff0c\u867d\u7136\u8fd8\u4e0d\u80fd\u8fbe\u5230\u4e0a\u8ff0\u7684\u9ad8\u5206\u8fa8\u7387\uff0c\u4e0d\u8fc7\uff0c\u524d\u6240\u672a\u6709\u7684\u662f\uff0cONE\u663e\u5fae\u955c\u505a\u5230\u4e86\u76f4\u63a5\u5bf9\u5355\u4e2a\u86cb\u767d\u8d28\u548c\u591a\u86cb\u767d\u590d\u5408\u7269\u7684\u7cbe\u7ec6\u7ed3\u6784\u8fdb\u884c\u6210\u50cf[15]\uff0c\u4e0d\u4ec5\u662f\u5206\u79bb\u7eaf\u5316\u7684\u86cb\u767d\uff0c\u8fd8\u53ef\u5e94\u7528\u4e8e\u80de\u5185\u86cb\u767d\u8d28\u3002<\/p>\n

ONE\u57fa\u4e8e\u81a8\u80c0\u663e\u5fae\u6210\u50cf\u6280\u672f\uff0c\u5c06\u6837\u54c1\u4e2d\u7684\u86cb\u767d\u8d28\u4e0e\u6c34\u51dd\u80f6\u57fa\u8d28\u8fdb\u884c\u5316\u5b66\u8026\u5408\uff0c\u518d\u5c06\u86cb\u767d\u8d28\u9176\u89e3\uff0c\u968f\u540e\u8ba9\u6c34\u51dd\u80f6\u7684\u4f53\u79ef\u81a8\u80c0\u52301000\u500d\u3002\u86cb\u767d\u788e\u7247\u56e0\u6b64\u5728\u5404\u4e2a\u65b9\u5411\u4e0a\u88ab\u5747\u5300\u62c9\u4f38\uff0c\u65e2\u4fdd\u7559\u4e86\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u53c8\u8ba9\u4f7f\u7528\u8005\u80fd\u591f\u4f7f\u7528\u5e38\u89c1\u5171\u805a\u7126\u663e\u5fae\u955c\uff0c\u5206\u8fa8\u51fa\u539f\u672c\u4ec5\u4ec5\u76f8\u9694\u51e0\u7eb3\u7c73\u7684\u7279\u5f81\u3002\u5728\u8c08\u5230\u86cb\u767d\u8d28\u7684\u7279\u5f81\u5f62\u72b6\u65f6\uff0c\u91cc\u4f50\u5229\u8bf4\uff1a\u201c\u6211\u4eec\u63d0\u53d6\u6297\u4f53\uff0c\u5c06\u5b83\u4eec\u653e\u5165\u51dd\u80f6\u4e2d\uff0c\u5728\u81a8\u80c0\u540e\u5bf9\u5b83\u4eec\u8fdb\u884c\u6807\u8bb0\uff0c\u7ed3\u679c\u53d1\u73b0\uff0c\u2018\u54c7\u2014\u2014\u53ef\u4ee5\u770b\u5230Y\u5f62\u72b6\uff01\u2019\u201d<\/p>\n

\u91cc\u4f50\u5229\u8bf4\uff0cONE\u663e\u5fae\u955c\u6280\u672f\u53ef\u4ee5\u5e2e\u52a9\u4eba\u4eec\u6df1\u5165\u4e86\u89e3\u5448\u73b0\u52a8\u6001\u6784\u8c61\u7684\u751f\u7269\u5206\u5b50\uff0c\u6216\u662f\u901a\u8fc7\u8840\u6db2\u6837\u672c\u5bf9\u5e15\u91d1\u68ee\u75c5\u7b49\u86cb\u767d\u8d28\u9519\u6784\u75be\u75c5\u8fdb\u884c\u53ef\u89c6\u5316\u8bca\u65ad\u3002\u5bb9\u66fc\u540c\u6837\u5bf9RESI\u7684\u6f5c\u529b\u5145\u6ee1\u6fc0\u60c5\u3002\u5b83\u53ef\u4ee5\u7528\u6765\u8bb0\u5f55\u75be\u75c5\u6216\u836f\u7269\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5355\u4e2a\u86cb\u767d\u8d28\u91cd\u7ec4\uff0c\u751a\u81f3\u6709\u53ef\u80fd\u653e\u5230\u66f4\u5c0f\u7684\u8303\u56f4\u3002\u201c\u4e5f\u8bb8\u8fd9\u8fd8\u4e0d\u662f\u7a7a\u95f4\u5206\u8fa8\u7387\u6781\u9650\u7684\u7ec8\u70b9\u201d\uff0c\u5bb9\u66fc\u8bf4\uff0c\u201c\u8fd8\u53ef\u4ee5\u66f4\u8fdb\u4e00\u6b65\u3002\u201d
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\u5982\u679c\u4f60\u60f3\u5c31\u8fd1\u627e\u4e00\u5bb6\u5496\u5561\u9986\uff0c\u8c37\u6b4c\u5730\u56fe\u53ef\u4ee5\u627e\u5230\u9644\u8fd1\u7684\u95e8\u5e97\uff0c\u5e76\u544a\u8bc9\u4f60\u8be5\u600e\u4e48\u8d70\u3002<\/span>\u4eba\u4f53\u7684\u5730\u5f62\u5219\u8981\u590d\u6742\u5f97\u591a\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u80fd\u4e0e\u4e4b\u76f8\u5ab2\u7f8e\u7684\u5bfc\u822a\u4f53\u7edf\u3002<\/span>\u4e0d\u8fc7\uff0c\u5728\u5355\u7ec6\u80de\u5206\u6790\u548c\u201c\u7a7a\u95f4\u7ec4\u5b66\u201d\u65b9\u6cd5\u7684\u63a8\u52a8\u4e0b\uff0c\u5404\u79cd\u7ec6\u80de\u56fe\u8c31\u8ba1\u5212\u6b63\u5728\u53d6\u5f97\u8fdb\u5c55\uff0c\u5c06\u5f88\u5feb\u4e3a\u751f\u7269\u5b66\u5bb6\u5e26\u6765\u4ed6\u4eec\u6e34\u671b\u5df2\u4e45\u7684\u8de8\u7ec4\u7ec7\u7ec6\u80de\u56fe\u8c31\u3002<\/span><\/section>\n<\/section>\n
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\u5728\u8fd9\u4e9b\u8ba1\u5212\u4e2d\uff0c\u89c4\u6a21\u6700\u5927\u7684\u2014\u2014\u6216\u8bb8\u4e5f\u662f\u6700\u5177\u91ce\u5fc3\u7684\u2014\u2014\u662f\u4eba\u7c7b\u7ec6\u80de\u56fe\u8c31<\/span>\uff08Human Cell Atlas\uff09<\/span>\u30022016\u5e74\uff0c\u82f1\u56fd\u8f9b\u514b\u65af\u987f\u7ef4\u5eb7\u6851\u683c\u7814\u7a76\u6240\u7684\u7ec6\u80de\u751f\u7269\u5b66\u5bb6\u838e\u62c9\u00b7\u6cf0\u514b\u66fc<\/span>\uff08Sarah Teichmann\uff09<\/span>\u548c\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5357\u65e7\u91d1\u5c71\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\u57fa\u56e0\u6cf0\u514b\u7684\u7814\u7a76\u4e0e\u65e9\u671f\u5f00\u53d1\u90e8\u8d1f\u8d23\u4eba\u963f\u7ef4\u592b\u00b7\u96f7\u683c\u592b<\/span>\uff08Aviv Regev\uff09<\/span>\u5171\u540c\u53d1\u8d77\u4e86\u8be5\u9879\u8054\u5408\u8ba1\u5212\u3002\u8be5\u9879\u76ee\u7ec4\u5927\u7ea6\u67093000\u540d\u79d1\u5b66\u5bb6\uff0c\u4ed6\u4eec\u6765\u81ea\u8fd1100\u4e2a\u56fd\u5bb6\uff0c\u7814\u7a76\u5bf9\u8c61\u5219\u662f\u6765\u81ea1\u4e07\u540d\u6350\u732e\u8005\u7684\u7ec4\u7ec7\u3002\u4e0d\u8fc7\uff0c\u7ec6\u80de\u56fe\u8c31\u548c\u5206\u5b50\u56fe\u8c31\u7684\u76f8\u4e92\u4ea4\u53c9\u6784\u6210\u4e86\u4e00\u4e2a\u5de8\u5927\u7684\u751f\u6001\u7cfb\u7edf\uff0c\u4eba\u7c7b\u7ec6\u80de\u56fe\u8c31\u53ea\u662f\u5176\u4e2d\u7684\u4e00\u90e8\u5206\u3002\u4eba\u7c7b\u751f\u7269\u5206\u5b50\u56fe\u8c31\u8ba1\u5212<\/span>\uff08HuBMAP\uff09<\/span>\u548c\u901a\u8fc7\u63a8\u8fdb\u521b\u65b0\u795e\u7ecf\u6280\u672f\u8fdb\u884c\u5927\u8111\u7814\u7a76\u00ae<\/span> (BRAIN) <\/span>\u5021\u8bae\u7684\u7ec6\u80de\u666e\u67e5\u8054\u76df<\/span>\uff08BICCN\uff09<\/span>\u4e5f\u96b6\u5c5e\u4e8e\u5176\u4e2d\uff0c\u8fd9\u4e24\u4e2a\u8ba1\u5212\u5747\u7531\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u8d44\u52a9\u3002\u6b64\u5916\uff0c\u8fd8\u6709\u7531\u534e\u76db\u987f\u5dde\u897f\u96c5\u56fe\u5e02\u827e\u4f26\u7814\u7a76\u6240\u8d44\u52a9\u7684\u827e\u4f26\u8111\u7ec6\u80de\u56fe\u8c31<\/span>\uff08Allen Brain Cell Atlas\uff09<\/span>\u3002<\/span><\/section>\n

\u636e\u65af\u5766\u798f\u5927\u5b66\u57fa\u56e0\u7ec4\u5b66\u5bb6\u3001HuBMAP\u6307\u5bfc\u59d4\u5458\u4f1a\u524d\u8054\u5408\u4e3b\u5e2d\u8fc8\u514b\u5c14\u00b7\u65af\u5948\u5fb7<\/span>\uff08Michael Snyder\uff09<\/span>\u6240\u8bf4\uff0c\u901a\u8fc7\u5f00\u53d1\u80fd\u591f\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u89e3\u8bfb\u5206\u5b50\u5185\u5bb9\u7684\u5206\u6790\u5de5\u5177\uff0c\u5e76\u5c06\u8fd9\u4e9b\u6280\u672f\u5feb\u901f\u5546\u4e1a\u5316\uff0c\u8fd9\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u4e3a\u56fe\u8c31\u5de5\u4f5c\u7684\u5f00\u5c55\u63d0\u4f9b\u4e86\u57fa\u7840\u3002\u4f8b\u5982\uff0c\u65af\u5948\u5fb7\u7684\u56e2\u961f\u5e38\u89c4\u4f7f\u7528\u52a0\u5dde\u666e\u83b1\u68ee\u987f10X Genomics\u516c\u53f8\u7684Xenium \u5e73\u53f0\uff0c\u8fdb\u884c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u5206\u6790\uff0c\u8be5\u5e73\u53f0\u6bcf\u5468\u53ef\u4ee5\u540c\u65f6\u68c0\u6d4b 4 \u4e2a\u7ec4\u7ec7\u6837\u672c\u4e2d\u7ea6400\u4e2a\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u800c\u591a\u91cd\u6297\u4f53\u65b9\u6cd5\u80fd\u5728\u5355\u7ec6\u80de\u5c42\u9762\u8ffd\u8e2a\u5927\u91cf\u86cb\u767d\u8d28\uff0c\u4f8b\u5982\u9a6c\u8428\u8bf8\u585e\u5dde\u9a6c\u5c14\u4f2f\u52d2\u7684Akoya\u751f\u7269\u79d1\u5b66\u516c\u53f8\u6240\u5f00\u53d1\u7684PhenoCycler\u5e73\u53f0\u3002\u7814\u7a76\u8005\u53ef\u4f7f\u7528\u5176\u751f\u6210\u7684\u6570\u636e\u91cd\u5efa\u7ec4\u7ec7\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u6b64\u5916\uff0c\u5176\u4ed6\u7684\u201c\u591a\u7ec4\u5b66\u201d\u65b9\u6cd5\u8ba9\u79d1\u5b66\u5bb6\u80fd\u591f\u540c\u65f6\u5206\u6790\u540c\u4e00\u7ec6\u80de\u4e2d\u7684\u591a\u79cd\u4e0d\u540c\u5206\u5b50\uff0c\u5305\u62ecRNA\u7684\u8868\u8fbe\u3001\u67d3\u8272\u8d28\u7684\u7ed3\u6784\u548c\u86cb\u767d\u8d28\u7684\u5206\u5e03\u3002<\/p>\n

\u501f\u52a9\u8fd9\u4e9b\u6280\u672f\uff0c2023\u5e74\u6709\u6570\u5341\u9879\u7814\u7a76\u516c\u5e03\u4e86\u4ed6\u4eec\u5728\u5668\u5b98\u7279\u5f02\u6027\u7ec6\u80de\u56fe\u8c31\u65b9\u9762\u6240\u53d6\u5f97\u7684\u8fdb\u5c55\u3002\u4f8b\u5982\uff0c\u4eba\u7c7b\u7ec6\u80de\u56fe\u8c31\u57286\u6708\u4efd\u53d1\u5e03\u4e86\u5bf9\u4eba\u7c7b\u80ba\u90e849\u4e2a\u6570\u636e\u96c6\u7684\u7efc\u5408\u5206\u6790[16]\u3002\u6cf0\u514b\u66fc\u8bf4\uff1a\u201c\u6709\u4e86\u8fd9\u4e2a\u975e\u5e38\u6e05\u6670\u7684\u80ba\u90e8\u56fe\u8c31\uff0c\u6211\u4eec\u5c31\u80fd\u4e86\u89e3\u80ba\u7ea4\u7ef4\u5316\u3001\u5404\u7c7b\u80bf\u7624\uff0c\u751a\u81f3\u662fCOVID-19\u7b49\u75be\u75c5\u4e2d\u53d1\u751f\u7684\u53d8\u5316\u201d\u30022023\u5e74\uff0c\u300a\u81ea\u7136\u300b\u6742\u5fd7\u53d1\u5e03\u4e86\u4e00\u7bc7\u6587\u7ae0<\/span>\uff08\u89c1go.nature.com\/3vbznk7\uff09<\/span>\uff0c\u91cd\u70b9\u4ecb\u7ecd\u4e86HuBMAP\u53d6\u5f97\u7684\u8fdb\u5c55\uff0c\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e5f\u53d1\u6587\u8be6\u7ec6\u4ecb\u7ecd\u4e86BICCN\u7684\u5de5\u4f5c<\/span>\uff08\u89c1go.nature.com\/3nsf4ys\uff09<\/span>\u3002<\/p>\n

\u76ee\u524d\u4eba\u7c7b\u7ec6\u80de\u56fe\u8c31\u8fd8\u6709\u5927\u91cf\u5de5\u4f5c\u9700\u8981\u5b8c\u6210\uff0c\u6839\u636e\u6cf0\u514b\u66fc\u7684\u4f30\u8ba1\uff0c\u81f3\u5c11\u9700\u8981\u4e94\u5e74\u65f6\u95f4\u3002\u4f46\u662f\uff0c\u4e00\u65e6\u5b8c\u5168\u7ed8\u5236\u51fa\u6765\uff0c\u8fd9\u5c06\u662f\u65e0\u4ef7\u4e4b\u5b9d\u3002\u4f8b\u5982\uff0c\u6cf0\u514b\u66fc\u9884\u6d4b\u672a\u6765\u53ef\u4ee5\u5229\u7528\u56fe\u8c31\u6570\u636e\uff0c\u6765\u6307\u5bfc\u7ec4\u7ec7\u548c\u7ec6\u80de\u7279\u5f02\u6027\u836f\u7269\u9776\u5411\u3002\u65af\u5948\u5fb7\u5219\u8feb\u5207\u5e0c\u671b\u4e86\u89e3\uff0c\u5bf9\u4e8e\u764c\u75c7\u548c\u80a0\u6613\u6fc0\u7efc\u5408\u5f81\u7b49\u590d\u6742\u75be\u75c5\uff0c\u7ec6\u80de\u5fae\u73af\u5883\u4f1a\u5982\u4f55\u63d0\u793a\u75be\u75c5\u98ce\u9669\u548c\u75c5\u56e0\u3002\u201c\u8fd9\u4e2a\u95ee\u9898\u80fd\u57282024\u5e74\u89e3\u51b3\u5417\uff1f\u6211\u8ba4\u4e3a\u4e0d\u5927\u53ef\u80fd\u2014\u2014\u56de\u7b54\u8fd9\u4e00\u95ee\u9898\u8fd8\u9700\u8981\u7ecf\u5e74\u7d2f\u6708\u7684\u52aa\u529b\u201d\uff0c\u65af\u5948\u5fb7\u8bf4\uff0c\u201c\u4f46\u5b83\u662f\u6574\u4e2a\u9886\u57df\u7684\u5de8\u5927\u9a71\u52a8\u529b\u201d\u3002<\/span><\/section>\n


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\u7eb3\u7c73\u5c3a\u5ea6\u6709\u65f6\u4f1a\u53d1\u751f\u5947\u602a\u800c\u6709\u8da3\u7684\u4e8b\u60c5\u3002<\/span>\u8fd9\u53ef\u80fd\u4f1a\u7ed9\u6750\u6599\u79d1\u5b66\u7684\u9884\u6d4b\u5e26\u6765\u56f0\u96be\uff0c\u4f46\u4e5f\u610f\u5473\u7740\u7eb3\u7c73\u7ea7\u5efa\u7b51\u5e08\u53ef\u4ee5\u5236\u9020\u51fa\u5177\u6709\u72ec\u7279\u7279\u6027\u7684\u8f7b\u8d28\u6750\u6599\uff0c\u5982\u66f4\u9ad8\u7684\u5f3a\u5ea6\u3001\u4e0e\u5149\u6216\u58f0\u97f3\u53d1\u751f\u7279\u5b9a\u53cd\u5e94\uff0c\u4ee5\u53ca\u66f4\u5f3a\u7684\u50ac\u5316\u6216\u50a8\u80fd\u80fd\u529b\u3002<\/span><\/section>\n<\/section>\n
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\u76ee\u524d\u6709\u5f88\u591a\u65b9\u6cd5\u7528\u4ee5\u7cbe\u786e\u5236\u9020\u8fd9\u7c7b\u7eb3\u7c73\u6750\u6599\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u90fd\u662f\u4f7f\u7528\u6fc0\u5149\u6765\u5f15\u53d1\u5149\u654f\u6750\u6599\u7684\u201c\u5149\u805a\u5408\u201d<\/span>\uff08photopolymerization\uff09<\/span>\u6210\u578b\u3002\u8fd9\u4e9b\u65b9\u6cd5\u7684\u5e7f\u6cdb\u4f7f\u7528\u5b58\u5728\u8bb8\u591a\u963b\u788d\uff0c\u8fc7\u53bb\u51e0\u5e74\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u5728\u514b\u670d\u8fd9\u4e9b\u963b\u788d\u65b9\u9762\u53d6\u5f97\u4e86\u957f\u8db3\u7684\u8fdb\u6b65\u3002<\/p>\n

\u5176\u4e2d\u4e4b\u4e00\u4fbf\u662f\u901f\u5ea6\u3002\u4e9a\u7279\u5170\u5927\u4f50\u6cbb\u4e9a\u7406\u5de5\u5b66\u9662\u7684\u5de5\u7a0b\u5e08\u82cf\u62c9\u5e03\u00b7\u8428\u54c8<\/span>\uff08Sourabh Saha\uff09<\/span>\u8bf4\uff0c\u4e0e\u5176\u4ed6\u7eb3\u7c73\u7ea73D\u6253\u5370\u65b9\u6cd5\u76f8\u6bd4\uff0c\u4f7f\u7528\u5149\u805a\u5408\u6cd5\u7ec4\u88c5\u7eb3\u7c73\u7ed3\u6784\u7684\u901f\u5ea6\u5927\u7ea6\u5feb\u4e09\u4e2a\u6570\u91cf\u7ea7\u3002\u8fd9\u5bf9\u4e8e\u5b9e\u9a8c\u5ba4\u4f7f\u7528\u6765\u8bf4\u53ef\u80fd\u5df2\u7ecf\u8db3\u591f\uff0c\u4f46\u5bf9\u4e8e\u5927\u89c4\u6a21\u751f\u4ea7\u6216\u5de5\u4e1a\u52a0\u5de5\u6765\u8bf4\u8fd8\u662f\u592a\u6162\u30022019 \u5e74\uff0c\u8428\u54c8\u548c\u9999\u6e2f\u4e2d\u6587\u5927\u5b66\u7684\u673a\u68b0\u5de5\u7a0b\u5e08\u9648\u4e16\u7948<\/span>\uff08Shih-Chi Chen\uff09<\/span>\u53ca\u5176\u540c\u4e8b\u8868\u793a\uff0c\u4ed6\u4eec\u53ef\u4ee5\u901a\u8fc7\u4f7f\u7528\u56fe\u6848\u5316\u7684\u4e8c\u7ef4\u5149\u7247<\/span>\uff08patterned 2D light-sheet\uff09<\/span>\u800c\u4e0d\u662f\u4f20\u7edf\u7684\u8109\u51b2\u6fc0\u5149\u6765\u52a0\u901f\u805a\u5408\u53cd\u5e94[17]\u3002\u8428\u54c8\u8bf4\uff0c\u201c\u8fd9\u6837\u4e00\u6765\uff0c\u805a\u5408\u901f\u5ea6\u5c31\u63d0\u9ad8\u4e86\u4e00\u5343\u500d\uff0c\u800c\u4e14\u8fd8\u80fd\u4fdd\u6301100\u7eb3\u7c73\u5c3a\u5ea6\u7684\u6750\u6599\u7279\u5f81\u201d\u3002\u5305\u62ec\u9648\u4e16\u7948\u5728\u5185\u7684\u7814\u7a76\u4eba\u5458\u5728\u968f\u540e\u7684\u5de5\u4f5c\u4e2d\u5efa\u7acb\u4e86\u66f4\u5feb\u5b9e\u73b0\u7eb3\u7c73\u5236\u9020\u7684\u5176\u4ed6\u65b9\u6cd5[18]\u3002<\/p>\n

\u53e6\u4e00\u9879\u6311\u6218\u662f\uff0c\u5e76\u975e\u6240\u6709\u6750\u6599\u90fd\u80fd\u901a\u8fc7\u5149\u805a\u5408\u53cd\u5e94\u76f4\u63a5\u6253\u5370\uff0c\u4f8b\u5982\u91d1\u5c5e\u3002\u4e0d\u8fc7\uff0c\u4f4d\u4e8e\u7f8e\u56fd\u5e15\u8428\u8fea\u7eb3\u7684\u52a0\u5dde\u7406\u5de5\u5b66\u9662\u6750\u6599\u79d1\u5b66\u5bb6\u8331\u8389\u4e9a\u00b7\u683c\u91cc\u5c14<\/span>\uff08Julia Greer\uff09<\/span>\u5de7\u5999\u5730\u5f00\u53d1\u51fa\u53e6\u4e00\u79cd\u65b9\u6cd5\u30022022 \u5e74\uff0c\u5979\u548c\u5979\u7684\u540c\u4e8b\u63cf\u8ff0\u4e86\u4e00\u79cd\u65b9\u6cd5\uff0c\u5728\u8fd9\u79cd\u65b9\u6cd5\u4e2d\uff0c\u5149\u805a\u5408\u6c34\u51dd\u80f6\u53ef\u7528\u4f5c\u5fae\u5c3a\u5ea6\u6a21\u677f\uff1b\u7136\u540e\u5728\u8fd9\u4e9b\u6a21\u677f\u4e2d\u6ce8\u5165\u91d1\u5c5e\u76d0\u5e76\u8fdb\u884c\u5904\u7406\uff0c\u4ece\u800c\u8bf1\u5bfc\u91d1\u5c5e\u5728\u6536\u7f29\u7684\u540c\u65f6\u5f62\u6210\u6a21\u677f\u7ed3\u6784[19]\u3002\u867d\u7136\u8fd9\u9879\u6280\u672f\u6700\u521d\u662f\u9488\u5bf9\u5fae\u5c3a\u5ea6\u7ed3\u6784\u5f00\u53d1\u7684\uff0c\u4f46\u683c\u91cc\u5c14\u56e2\u961f\u4e5f\u5c06\u8fd9\u79cd\u7b56\u7565\u7528\u4e8e\u7eb3\u7c73\u5236\u9020\uff0c\u7814\u7a76\u4eba\u5458\u5341\u5206\u671f\u5f85\u672a\u6765\u5229\u7528\u575a\u56fa\u8010\u7528\u7684\u9ad8\u7194\u70b9\u91d1\u5c5e\u548c\u5408\u91d1\uff0c\u6765\u5236\u9020\u51fa\u529f\u80fd\u6027\u7eb3\u7c73\u7ed3\u6784\u3002<\/p>\n

\u6700\u540e\u4e00\u4e2a\u969c\u788d\u53ef\u80fd\u662f\u6700\u96be\u7a81\u7834\u7684\u2014\u2014\u7ecf\u6d4e\u9002\u7528\u6027\u3002\u6839\u636e\u8428\u54c8\u7684\u8bf4\u6cd5\uff0c\u8bb8\u591a\u5149\u805a\u5408\u65b9\u6cd5\u4e2d\u4f7f\u7528\u7684\u8109\u51b2\u6fc0\u5149\u7cfb\u7edf\u6210\u672c\u9ad8\u8fbe50\u4e07\u7f8e\u5143\u4ee5\u4e0a\u3002\u4f46\u662f\uff0c\u66f4\u4fbf\u5b9c\u7684\u66ff\u4ee3\u54c1\u6b63\u5728\u4e0d\u65ad\u6d8c\u73b0\u3002\u4f8b\u5982\uff0c\u5fb7\u56fd\u5361\u5c14\u65af\u9c81\u5384\u7406\u5de5\u5b66\u9662\u7684\u7269\u7406\u5b66\u5bb6\u9a6c\u4e01\u00b7\u97e6\u683c\u7eb3<\/span>\uff08Martin Wegener\uff09<\/span>\u548c\u540c\u4e8b\u4eec\u7814\u7a76\u51fa\u4e86\u8fde\u7eed\u6fc0\u5149\u5668\u3002\u8fd9\u79cd\u6fc0\u5149\u5668\u6bd4\u6807\u51c6\u8109\u51b2\u6fc0\u5149\u5668\u66f4\u4fbf\u5b9c\u3001\u66f4\u7d27\u51d1\u3001\u8017\u7535\u66f4\u5c11[20]\u3002\u5e76\u4e14\uff0c\u683c\u91cc\u5c14\u5df2\u7ecf\u6210\u7acb\u4e86\u4e00\u5bb6\u516c\u53f8\uff0c\u65e8\u5728\u5c06\u5236\u9020\u7eb3\u7c73\u7ed3\u6784\u91d1\u5c5e\u677f\u7684\u5de5\u827a\u5546\u4e1a\u5316\uff0c\u8fd9\u79cd\u91d1\u5c5e\u677f\u6216\u53ef\u7528\u4e8e\u5236\u9020\u4e0b\u4e00\u4ee3\u4eba\u4f53\u88c5\u7532\u6216\u98de\u673a\u548c\u5176\u4ed6\u8fd0\u8f93\u5668\u7684\u8d85\u8010\u7528\u6297\u51b2\u51fb\u5916\u5c42\u7b49\u3002<\/span><\/section>\n<\/section>\n


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\u539f\u6587\uff1ahttps:\/\/doi.org\/10.1038\/d41586-024-00173-x<\/span><\/section>\n<\/section>\n<\/blockquote>\n<\/section>\n<\/section>\n<\/section>\n
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\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1a<\/strong><\/p>\n

AI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/a><\/span><\/p>\n


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\u8ba1\u7b97\u795e\u7ecf\u79d1\u5b66\u8bfb\u4e66\u4f1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span>\u8ba1\u7b97\u795e\u7ecf\u79d1\u5b66\u8bfb\u4e66\u4f1a\u542f\u52a8\uff1a\u4ece\u590d\u6742\u795e\u7ecf\u52a8\u529b\u5b66\u5230\u7c7b\u8111\u4eba\u5de5\u667a\u80fd<\/strong><\/a><\/p>\n


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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/p>\n

1. <\/strong>AI\u4f55\u4ee5\u6d8c\u73b0\uff1a\u590d\u6742\u9002\u5e94\u7cfb\u7edf\u89c6\u89d2\u7684ChatGPT\u548c\u5927\u8bed\u8a00\u6a21\u578b<\/a><\/strong><\/span><\/section>\n
2. <\/strong>AI4Science\u7684\u57fa\u77f3\uff1a\u51e0\u4f55\u56fe\u795e\u7ecf\u7f51\u7edc\uff0c\u6700\u5168\u7efc\u8ff0\u6765\u4e86\uff01<\/a><\/strong><\/span><\/strong><\/strong><\/section>\n
3. <\/strong>\u6570\u5343\u4f4dAI\u7814\u7a76\u8005\u63a2\u8ba8\u4eba\u5de5\u667a\u80fd\u7684\u672a\u6765\uff1a\u597d\u7ed3\u679c\u6bd4\u574f\u7ed3\u679c\u66f4\u53ef\u80fd\u51fa\u73b0\uff1f<\/a><\/strong><\/span><\/strong>
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4. <\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
5.<\/strong> \u9f99\u5e74\u5927\u8fd0\u8d77\uff0c\u5b66\u4e60\u6b63\u5f53\u65f6\uff01\u89e3\u9501\u96c6\u667a\u5168\u7ad9\u5185\u5bb9\uff0c\u5f00\u542f\u65b0\u5e74\u5b66\u4e60\u8ba1\u5212<\/a><\/strong><\/strong><\/strong><\/strong><\/span><\/section>\n
6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/section>\n


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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/span><\/strong><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: \u96c6\u667a\u4ff1\u4e50\u90e8 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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