{"id":51423,"date":"2024-07-10T23:18:19","date_gmt":"2024-07-10T15:18:19","guid":{"rendered":"https:\/\/swarma.org\/?p=51423"},"modified":"2024-07-10T23:18:19","modified_gmt":"2024-07-10T15:18:19","slug":"%e4%ba%ba%e5%b7%a5%e6%99%ba%e8%83%bd%e7%bb%88%e7%bb%93%e4%ba%86%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%a0%94%e7%a9%b6%e5%90%97%ef%bc%9f%e4%b8%80%e6%96%87%e8%af%bb%e6%87%82%e8%9b%8b%e7%99%bd%e8%b4%a8%e6%8a%98","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=51423","title":{"rendered":"\u4eba\u5de5\u667a\u80fd\u7ec8\u7ed3\u4e86\u86cb\u767d\u8d28\u7814\u7a76\u5417\uff1f\u4e00\u6587\u8bfb\u61c2\u86cb\u767d\u8d28\u6298\u53e0\u7684\u524d\u4e16\u4eca\u751f"},"content":{"rendered":"
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 Yasemin Saplakoglu<\/span><\/span> | \u4f5c\u8005<\/span><\/strong><\/section>\n
Vicky <\/span>| \u7f16\u8bd1<\/span><\/strong><\/span><\/strong><\/section>\n
Vicky<\/span> <\/span>| \u5ba1\u6821&\u7f16\u8f91<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/section>\n
\u8ffd\u95eenextquestion<\/span> <\/span>| \u6765\u6e90<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/section>\n<\/section>\n


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\u5f53\u8c37\u6b4c\u7684\u516c\u5173\u90e8\u95e8\u5411\u5168\u4e16\u754c\u53d1\u5e03\u8fd9\u4e00\u6d88\u606f\u65f6\uff0c\u5a92\u4f53\u4e3a\u4e4b\u75af\u72c2\u3002AlphaFold2\u201c\u5c06\u4f1a\u6539\u53d8\u4e00\u5207\u201d\u7684\u8bf4\u6cd5\u5360\u636e\u4e86\u5404\u5927\u65b0\u95fb\u7684\u5934\u7248\u5934\u6761\u3002\u90a3\u4e9b\u6bd5\u751f\u81f4\u529b\u4e8e\u7814\u7a76\u5355\u4e2a\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u86cb\u767d\u8d28\u751f\u7269\u5b66\u5bb6\u62c5\u5fc3\u81ea\u5df1\u4f1a\u4e22\u6389\u996d\u7897\u3002\u8fd8\u6709\u4eba\u58f0\u79f0\uff0cAlphaFold2\u5c06\u5f7b\u5e95\u6539\u53d8\u836f\u7269\u7814\u53d1\uff0c\u56e0\u4e3a\u751f\u7269\u5b66\u5bb6\u53ef\u4ee5\u5feb\u901f\u4e86\u89e3\u86cb\u767d\u8d28\u7684\u7ed3\u6784\uff0c\u4ece\u800c\u66f4\u9ad8\u6548\u5730\u7814\u53d1\u51fa\u4ee5\u86cb\u767d\u8d28\u4e3a\u9776\u70b9\u7684\u65b0\u836f\u3002\u5176\u4ed6\u4eba\u5219\u53cd\u9a73\u8bf4\uff0c\u8fd9\u4e9b\u7ed3\u679c\u5927\u591a\u662f\u7092\u4f5c\uff0c\u4e0d\u4f1a\u5e26\u6765\u5b9e\u8d28\u6027\u6539\u53d8\u3002<\/span><\/p>\n


<\/p>\n

Moult\u81ea\u5df1\u4e5f\u51e0\u4e4e\u65e0\u6cd5\u7406\u89e3\u8fd9\u4ef6\u4e8b\u672c\u8eab\u610f\u5473\u7740\u4ec0\u4e48\u3002\u4ed6\u5728\u4f1a\u8bae\u6700\u540e\u95ee\u51fa\u4e86\u5927\u5bb6\u90fd\u60f3\u95ee\u7684\u95ee\u9898\uff1a\u201c\u63a5\u4e0b\u6765\u600e\u4e48\u529e\uff1f\u201d<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e2a\u95ee\u9898\u5df2\u7ecf\u662f\u4e09\u5e74\u534a\u4ee5\u524d\u7684\u4e8b\u4e86\uff0c\u73b0\u5728\u6211\u4eec\u7ec8\u4e8e\u80fd\u591f\u5c1d\u8bd5\u56de\u7b54\u4ed6\u7684\u95ee\u9898\u4e86\u3002<\/span><\/p>\n


<\/p>\n

\u4e0d\u53ef\u5426\u8ba4\uff0cAlphaFold2\u7684\u786e\u6539\u53d8\u4e86\u751f\u7269\u5b66\u5bb6\u7814\u7a76\u86cb\u767d\u8d28\u7684\u65b9\u5f0f\u3002\u7136\u800c\uff0c\u867d\u7136AlphaFold2\u662f\u4e00\u4e2a\u5f3a\u5927\u7684\u9884\u6d4b\u5de5\u5177\uff0c\u4f46\u5b83\u5e76\u4e0d\u662f\u4e00\u4e2a\u5168\u77e5\u5168\u80fd\u7684\u673a\u5668\u3002\u5b83\u975e\u5e38\u5de7\u5999\u5730\u89e3\u51b3\u4e86\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u7684\u4e00\u90e8\u5206\uff0c\u4f46\u5e76\u4e0d\u662f\u79d1\u5b66\u5bb6\u6240\u60f3\u7684\u90a3\u6837\u3002\u5b83\u5e76\u6ca1\u6709\u53d6\u4ee3\u751f\u7269\u5b9e\u9a8c\uff0c\u800c\u662f\u5f3a\u8c03\u4e86\u751f\u7269\u5b9e\u9a8c\u7684\u5fc5\u8981\u6027\u3002<\/span><\/p>\n


<\/p>\n

AlphaFold2\u6700\u5927\u7684\u5f71\u54cd\u53ef\u80fd\u662f\u8ba9\u751f\u7269\u5b66\u5bb6\u5173\u6ce8\u4eba\u5de5\u667a\u80fd\u7684\u529b\u91cf\u3002\u5b83\u5df2\u7ecf\u542f\u53d1\u4e86\u65b0\u7684\u7b97\u6cd5\uff0c\u5305\u62ec\u8bbe\u8ba1\u5728\u81ea\u7136\u754c\u4e2d\u4e0d\u5b58\u5728\u7684\u65b0\u86cb\u767d\u8d28\u7684\u7b97\u6cd5\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u50ac\u751f\u4e86\u65b0\u578b\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u5f15\u9886\u4e86\u65b0\u7684\u79d1\u5b66\u5b9e\u8df5\u65b9\u5f0f\u30022024\u5e745\u6708\uff0c\u5176\u7ee7\u4efb\u8005AlphaFold3\u53d1\u5e03\uff0c\u5b83\u80fd\u591f\u6a21\u62df\u86cb\u767d\u8d28\u548cDNA\u6216RNA\u7b49\u5176\u4ed6\u5206\u5b50\u7684\u7ed3\u6784\u4e0e\u76f8\u4e92\u4f5c\u7528\uff0c\u6807\u5fd7\u7740\u751f\u7269\u9886\u57df\u7684\u9884\u6d4b\u6a21\u578b\u8fdb\u5165\u4e86\u65b0\u7684\u53d1\u5c55\u9636\u6bb5\u3002<\/span><\/p>\n


<\/p>\n

AlQuraishi\u8868\u793a\uff1a\u201c\u8fd9\u662f\u8fc4\u4eca\u4e3a\u6b62\u79d1\u5b66\u9886\u57df\u6700\u91cd\u8981\u7684\u2018\u673a\u5668\u5b66\u4e60\u2019\u6545\u4e8b\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u7136\u800c\uff0c\u751f\u7269\u79d1\u5b66\u9886\u57df\u4ecd\u6709\u8bb8\u591a\u4eba\u5de5\u667a\u80fd\u672a\u80fd\u8de8\u8d8a\u7684\u9e3f\u6c9f\u3002\u8fd9\u4e9b\u5de5\u5177\u65e0\u6cd5\u6a21\u62df\u86cb\u767d\u8d28\u5982\u4f55\u968f\u65f6\u95f4\u53d1\u751f\u53d8\u5316\uff0c\u4e5f\u65e0\u6cd5\u6839\u636e\u86cb\u767d\u8d28\u5b58\u5728\u7684\u73af\u5883\uff08\u5373\u7ec6\u80de\u5185\uff09\u5bf9\u5176\u8fdb\u884c\u5efa\u6a21\u3002\u5728\u52b3\u4f26\u65af\u4f2f\u514b\u5229\u56fd\u5bb6\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u751f\u7269\u5206\u5b50\u7ed3\u6784\u5efa\u6a21\u7b97\u6cd5\u7684\u7ed3\u6784\u751f\u7269\u5b66\u5bb6Paul Adams\u8868\u793a\uff1a\u201cAlphaFold\u4f3c\u4e4e\u6539\u53d8\u4e86\u4e00\u5207\uff0c\u53c8\u597d\u50cf\u4ec0\u4e48\u90fd\u6ca1\u6709\u6539\u53d8\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u672c\u6587\u4fbf\u662f\u6709\u5173\u6765\u81ea\u8c37\u6b4cDeepMind\u7684Jumper\u56e2\u961f\u662f\u5982\u4f55\u53d8\u9769\u86cb\u767d\u8d28\u79d1\u5b66\u53ca\u5176\u5982\u4f55\u5f71\u54cd\u4eba\u5de5\u667a\u80fd\u5728\u751f\u7269\u5b66\u9886\u57df\u672a\u6765\u5e94\u7528\u7684\u6545\u4e8b\u3002<\/span><\/p>\n<\/section>\n


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1. \u524d\u591c<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<\/section>\n
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\uff081\uff09\u7269\u7406\u57fa\u7840<\/span><\/strong><\/p>\n<\/section>\n

\n

\u4e00\u5f20\u6298\u7eb8\u5728\u4ee5\u7279\u5b9a\u65b9\u5f0f\u6298\u53e0\u4e4b\u524d\uff0c\u53ea\u4e0d\u8fc7\u662f\u538b\u5236\u7684\u6728\u6d46\uff0c\u800c\u5728\u6298\u53e0\u4e4b\u540e\uff0c\u5b83\u624d\u80fd\u7115\u7136\u4e00\u65b0\u3002\u51e0\u7ecf\u7cbe\u5999\u7684\u5377\u66f2\u4e0e\u7ffb\u6298\uff0c\u5b83\u5c31\u53d8\u6210\u4e86\u4e00\u4e2a\u7eb8\u5236\u7684\u7b97\u547d\u5de5\u5177\uff0c\u53ef\u4ee5\u7528\u6765\u9884\u6d4b\u4f60\u7684\u672a\u6765\u3002\u800c\u53ea\u9700\u6539\u53d8\u51e0\u4e2a\u6298\u53e0\u6b65\u9aa4\uff0c\u540c\u4e00\u5f20\u7eb8\u5c31\u53ef\u4ee5\u53d8\u6210\u4e00\u53ea\u5c55\u7fc5\u98de\u7fd4\u7684\u4ed9\u9e64\uff0c\u7ed9\u4eba\u5e26\u6765\u597d\u8fd0\u3002<\/span><\/p>\n


<\/p>\n

\u540c\u6837\uff0c\u4e00\u957f\u4e32\u6c28\u57fa\u9178\u5206\u5b50\u5728\u81ea\u53d1\u6298\u53e0\u6210\u5176\u56fa\u6709\u5f62\u72b6\uff08\u751f\u7269\u5b66\u5bb6\u79f0\u4e4b\u4e3a\u7ed3\u6784\uff09\u4e4b\u524d\u6ca1\u6709\u4efb\u4f55\u529f\u80fd\u3002\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u51b3\u5b9a\u4e86\u5b83\u5982\u4f55\u4e0e\u5176\u4ed6\u5206\u5b50\u7ed3\u5408\u6216\u76f8\u4e92\u4f5c\u7528\uff0c\u56e0\u6b64\u4e5f\u51b3\u5b9a\u4e86\u5b83\u5728\u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\u3002<\/span><\/p>\n<\/section>\n

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<\/p>\n

\u56fe\u6e90\uff1aMark Belan\uff0c\u7ffb\u8bd1\uff1avicky\uff0c\u5236\u56fe\uff1a\u5b58\u6e90<\/span><\/p>\n<\/section>\n<\/section>\n

\n

\u5730\u7403\u4e0a\u6709\u51e0\u4ebf\u79cd\u5df2\u77e5\u7684\u86cb\u767d\u8d28\uff0c\u8fd8\u6709\u66f4\u591a\u672a\u77e5\u7684\u86cb\u767d\u8d28\u3002\u5b83\u4eec\u65e0\u6240\u4e0d\u80fd\uff1a\u8840\u7ea2\u86cb\u767d\u548c\u808c\u7ea2\u86cb\u767d\u5c06\u6c27\u6c14\u8fd0\u9001\u5230\u808c\u8089\u548c\u8eab\u4f53\u5404\u5904\u3002\u89d2\u86cb\u767d\u6784\u6210\u5934\u53d1\u3001\u6307\u7532\u548c\u76ae\u80a4\u7684\u5916\u5c42\u7ed3\u6784\u3002\u80f0\u5c9b\u7d20\u4f7f\u8461\u8404\u7cd6\u8fdb\u5165\u7ec6\u80de\uff0c\u8f6c\u5316\u4e3a\u80fd\u91cf\u3002\u86cb\u767d\u8d28\u7684\u5f62\u6001\u4f3c\u4e4e\u53d8\u5e7b\u83ab\u6d4b\uff0c\u4ee5\u6ee1\u8db3\u5b9e\u9645\u751f\u6d3b\u4e2d\u5404\u79cd\u5404\u6837\u7684\u9700\u6c42\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u4ece\u539f\u5b50\u5230\u751f\u6001\u7cfb\u7edf\uff0c<\/span>\uff08\u86cb\u767d\u8d28\u7ed3\u6784\uff09<\/span>\u50cf\u662f\u4e00\u79cd\u901a\u7528\u8bed\u8a00\uff0c\u662f\u4e00\u5207\u7684\u8d77\u6e90\uff0c\u201dAlQuraishi\u8bf4\u9053\u3002<\/span><\/p>\n


<\/p>\n

\u7ec6\u80de\u901a\u8fc7\u83ca\u82b1\u94fe\u7684\u65b9\u5f0f\u5c06\u6c28\u57fa\u9178\u8fd9\u79cd\u5c0f\u5206\u5b50\u8fde\u63a5\u6210\u957f\u957f\u7684\u591a\u80bd\u4e32\uff0c\u4ece\u800c\u751f\u6210\u86cb\u767d\u8d28\u3002\u5b83\u6240\u9009\u62e9\u7684\u6c28\u57fa\u9178\u53d6\u51b3\u4e8eDNA\u63d0\u4f9b\u7ed9\u5b83\u7684\u4e00\u7ec4\u57fa\u672c\u6307\u4ee4\u3002\u751f\u6210\u540e\u4e0d\u5230\u4e00\u79d2\uff0c\u591a\u80bd\u4e32\u5c31\u4f1a\u5f00\u59cb\u7cbe\u786e\u5730\u5f2f\u66f2\u3001\u6263\u5408\u3001\u6298\u53e0\u6210\u86cb\u767d\u8d28\u7684\u6700\u7ec8\u4e09\u7ef4\u7ed3\u6784\u3002\u4e00\u65e6\u88c5\u914d\u5b8c\u6210\uff0c\u5b83\u4eec\u4fbf\u4f1a\u7acb\u523b\u5f00\u59cb\u5c65\u884c\u81ea\u5df1\u7684\u751f\u7269\u804c\u80fd\u3002<\/span><\/p>\n


<\/p>\n

\u5982\u679c\u86cb\u767d\u8d28\u4e0d\u80fd\u5f88\u597d\u5730\u5b8c\u6210\u8fd9\u4e00\u6298\u53e0\u8fc7\u7a0b\uff0c\u90a3\u4e48\u4eba\u4f53\u5c06\u4f1a\u7ecf\u53d7\u4e00\u7cfb\u5217\u5371\u53ca\u6027\u547d\u7684\u6253\u51fb\u3002\u9519\u8bef\u6298\u53e0\u6216\u7ed3\u6784\u89e3\u5f00\u7684\u86cb\u767d\u8d28\u4f1a\u5bfc\u81f4\u4e2d\u6bd2\u548c\u7ec6\u80de\u6b7b\u4ea1\u3002\u8bb8\u591a\u75be\u75c5\u548c\u5931\u8c03\u90fd\u662f\u7531\u9519\u8bef\u6298\u53e0\u7684\u86cb\u767d\u8d28\u5f15\u8d77\u7684\uff0c\u5982\u9570\u72b6\u7ec6\u80de\u8d2b\u8840\u3002\u6b64\u7c7b\u86cb\u767d\u8d28\u8fd8\u4f1a\u805a\u96c6\u6210\u5757\uff0c\u8fd9\u4e5f\u662f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u7279\u5f81\u3002<\/span><\/p>\n


<\/p>\n

\u7136\u800c\uff0c\u6ca1\u6709\u4eba\u771f\u6b63\u4e86\u89e3\u86cb\u767d\u8d28\u662f\u5982\u4f55\u6298\u53e0\u7684\u3002\u8fd9\u4e9b\u7b80\u5355\u5206\u5b50\u94fe\u4e2d\u7684\u5e8f\u5217\u4fe1\u606f\u53c8\u662f\u5982\u4f55\u7f16\u7801\u86cb\u767d\u8d28\u7684\u590d\u6742\u7ed3\u6784\u5462\uff1f\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u751f\u7269\u7269\u7406\u5b66\u540d\u8a89\u6559\u6388George Rose\u8868\u793a\u201c\u8fd9\u662f\u6211\u4eec\u80fd\u63d0\u51fa\u7684\u6700\u6df1\u5965\u7684\u95ee\u9898\u3002\u201d<\/span><\/p>\n<\/section>\n

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20\u4e16\u7eaa50\u5e74\u4ee3\uff0c\u751f\u7269\u5316\u5b66\u5bb6Christian Anfinsen\u8fdb\u884c\u7684\u5b9e\u9a8c\u8868\u660e\uff0c\u6c28\u57fa\u9178\u4e32\u5185\u90e8\u542b\u6709\u4e00\u79cd\u5185\u5728\u7684\u4ee3\u7801\uff0c\u6307\u793a\u5b83\u5982\u4f55\u6298\u53e0\u6210\u86cb\u767d\u8d28\u2014\u2014\u5e76\u4e14\u5e94\u8be5\u6709\u4e00\u79cd\u65b9\u6cd5\u53ef\u4ee5\u4ece\u8fd9\u4e00\u4ee3\u7801\u4e2d\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002\u8fd9\u4e2a\u5047\u8bbe\u88ab\u79f0\u4e3a\u5b89\u82ac\u68ee\u6559\u6761\uff08Anfinsen\u2019s dogma\uff09\u3002\u56fe\u6e90\uff1aPBH Images\/Alamy<\/span><\/section>\n<\/section>\n<\/section>\n
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\u65e9\u572820\u4e16\u7eaa30\u5e74\u4ee3\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c31\u5f00\u59cb\u63a2\u7a76\u8fd9\u4e2a\u95ee\u9898\u3002\u4f46\u771f\u6b63\u53d6\u5f97\u7a81\u7834\u8981\u7b49\u523020\u4e16\u7eaa50\u5e74\u4ee3\u4e2d\u671f\uff0c\u5f53\u65f6\u4e00\u4f4d\u540d\u53ebChristian Anfinsen\u7684\u751f\u7269\u5316\u5b66\u5bb6\u5c06\u86cb\u767d\u8d28\u52a0\u5165\u5316\u5b66\u6eb6\u6db2\u4e2d\uff0c\u8fd9\u4e00\u505a\u6cd5\u8981\u4e48\u4f1a\u5bfc\u81f4\u86cb\u767d\u8d28\u7684\u952e\u65ad\u88c2\uff0c\u4f7f\u5176\u7ed3\u6784\u5c55\u5f00\uff1b\u8981\u4e48\u4f1a\u5bfc\u81f4\u86cb\u767d\u8d28\u53d1\u751f\u9519\u8bef\u6298\u53e0\u3002\u901a\u8fc7\u89c2\u5bdf\uff0c\u4ed6\u53d1\u73b0\uff0c\u5c55\u5f00\u6216\u6298\u53e0\u9519\u8bef\u7684\u86cb\u767d\u8d28\u53ef\u4ee5\u81ea\u53d1\u5730\u91cd\u65b0\u6298\u53e0\u6210\u6b63\u786e\u7684\u7ed3\u6784\u3002\u8fd9\u4e00\u53d1\u73b0\u8bc1\u660e\u4e86\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\u662f\u7531\u5185\u90e8\u7f16\u7801<\/span>\uff08\u7531\u6c28\u57fa\u9178\u4e32\u7684\u7f16\u7801\uff09<\/span>\u51b3\u5b9a\u7684\uff0cChristian Anfinsen\u4e5f\u51ed\u6b64\u83b7\u5f97\u4e86\u8bfa\u8d1d\u5c14\u5956\u3002<\/span><\/p>\n


<\/p>\n

\u57fa\u4e8e\u8fd9\u4e00\u53d1\u73b0\uff0cAnfinsen\u63d0\u51fa\u4e86\u4e00\u4e2a\u5047\u8bbe\uff1a\u5e94\u8be5\u6709\u4e00\u79cd\u65b9\u6cd5\u53ef\u4ee5\u6839\u636e\u6c28\u57fa\u9178\u5e8f\u5217\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u2014\u2014\u8fd9\u5c31\u662f\u540e\u6765\u5e7f\u4e3a\u4eba\u77e5\u7684\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u3002<\/span><\/p>\n


<\/p>\n

\u4e00\u65e6\u591a\u80bd\u94fe\u7ec4\u88c5\u5b8c\u6210\uff0c\u5b83\u4eec\u5c31\u80fd\u5728\u5343\u5206\u4e4b\u4e00\u79d2\u5185\u6298\u53e0\u6210\u6b63\u786e\u7684\u7ed3\u6784\uff0c\u901f\u5ea6\u4e4b\u5feb\u4ee4\u5206\u5b50\u751f\u7269\u5b66\u5bb6Cyrus Levinthal\u548b\u820c\u3002\u57281969\u5e74\u53d1\u8868\u7684\u8bba\u6587\u300a\u5982\u4f55\u4f18\u96c5\u5730\u6298\u53e0\u300b<\/span>\uff08How to Fold Graciously\uff09<\/span>\u4e2d\uff0cLevinthal\u8ba1\u7b97\u51fa\uff0c\u5982\u679c\u4e00\u4e2a\u86cb\u767d\u8d28\u8981\u5c1d\u8bd5\u6bcf\u4e00\u79cd\u53ef\u80fd\u7684\u6298\u53e0\u65b9\u6848\uff0c\u90a3\u4e48\u5b83\u7684\u7ec4\u88c5\u65f6\u95f4\u5c06\u957f\u5f97\u65e0\u6cd5\u60f3\u8c61\u3002\u4ed6\u63a8\u6d4b\uff0c\u663e\u7136\u662f\u6709\u67d0\u79cd\u66f4\u4e3a\u76f4\u63a5\u5730\u65b9\u5f0f\u5f15\u5bfc\u4e86\u86cb\u767d\u8d28\u7684\u6b63\u786e\u6298\u53e0\u3002<\/span><\/p>\n


<\/p>\n

\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u53c8\u884d\u751f\u51fa\u65b0\u7684\u95ee\u9898\uff0c\u4e3b\u8981\u6709\u4e09\u4e2a\uff1a\u80fd\u5426\u6839\u636e\u6c28\u57fa\u9178\u5e8f\u5217\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u7ed3\u6784\uff1f\u6298\u53e0\u7f16\u7801\u662f\u4ec0\u4e48\uff1f\u6298\u53e0\u673a\u5236\u662f\u4ec0\u4e48\uff1f<\/span><\/p>\n


<\/p>\n

20 \u4e16\u7eaa 60 \u5e74\u4ee3\u521d\uff0c\u5f53\u7b2c\u4e00\u6279\u901a\u8fc7\u5b9e\u9a8c\u51b3\u5b9a\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u95ee\u4e16\u65f6\uff0c\u8fd9\u4e9b\u95ee\u9898\u5f00\u59cb\u5728\u79d1\u5b66\u5bb6\u7684\u5fc3\u4e2d\u751f\u6839\u53d1\u82bd\u3002\u5251\u6865\u5927\u5b66\u7684\u4e24\u4f4d\u751f\u7269\u5b66\u5bb6Max Perutz\u548cJohn Kendrew\u5c06\u86cb\u767d\u8d28\u57f9\u80b2\u6210\u6676\u4f53\uff0c\u7528X\u5c04\u7ebf\u8f70\u51fb\u5b83\u4eec\uff0c\u5e76\u6d4b\u91cf\u5c04\u7ebf\u5982\u4f55\u5f2f\u66f2\u2014\u2014\u8fd9\u79cd\u6280\u672f\u88ab\u79f0\u4e3aX\u5c04\u7ebf\u6676\u4f53\u5b66<\/span>\uff08X-ray crystallography\uff09<\/span>\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u4ed6\u4eec\u786e\u5b9a\u4e86\u8840\u7ea2\u86cb\u767d\u548c\u808c\u7ea2\u86cb\u767d\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u8fd9\u9879\u5b9e\u9a8c\u8017\u65f6\u4e8c\u5341\u591a\u5e74\uff0c\u4e3a\u4e24\u4eba\u8d62\u5f97\u4e86\u8bfa\u8d1d\u5c14\u5956\u3002<\/span><\/p>\n<\/section>\n

\n
\n
<\/span><\/section>\n
John Kendrew\uff08\u5de6\uff09\u548cMax Perutz\uff08\u53f3\uff09\u5229\u7528 X \u5c04\u7ebf\u6676\u4f53\u5b66\u4ed4\u7ec6\u63ed\u793a\u4e86\u8840\u7ea2\u86cb\u767d\u548c\u808c\u7ea2\u86cb\u767d\u7684\u7ed3\u6784\u3002\u968f\u540e\uff0c\u4ed6\u4eec\u4f7f\u7528\u5c0f\u7403\uff08\u4ee3\u8868\u539f\u5b50\uff09\u548c\u68cd\u5b50\uff08\u4ee3\u8868\u5316\u5b66\u952e\uff09\u6784\u5efa\u4e86\u7269\u7406\u6a21\u578b\u3002\u56fe\u6e90\uff1aMRC Laboratory of Molecular Biology<\/span><\/section>\n<\/section>\n<\/section>\n
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\u4ece\u90a3\u65f6\u8d77\uff0c\u65e0\u6570\u7814\u7a76\u4eba\u5458\u4e0d\u61c8\u52aa\u529b\uff0c\u8bd5\u56fe\u4e86\u89e3\u4e0d\u540c\u86cb\u767d\u8d28\u7684\u7ed3\u6784\uff0c\u53ca\u5176\u5e95\u5c42\u7684\u673a\u5236\u3002\u683c\u62c9\u65af\u54e5\u5927\u5b66\u7684\u7ed3\u6784\u751f\u7269\u5b66\u5bb6Helen Walden\u8868\u793a\uff1a\u201c\u60f3\u5f04\u6e05\u695a\u4e8b\u7269\u7684\u5916\u89c2\u662f\u4eba\u7c7b\u7684\u672c\u80fd\uff0c\u56e0\u4e3a\u8fd9\u6837\u6211\u4eec\u4fbf\u80fd\u4e86\u89e3\u5176\u529f\u80fd\u3002\u201d\u8fd8\u6709\u4e00\u4e9b\u79d1\u5b66\u5bb6\u5c1d\u8bd5\u4ece\u5316\u5b66\u6216\u7269\u7406\u7684\u89d2\u5ea6\u89e3\u51b3\u95ee\u9898\u3002\u4ed6\u4eec\u65e5\u590d\u4e00\u65e5\u5730\u5728\u5b9e\u9a8c\u5ba4\u91cc\u8f9b\u52e4\u5de5\u4f5c\uff0c\u6700\u7ec8\u6210\u529f\u91cd\u5efa\u4e86\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\u901a\u8fc7\u6a21\u578b\u548c\u6a21\u62df\u5bfb\u627e\u7ebf\u7d22\uff0c\u4ed6\u4eec\u7528\u4e0d\u540c\u7684\u7b97\u6cd5\u89c4\u5219\u7ec4\u5408\u5bf9\u6a21\u578b\u548c\u6a21\u62df\u8fdb\u884c\u7f16\u7a0b\u5e76\u4e0d\u65ad\u6539\u8fdb\u66f4\u65b0\u3002<\/span><\/p>\n


<\/p>\n

\u968f\u7740\u8d8a\u6765\u8d8a\u591a\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u88ab\u53d1\u73b0\uff0c\u86cb\u767d\u8d28\u79d1\u5b66\u754c\u9700\u8981\u4e00\u79cd\u65b9\u6cd5\u6765\u7ec4\u7ec7\u548c\u5171\u4eab\u8fd9\u4e9b\u4fe1\u606f\u30021971\u5e74\uff0c\u86cb\u767d\u8d28\u6570\u636e\u5e93<\/span>\uff08Protein Data Bank\uff09<\/span>\uff0c\u4f5c\u4e3a\u4e00\u4e2a\u5b58\u50a8\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u6863\u6848\u5e93\uff0c\u5e94\u8fd0\u800c\u751f\u3002\u8be5\u6570\u636e\u5e93\u53ef\u514d\u8d39\u4f7f\u7528\uff0c\u5bf9\u4e8e\u6240\u6709\u60f3\u8981\u901a\u8fc7\u4e86\u89e3\u86cb\u767d\u8d28\u7ed3\u6784\u6765\u63a2\u7a76\u751f\u7269\u95ee\u9898\u7684\u7814\u7a76\u8005\u6765\u8bf4\uff0c\u90fd\u662f\u4e00\u4e2a\u53ef\u9760\u7684\u5de5\u5177\u3002<\/span><\/p>\n


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\u86cb\u767d\u8d28\u6570\u636e\u5e93\u5efa\u7acb\u4e4b\u521d\uff0c\u53ea\u4fdd\u5b58\u4e867\u79cd\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002\u5c06\u8fd150\u5e74\u540e\uff0c\u5f53\u8c37\u6b4cDeepMind\u5229\u7528\u5b83\u6765\u8bad\u7ec3AlphaFold2\u65f6\uff0c\u5b83\u5df2\u8bb0\u5f55\u4e86\u8d85\u8fc714\u4e07\u79cd\u86cb\u767d\u8d28\u7ed3\u6784\u2014\u2014\u6bcf\u4e2a\u7ed3\u6784\u90fd\u662f\u7531\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\u8d39\u5c3d\u5468\u6298\u89e3\u7801\u51fa\u6765\u7684\u3002<\/span><\/p>\n<\/section>\n

\n

\uff082\uff09\u5b9e\u9a8c\u6d3e\u7684\u82e6\u607c<\/span><\/strong><\/span><\/p>\n<\/section>\n

\n

\u4ece20\u4e16\u7eaa70\u5e74\u4ee3\u4e2d\u671f\u8d77\uff0c\u725b\u6d25\u5927\u5b66\u7684\u751f\u7269\u7269\u7406\u5b66\u5bb6Janet Thornton\u6bcf\u9694\u51e0\u4e2a\u6708\u5c31\u4f1a\u6536\u5230\u4e00\u4e2a\u90ae\u5305\u3002\u91cc\u9762\u662f\u4e00\u537712\u82f1\u5bf8\u7684\u78c1\u5e26\uff0c\u5305\u542b\u4e86\u5b58\u5165\u86cb\u767d\u8d28\u6570\u636e\u5e93\u7684\u65b0\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\u3002\u5979\u4f1a\u8feb\u4e0d\u53ca\u5f85\u5730\u6495\u5f00\u5305\u88f9\uff0c\u60f3\u8981\u7acb\u523b\u5f00\u59cb\u5206\u6790\u65b0\u53d1\u73b0\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u5979\u6536\u5230\u7684\u7b2c\u4e00\u76d8\u78c1\u5e26\u4e0a\u53ea\u5305\u542b20\u79cd\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u6570\u636e\u3002<\/span><\/p>\n<\/section>\n

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\u201c\u6709\u5f88\u591a\u5b66\u751f\u8bf4\uff0c\u2018\u6211\u60f3\u6765\u89e3\u51b3\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\uff0c\u2019\u201d\u53bb\u5e74\u4ece\u6b27\u6d32\u5206\u5b50\u751f\u7269\u5b66\u5b9e\u9a8c\u5ba4\u9000\u4f11\u7684\u7ed3\u6784\u751f\u7269\u5b66\u5bb6Janet Thornton\u8bf4\u3002\u201c\u4f46\u5766\u7387\u5730\u8bf4\uff0c\u6211\u5bf9\u5982\u4f55\u505a\u5230\u8fd9\u4e00\u70b9\u6ca1\u6709\u4efb\u4f55\u65b0\u60f3\u6cd5\u3002\u201d\u56fe\u6e90\uff1aJeff Dowling, EMBL-EBI<\/span><\/section>\n<\/section>\n<\/section>\n
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\u78c1\u5e26\u8bb0\u5f55\u7684\u6bcf\u4e00\u4e2a\u86cb\u767d\u8d28\u90fd\u662f\u591a\u5e74\u5fc3\u8840\u7684\u7ed3\u6676\u3002\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u4e00\u540d\u535a\u58eb\u751f\u4f1a\u5728\u8bfb\u7814\u7684\u56db\u5e74\u95f4\u6216\u82b1\u8d39\u66f4\u957f\u65f6\u95f4\u7814\u7a76\u5355\u4e2a\u86cb\u767d\u8d28\u7684\u7ed3\u6676\uff0c\u4ece\u4e2d\u6536\u96c6\u6570\u636e\u6216\u89e3\u8bfb\u6570\u636e\uff0c\u4ece\u800c\u5398\u6e05\u5176\u6298\u53e0\u7ed3\u6784\u3002<\/span><\/p>\n


<\/p>\n

\u725b\u6d25\u5927\u5b66\u751f\u7269\u7269\u7406\u7cfb\u5f53\u65f6\u662f\u4e16\u754cX\u5c04\u7ebf\u6676\u4f53\u5b66\u4e2d\u5fc3\u4e4b\u4e00\u30021965\u5e74\uff0c\u86cb\u767d\u8d28\u6676\u4f53\u5b66\u7684\u5148\u9a71\u4e4b\u4e00David Phillips\u5728\u725b\u6d25\u5927\u5b66\u9996\u6b21\u6d4b\u5b9a\u4e86\u6eb6\u83cc\u9176\u7684\u7ed3\u6784\uff0c\u8fd9\u79cd\u9176\u4f1a\u88ab\u514d\u75ab\u7cfb\u7edf\u7528\u6765\u5bf9\u6297\u7ec6\u83cc\u3002\u725b\u6d25\u5927\u5b66\u7684\u751f\u7269\u7269\u7406\u5b66\u5bb6\u5229\u7528X\u5c04\u7ebf\u6676\u4f53\u5b66\u7ed8\u5236\u4e86\u86cb\u767d\u8d28\u7684\u7535\u5b50\u5bc6\u5ea6\u56fe\uff1b\u7535\u5b50\u805a\u96c6\u7684\u533a\u57df\u5f88\u53ef\u80fd\u542b\u6709\u4e00\u4e2a\u539f\u5b50\u3002Thornton\u548c\u5979\u7684\u540c\u4e8b\u4eec\u5c06\u8fd9\u4e9b\u7535\u5b50\u5bc6\u5ea6\u56fe\u6253\u5370\u5230\u5851\u6599\u677f\u4e0a\uff0c\u7136\u540e\u5c06\u5b83\u4eec\u53e0\u653e\u5728\u4e00\u8d77\uff0c\u4ece\u800c\u7ed8\u5236\u51fa\u86cb\u767d\u8d28\u7684\u5f62\u6001\u201c\u8f6e\u5ed3\u56fe\u201d\u3002<\/span><\/p>\n<\/section>\n

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X\u5c04\u7ebf\u6676\u4f53\u5b66\u53ef\u4ee5\u5e2e\u52a9\u79d1\u5b66\u5bb6\u7ed8\u5236\u7535\u5b50\u5bc6\u5ea6\u56fe\uff0c\u76f4\u89c2\u5730\u663e\u793a\u7535\u5b50\u805a\u96c6\u7684\u4f4d\u7f6e\uff0c\u4ece\u800c\u663e\u793a\u5206\u5b50\u4e2d\u53ef\u80fd\u5b58\u5728\u539f\u5b50\u7684\u4f4d\u7f6e\u3002\u901a\u8fc7\u5c06\u7535\u5b50\u5bc6\u5ea6\u56fe\u53e0\u653e\u5728\u4e00\u8d77\uff08\u5de6\u56fe\uff09\uff0c\u79d1\u5b66\u5bb6\u53ef\u4ee5\u63a8\u65ad\u51fa\u86cb\u767d\u8d28\u6216\u9752\u9709\u7d20\u7b49\u5176\u4ed6\u5206\u5b50\u7684\u7ed3\u6784\uff08\u53f3\u56fe\uff09\u3002\u56fe\u6e90\uff1aScience Museum Group<\/span><\/section>\n<\/section>\n<\/section>\n
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\u968f\u540e\uff0c\u4ed6\u4eec\u5c06\u8f6e\u5ed3\u56fe\u8f6c\u6362\u6210\u4e86\u7269\u7406\u6a21\u578b\u3002\u4ed6\u4eec\u5148\u5c06\u5851\u6599\u5e73\u9762\u56fe\u653e\u5165\u7406\u67e5\u5179\u76d2\u4e2d\u2014\u2014\u4ee5\u725b\u6d25\u5927\u5b66\u751f\u7269\u7269\u7406\u5b66\u5bb6\u5f17\u96f7\u5fb7\u91cc\u514b\u00b7\u7406\u67e5\u5179<\/span>\uff08Frederic Richards\uff09<\/span>\u547d\u540d\u7684\u88c5\u7f6e\uff0c\u4ed6\u4e8e1968\u5e74\u53d1\u660e\u4e86\u8fd9\u79cd\u88c5\u7f6e\u3002\u7406\u67e5\u5179\u76d2\u5185\u8bbe\u6709\u4e00\u9762\u503e\u659c\u7684\u955c\u5b50\uff0c\u80fd\u5c06\u8f6e\u5ed3\u56fe\u53cd\u5c04\u5230\u4e00\u4e2a\u5de5\u4f5c\u533a\u5185\uff0c\u8fd9\u8ba9\u79d1\u5b66\u5bb6\u4eec\u80fd\u770b\u5230\u6bcf\u4e2a\u539f\u5b50\u76f8\u5bf9\u4e8e\u5176\u4ed6\u539f\u5b50\u7684\u51c6\u786e\u4f4d\u7f6e\u3002\u7136\u540e\uff0c\u4ed6\u4eec\u7528\u5c0f\u7403\u548c\u68cd\u5b50\u642d\u5efa\u51fa\u4e86\u4e00\u4e2a\u7269\u7406\u6a21\u578b\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u79cd\u65b9\u6cd5\u65e2\u7e41\u7410\u53c8\u6709\u5c40\u9650\u6027\u30021971\u5e74\uff0cLouise Johnson\u7740\u624b\u4e3a\u78f7\u9178\u5316\u9176\u5efa\u6a21\uff0c\u5305\u542b842\u4e2a\u6c28\u57fa\u9178\u7684\u78f7\u9178\u5316\u9176\u662f\u5f53\u65f6\u5b66\u754c\u7814\u7a76\u8fc7\u7684\u6700\u5927\u7684\u86cb\u767d\u8d28\u3002\u4e3a\u4e86\u6210\u529f\u5efa\u7acb\u6a21\u578b\uff0cJohnson\u4e0d\u5f97\u4e0d\u722c\u68af\u5b50\u8fdb\u5165\u725b\u6d25\u5927\u5b66\u4e13\u95e8\u4e3a\u5979\u7684\u9879\u76ee\u5efa\u9020\u7684\u4e24\u5c42\u697c\u9ad8\u7684\u7406\u67e5\u5179\u76d2\u4e2d\u3002\u5979\u65e5\u540e\u6210\u4e3a\u4e86\u77e5\u540d\u6676\u4f53\u5b66\u5bb6\u3002<\/span><\/p>\n


<\/p>\n

\u6a21\u578b\u5b8c\u6210\u540e\uff0c\u79d1\u5b66\u5bb6\u4eec\u7528\u5c3a\u5b50\u6d4b\u91cf\u4e86\u539f\u5b50\u95f4\u7684\u8ddd\u79bb\uff0c\u4ece\u800c\u5f97\u51fa\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u5404\u4e2a\u5750\u6807\u3002Thornton\u8868\u793a\uff1a\u201c\u8fd9\u79cd\u65b9\u6cd5\u592a\u8fc7\u65f6\u4e86\u3002\u201d\u7136\u540e\uff0c\u4ed6\u4eec\u5c06\u5750\u6807\u8f93\u5165\u8ba1\u7b97\u673a\u3002\u5979\u8bf4\uff0c\u7535\u8111\u4e0a\u770b\u8d77\u6765\u5c31\u50cf\u4e00\u7247\u8302\u5bc6\u7684\u68ee\u6797\uff0c\u539f\u5b50\u4eec\u6742\u4e71\u65e0\u7ae0\u5730\u6324\u5728\u4e00\u8d77\u3002\u53ea\u6709\u6234\u4e0a3D\u773c\u955c\u89c2\u5bdf\u7ed3\u6784\u65f6\uff0c\u624d\u80fd\u770b\u6e05\u86cb\u767d\u8d28\u7684\u62d3\u6251\u7ed3\u6784\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u8fd9\u4e2a\u8fc7\u7a0b\u592a\u6298\u78e8\u4eba\u4e86\uff0c\u80fd\u575a\u6301\u5230\u5e95\u5df2\u7ecf\u975e\u5e38\u4e86\u4e0d\u8d77\u4e86,\u201dThornton\u611f\u6168\u9053\u3002<\/span><\/p>\n<\/section>\n

\n
\n

<\/span><\/p>\n

X\u5c04\u7ebf\u6676\u4f53\u5b66\u7684\u5de5\u4f5c\u539f\u7406\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

\n

\u5e74\u590d\u4e00\u5e74\uff0c\u4ed6\u4eec\u7ec8\u4e8e\u6210\u529f\u4e86\u3002\u4e00\u65e6\u7814\u7a76\u4eba\u5458\u786e\u8ba4\u4e86\u81ea\u5df1\u6240\u590d\u6784\u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u4ed6\u4eec\u5c31\u4f1a\u5c06\u5176\u63d0\u4ea4\u7ed9\u86cb\u767d\u8d28\u6570\u636e\u5e93\u3002\u52301984\u5e74\uff0c\u5df2\u6709152\u4e2a\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u88ab\u5b58\u5165\u4e86\u6570\u636e\u5e93\u30021992\u5e74\uff0c\u8fd9\u4e00\u6570\u5b57\u6500\u5347\u81f3747\u4e2a\u3002<\/span><\/p>\n


<\/p>\n

\u5f53\u5b9e\u9a8c\u5b66\u5bb6\u4eec\u8fd8\u5728\u82e6\u82e6\u7814\u7a76\u7269\u7406\u6a21\u578b\u65f6\uff0c\u53e6\u4e00\u5b66\u6d3e\u7684\u86cb\u767d\u8d28\u751f\u7269\u5b66\u5bb6\u2014\u2014\u8ba1\u7b97\u79d1\u5b66\u5bb6\u4eec\u2014\u2014\u5374\u91c7\u53d6\u4e86\u4e0d\u540c\u7684\u65b9\u6cd5\u3002\u4f46\u662f\uff0c\u5f53\u4ed6\u4eec\u8003\u91cfAnfinsen\u6240\u63d0\u51fa\u7684\u5047\u8bbe\uff0c\u5373\u6839\u636e\u6c28\u57fa\u9178\u5e8f\u5217\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u65f6\uff0c\u5374\u663e\u5f97\u6709\u70b9\u8fc7\u4e8e\u81ea\u4fe1\u4e86\u3002<\/span><\/p>\n<\/section>\n

\n

\uff083\uff09\u5236\u5b9a\u89c4\u5219<\/span><\/strong><\/span><\/p>\n<\/section>\n

\n

20\u4e16\u7eaa60\u5e74\u4ee3\u521d\uff0cJohn Moult\u8fd8\u662f\u4e00\u540d\u5927\u5b66\u751f\u65f6\uff0c\u5c31\u8ba1\u5212\u6210\u4e3a\u4e00\u540d\u7269\u7406\u5b66\u5bb6\u3002\u540e\u6765\uff0c\u4ed6\u4e86\u89e3\u5230\u4e86\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u3002\u4ed6\u8bf4\uff1a\u201c\u6709\u4eba\u6765\u7ed9\u6211\u4eec\u8bb2\u4e86\u4e00\u5802\u8bfe\uff0c\u8bf4\u751f\u7269\u5b66\u95ee\u9898\u592a\u91cd\u8981\u4e86\uff0c\u4e0d\u80fd\u7559\u7ed9\u751f\u7269\u5b66\u5bb6\u6765\u89e3\u51b3\u3002\u6211\u5f53\u65f6\u5f88\u50b2\u6162\uff0c\u6240\u4ee5\u5f53\u771f\u4e86\u3002\u201d\u88ab\u751f\u7269\u5b66\u8ff7\u4f4f\u7684\u4ed6\u5c06\u804c\u4e1a\u751f\u6daf\u8f6c\u5411\u4e86\u53e6\u4e00\u4e2a\u65b9\u5411\u3002<\/span><\/p>\n


<\/p>\n

\u6bd5\u4e1a\u540e\uff0cMoult\u8fdb\u5165\u4e86\u86cb\u767d\u8d28\u6676\u4f53\u5b66\u9886\u57df\u3002\u4ed6\u89e3\u7801\u4e86\u51e0\u79cd\u86cb\u767d\u8d28\u7684\u7ed3\u6784\uff0c\u5305\u62ec\u03b2-\u5185\u9170\u80fa\u9176\uff0c\u8fd9\u662f\u4e00\u79cd\u80fd\u591f\u7834\u574f\u9752\u9709\u7d20\u7684\u7ec6\u83cc\u9176\u30021970\u5e74\uff0c\u4ed6\u5728\u725b\u6d25\u5927\u5b66\u83b7\u5f97\u5206\u5b50\u751f\u7269\u7269\u7406\u5b66\u535a\u58eb\u5b66\u4f4d\u3002\u4f46\u5f53\u5f00\u542f\u535a\u58eb\u540e\u7814\u7a76\u540e\uff0c\u4ed6\u538c\u5026\u4e86\u5b9e\u9a8c\u6d3e\u7684\u65b9\u6cd5\uff0c\u5e76\u5f00\u59cb\u8f6c\u5411\u9010\u6b65\u53d1\u5c55\u58ee\u5927\u7684\u8ba1\u7b97\u6d3e\u3002\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\u4e0e\u5b9e\u9a8c\u5b66\u5bb6\u4e0d\u540c\uff0c\u4ed6\u4eec\u7f16\u5199\u8ba1\u7b97\u673a\u7b97\u6cd5\uff0c\u8bd5\u56fe\u8bc1\u660eAnfinsen\u7684\u5047\u8bbe\uff0c\u5373\u4ed6\u4eec\u53ef\u4ee5\u5411\u4e00\u4e2a\u7a0b\u5e8f\u8f93\u5165\u4e00\u4e32\u6c28\u57fa\u9178\uff0c\u4ece\u800c\u751f\u6210\u6b63\u786e\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002<\/span><\/p>\n<\/section>\n

\n
\n
<\/span><\/section>\n
John Moult\u4e0e\u4eba\u5171\u540c\u521b\u7acb\u4e86\u201c\u7ed3\u6784\u9884\u6d4b\u5173\u952e\u8bc4\u4f30\u201d(CASP) \u5b9e\u9a8c\uff0c\u8feb\u4f7f\u4ed6\u81ea\u5df1\u548c\u5176\u4ed6\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\u6839\u636e\u5b9e\u9a8c\u786e\u5b9a\u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u6765\u6d4b\u8bd5\u4ed6\u4eec\u7684\u86cb\u767d\u8d28\u8ba1\u7b97\u673a\u6a21\u578b\u3002\u56fe\u6e90\uff1aUmit Gulsen \/ Quanta Magazine<\/span><\/section>\n<\/section>\n<\/section>\n
\n

\u4ece\u751f\u7269\u5b9e\u9a8c\u5230\u8ba1\u7b97\u7684\u8f6c\u53d8\u5e76\u975e\u5766\u9014\u3002Moult\u5df2\u7ecf\u4e60\u60ef\u4e86\u4ee5\u6162\u5de5\u51fa\u7ec6\u6d3b\u5730\u65b9\u5f0f\u89e3\u6790\u5355\u4e00\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002\u4f46\u5728\u8ba1\u7b97\u751f\u7269\u5b66\u9886\u57df\uff0c\u6bcf\u9694\u4e00\u6bb5\u65f6\u95f4\u5c31\u6709\u8bba\u6587\u58f0\u79f0\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u548c\u76f8\u5173\u5b50\u95ee\u9898\u5df2\u7ecf\u5f97\u5230\u4e86\u89e3\u51b3\u3002<\/span><\/p>\n


<\/p>\n

Moult\u5bf9\u6b64\u8868\u793a\u6000\u7591\u3002\u4ed6\u8bf4\uff1a\u201c\u5728\u8fd9\u4e00\u9886\u57df\u53d1\u8868\u7684\u8bba\u6587\u4e0d\u50cf\u6211\u4ee5\u524d\u6240\u5728\u9886\u57df\u90a3\u6837\u4e25\u8c28\u3002\u8fd9\u5e76\u4e0d\u662f\u8bf4\u8ba1\u7b97\u751f\u7269\u5b66\u9886\u57df\u90fd\u662f\u9a97\u5b50\uff0c\u800c\u662f\u56e0\u4e3a\u6b64\u7c7b\u8ba1\u7b97\u5de5\u4f5c\u90fd\u662f\u5728\u865a\u62df\u4e16\u754c\u4e2d\u5b8c\u6210\u7684\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u5728\u865a\u62df\u4e16\u754c\u4e2d\uff0c\u5f53\u81ea\u7136\u754c\u7684\u89c4\u5219\u4e0d\u8d77\u4f5c\u7528\u65f6\uff0c\u8ba1\u7b97\u5b66\u5bb6\u4eec\u5c31\u4f1a\u5236\u5b9a\u81ea\u5df1\u7684\u89c4\u5219\u3002\u4ed6\u4eec\u4f1a\u8bbe\u8ba1\u7b97\u6cd5\uff0c\u8ba9\u539f\u5b50\u4ee5\u67d0\u79cd\u65b9\u5f0f\u7c98\u5728\u4e00\u8d77\uff0c\u6216\u8005\u8ba9\u86cb\u767d\u8d28\u603b\u662f\u5411\u53f3\u6216\u5411\u5de6\u6298\u53e0\u3002\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u8fd9\u4e9b\u6a21\u578b\u53d8\u5f97\u8d8a\u6765\u8d8a\u8131\u79bb\u73b0\u5b9e\u3002Moult\u8ba4\u4e3a\uff0c\u5728\u4e00\u4e2a\u4f60\u53ef\u4ee5\u5b8c\u5168\u63a7\u5236\u7684\u4e16\u754c\u91cc\uff0c\u4eba\u5f88\u96be\u4fdd\u6301\u4e25\u8c28\u3002<\/span><\/p>\n


<\/p>\n

\u4e0d\u8fc7\uff0c\u4ed6\u8fd8\u662f\u8ba4\u4e3a\u4e24\u79cd\u65b9\u6cd5\u90fd\u6709\u53ef\u53d6\u4e4b\u5904\u3002\u5b9e\u9a8c\u6d3e\u5de5\u4f5c\u7cbe\u7ec6\uff0c\u4f46\u901f\u5ea6\u7f13\u6162\uff1b\u8ba1\u7b97\u6d3e\u8fdb\u5c55\u8fc5\u901f\uff0c\u4f46\u5374\u8fdc\u79bb\u751f\u7269\u7269\u7406\u73b0\u5b9e\uff0c\u4ee5\u81f3\u4e8e\u7ecf\u5e38\u51fa\u9519\u3002<\/span><\/p>\n


<\/p>\n

\u4ed6\u60f3\uff0c\u4e00\u5b9a\u6709\u529e\u6cd5\u628a\u4e24\u79cd\u65b9\u6cd5\u7684\u4f18\u70b9\u7ed3\u5408\u8d77\u6765\u3002<\/span><\/p>\n<\/section>\n

\n

\uff084\uff09\u8dfa\u811a\u4ee5\u793a\u53cd\u5bf9<\/span><\/strong><\/span><\/p>\n<\/section>\n

\n

20\u4e16\u7eaa90\u5e74\u4ee3\u521d\uff0cMoult\u548c\u4ed6\u7684\u540c\u4e8bKrzysztof Fidelis\u60f3\u51fa\u4e86\u4e00\u4e2a\u529e\u6cd5\u6765\u89c4\u8303\u8ba1\u7b97\u751f\u7269\u5b66\u9886\u57df\u7684\u6df7\u4e71\u5c40\u9762\u3002\u4ed6\u4eec\u542f\u52a8\u4e86\u4e00\u4e2a\u540d\u4e3a\u201c\u7ed3\u6784\u9884\u6d4b\u5173\u952e\u8bc4\u4f30\u201d<\/span>\uff08Critical Assessment of Structure Prediction\uff0c\u7b80\u79f0 CASP\uff09<\/span>\u7684\u793e\u533a\u79d1\u5b66\u5b9e\u9a8c\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e2a\u60f3\u6cd5\u5f88\u7b80\u5355\u3002\u4f5c\u4e3aCASP\u7684\u53d1\u8d77\u4eba\uff0cMoult\u548cFidelis\u4f1a\u516c\u5e03\u4e00\u4efd\u86cb\u767d\u8d28\u6c28\u57fa\u9178\u5e8f\u5217\u5217\u8868\uff0c\u4e0a\u9762\u5217\u4e3e\u4e86\u8fd1\u671f\u5df2\u88ab\u89e3\u6790\u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u76f8\u5173\u6570\u636e\u7531\u76f8\u5e94\u7684\u5b9e\u9a8c\u4eba\u5458\u63d0\u4f9b\uff0c\u4f46\u7ed3\u679c\u5c1a\u672a\u53d1\u5e03\u3002\u7136\u540e\uff0c\u4e16\u754c\u5404\u5730\u7684\u8ba1\u7b97\u7814\u7a76\u5c0f\u7ec4\u5c06\u4f7f\u51fa\u6d51\u8eab\u89e3\u6570\u6765\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002\u4e00\u4e2a\u72ec\u7acb\u7684\u79d1\u5b66\u5bb6\u5c0f\u7ec4\u5c06\u901a\u8fc7\u6bd4\u8f83\u4ed6\u4eec\u7684\u7b54\u6848\u548c\u5b9e\u9a8c\u8bc1\u5b9e\u7684\u7ed3\u6784\u6765\u8bc4\u4f30\u8fd9\u4e9b\u9884\u6d4b\u6a21\u578b\u3002<\/span><\/p>\n


<\/p>\n

\u8fd9\u4e2a\u60f3\u6cd5\u88ab\u4ed8\u8bf8\u5b9e\u8df5\u3002\u4e8e\u662f\uff0cCASP\u5f88\u5feb\u5c31\u6210\u4e3a\u4ee5\u8ba1\u7b97\u65b9\u6cd5\u89e3\u51b3\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u7684\u8bd5\u9a8c\u573a\u3002\u90a3\u65f6\u8fd8\u6ca1\u6709\u4eba\u5de5\u667a\u80fd\uff0c\u8ba1\u7b97\u65b9\u6cd5\u4e3b\u8981\u662f\u6a21\u62df\u5206\u5b50\u7684\u7269\u7406\u5b66\u539f\u7406\u3002\u8fd9\u662f\u79d1\u5b66\u5bb6\u4eec\u516c\u5f00\u4e0e\u540c\u884c\u540c\u573a\u7ade\u6280\uff0c\u9a8c\u8bc1\u81ea\u5df1\u89c2\u70b9\u7684\u673a\u4f1a\u3002Thornton\u8868\u793a\uff1a\u201cCASP\u672c\u610f\u5e76\u4e0d\u662f\u4e3a\u4e86\u6bd4\u8d5b\uff0c\u4f46\u5b9e\u9645\u4e0a\u5df2\u7ecf\u6210\u4e3a\u4e00\u9879\u8d5b\u4e8b\u3002\u201d<\/span><\/p>\n


<\/p>\n

CASP\u6bcf\u4e24\u5e74\u4e3e\u529e\u4e00\u6b21\uff0c\u79d1\u5b66\u5bb6\u4eec\u4f1a\u5728\u963f\u897f\u6d1b\u9a6c\u4f1a\u8bae\u4e2d\u5fc3\u9f50\u805a\u4e00\u5802\uff0c\u8fd9\u662f\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u8499\u7279\u96f7\u9644\u8fd1\u4e00\u5ea7\u53e4\u8001\u7684\u5c0f\u6559\u5802\uff0c\u66fe\u7ecf\u662f\u536b\u7406\u516c\u4f1a\u6559\u5f92\u7684\u9690\u5c45\u5730\u3002\u4e0e\u4f1a\u671f\u95f4\uff0c\u7ec4\u7ec7\u8005\u4f1a\u5ba3\u5e03\u7ade\u8d5b\u7ed3\u679c\uff0c\u8ba1\u7b97\u5b66\u5bb6\u4eec\u4f1a\u53d1\u8868\u6f14\u8bb2\uff0c\u4ecb\u7ecd\u81ea\u5df1\u6240\u7528\u7684\u65b9\u6cd5\u3002Moult\u9f13\u52b1\u4e0e\u4f1a\u8005\u5982\u679c\u4e0d\u8d5e\u540c\u9648\u8ff0\u7684\u5185\u5bb9\uff0c\u53ef\u4ee5\u5728\u6728\u5730\u677f\u4e0a\u8dfa\u51e0\u811a\u4ee5\u793a\u53cd\u5bf9\u3002<\/span><\/p>\n


<\/p>\n

\u4ed6\u8bf4\uff1a\u201c\u521a\u5f00\u59cb\u7684\u65f6\u5019\uff0c\u8dfa\u811a\u58f0\u786e\u5b9e\u662f\u6b64\u8d77\u5f7c\u4f0f\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u66fe\u5e08\u4eceThornton\u7684\u4f26\u6566\u5927\u5b66\u5b66\u9662\u751f\u7269\u4fe1\u606f\u5b66\u6559\u6388David Jones\u56de\u5fc6\u8bf4\uff1a\u201c\u8dfa\u811a\u58f0\u4eff\u4f5b\u9f13\u58f0\u4e00\u6837\u3002\u201d\u5982\u679c\u6f14\u8bb2\u8005\u6240\u5206\u4eab\u7684\u7ec6\u8282\u592a\u5197\u957f\uff0c\u751f\u7269\u5b66\u5bb6\u4eec\u4f1a\u8dfa\u811a\uff1b\u5982\u679c\u9648\u8ff0\u5185\u5bb9\u5938\u5927\u5176\u8bcd\uff0c\u4ed6\u4eec\u4e5f\u4f1a\u8dfa\u811a\uff1b\u5982\u679c\u6f14\u8bb2\u8005\u7684\u89c2\u70b9\u91cd\u590d\u6216\u8fc7\u4e8e\u6742\u4e71\uff0c\u4ed6\u4eec\u8fd8\u4f1a\u8dfa\u811a\u3002Jones\u8868\u793a\uff1a\u201c\u8dfa\u811a\u58f0\u5e76\u4e0d\u8ba8\u538c\uff0c\u201d\u56e0\u4e3a\u8fd9\u90fd\u662f\u5584\u610f\u7684\u58f0\u97f3\u3002<\/span><\/p>\n<\/section>\n

\n
\n
<\/span><\/section>\n
\u65e9\u671f\u7684CASP\u4f1a\u8bae\u5728\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u8499\u7279\u96f7\u7684\u963f\u897f\u6d1b\u739b\u4f1a\u8bae\u4e2d\u5fc3\u4e3e\u884c\u3002\u5f53\u4e0e\u4f1a\u8005\u5728\u6728\u5730\u677f\u4e0a\u8dfa\u811a\u65f6\uff0c\u58f0\u97f3\u5c31\u50cf\u9f13\u58f0\u4e00\u6837\u3002\u56fe\u6e90\uff1aAramark Destinations<\/span><\/section>\n<\/section>\n<\/section>\n
\n

\u4e0d\u7ba1\u8dfa\u811a\u662f\u51fa\u4e8e\u4ec0\u4e48\u539f\u56e0\uff0c\u5f53\u8dfa\u811a\u58f0\u5728\u6f14\u8bb2\u8005\u8033\u8fb9\u54cd\u8d77\u65f6\uff0c\u90fd\u4f1a\u8ba9\u4eba\u611f\u5230\u5c34\u5c2c\u3002Jones\u8bf4:\u201c\u611f\u8c22\u8001\u5929\u7237\uff0c\u6211\u6f14\u8bb2\u65f6\u6ca1\u4eba\u8dfa\u8fc7\u811a\u3002\u6709\u4e00\u5e74\uff0c\u4ed6\u548c\u540c\u4e8b\u4eec\u63d0\u51fa\u4e86\u4e00\u79cd\u540d\u4e3a\u201c\u7a7f\u7ebf\u6cd5<\/span>\uff08threading\uff09<\/span>\u201d\u7684\u8ba1\u7b97\u65b9\u6cd5\uff0c\u5373\u901a\u8fc7\u5df2\u77e5\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u7f16\u7ec7\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u5bfb\u627e\u5951\u5408\u70b9\u3002\u4ed6\u4eec\u7684\u8868\u73b0\u8fd8\u53ef\u4ee5\u3002\u201c\u6211\u4eec\u5f53\u65f6\u5f88\u9ad8\u5174\u3002……\u4f46\u4e4b\u540e\u5c31\u5f00\u59cb\u8d70\u4e0b\u5761\u8def\u4e86\uff0c\u201dJones\u7b11\u7740\u56de\u5fc6\u9053.\u201c\u771f\u7684\uff0c\u633a\u5f88\u610f\u601d\u7684\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u5e15\u591a\u74e6\u5927\u5b66\u751f\u7269\u4fe1\u606f\u5b66\u6559\u6388Silvio Tosatto\u8868\u793a\uff0c\u5f53\u65f6\u5b66\u754c\u5174\u81f4\u76ce\u7136\u3002\u201c\u5927\u5bb6\u89c9\u5f97\u5982\u679c\u81ea\u5df1\u6709\u80fd\u591f\u6b63\u786e\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u7b97\u6cd5\uff0c\u5c31\u53ef\u4ee5\u6210\u4e3a\u767e\u4e07\u5bcc\u7fc1\u3002\u8fd8\u6709\u4e00\u4e9b\u4eba\u8ba4\u4e3a\u8bfa\u8d1d\u5c14\u5956\u5df2\u7ecf\u8fd1\u5728\u54ab\u5c3a\u4e86\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u5f53\u7136\uff0c\u65e9\u5e74\u8fd9\u4e9b\u7f8e\u68a6\u90fd\u6ca1\u6210\u771f\u3002\u5f53\u88ab\u95ee\u53ca\u5728\u6b64\u671f\u95f4\uff0cCASP\u6536\u5230\u7684\u5206\u4eab\u62a5\u544a\u8d28\u91cf\u5982\u4f55\u65f6\uff0cMoult\u505c\u987f\u4e86\u4e00\u4e0b\uff0c\u8bf4\u9053\uff1a\u201c\u53ef\u4ee5\u7528\u53c2\u5dee\u4e0d\u9f50<\/span>\uff08Random\uff09<\/span>\u6765\u5f62\u5bb9\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u6709\u4e9b\u65b9\u6cd5\u7684\u6548\u679c\u6bd4\u9884\u671f\u7684\u8981\u597d\uff0c\u6bd4\u5982\u201c\u540c\u6e90\u5efa\u6a21<\/span>\uff08homology modeling\uff09<\/span>\u201d\uff0c\u5b83\u901a\u8fc7\u6bd4\u8f83\u5df2\u77e5\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u6765\u63a8\u5bfc\u672a\u77e5\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002\u8fd8\u6709\u4e9b\u65b9\u6cd5\u5219\u4e00\u8d25\u6d82\u5730\u3002Moult\u8bf4\uff0c\u5927\u591a\u6570\u6a21\u578b\u7684\u9884\u6d4b\u7ed3\u679c\u90fd\u662f\u201c\u626d\u66f2\u53d8\u5f62\u7684\u201d\u3002<\/span><\/p>\n


<\/p>\n

\u8377\u5170\u764c\u75c7\u7814\u7a76\u6240\u548c\u4e4c\u7279\u52d2\u652f\u5927\u5b66\u7684\u7ed3\u6784\u751f\u7269\u5b66\u5bb6Anastassis Perrakis\u5f00\u73a9\u7b11\u8bf4\uff1a\u201c\u6211\u5f88\u559c\u6b22\u770b\u5230\u4ed6\u4eec\u5931\u8d25\u3002\u201d\u4ed6\u66fe\u5c06\u5b9e\u9a8c\u9a8c\u8bc1\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u63d0\u4f9b\u7ed9CASP\u7ec4\u7ec7\u8005\u4f5c\u4e3a\u6bd4\u8d5b\u53c2\u8003\u3002\u201c\u8fd9\u4e0d\u662f\u8f83\u52b2\uff0c\u6211\u4eec\u53ea\u662f\u559c\u6b22\u5c31\u79d1\u5b66\u95ee\u9898\u6349\u5f04\u5f7c\u6b64\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u4e0d\u8fc7\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\uff0c\u4e5f\u6709\u4e00\u4e9b\u4eba\u5d2d\u9732\u5934\u89d2\u30021996\u5e74\uff0c\u7b2c\u4e8c\u5c4aCASP\u7ed3\u675f\u540e\uff0c\u4e00\u4f4d\u540d\u53ebDavid Baker\u7684\u5e74\u8f7b\u4eba\u9080\u8bf7Jones\u5171\u4e58\u4e00\u8f86\u51fa\u79df\u8f66\u524d\u5f80\u673a\u573a\u3002\u4ed6\u542c\u8fc7Jones\u7684\u6f14\u8bb2\uff0c\u6b63\u5728\u7814\u7a76\u81ea\u5df1\u7684\u8ba1\u7b97\u6a21\u578b\u3002\u867d\u7136\u4ed6\u8fd8\u6ca1\u51c6\u5907\u597d\u53c2\u52a0\u8fd9\u6b21\u7684CASP\uff0c\u4f46\u4ed6\u60f3\u548cJones\u804a\u804a\u3002\u4e8e\u662f\uff0cJones\u5728\u51fa\u79df\u8f66\u4e0a\u503e\u542c\u4e86\u4ed6\u7684\u60f3\u6cd5\uff0c\u4f46\u6ca1\u60f3\u8fc7\u4f1a\u518d\u89c1\u5230\u4ed6\u3002<\/span><\/p>\n


<\/p>\n

\u7b49\u52301998\u5e74\uff0c\u8fd9\u4f4d\u5e74\u8f7b\u4eba\u51ed\u501f\u81ea\u5df1\u7684\u7b97\u6cd5Rosetta\u60ca\u8273\u5168\u573a\u3002Jones\u8bf4\uff0c\u4ed6\u5f53\u65f6\u53ef\u8c13\u662f\u201c\u4e00\u9a6c\u5f53\u5148\u201d\u3002<\/span><\/p>\n<\/section>\n

\n
\n
<\/span><\/section>\n
David Baker \u73b0\u5728\u662f\u4e16\u754c\u9886\u5148\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u4e13\u5bb6\u4e4b\u4e00\uff0c\u4ed6\u51ed\u501f\u540d\u4e3a Rosetta \u7684\u9ad8\u6027\u80fd\u7b97\u6cd5\uff0c\u5728CASP\u4e2d\u6210\u4e3a\u4e86\u4f17\u77e2\u4e4b\u7684\u3002\u3002\u56fe\u6e90\uff1aBBVA Foundation<\/span><\/section>\n<\/section>\n<\/section>\n
\n

Rosetta\u8fd9\u6837\u7684\u7b97\u6cd5\u53ef\u4ee5\u6a21\u62df\u6c28\u57fa\u9178\u5206\u5b50\u7684\u539f\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u9884\u6d4b\u5b83\u4eec\u5c06\u5982\u4f55\u6298\u53e0\u3002\u5b83\u4eec\u201c\u8868\u660e\u4f60\u786e\u5b9e\u53ef\u4ee5\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u4f46\u5b83\u8fd8\u4e0d\u591f\u597d\uff0c\u4e5f\u4e0d\u591f\u51c6\u786e\uff0c\u56e0\u6b64\u5b9e\u7528\u4ef7\u503c\u6709\u9650\uff0c\u201dBaker\u8bc4\u8bba\u9053\u3002<\/span><\/p>\n


<\/p>\n

2008\u5e74\uff0c\u8ba1\u7b97\u673a\u7684\u8868\u73b0\u4f9d\u7136\u4e0d\u5982\u4eba\u7c7b\u3002Baker\u5f53\u65f6\u6b63\u5728\u534e\u76db\u987f\u5927\u5b66\u7ba1\u7406\u81ea\u5df1\u7684\u5b9e\u9a8c\u5ba4\uff0c\u4ed6\u521b\u5efa\u4e86\u4e00\u6b3e\u540d\u4e3aFoldit\u7684\u514d\u8d39\u5728\u7ebf\u6e38\u620f\uff0c\u73a9\u5bb6\u53ef\u4ee5\u5c06\u4e00\u4e32\u4e32\u6c28\u57fa\u9178\u6298\u53e0\u6210\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u4ed6\u7684\u56e2\u961f\u5728\u53d1\u8868\u4e8e\u300a\u81ea\u7136\u300b\u671f\u520a\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d\u62a5\u544a\u8bf4\uff0c\u4eba\u7c7b\u73a9\u5bb6\u5728\u86cb\u767d\u8d28\u5efa\u6a21\u65b9\u9762\u7684\u8868\u73b0\u4f18\u4e8eRosetta\u3002<\/span><\/p>\n


<\/p>\n

\u4f46\u4eba\u7c7b\u7684\u9886\u5148\u4f18\u52bf\u4e0d\u4f1a\u6301\u7eed\u592a\u4e45\u30022010\u5e74\u4ee3\u521d\uff0c\u79d1\u5b66\u5bb6\u4eec\u5728\u4e00\u4e2a\u88ab\u79f0\u4e3a\u201c\u534f\u540c\u8fdb\u5316<\/span>\uff08co-evolution\uff09<\/span>\u201d\u7684\u6982\u5ff5\u4e0a\u53d6\u5f97\u4e86\u91cd\u5927\u7a81\u7834\uff0c\u8fd9\u63a8\u52a8\u4e86\u8fd9\u4e00\u9886\u57df\u7684\u53d1\u5c55\uff0c\u5e76\u4e3a\u65e5\u540e\u4eba\u5de5\u667a\u80fd\u7684\u53d1\u5c55\u6253\u4e0b\u4e86\u91cd\u8981\u57fa\u77f3\u3002\u8fd9\u4e2a\u6982\u5ff5\u5176\u5b9e\u5df2\u7ecf\u5b58\u5728\u4e86\u51e0\u5341\u5e74\uff0c\u7b80\u5355\u660e\u4e86\u7684\u8bf4\u5c31\u662f\uff1a\u901a\u8fc7\u6bd4\u8f83\u6210\u767e\u4e0a\u5343\u4e2a\u86cb\u767d\u8d28\u4e2d\u5bc6\u5207\u76f8\u5173\u7684\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u79d1\u5b66\u5bb6\u4eec\u53ef\u4ee5\u8bc6\u522b\u51fa\u53d1\u751f\u53d8\u5f02\u7684\u6c28\u57fa\u9178\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u53ef\u4ee5\u786e\u5b9a\u5b83\u4eec\u662f\u5426\u4e0e\u5176\u4ed6\u6c28\u57fa\u9178\u540c\u6b65\u53d1\u751f\u53d8\u5f02\u3002\u5982\u679c\u4e24\u4e2a\u6c28\u57fa\u9178\u540c\u65f6\u53d1\u751f\u4e86\u53d8\u5316\uff0c\u90a3\u4e48\u5b83\u4eec\u4e4b\u95f4\u5f88\u53ef\u80fd\u5b58\u5728\u67d0\u79cd\u8054\u7cfb\u3002\u4f2f\u514b\u5229\u5b9e\u9a8c\u5ba4\u7684\u7ed3\u6784\u751f\u7269\u5b66Adams\u8868\u793a\uff1a\u201c\u6211\u4eec\u53ef\u4ee5\u8bf4\uff0c\u8fd9\u4e24\u4e2a\u6c28\u57fa\u9178\u4e5f\u8bb8\u5728\u7a7a\u95f4\u4e0a\u5f88\u9760\u8fd1\u3002\u201d<\/span><\/p>\n<\/section>\n

\n
\n
<\/span><\/section>\n

\u86cb\u767d\u8d28\u7684\u534f\u540c\u8fdb\u5316\u80fd\u591f\u63ed\u793a\u5176\u7ed3\u6784\u3002\u56fe\u6e90\uff1aMark Belan<\/span><\/p>\n<\/section>\n<\/section>\n

\n

\u4f46\u76f4\u52302010\u5e74\u4ee3\u521d\uff0c\u8fd9\u79cd\u9884\u6d4b\u54ea\u4e9b\u6c28\u57fa\u9178\u4f1a\u53d1\u751f\u63a5\u89e6\u7684\u65b9\u6cd5\u4ee4\u4eba\u5931\u671b\uff0c\u51c6\u786e\u7387\u5f98\u5f8a\u572820% \u523024%\u4e4b\u95f4\u3002\u968f\u540e\uff0c\u79d1\u5b66\u5bb6\u4eec\u6ce8\u610f\u5230\uff0c\u4ed6\u4eec\u7684\u7edf\u8ba1\u65b9\u6cd5\u5b58\u5728\u8bef\u5dee\uff0c\u4e5f\u5c31\u662f\u8bf4\u4e00\u4e9b\u770b\u4f3c\u5f7c\u6b64\u63a5\u89e6\u7684\u6c28\u57fa\u9178\u5b9e\u9645\u4e0a\u5e76\u6ca1\u6709\u4efb\u4f55\u63a5\u89e6\u3002\u540e\u6765\uff0cMoult\u4e86\u89e3\u5230\uff0c\u51e0\u5341\u5e74\u6765\uff0c\u7edf\u8ba1\u5b66\u5bb6\u4e00\u76f4\u5bf9\u8fd9\u79cd\u8bef\u5dee\u7684\u5b58\u5728\u5fc3\u77e5\u809a\u660e\u3002\u4ed6\u8bf4\uff0c\u56de\u9996\u5f80\u4e8b\uff0c\u4f60\u4f1a\u60f3\u201c\u6211\u5f53\u521d\u600e\u4e48\u8fd9\u4e48\u7b28\uff1f\u201d<\/span><\/p>\n


<\/p>\n

\u968f\u540e\uff0c\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\u6e05\u7406\u4e86\u7edf\u8ba1\u5de5\u5177\u3002\u5230\u4e862016\u5e74\uff0c\u63a5\u89e6\u9884\u6d4b\u7684\u51c6\u786e\u7387\u5df2\u7ecf\u98d9\u5347\u81f347%\u3002\u4e24\u5e74\u540e\uff0c\u51c6\u786e\u7387\u8fbe\u5230\u4e8670%\u3002Baker\u7684\u7b97\u6cd5\u4e4b\u6240\u4ee5\u80fd\u53d6\u5f97\u6210\u529f\u8fd8\u8981\u5f52\u529f\u4e8e\u4ee5\u4e0b\u539f\u56e0\uff1a2014\u5e74\uff0cRosetta\u751f\u6210\u4e86\u4e24\u4e2a\u975e\u5e38\u7cbe\u786e\u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u4ee5\u81f3\u4e8eCASP\u8bc4\u5ba1\u5458\u8ba4\u4e3aBaker\u53ef\u80fd\u5df2\u7ecf\u89e3\u51b3\u4e86\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u3002<\/span><\/p>\n


<\/p>\n

Adams\u8868\u793a\uff0c\u534f\u540c\u8fdb\u5316\u7684\u6d1e\u89c1\u201c\u975e\u5e38\u5947\u5999\u201d\u3002\u5728\u4e0d\u4f7f\u7528\u673a\u5668\u5b66\u4e60\u7684\u60c5\u51b5\u4e0b\uff0c\u534f\u540c\u8fdb\u5316\u662f\u201c\u771f\u6b63\u63a8\u52a8\u8be5\u9886\u57df\u53d1\u5c55\u7684\u91cd\u5927\u4e8b\u4ef6\u4e4b\u4e00\u201d\u3002<\/span><\/p>\n


<\/p>\n

\u7136\u800c\uff0c\u8fd9\u9879\u7a81\u7834\u5e76\u6ca1\u80fd\u5e26\u9886\u8be5\u9886\u57df\u8d70\u5f97\u592a\u8fdc\u3002\u534f\u540c\u8fdb\u5316\u9700\u8981\u5927\u91cf\u76f8\u4f3c\u7684\u86cb\u767d\u8d28\u8fdb\u884c\u6bd4\u8f83\uff0c\u800c\u5b9e\u9a8c\u4eba\u5458\u89e3\u6790\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u901f\u5ea6\u4e0d\u8db3\u4ee5\u6ee1\u8db3\u8ba1\u7b97\u4eba\u5458\u7684\u9700\u6c42\u3002<\/span><\/p>\n


<\/p>\n

\u8c08\u53ca\u8fd9\u4e00\u5207\u65f6\uff0cMoult\u5f15\u7528\u4e86\u8fdb\u5316\u751f\u7269\u5b66\u4e2d\u7684\u4e00\u4e2a\u672f\u8bed\uff1a\u5c81\u6708\u5728\u95f4\u65ad\u5e73\u8861<\/span>\uff08punctuated equilibrium\uff09<\/span>\u4e2d\u6d41\u901d\u3002\u6709\u65f6\uff0c\u4eba\u4eec\u611f\u89c9\u597d\u50cf\u5341\u4ebf\u5e74\u90fd\u6ca1\u6709\u8fdb\u5316\u51fa\u597d\u7684\u60f3\u6cd5\uff0c\u4f46\u7d27\u63a5\u7740\u4fbf\u6709\u53ef\u80fd\u53d1\u751f\u4ee4\u4eba\u5174\u594b\u7684\u8fdb\u5c55\u3002<\/span><\/p>\n


<\/span><\/p>\n<\/section>\n

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<\/svg><\/section>\n<\/section>\n<\/section>\n
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2. \u95ee\u4e16<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\uff081\uff09\u4ed3\u4fc3\u4e0a\u9635<\/span><\/strong><\/span><\/p>\n<\/section>\n

\n

2016\u5e74\uff0cDavid Jones\u5728\u300a\u81ea\u7136\u300b\u671f\u520a\u4e0a\u53d1\u8868\u7684\u4e00\u7bc7\u65b0\u8bba\u6587\u4e2d\u77a5\u89c1\u4e86\u672a\u6765\u7684\u666f\u8c61\u3002\u6765\u81ea\u8c37\u6b4cDeepMind<\/span>\uff08\u4e00\u4e2a\u4f4d\u4e8e\u4f26\u6566\u7684\u4eba\u5de5\u667a\u80fd\u56e2\u961f\uff09<\/span>\u7684\u7814\u7a76\u4eba\u5458\u8be6\u7ec6\u4ecb\u7ecd\u4e86\u4ed6\u4eec\u7684\u7b97\u6cd5\u662f\u5982\u4f55\u5229\u7528\u4e00\u79cd\u88ab\u79f0\u4e3a\u6df1\u5ea6\u5b66\u4e60\u7684\u65b9\u6cd5\uff0c\u5728\u56f4\u68cb\u8fd9\u9879\u53e4\u8001\u7684\u68cb\u76d8\u6e38\u620f\u4e2d\u51fb\u8d25\u4eba\u7c7b\u51a0\u519b\u7684\u3002<\/span><\/p>\n


<\/p>\n

Jones\u5927\u5403\u4e00\u60ca\u3002\u201c\u5927\u4e8b\u5373\u5c06\u53d1\u751f\uff0c\u6211\u771f\u7684\u8981\u4e86\u89e3\u6df1\u5ea6\u5b66\u4e60\u4e86\uff0c\u201d\u4ed6\u56de\u5fc6\u9053\u3002<\/span><\/p>\n


<\/p>\n

\u6df1\u5ea6\u5b66\u4e60\u662f\u4e00\u79cd\u53d7\u4eba\u7c7b\u5927\u8111\u542f\u53d1\u7684\u4eba\u5de5\u667a\u80fd\u6280\u672f\u3002\u5728\u4f60\u7684\u5927\u8111\u4e2d\uff0c\u5206\u5b50\u4fe1\u606f\u901a\u8fc7\u7531\u795e\u7ecf\u5143\u8fd9\u79cd\u8111\u7ec6\u80de\u6784\u6210\u7684\u4e92\u901a\u4e92\u8054\u7f51\u7edc\u8fdb\u884c\u4f20\u8f93\u3002\u795e\u7ecf\u5143\u5411\u5916\u5ef6\u4f38\u7684\u7a81\u8d77\u53eb\u505a\u6811\u7a81\uff0c\u53ef\u4ee5\u6355\u6349\u90bb\u8fd1\u795e\u7ecf\u5143\u6d3e\u51fa\u7684\u5206\u5b50\uff0c\u8fd9\u4e9b\u5206\u5b50\u4f1a\u544a\u8bc9\u63a5\u6536\u795e\u7ecf\u5143\uff0c\u662f\u5426\u9700\u8981\u53d1\u5c04\u548c\u4f20\u64ad\u4fe1\u53f7\u3002<\/span><\/p>\n


<\/p>\n

\u5e03\u6717\u5927\u5b66\u8ba1\u7b97\u673a\u79d1\u5b66\u7cfb\u7684\u6559\u6388Michael Littman\u8bf4\uff1a\u201c\u5982\u679c\u8be5\u795e\u7ecf\u5143\u63a5\u53d7\u5230\u4e86\u8db3\u591f\u591a\u7684\u6d3b\u52a8\u5206\u5b50\uff0c\u90a3\u4e48\u8be5\u795e\u7ecf\u5143\u5c31\u4f1a\u88ab\u6fc0\u6d3b\uff0c\u4ece\u800c\u53d1\u51fa\u4fe1\u53f7\u3002\u8fd9\u5c06\u5bfc\u81f4\u53e6\u4e00\u6ce2\u5206\u5b50\u88ab\u91ca\u653e\u5230\u4e0b\u4e00\u4e2a\u795e\u7ecf\u5143\u3002\u201d<\/span><\/p>\n


<\/p>\n

20\u4e16\u7eaa50\u5e74\u4ee3\uff0c\u8ba1\u7b97\u673a\u79d1\u5b66\u5bb6\u610f\u8bc6\u5230\uff0c\u4ed6\u4eec\u53ef\u4ee5\u5c06\u7535\u5b50\u6bd4\u7279\u8fde\u63a5\u8d77\u6765\uff0c\u521b\u5efa\u201c\u795e\u7ecf\u7f51\u7edc\u201d\u3002\u795e\u7ecf\u7f51\u7edc\u4e2d\u7684\u6bcf\u4e2a\u5355\u5143\u90fd\u662f\u4e00\u4e2a\u8282\u70b9\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u5176\u6bd4\u55bb\u4e3a\u795e\u7ecf\u5143\uff1a\u4e00\u4e2a\u795e\u7ecf\u5143\u63a5\u6536\u6765\u81ea\u5176\u4ed6\u795e\u7ecf\u5143\u7684\u4fe1\u606f\uff0c\u7136\u540e\u8ba1\u7b97\u662f\u5426\u5411\u4e0b\u4e00\u4e2a\u795e\u7ecf\u5143\u53d1\u5c04\u4fe1\u606f\u3002\u5728\u8fd9\u6837\u7684\u795e\u7ecf\u7f51\u7edc\u4e2d\uff0c\u4fe1\u606f\u901a\u8fc7\u591a\u5c42\u795e\u7ecf\u5143\u4f20\u64ad\uff0c\u4ea7\u751f\u7279\u5b9a\u7684\u7ed3\u679c\uff0c\u6bd4\u5982\u8bc6\u522b\u56fe\u50cf\u4e2d\u7684\u72d7\u7b49\u3002<\/span><\/p>\n<\/section>\n

\n
\n

<\/span><\/p>\n

<\/span><\/p>\n

\u795e\u7ecf\u7f51\u7edc\u7684\u5de5\u4f5c\u539f\u7406\u3002\u56fe\u6e90\uff1aMark Belan<\/span><\/p>\n<\/section>\n<\/section>\n

\n

\u795e\u7ecf\u5143\u7684\u5c42\u6570\u8d8a\u591a\uff0c\u80fd\u8fdb\u884c\u7684\u8ba1\u7b97\u8d8a\u590d\u6742\u3002\u4f46\u65e9\u671f\u7684\u795e\u7ecf\u7f51\u7edc\u4e00\u822c\u53ea\u6709\u4e24\u5c42\u3002\u5230\u4e8620\u4e16\u7eaa90\u5e74\u4ee3\uff0c\u795e\u7ecf\u5143\u5c42\u6570\u589e\u52a0\u5230\u4e86\u4e09\u5c42\uff0c\u5e76\u5728\u63a5\u4e0b\u676520\u5e74\u95f4\u90fd\u672a\u589e\u52a0\u3002Littman\u8bf4\uff1a\u201c\u6211\u4eec\u4e0d\u77e5\u9053\u5982\u4f55\u53ef\u9760\u5730\u521b\u5efa\u6bd4\u8fd9\u66f4\u6df1\u5c42\u7684\u795e\u7ecf\u7f51\u7edc\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u81ea20\u4e16\u7eaa90\u5e74\u4ee3\u4ee5\u6765\uff0c\u5305\u62ecJones\u548cMoult\u5728\u5185\u7684\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\u4e00\u76f4\u5c1d\u8bd5\u5c06\u795e\u7ecf\u79d1\u5b66\u7f51\u7edc\u8fd0\u7528\u5230\u86cb\u767d\u8d28\u79d1\u5b66\u4e2d\uff0c\u4f46\u6d45\u5c42\u7f51\u7edc\u548c\u7a00\u758f\u6570\u636e\u7684\u5c40\u9650\u6027\u8ba9\u4ed6\u4eec\u6b62\u6b65\u4e0d\u524d\u3002\u968f\u540e\u65f6\u95f4\u6765\u523020\u4e16\u7eaa10\u5e74\u4ee3\u521d\uff0c\u8ba1\u7b97\u673a\u79d1\u5b66\u5bb6\u4eec\u5b66\u4f1a\u4e86\u5982\u4f55\u66f4\u597d\u5730\u6784\u5efa\u795e\u7ecf\u7f51\u7edc\uff0c\u4ee5\u4fbf\u5bf9\u66f4\u591a\u5c42\u795e\u7ecf\u5143\u8fdb\u884c\u7a33\u5b9a\u7684\u8bad\u7ec3\u3002\u795e\u7ecf\u7f51\u7edc\u7684\u5c42\u6570\u4e5f\u9010\u6e10\u4ece20\u5c42\u300150\u5c42\u3001100\u5c42\u53d1\u5c55\u5230\u6570\u5343\u5c42\u3002Littman\u8868\u793a\uff1a\u201c\u4e3a\u4e86\u533a\u522b\u4e8e\u6211\u4eec\u572890\u5e74\u4ee3\u7684\u505a\u6cd5\uff0c\u4eba\u4eec\u5f00\u59cb\u79f0\u4e4b\u4e3a\u2018\u6df1\u5ea6\u5b66\u4e60\u2019\u3002\u8981\u8bf4\u673a\u5668\u5b66\u4e60\u9886\u57df\u7684\u7814\u7a76\u8005\u4eec\u64c5\u957f\u4ec0\u4e48\uff0c\u90a3\u53ef\u4ee5\u8bf4\u662f\u521b\u9020\u4e00\u4e9b\u9177\u70ab\u7684\u540d\u8bcd\u4e86\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u6df1\u5ea6\u5b66\u4e60\u6539\u53d8\u4e86\u4eba\u5de5\u667a\u80fd\uff0c\u4f7f\u7b97\u6cd5\u80fd\u591f\u51fa\u8272\u5730\u8bc6\u522b\u7167\u7247\u6216\u58f0\u97f3\u4e2d\u7684\u7279\u5f81\uff0c\u5e76\u5728\u6e38\u620f\u4e2d\u51fb\u8d25\u4e86\u4eba\u7c7b\u3002<\/span><\/p>\n


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2016\u5e743\u6708\uff0c\u5f53DeepMind\u8054\u5408\u521b\u59cb\u4ebaDemis Hassabis\u5728\u9996\u5c14\u89c1\u8bc1\u5176\u65d7\u4e0b\u7684\u4eba\u5de5\u667a\u80fd\u7cfb\u7edfAlphaGo\u5728\u5386\u53f2\u60a0\u4e45\u7684\u56f4\u68cb\u6bd4\u8d5b\u4e2d\u51fb\u8d25\u4eba\u7c7b\u4e16\u754c\u51a0\u519b\u65f6\uff0c\u4ed6\u56de\u60f3\u8d77\u4e86\u81ea\u5df1\u5728\u5927\u5b66\u65f6\u73a9Foldit\u7684\u60c5\u666f\u3002\u4ed6\u60f3\u77e5\u9053\uff0c\u5982\u679cDeepMind\u7684\u7814\u7a76\u4eba\u5458\u80fd\u5199\u51fa\u6a21\u4eff\u56f4\u68cb\u5927\u5e08\u76f4\u89c9\u7684\u7b97\u6cd5\uff0c\u96be\u9053\u4ed6\u4eec\u4e0d\u80fd\u5199\u51fa\u6a21\u4effFoldit\u6e38\u620f\u73a9\u5bb6\u76f4\u89c9\u7684\u7b97\u6cd5\u5417\uff1f\u8fd9\u6837\u7684\u7b97\u6cd5\u867d\u7136\u4e0d\u61c2\u751f\u7269\u5b66\uff0c\u5374\u77e5\u9053\u5982\u4f55\u6298\u53e0\u86cb\u767d\u8d28\u3002<\/span><\/p>\n<\/section>\n

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2016\u5e74\uff0c\u8c37\u6b4cDeepMind\u7684\u4eba\u5de5\u667a\u80fd\u7cfb\u7edfAlphaGo\u6218\u80dc\u4e86\u4e16\u754c\u56f4\u68cb\u51a0\u519b\u674e\u4e16\u77f3\uff08\u53f3\uff09\uff0c\u5176\u6a21\u4eff\u4eba\u7c7b\u76f4\u89c9\u7684\u80fd\u529b\u5f15\u8d77\u4e86\u751f\u7269\u5b66\u5bb6\u5bf9\u6df1\u5ea6\u5b66\u4e60\u5728\u86cb\u767d\u8d28\u79d1\u5b66\u4e2d\u6f5c\u529b\u7684\u5173\u6ce8\u3002\u56fe\u6e90\uff1aGoogle DeepMind<\/span><\/section>\n<\/section>\n<\/section>\n
\n

\u829d\u52a0\u54e5\u4e30\u7530\u5de5\u4e1a\u5927\u5b66\u7684\u6559\u6388\u8bb8\u9526\u6ce2<\/span>\uff08Jinbo Xu\uff09<\/span>\u4e5f\u8ba4\u8bc6\u5230\u4e86\u5229\u7528\u6df1\u5ea6\u5b66\u4e60\u89e3\u51b3\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u7684\u6f5c\u529b\u3002\u4ed6\u53d7\u5230\u4e86\u795e\u7ecf\u7f51\u7edc\u5728\u56fe\u50cf\u8bc6\u522b\u65b9\u9762\u6240\u53d6\u5f97\u7684\u6210\u7ee9\u7684\u542f\u53d1\u3002\u5f53\u65f6\uff0c\u8ba1\u7b97\u673a\u79d1\u5b66\u5bb6\u5df2\u7ecf\u5728\u5377\u79ef\u7f51\u7edc\u65b9\u9762\u53d6\u5f97\u4e86\u5de8\u5927\u6210\u529f\uff0c\u5377\u79ef\u7f51\u7edc\u5229\u7528\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5\u5c06\u56fe\u50cf\u5206\u5272\u6210\u82e5\u5e72\u5757\uff0c\u5e76\u8bc6\u522b\u5b83\u4eec\u4e4b\u95f4\u7684\u6a21\u5f0f\u3002\u8bb8\u6559\u6388\u5c06\u8fd9\u4e00\u6280\u672f\u5f15\u5165\u4e86\u86cb\u767d\u8d28\u6298\u53e0\u9886\u57df\u3002\u4ed6\u4f7f\u7528\u4e00\u79cd\u79f0\u4e3a\u77e9\u9635\u7684\u6570\u5b66\u5bf9\u8c61\u6765\u8868\u793a\u54ea\u4e9b\u6c28\u57fa\u9178\u5728\u7a7a\u95f4\u4e2d\u5f7c\u6b64\u90bb\u8fd1\uff0c\u7136\u540e\u5c06\u6570\u636e\u4f5c\u4e3a\u56fe\u50cf\u8f93\u5165\u5377\u79ef\u7f51\u7edc\u3002\u8be5\u7b97\u6cd5\u901a\u8fc7\u5bfb\u627e\u8fd9\u4e9b\u56fe\u50cf\u4e4b\u95f4\u7684\u6a21\u5f0f\u6765\u9884\u6d4b\u7ec4\u6210\u86cb\u767d\u8d28\u7684\u539f\u5b50\u7684\u4e09\u7ef4\u5750\u6807\u3002<\/span><\/p>\n


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2016\u5e74\uff0c\u4ed6\u5728arxiv.org\u4e0a\u53d1\u5e03\u4e86\u8fd9\u9879\u7684\u9884\u5370*<\/span>\uff08\u540e\u6765\u53d1\u8868\u5728PLOS Computational Biology\u4e0a\uff09<\/span>\uff0c\u5411\u4eba\u4eec\u5c55\u793a\u4e86\u201c\u6df1\u5ea6\u5b66\u4e60\u7684\u6f5c\u5728\u5e94\u7528\u201d\u3002Moult\u8868\u793a\uff1a\u201c\u8fd9\u5728\u5f53\u65f6\u5bf9\u86cb\u767d\u8d28\u6298\u53e0\u9886\u57df\u5f71\u54cd\u9887\u6df1\u3002\u201d<\/span><\/p>\n<\/section>\n

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Wang, Sheng, et al. “Accurate de novo prediction of protein contact map by ultra-deep learning model.” PLoS computational biology 13.1 (2017): e1005324.<\/span><\/section>\n<\/section>\n<\/blockquote>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u4e0d\u4e45\u4e4b\u540e\uff0c\u86cb\u767d\u8d28\u7ed3\u6784\u7814\u7a76\u5c0f\u7ec4\u5f00\u59cb\u6d89\u8db3\u6df1\u5ea6\u5b66\u4e60\u3002AlQuraishi\u548c\u4ed6\u7684\u56e2\u961f\u7387\u5148\u5f00\u53d1\u51fa\u4e86\u4e00\u79cd\u65b9\u6cd5\uff0c\u53ef\u4ee5\u5b8c\u5168\u901a\u8fc7\u795e\u7ecf\u7f51\u7edc\u76f4\u63a5\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u4e5f\u5c31\u662f\u6240\u8c13\u7684\u201c\u7aef\u5230\u7aef\u201d<\/span>\uff08end-to-end\uff09<\/span>\u65b9\u6cd5\uff0c\u53ea\u662f\u6548\u679c\u5e76\u4e0d\u7406\u60f3\u3002\u5176\u4ed6\u4eba\u5219\u662f\u5404\u663e\u795e\u901a\uff0c\u52aa\u529b\u60f3\u8981\u8ddf\u4e0a\u8fd9\u6ce2\u79d1\u7814\u7684\u65b0\u6d6a\u6f6e\u3002<\/span><\/p>\n


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Jones\u8bf4\uff1a\u201c\u6211\u5f53\u65f6\u5e76\u4e0d\u6e05\u695a\u81ea\u5df1\u60f3\u7528\u6df1\u5ea6\u5b66\u4e60\u505a\u4ec0\u4e48\uff0c\u4f46\u6211\u610f\u8bc6\u5230\u6211\u9700\u8981\u4e86\u89e3\u548c\u8fd0\u7528\u6df1\u5ea6\u5b66\u4e60\u3002\u201d<\/span><\/p>\n


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\u5728\u4ed6\u5df2\u7ecf\u5f00\u59cb\u64b0\u5199\u8d44\u52a9\u7533\u8bf7\uff0c\u81ea\u5bfb\u51fa\u8def\u65f6\uff0c\u4ed6\u6536\u5230\u4e86\u8c37\u6b4cDeepMind\u7684\u4e00\u5c01\u7535\u5b50\u90ae\u4ef6\u3002\u4ed6\u4eec\u5411Jones\u8be2\u95ee\u4e86CASP\u7ade\u8d5b\u7684\u60c5\u51b5\uff0c\u5e76\u8868\u793a\u613f\u610f\u63d0\u4f9b\u5e2e\u52a9\u3002\u201c\u6211\u4ee5\u4e3a\u4ed6\u4eec\u7684\u610f\u601d\u662f\uff1a\u6211\u4eec\u53ef\u4ee5\u63d0\u4f9b\u5f3a\u5927\u7684\u8ba1\u7b97\u673a\u80fd\u529b\uff0c\u201d\u743c\u65af\u8bf4\u9053\u3002<\/span><\/p>\n


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\u53cc\u65b9\u89c1\u9762\u4e4b\u540e\uff0cJones\u53d1\u73b0\u8c37\u6b4c\u7684\u91ce\u5fc3\u663e\u7136\u4e0d\u6b62\u4e8e\u6b64\u3002\u4f46\u8981\u5b9e\u73b0\u81ea\u5df1\u7684\u96c4\u5fc3\u58ee\u5fd7\uff0c\u8fd9\u5bb6\u79d1\u6280\u5de8\u5934\u516c\u53f8\u9700\u8981\u66f4\u591a\u7684\u79d1\u5b66\u4eba\u624d\u3002<\/span><\/p>\n<\/section>\n

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\uff082\uff09\u65b0\u79c0\u5165\u573a<\/span><\/strong><\/p>\n<\/section>\n

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2016\u5e74\uff0cJones\u5f00\u59cb\u62c5\u4efb\u8c37\u6b4cDeepMind\u7684\u987e\u95ee\uff0c\u8d1f\u8d23\u4e00\u4e2a\u540e\u6765\u88ab\u79f0\u4e3aAlphaFold\u7684\u9879\u76ee\uff1b\u4e0e\u6b64\u540c\u65f6\uff0cJohn Jumper\u6b63\u5728\u829d\u52a0\u54e5\u5927\u5b66\u5b8c\u6210\u4ed6\u7684\u7406\u8bba\u5316\u5b66\u535a\u58eb\u5b66\u4f4d\u3002<\/span><\/p>\n


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\u5c11\u5e74\u65f6\u671f\uff0cJumper\u81ea\u5b66\u4e86\u8ba1\u7b97\u673a\u7f16\u7a0b\u3002\u4ed6\u5728\u7269\u7406\u65b9\u9762\u4e5f\u5f88\u6709\u5929\u8d4b\u3002\u56e0\u6b64\uff0c\u5230\u4e86\u9009\u62e9\u5927\u5b66\u4e13\u4e1a\u65f6\uff0c\u5c3d\u7ba1\u4ed6\u7684\u7236\u6bcd\u90fd\u662f\u5de5\u7a0b\u5e08\u4e14\u62c5\u5fc3\u4ed6\u627e\u4e0d\u5230\u5de5\u4f5c\uff0c\u4f46\u4ed6\u8fd8\u662f\u51b3\u5b9a\u5b66\u4e60\u6570\u5b66\u548c\u7269\u7406\u3002<\/span><\/p>\n


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\u201c\u6211\u4e00\u76f4\u4ee5\u4e3a\u81ea\u5df1\u4f1a\u6210\u4e3a\u4e00\u540d\u7814\u7a76\u2018\u5b87\u5b99\u6cd5\u5219\u2019\u7684\u7269\u7406\u5b66\u5bb6\uff0c\u201dJumper\u8bf4\u3002\u201c\u6211\u4e00\u76f4\u70ed\u7231\u63a2\u7d22\u5b87\u5b99\u771f\u7406\u7684\u8fd9\u4e00\u7406\u5ff5\u3002\u201d<\/span><\/p>\n<\/section>\n

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\u4f5c\u4e3a\u4e00\u540d\u672c\u79d1\u751f\uff0cJohn Jumper\u5b66\u4e60\u4e86\u7269\u7406\u548c\u6570\u5b66\uff0c\u7136\u540e\u627e\u5230\u4e86\u4e00\u4efd\u521b\u5efa\u86cb\u767d\u8d28\u8ba1\u7b97\u673a\u6a21\u62df\u7684\u5de5\u4f5c\u3002\u8fd9\u4e9b\u7ecf\u5386\u4f7f\u4ed6\u80fd\u591f\u9886\u5bfc\u8c37\u6b4cDeepMind \u7684AlphaFold\u9879\u76ee\u3002\u56fe\u6e90\uff1aJohn Jumper<\/span><\/section>\n<\/section>\n<\/section>\n
\n

\u5728\u8303\u5fb7\u6bd4\u5c14\u7279\u5927\u5b66\u8bfb\u672c\u79d1\u65f6\uff0c\u4ed6\u4e0e\u8d39\u7c73\u56fd\u5bb6\u52a0\u901f\u5668\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u4eba\u5458\u5408\u4f5c\uff0c\u7814\u7a76\u5938\u514b<\/span>\uff08quarks\uff09<\/span>\u8fd9\u79cd\u4e9a\u539f\u5b50\u7c92\u5b50\u7684\u5947\u7279\u5c5e\u6027\u3002\u4e00\u5929\uff0c\u5f53\u4ed6\u548c\u7814\u7a76\u4eba\u5458\u5750\u5728\u4e00\u8d77\u5403\u5348\u996d\u65f6\uff0c\u4ed6\u5f97\u77e5\u4e86\u4e00\u4e2a\u574f\u6d88\u606f\u3002\u201c\u90a3\u4e48\uff0c\u6211\u4eec\u6b63\u5728\u8fdb\u884c\u7684\u8fd9\u9879\u5b9e\u9a8c\u4ec0\u4e48\u65f6\u5019\u624d\u80fd\u542f\u52a8\u5462\uff1f\u201dJumper\u56de\u5fc6\u81ea\u5df1\u66fe\u8fd9\u6837\u95ee\u4ed6\u4eec\u3002\u5176\u4e2d\u4e00\u4f4d\u6559\u6388\u8bf4\uff0c\u4ed6\u53ef\u80fd\u9000\u4f11\u524d\u7b49\u4e0d\u5230\u4e86\u3002\u53e6\u4e00\u4f4d\u5e74\u7eaa\u7a0d\u957f\u7684\u6559\u6388\u8bf4\uff0c\u4ed6\u53ef\u80fd\u90fd\u6d3b\u4e0d\u5230\u90a3\u4e00\u5929\u3002<\/span><\/p>\n


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\u201c\u6211\u5e0c\u671b\u81ea\u5df1\u505a\u79d1\u7814\u8017\u8d39\u7684\u65f6\u95f4\u6bd4\u4e24\u4f4d\u6559\u6388\u8bf4\u7684\u77ed\u4e00\u70b9\uff0c\u201dJumper\u8bf4\u3002\u5728\u5b8c\u6210\u672c\u79d1\u5b66\u4e1a\u540e\uff0c\u4ed6\u53c2\u4e0e\u4e86\u4e00\u4e2a\u7406\u8bba\u51dd\u805a\u6001\u7269\u8d28\u7269\u7406\u5b66\u7684\u535a\u58eb\u8bfe\u7a0b\u2014\u2014\u4f46\u5f88\u5feb\u5c31\u8f8d\u5b66\u4e86\u3002\u4ed6\u5728D.E. Shaw\u7814\u7a76\u516c\u53f8\u627e\u5230\u4e86\u4e00\u4efd\u5de5\u4f5c\uff0c\u8fd9\u662f\u4e00\u5bb6\u7ebd\u7ea6\u7684\u516c\u53f8\uff0c\u5f53\u65f6\u6b63\u5728\u8fdb\u884c\u86cb\u767d\u8d28\u57fa\u672c\u6a21\u62df\u7684\u7814\u7a76\u3002\u901a\u8fc7\u4e86\u89e3\u86cb\u767d\u8d28\u5982\u4f55\u8fd0\u52a8\u548c\u53d8\u5316\uff0c\u4ed6\u4eec\u5e0c\u671b\u80fd\u66f4\u597d\u5730\u7406\u89e3\u5404\u79cd\u75be\u75c5\u7684\u673a\u5236\uff0c\u4f8b\u5982\u80ba\u764c\u3002<\/span><\/p>\n


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\u8fd9\u662fJumper\u7b2c\u4e00\u6b21\u610f\u8bc6\u5230\u81ea\u5df1\u5de5\u4f5c\u7684\u6f5c\u5728\u91cd\u8981\u6027\u3002\u201c\u8fd9\u5173\u4e4e\u5065\u5eb7\u548c\u5ef6\u957f\u4eba\u4eec\u7684\u5bff\u547d\uff0c\u201d\u4ed6\u8bf4\u3002\u5728\u63a5\u4e0b\u6765\u7684\u4e09\u5e74\u91cc\uff0cJumper\u5728\u516c\u53f8\u7684\u8d85\u7ea7\u8ba1\u7b97\u673a\u4e0a\u5bf9\u86cb\u767d\u8d28\u7684\u8fd0\u52a8\u8fdb\u884c\u4e86\u5efa\u6a21\uff0c\u8fd9\u4e9b\u8d85\u7ea7\u8ba1\u7b97\u673a\u662f\u4e13\u95e8\u4e3a\u66f4\u5feb\u5730\u6a21\u62df\u5206\u5b50\u800c\u5efa\u9020\u7684\u3002\u201c\u6709\u65f6\u5019\uff0c\u6211\u5728\u5468\u4e8c\u4e00\u5929\u505a\u7684\u6a21\u62df\u6bd4\u6211\u6574\u4e2a\u535a\u58eb\u671f\u95f4\u8981\u505a\u7684\u8fd8\u591a\uff0c\u201d\u4ed6\u8bf4\u3002<\/span><\/p>\n


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2011\u5e74\uff0c\u4ed6\u51b3\u5b9a\u518d\u6b21\u5c1d\u8bd5\u8bfb\u7814\uff0c\u8fd9\u6b21\u662f\u5728\u829d\u52a0\u54e5\u5927\u5b66\u5b66\u4e60\u7406\u8bba\u5316\u5b66\u3002\u4ed6\u4ecd\u7136\u5bf9\u86cb\u767d\u8d28\u7ed3\u6784\u548c\u8fd0\u52a8\u611f\u5174\u8da3\u3002\u4f46\u4ed6\u5bf9\u5b66\u672f\u754c\u7684\u7f13\u6162\u8fdb\u5c55\u611f\u5230\u6cae\u4e27\u3002\u201c\u6211\u518d\u4e5f\u65e0\u6cd5\u4f7f\u7528\u6211\u5728D.E. Shaw\u516c\u53f8\u7528\u8fc7\u7684\u90a3\u79cd\u5b9a\u5236\u8ba1\u7b97\u673a\u786c\u4ef6\u4e86\uff0c\u201dJumper\u8bf4\u3002\u4ed6\u60f3\u77e5\u9053\u662f\u5426\u53ef\u4ee5\u4f7f\u7528\u4eba\u5de5\u667a\u80fd<\/span>\uff08\u5f53\u65f6\u88ab\u79f0\u4e3a\u7edf\u8ba1\u7269\u7406\uff09<\/span>\u6765\u5b9e\u73b0\u5feb\u901f\u6a21\u62df\uff0c\u800c\u8fd9\u901a\u5e38\u9700\u8981\u5148\u8fdb\u7684\u673a\u5668\u3002\u4ed6\u5f00\u59cb\u6d89\u8db3\u673a\u5668\u5b66\u4e60\u548c\u795e\u7ecf\u7f51\u7edc\u3002<\/span><\/p>\n


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\u5728\u6b64\u671f\u95f4\uff0c\u4ed6\u4e5f\u5f00\u59cb\u601d\u8003\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u3002\u4ed6\u89c9\u5f97\u8fd9\u4e2a\u95ee\u9898\u5e94\u8be5\u53ef\u4ee5\u7528\u86cb\u767d\u8d28\u6570\u636e\u5e93\u4e2d\u7684\u8bad\u7ec3\u6570\u636e\u6765\u89e3\u51b3\u2014\u2014\u52302012\u5e74\uff0c\u8be5\u6570\u636e\u5e93\u5df2\u5305\u542b\u8d85\u8fc776,000\u79cd\u86cb\u767d\u8d28\u7ed3\u6784\u3002<\/span><\/p>\n


<\/p>\n

Jumper\u8bf4\uff1a\u201c\u6211\u5f53\u65f6\u76f8\u4fe1\u6570\u636e\u91cf\u5df2\u7ecf\u8db3\u591f\u591a\u4e86\uff0c\u4f46\u662f\u60f3\u6cd5\u8fd8\u4e0d\u591f\u6210\u719f\u3002\u201d<\/span><\/p>\n


<\/p>\n

2017\u5e74\uff0cJumper\u542c\u8bf4\u8c37\u6b4cDeepMind\u5f00\u59cb\u6d89\u8db3\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u3002\u4ed6\u521a\u521a\u5b8c\u6210\u535a\u58eb\u5b66\u4f4d\uff0c\u8bfb\u535a\u671f\u95f4\u6070\u597d\u4e3b\u653b\u5229\u7528\u673a\u5668\u5b66\u4e60\u6765\u6a21\u62df\u86cb\u767d\u8d28\u6298\u53e0\u548c\u52a8\u6001\u3002\u4e8e\u662f\uff0c\u4ed6\u7533\u8bf7\u4e86\u8c37\u6b4c\u7684\u7814\u7a76\u79d1\u5b66\u5bb6\u804c\u4f4d\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u8fd9\u4e2a\u9879\u76ee\u5f53\u65f6\u5904\u4e8e\u4fdd\u5bc6\u9636\u6bb5\uff0c\u201d\u4ed6\u8bf4\u3002\u5982\u679c\u4ed6\u5728\u9762\u8bd5\u4e2d\u63d0\u5230\u86cb\u767d\u8d28\u6298\u53e0\uff0cDeepMind\u56e2\u961f\u5c31\u4f1a\u8f6c\u79fb\u8bdd\u9898\u3002\u201c\u60a8\u8f6c\u79fb\u8bdd\u9898\u592a\u591a\u6b21\u7684\u8bdd\uff0c\u53ea\u4f1a\u8ba9\u6211\u66f4\u52a0\u786e\u5b9a\u8d35\u516c\u53f8\u5728\u505a\u4ec0\u4e48\u3002\u201dJumper\u8bf4\u3002<\/span><\/p>\n<\/section>\n

\n
\n

<\/span><\/p>\n

\u8c37\u6b4c DeepMind \u603b\u90e8\u4f4d\u4e8e\u4f26\u6566\u3002\u56fe\u6e90\uff1aBuildington<\/span><\/p>\n<\/section>\n<\/section>\n

\n

2017\u5e7410\u6708\uff0c\u4ed6\u6765\u5230\u4e86DeepMind\u4f4d\u4e8e\u4f26\u6566\u7684\u529e\u516c\u5ba4\u3002\u5728\u987e\u95eeJones\u7684\u5e2e\u52a9\u4e0b\uff0c\u56e2\u961f\u5df2\u7ecf\u5f00\u59cb\u6df1\u5165\u5f00\u53d1AlphaFold\u3002\u201c\u90a3\u4f1a\u513f\u771f\u7684\u592a\u6709\u610f\u601d\u4e86\uff0c\u6211\u4eec\u4e0d\u65ad\u63d0\u51fa\u5404\u79cd\u60f3\u6cd5\uff0c\u201dJones\u8bf4\u3002\u201c\u6700\u7ec8\u4f1a\u6709\u4e00\u4e2a\u6bd4\u8f83\u597d\u7684\u6838\u5fc3\u60f3\u6cd5\u8131\u9896\u800c\u51fa\uff0c\u7136\u540e\u4ed6\u4eec\u4fbf\u5f00\u59cb\u5168\u529b\u63a8\u8fdb\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u4e3a\u4e86\u8bad\u7ec3\u7b97\u6cd5\uff0cDeepMind\u56e2\u961f\u4f7f\u7528\u4e86\u8d85\u8fc7140,000\u4e2a\u6765\u81ea\u86cb\u767d\u8d28\u6570\u636e\u5e93\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u4ed6\u4eec\u5c06\u8fd9\u4e9b\u4fe1\u606f\u8f93\u5165\u5230\u4e00\u4e2a\u5377\u79ef\u7f51\u7edc\u4e2d\uff0c\u4f46\u5e76\u6ca1\u6709\u5bf9AI\u67b6\u6784\u672c\u8eab\u8fdb\u884c\u592a\u591a\u6539\u52a8\u3002\u201c\u8fd9\u662f\u2018\u6807\u51c6\u7684\u673a\u5668\u5b66\u4e60\u2019\uff0c\u201dJumper\u8bf4\u9053\u3002<\/span><\/p>\n


<\/p>\n

\u5230\u4e862018\u5e74\u6625\u5b63\uff0cAlphaFold\u51c6\u5907\u53c2\u52a0CASP\uff0c\u4e0e\u201c\u6b63\u7edf\u7684\u201d\u86cb\u767d\u8d28\u79d1\u5b66\u5bb6\u4eec\u540c\u53f0\u7ade\u6280\u3002\u201c\u6709\u70b9\u50cf\u4e00\u7ea7\u65b9\u7a0b\u5f0f\u8d5b\u8f66\uff0c\u201dJones\u56de\u5fc6\u9053\u3002\u201c\u4f60\u8ba4\u4e3a\u81ea\u5df1\u5efa\u9020\u4e86\u6700\u597d\u7684\u8d5b\u8f66\uff0c\u4f46\u4f60\u4e0d\u77e5\u9053\u5176\u4ed6\u8f66\u961f\u7684\u5b9e\u529b\u5982\u4f55\u3002\u201d\u7531\u4e8e\u98ce\u9669\u5f88\u9ad8\uff0cDeepMind\u56e2\u961f\u8ba8\u8bba\u662f\u5426\u5e94\u533f\u540d\u53c2\u8d5b\uff0c\u56e0\u4e3a\u4ed6\u4eec\u4e0d\u60f3\u88ab\u5f53\u4f17\u7f9e\u8fb1\u3002<\/span><\/p>\n


<\/p>\n

Jones\u8bf4\uff1a\u201c\u6ca1\u6709\u4eba\u60f3\u5931\u8d25\u3002\u201d\u5728\u5b66\u672f\u754c\uff0c\u5931\u8d25\u662f\u5de5\u4f5c\u7684\u4e00\u90e8\u5206\uff1b\u4f60\u5931\u8d25\u4e86\uff0c\u53ea\u80fd\u7ee7\u7eed\u524d\u884c\uff0c\u56e0\u4e3a\u4f60\u522b\u65e0\u9009\u62e9\u3002\u201c\u4f46\u5982\u679c\u662f\u4e00\u5bb6\u4ef7\u503c\u6570\u5341\u4ebf\u7f8e\u5143\u7684\u79d1\u6280\u516c\u53f8\uff0c\u90a3\u4e48\u5931\u8d25\u7684\u5c1d\u8bd5\u663e\u7136\u4f1a\u5f88\u8ba9\u516c\u53f8\u770b\u7740\u72fc\u72c8\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u4ed6\u4eec\u6700\u7ec8\u51b3\u5b9a\u4ee5\u8c37\u6b4cDeepMind\u7684\u540d\u4e49\u63d0\u4ea4\u53c2\u8d5b\u6210\u679c\u3002\u572812\u6708\u4f1a\u8bae\u5f00\u59cb\u524d\u51e0\u4e2a\u6708\uff0cJones\u6536\u5230\u4e86CASP\u7ec4\u7ec7\u65b9\u7684\u56de\u590d\uff0c\u4ed6\u4eec\u5efa\u8baeDeepMind\u56e2\u961f\u7ebf\u4e0b\u53c2\u52a0\u4f1a\u8bae\uff0c\u56e0\u4e3aAlphaFold\u8868\u73b0\u975e\u5e38\u51fa\u8272\u3002<\/span><\/p>\n


<\/p>\n

\u867d\u7136\u4ed6\u4eec\u5728\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u65b9\u9762\u7684\u51c6\u786e\u6027\u5927\u7ea6\u662f\u7b2c\u4e8c\u540d\u76842.5\u500d\uff0c\u4f46\u5e76\u975e\u7edd\u5bf9\u78be\u538b\u3002\u4e0d\u8fc7\uff0c\u4ed6\u4eec\u7684\u51ef\u65cb\u4f9d\u65e7\u7ed9\u4eba\u7559\u4e0b\u4e86\u6df1\u523b\u5370\u8c61\u3002\u201c\u663e\u7136\uff0c\u6709\u8da3\u7684\u4e8b\u60c5\u6b63\u5728\u4e0a\u6f14\uff0c\u201dMoult\u8bf4\u9053\u3002<\/span><\/p>\n<\/section>\n

\n

\uff083\uff09\u91cd\u542f\u7b97\u6cd5<\/span><\/strong><\/p>\n<\/section>\n

\n

\u8fd9\u6b21\u80dc\u5229\u5bf9DeepMind\u56e2\u961f\u6765\u8bf4\u672c\u5e94\u662f\u4e00\u9488\u5f3a\u5fc3\u5242\uff0c\u4f46\u4ed6\u4eec\u77e5\u9053\u81ea\u5df1\u79bb\u771f\u7684\u89e3\u51b3\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u8fd8\u76f8\u8ddd\u751a\u8fdc\u3002\u51e0\u4e2a\u6708\u524d\uff0cHassabis\u5c06\u56e2\u961f\u6210\u5458\u53ec\u96c6\u5728\u4e00\u8d77\u3002\u201c\u6211\u4eec\u7684\u76ee\u6807\u662f\u5426\u662f\u771f\u6b63\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff1f\u201dJumper\u56de\u5fc6\u8d77\u4ed6\u5f53\u65f6\u8bf4\u7684\u8bdd\u3002\u201c\u5982\u679c\u8fd9\u4e0d\u662f\u6211\u4eec\u7684\u76ee\u6807\uff0c\u90a3\u6211\u4eec\u5c31\u7740\u624b\u89e3\u51b3\u80fd\u591f\u771f\u6b63\u4ea7\u751f\u5de8\u5927\u5f71\u54cd\u7684\u95ee\u9898\u3002\u201d<\/span><\/p>\n<\/section>\n

\n
\n
<\/span><\/section>\n
John Jumper\u6000\u7591\u751f\u7269\u5b66\u5bb6\u5df2\u7ecf\u7814\u7a76\u4e86\u8db3\u591f\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u6765\u89e3\u51b3\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u30022017\u5e74\u5f00\u59cb\u5728\u8c37\u6b4cDeepMind\u5de5\u4f5c\u7684Jumper \u8bf4\uff1a\u201c\u6211\u76f8\u4fe1\u6570\u636e\u5df2\u7ecf\u8db3\u591f\u4e86\u3002\u201d\u4f46\u201c\u60f3\u6cd5\u8fd8\u4e0d\u591f\u201d\u3002\u56fe\u6e90\uff1aGoogle DeepMind<\/span><\/section>\n<\/section>\n<\/section>\n
\n

\u51ed\u501f\u5728\u7269\u7406\u5b66\u3001\u5316\u5b66\u3001\u751f\u7269\u5b66\u548c\u8ba1\u7b97\u9886\u57df\u7684\u591a\u91cd\u80cc\u666f\uff0cJumper\u5728\u5934\u8111\u98ce\u66b4\u4f1a\u8bae\u4e0a\u5206\u4eab\u4e86\u72ec\u5230\u7684\u89c1\u89e3\u3002\u5f88\u5feb\uff0c\u4ed6\u5f00\u59cb\u9886\u5bfc\u8fd9\u4e2a\u4ece\u516d\u4eba\u6269\u5c55\u5230\u5341\u4e94\u4eba\u7684\u56e2\u961f\u3002\u201c\u4ed6\u4eec\u5728\u505a\u4e00\u4ef6\u5f88\u7279\u522b\u7684\u4e8b\u60c5\uff0c\u201dRaphael Townshend\u8bc4\u4ef7\u9053\u30022019\u5e74\uff0c\u4ed6\u66fe\u5728\u8c37\u6b4cDeepMind\u5b9e\u4e60\uff0c\u540e\u6765\u81ea\u5df1\u6210\u7acb\u4e86AI\u9a71\u52a8\u7684\u751f\u7269\u6280\u672f\u516c\u53f8Atomic AI\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u5b66\u672f\u754c\uff0c\u4e13\u5bb6\u4eec\u7ecf\u5e38\u5404\u81ea\u4e3a\u653f\uff0c\u8d1f\u8d23\u72ec\u7acb\u7684\u9879\u76ee\uff0c\u5f88\u5c11\u6709\u5408\u4f5c\u3002\u800c\u5728DeepMind\uff0c\u7edf\u8ba1\u5b66\u3001\u7ed3\u6784\u751f\u7269\u5b66\u3001\u8ba1\u7b97\u5316\u5b66\u3001\u8f6f\u4ef6\u5de5\u7a0b\u7b49\u9886\u57df\u7684\u4e13\u5bb6\u4eec\u534f\u540c\u5408\u4f5c\uff0c\u5171\u540c\u89e3\u51b3\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u3002\u4ed6\u4eec\u8fd8\u62e5\u6709\u8c37\u6b4c\u5f3a\u5927\u7684\u8d22\u653f\u548c\u8ba1\u7b97\u8d44\u6e90\u652f\u6301\u3002\u201c\u4f5c\u4e3a\u535a\u58eb\u751f\uff0c\u6211\u53ef\u80fd\u8981\u82b1\u51e0\u4e2a\u6708\u7684\u65f6\u95f4\u624d\u80fd\u5b8c\u6210\u7684\u4e8b\u60c5\uff0c\u5728\u8fd9\u91cc\u4e00\u5929\u5185\u5c31\u80fd\u5b8c\u6210\uff0c\u201dTownshend\u8bf4\u3002<\/span><\/p>\n


<\/p>\n

\u4ed6\u8bf4\uff0c\u4f26\u6566DeepMind\u529e\u516c\u5ba4\u6c1b\u56f4\u6d3b\u8dc3\uff0c\u800c\u8fd9\u79cd\u6d3b\u529b\u5f88\u5927\u7a0b\u5ea6\u4e0a\u5f52\u529f\u4e8eJumper\u3002\u201c\u6211\u89c9\u5f97\u4ed6\u662f\u4e00\u4e2a\u771f\u6b63\u7684\u5929\u624d\uff0c\u540c\u65f6\u4e5f\u662f\u4e00\u4e2a\u975e\u5e38\u8c26\u900a\u7684\u4eba\uff0c\u56e2\u961f\u6210\u5458\u90fd\u975e\u5e38\u559c\u6b22\u4ed6\u3002\u201d\u8ba1\u7b97\u673a\u79d1\u5b66\u5bb6Ellen Zhong\u8fd9\u6837\u8bc4\u4ef7\u9053\u30022021\u5e74\uff0c\u5979\u66fe\u5728DeepMind\u5b9e\u4e60\uff0c\u73b0\u4efb\u666e\u6797\u65af\u987f\u5927\u5b66\u7684\u52a9\u7406\u6559\u6388\u3002<\/span><\/p>\n


<\/p>\n

\u5728Jumper\u7684\u9886\u5bfc\u4e0b\uff0c\u56e2\u961f\u5bf9AlphaFold\u8fdb\u884c\u4e86\u91cd\u6784\u3002\u4ed6\u4eec\u8bbe\u8ba1\u4e86\u4e00\u79cd\u65b0\u578b\u7684Transformer\u67b6\u6784\u2014\u2014\u8fd9\u662f\u4e00\u79cd\u6df1\u5ea6\u5b66\u4e60\u6280\u672f\uff0c\u201c\u5728\u8fc7\u53bb\u4e94\u5e74\u4e2d\u63a8\u52a8\u4e86\u51e0\u4e4e\u6bcf\u4e00\u6b21\u673a\u5668\u5b66\u4e60\u9886\u57df\u7684\u7a81\u7834\uff0c\u201dTownshend\u8bf4\u9053\u3002\u795e\u7ecf\u7f51\u7edc\u901a\u8fc7\u8c03\u6574\u795e\u7ecf\u5143\u8fde\u63a5\u7684\u5f3a\u5ea6\u6765\u521b\u5efa\u66f4\u7cbe\u786e\u7684\u6570\u636e\u8868\u5f81\uff0c\u4e3b\u8981\u662f\u5173\u4e8e\u86cb\u767d\u8d28\u8fdb\u5316\u548c\u7ed3\u6784\u7684\u6570\u636e\u3002\u5b83\u901a\u8fc7\u7b2c\u4e8c\u4e2aTransformer\u67b6\u6784\u8fd0\u884c\u8fd9\u4e9b\u6570\u636e\uff0c\u4ee5\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u7136\u540e\uff0c\u8be5\u7b97\u6cd5\u4f1a\u5c06\u9884\u6d4b\u6240\u5f97\u76843D\u7ed3\u6784\u4e0e\u4fee\u8ba2\u540e\u7684\u6570\u636e\u7ed3\u5408\u8d77\u6765\uff0c\u8fd4\u56de\u5230Transformer\u67b6\u6784\u4e2d\u8fd0\u884c\u6570\u6b21\uff0c\u4ee5\u8fbe\u5230\u63d0\u9ad8\u86cb\u767d\u8d283D\u7ed3\u6784\u9884\u6d4b\u51c6\u786e\u6027\u7684\u6548\u679c\u3002<\/span><\/span><\/p>\n<\/section>\n

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<\/span><\/p>\n

<\/span><\/p>\n

\u53d8\u9769\u6027\u7684\u67b6\u6784<\/span><\/p>\n<\/section>\n<\/section>\n

\n

\u5f53\u4ed6\u4eec\u521a\u5f00\u59cb\u7814\u53d1AlphaFold2\u65f6\uff0c\u4ed6\u4eec\u7684\u7b97\u6cd5\u201c\u5f88\u7cdf\u7cd5\uff0c\u4f46\u6ca1\u6709\u6211\u4eec\u9884\u671f\u7684\u90a3\u4e48\u7cdf\u7cd5\uff0c\u201dJumper\u8bf4\u3002\u201c<\/span>\uff08\u5b83\uff09<\/span>\u8f93\u51fa\u4e86\u4e00\u4e9b\u770b\u8d77\u6765\u6709\u70b9\u50cf\u86cb\u767d\u8d28\u7684\u87ba\u65cb\u7ed3\u6784\u3002\u201d\u4f46\u968f\u7740\u5bf9\u7b97\u6cd5\u7684\u8fdb\u4e00\u6b65\u4f18\u5316\uff0c\u4ed6\u4eec\u6ce8\u610f\u5230\u9884\u6d4b\u7684\u6548\u7387\u548c\u51c6\u786e\u6027\u5927\u5e45\u63d0\u5347\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u8fd9\u5b9e\u9645\u4e0a\u8ba9\u4eba\u611f\u5230\u5bb3\u6015\uff0c\u201dJumper\u8bf4\u3002\u5982\u679c\u5b83\u8868\u73b0\u5f97\u592a\u597d\uff0c\u901a\u5e38\u610f\u5473\u7740\u201c\u4f60\u505a\u9519\u4e86\u4e00\u4e9b\u4e8b\u60c5\u3002\u201d\u4f46\u68c0\u67e5\u8fc7\u540e\uff0c\u4ed6\u4eec\u6ca1\u6709\u53d1\u73b0\u95ee\u9898\uff0c\u4f18\u5316\u540e\u7684\u7b97\u6cd5\u5c31\u662f\u6709\u6548\u3002<\/span><\/p>\n


<\/p>\n

\u56e2\u961f\u51b3\u5b9a\u8fdb\u884c\u4e00\u6b21\u5185\u90e8\u5b9e\u9a8c\uff0c\u68c0\u9a8c\u4ed6\u4eec\u7684\u7cfb\u7edf\u662f\u5426\u5bf9\u751f\u7269\u5b66\u5bb6\u6709\u5e2e\u52a9\u3002\u4ed6\u4eec\u8bc6\u522b\u51fa\u5927\u7ea650\u7bc7\u53d1\u8868\u5728\u300a\u79d1\u5b66\u300b\u3001\u300a\u81ea\u7136\u300b\u548c\u300a\u7ec6\u80de\u300b\u7b49\u9876\u7ea7\u671f\u520a\u4e0a\u7684\u8bba\u6587\uff0c\u8fd9\u4e9b\u8bba\u6587\u4e0d\u4ec5\u63cf\u8ff0\u4e86\u65b0\u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u8fd8\u57fa\u4e8e\u7ed3\u6784\u5206\u4eab\u4e86\u6709\u5173\u86cb\u767d\u8d28\u529f\u80fd\u7684\u6df1\u523b\u89c1\u89e3\u3002\u4ed6\u4eec\u60f3\u770b\u770bAlphaFold2\u7684\u6548\u679c\u80fd\u5426\u4e0e\u5b9e\u9a8c\u4eba\u5458\u8d39\u65f6\u8d39\u529b\u7684\u5b9e\u9a8c\u65b9\u6cd5\u76f8\u5ab2\u7f8e\u3002<\/span><\/p>\n


<\/p>\n

\u4ed6\u4eec\u8f93\u5165\u4e86\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u7136\u540e\u5f00\u542f\u4e86AlphaFold2\u7684\u9884\u6d4b\u5f15\u64ce\u3002\u5bf9\u4e8e\u6bcf\u4e2a\u8f93\u5165\u7684\u5e8f\u5217\uff0cAlphaFold2\u9884\u6d4b\u51fa\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u90fd\u63a5\u8fd1\u8bba\u6587\u4e2d\u5b9e\u9a8c\u6240\u5f97\u7684\u7ed3\u679c\u3002\u7136\u800c\uff0c\u5728\u56e2\u961f\u770b\u6765\uff0c\u8fd9\u8fd8\u4e0d\u591f\u51c6\u786e\u3002\u8fd9\u4e9b\u7ed3\u6784\u7f3a\u5c11\u5b9e\u9a8c\u4eba\u5458\u53d1\u73b0\u7684\u5173\u952e\u7ec6\u8282\u3002\u201c\u4f60\u611f\u89c9\u597d\u50cf\u5df2\u7ecf\u8dd1\u5b8c\u4e86\u6bd4\u8d5b\uff0c\u5374\u53d1\u73b0\u5176\u5b9e\u53ea\u5b8c\u6210\u4e86\u4e00\u534a\uff0c\u201dJumper\u8bf4\u9053\u3002<\/span><\/p>\n


<\/p>\n

\u63a5\u4e0b\u6765\u7684\u516d\u4e2a\u6708\u91cc\uff0c\u56e2\u961f\u4e00\u70b9\u4e00\u70b9\u7684\u6539\u8fdb\u7cfb\u7edf\u3002\u8ddd\u79bb2020\u5e74CASP\u7ade\u8d5b\u7684\u86cb\u767d\u8d28\u5019\u9009\u540d\u5355\u53d1\u5e03\u8fd8\u6709\u51e0\u5468\u65f6\uff0c\u4ed6\u4eec\u8fdb\u884c\u4e86\u53e6\u4e00\u6b21\u6709\u7528\u6027\u6d4b\u8bd5\u3002Jumper\u5bf9\u8fd9\u6b21\u6d4b\u8bd5\u7ed3\u679c\u611f\u5230\u6ee1\u610f\u3002\u4e8e\u662f\uff0c\u8c37\u6b4cDeepMind\u57282020\u5e74\u6625\u5b63\u5411CASP\u63d0\u4ea4\u4e86\u4ed6\u4eec\u7684\u9884\u6d4b\u6548\u679c\uff0c\u7136\u540e\u7b49\u5f85\u8bc4\u4f30\u7ed3\u679c\u3002<\/span><\/p>\n<\/section>\n

\n

\uff084\uff09\u5b66\u79d1\u5927\u5730\u9707<\/span><\/strong><\/span><\/p>\n<\/section>\n

\n

\u521d\u590f\u65f6\u8282\uff0cMoult\u6536\u5230\u4e86\u4e00\u4f4dCASP\u8bc4\u4f30\u4eba\u5458\u53d1\u7ed9\u4ed6\u7684\u7535\u5b50\u90ae\u4ef6\uff1a\u201c\u770b\u770b\u8fd9\u4e2a\uff0c\u76f8\u5f53\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u3002\u201d\u90ae\u4ef6\u9644\u4e0a\u4e86\u7531\u8c37\u6b4cDeepMind\u56e2\u961f\u63d0\u51fa\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u89e3\u51b3\u65b9\u6848\u3002Moult\u786e\u5b9e\u88ab\u9707\u64bc\u5230\u4e86\uff0c\u4f46\u4ed6\u8ba4\u4e3a\u8fd9\u662f\u5355\u4e00\u6848\u4f8b\uff0c\u4e0d\u53ef\u590d\u73b0\u3002<\/span><\/p>\n


<\/p>\n

\u7136\u540e\u4ed6\u6536\u5230\u4e86\u53e6\u4e00\u5c01\u90ae\u4ef6\uff0c\u7136\u540e\u53c8\u4e00\u5c01\u90ae\u4ef6\u3002\u201c\u5947\u602a\u4e86\uff0c\u201d\u4ed6\u56de\u5fc6\u81ea\u5df1\u5f53\u65f6\u7684\u611f\u53d7\u3002\u4ed6\u6536\u5230\u4e86\u4e09\u4e2a\uff0c\u56db\u4e2a\uff0c\u8bb8\u591a\u4e2a\u63a5\u8fd1\u5b8c\u7f8e\u7684\u86cb\u767d\u8d28\u9884\u6d4b\u7ed3\u679c\u2014\u2014\u800c\u4e14\u5168\u90e8\u6765\u81eaDeepMind\u56e2\u961f\u3002\u5230\u4e86\u590f\u672b\uff0c\u201c\u6211\u4eec\u8fc5\u901f\u610f\u8bc6\u5230\u2026\u2026\u53d1\u751f\u4e86\u975e\u5e38\u975e\u5e38\u4e0d\u540c\u5bfb\u5e38\u7684\u4e8b\u60c5\uff0c\u201dMoult\u8bf4\u9053\u3002<\/span><\/p>\n


<\/p>\n

CASP\u7684\u8bc4\u4f30\u4eba\u5458\u901a\u8fc7\u6bd4\u8f83\u9884\u6d4b\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u4e0e\u5176\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u5b9e\u9a8c\u7ed3\u6784\u6765\u8bc4\u5206\u3002\u5982\u679c\u6a21\u578b\u9884\u6d4b\u548c\u5b9e\u9a8c\u7ed3\u679c\u4e00\u4e00\u5bf9\u5e94\uff0c\u5341\u5206\u5b8c\u7f8e\uff0c\u90a3\u4e48\u5f97\u5206\u662f100\u5206\u3002Moult\u4e00\u76f4\u8ba4\u4e3a\uff0c90\u4ee5\u4e0a\u7684\u5206\u6570\u8868\u660e\u7b97\u6cd5\u6709\u6548\u5730\u89e3\u51b3\u4e86\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002AlphaFold\u7684\u5927\u591a\u6570\u9884\u6d4b\u7ed3\u679c\u90fd\u8fbe\u5230\u6216\u8d85\u8fc7\u4e8690\u5206\u3002<\/span><\/p>\n


<\/p>\n

\u4f1a\u8bae\u524d\u51e0\u4e2a\u6708\uff0cMoult\u901a\u8fc7\u7535\u8bdd\u5c06\u8fd9\u4e2a\u6d88\u606f\u5206\u4eab\u7ed9\u4e86Jumper\u3002\u201c\u6211<\/span>\uff08\u5174\u594b\u5730\uff09<\/span>\u5f53\u573a\u5927\u58f0\u5492\u9a82\uff0c\u201dJumper\u56de\u5fc6\u9053\u3002\u201c\u6211\u59bb\u5b50\u8fd8\u5173\u5fc3\u5730\u95ee\u6211\u8fd8\u597d\u5417\u3002\u201d<\/span><\/p>\n


<\/p>\n

2020\u5e7412\u6708\uff0c\u5728\u65b0\u51a0\u75ab\u60c5\u7206\u53d1\u4e0d\u5230\u4e00\u5e74\u7684\u65f6\u95f4\u91cc\uff0cJumper\u5728CASP\u5728\u7ebf\u4f1a\u8bae\u4e0a\u901a\u8fc7Zoom\u5c55\u793a\u4e86AlphaFold2\u3002<\/span><\/p>\n


<\/p>\n

\u50cf\u5176\u4ed6\u4e0e\u4f1a\u8005\u4e00\u6837\uff0cJones\u4e5f\u5728\u5bb6\u4e2d\u89c2\u770b\u3002\u201c\u6211\u5f53\u65f6\u5c31\u5446\u4f4f\u4e86\u2026\u2026\u770b\u7740\u773c\u524d\u53d1\u751f\u7684\u4e00\u5207\uff0c\u201d\u4ed6\u8bf4\u3002\u201c\u56e0\u4e3a\u540c\u4e8b\u4e0d\u5728\u8eab\u8fb9\u2026\u2026\u6211\u4eec\u90fd\u88ab\u5c01\u9501\u5728\u5bb6\uff0c\u65e0\u6cd5\u5206\u4eab\u8fd9\u4e00\u5207\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u5bf9\u4e8e\u4efb\u4f55\u4e0d\u662f\u795e\u7ecf\u7f51\u7edc\u4e13\u5bb6\u7684\u4eba\u6765\u8bf4\uff0c\u8fd9\u4e9b\u60f3\u6cd5\u5f88\u590d\u6742\u3002\u5373\u4fbf\u5982\u6b64\uff0c\u7ed3\u8bba\u5374\u5f88\u660e\u786e\u3002DeepMind\u5df2\u7ecf\u89e3\u51b3\u4e86\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u4e2d\u7684\u7ed3\u6784\u9884\u6d4b\u90e8\u5206\u3002AlphaFold2\u80fd\u591f\u57fa\u4e8e\u6c28\u57fa\u9178\u5e8f\u5217\u51c6\u786e\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u554a\uff0c\u6211\u7684\u6700\u7231\u7814\u7a76\u8bfe\u9898\u8d70\u5230\u4e86\u5c3d\u5934\uff0c\u201dJones\u56de\u5fc6\u9053\u3002\u201cDeepMind\u7ec8\u7ed3\u4e86\u6bd4\u8d5b\uff0c\u8fd9\u5c31\u662f\u7ed3\u5c40\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u591a\u5e74\u6765\uff0cAnastassis Perrakis\u4e00\u76f4\u4e3aCASP\u7ade\u8d5b\u8d21\u732e\u672a\u53d1\u8868\u7684\u5b9e\u9a8c\u7ed3\u679c\u3002\u5f53\u4ed6\u770b\u5230AlphaFold2\u51c6\u786e\u9884\u6d4b\u51fa\u4ed6\u7684\u56e2\u961f\u715e\u8d39\u82e6\u5fc3\u89e3\u6790\u51fa\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u65f6\uff0c\u4ed6\u611f\u5230\u5fc3\u91cc\u54af\u5654\u4e00\u4e0b\u3002<\/span><\/p>\n


<\/p>\n

\u867d\u7136\u75ab\u60c5\u88ab\u72ec\u81ea\u56f0\u5728\u5bb6\u91cc\u65f6\uff0c\u4f46\u79d1\u5b66\u5bb6\u4eec\u4e00\u81f4\u8ba4\u4e3a\u86cb\u767d\u8d28\u79d1\u5b66\u7684\u4e16\u754c\u5df2\u7ecf\u53d1\u751f\u4e86\u6c38\u4e45\u6027\u7684\u6539\u53d8\u3002\u5f53\u8fd9\u4e2a\u4e16\u754c\u7684\u201c\u5c45\u6c11\u201d\u773a\u671b\u773c\u524d\u7684\u65b0\u666f\u8272\u65f6\uff0c\u4ed6\u4eec\u4e0d\u7531\u5f97\u95ee\u51fa\u4e86\u540c\u4e00\u4e2a\u95ee\u9898\uff1a\u63a5\u4e0b\u6765\u8be5\u600e\u4e48\u529e\uff1f<\/span><\/p>\n


<\/p>\n<\/section>\n

\n
\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

3. \u4f59\u6ce2<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<\/section>\n<\/section>\n
\n

\uff081\uff09\u60ca\u8bb6\u4e4b\u4f59\uff0c\u656c\u754f\u4e4b\u5fc3<\/span><\/strong><\/span><\/p>\n<\/section>\n

\n

\u7ed3\u6784\u751f\u7269\u5b66\u7a81\u7136\u5931\u53bb\u7ed3\u6784\u6027\u4e86\u3002<\/span><\/p>\n


<\/p>\n

Silvio Tosatto\u4eceCASP\u521b\u7acb\u65e9\u671f\u5c31\u5f00\u59cb\u53c2\u4e0e\u76f8\u5173\u8d5b\u4e8b\u4e86\uff0c\u4ed6\u8bf4\uff0c\u521a\u5f00\u59cb\u7684\u65f6\u5019\uff0c\u5f88\u591a\u4eba\u9677\u5165\u4e86\u6df1\u601d\u3002\u4e00\u4e9b\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\u62c5\u5fc3\u4ed6\u4eec\u7684\u5de5\u4f5c\u5c06\u4e0d\u590d\u5b58\u5728\uff0c\u53e6\u4e00\u4e9b\u5219\u4ea7\u751f\u4e86\u62b5\u89e6\u5fc3\u7406\uff0c\u58f0\u79f0AlphaFold2\u4e0d\u591f\u51c6\u786e\u3002<\/span><\/p>\n


<\/p>\n

\u6709\u4e9b\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\u5df2\u7ecf\u4e3a\u89e3\u51b3\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u4ed8\u51fa\u4e86\u6570\u5341\u5e74\u7684\u5fc3\u8840\uff0c\u4f46\u5f53\u8fd9\u4e00\u523b\u771f\u7684\u5230\u6765\u65f6\uff0c\u4ed6\u4eec\u7684\u611f\u53d7\u662f\u82e6\u4e50\u53c2\u534a\u7684\u3002\u5728CASP\u7ed3\u675f\u4e4b\u540e\u7684\u4e00\u7bc7\u535a\u5ba2\u6587\u7ae0\u4e2d\uff0cAlQuraishi\u5f15\u7528\u4e86\u4e00\u4f4d\u4e0e\u4f1a\u8005\u7684\u8bdd\uff0c\u5f62\u5bb9\u81ea\u5df1\u611f\u89c9\u50cf\u662f\u5b69\u5b50\u7b2c\u4e00\u6b21\u8d70\u51fa\u5bb6\u95e8\u7684\u7236\u6bcd\u3002<\/span><\/p>\n<\/section>\n

\n
\n
<\/span><\/section>\n
\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u6570\u5b66\u57fa\u56e0\u7ec4\u5b66\u9879\u76ee\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u5bb6 Mohammed AlQuraishi \u5e0c\u671b\uff0c\u52302040\u5e74\uff0c\u6df1\u5ea6\u5b66\u4e60\u80fd\u591f\u6a21\u62df\u6574\u4e2a\u7ec6\u80de\u53ca\u5176\u5185\u90e8\u7684\u6240\u6709\u7ed3\u6784\u548c\u52a8\u6001\u3002\u56fe\u6e90\uff1aNicole Pereira<\/span><\/section>\n<\/section>\n<\/section>\n
\n

\u4f46\u662f\uff0c\u5373\u4fbf\u5bf9\u8fd9\u4e2a\u8000\u773c\u7684\u65b0\u5de5\u5177\u611f\u5230\u60f4\u60f4\u4e0d\u5b89\uff0c\u8bb8\u591a\u79d1\u5b66\u5bb6\u8fd8\u662f\u975e\u5e38\u5174\u594b\u3002\u90a3\u4e9b\u4e0d\u8fdb\u884c\u7ed3\u6784\u7814\u7a76\u7684\u4eba\u8fc7\u53bb\u5fc5\u987b\u4e0e\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\u5408\u4f5c\u6765\u786e\u5b9a\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u73b0\u5728\u4ed6\u4eec\u53ea\u9700\u6309\u51e0\u4e2a\u6309\u94ae\u5c31\u53ef\u4ee5\u81ea\u5df1\u5f97\u51fa\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002<\/span><\/p>\n


<\/p>\n

\u5a92\u4f53\u53e3\u4e2d\u7684AlphaFold2\u6210\u4e3a\u4e86\u201c\u6539\u53d8\u4e00\u5207\u201d\u7684\u65b0\u4eba\u5de5\u667a\u80fd\u7a81\u7834\u3002\u4f46\u662f\uff0c\u79d1\u5b66\u5bb6\u4eec\u82b1\u4e86\u6570\u6708\u751a\u81f3\u6570\u5e74\u6765\u5256\u6790AlphaFold2\u7684\u4f18\u7f3a\u70b9\u3002Jumper\u6f14\u8bb2\u7ea6\u516d\u4e2a\u6708\u540e\uff0c\u8c37\u6b4cDeepMind\u6b63\u5f0f\u53d1\u5e03\u4e86\u8fd9\u6b3e\u4ea7\u54c1\u5e76\u5206\u4eab\u4e86AlphaFold2\u7684\u5e95\u5c42\u4ee3\u7801\u3002\u201cAlphaFold2\u53d1\u5e03\u7684\u7b2c\u4e8c\u5929\uff0c\u6211\u4eec\u5c31\u5c1d\u8bd5\u5c06\u5b83\u5b89\u88c5\u5230\u6211\u4eec\u7684GPU\u670d\u52a1\u5668\u4e0a\u4e86\uff0c\u201dPerrakis\u8868\u793a\u3002\u751f\u7269\u5b66\u5bb6\u4eec\u5f00\u59cb\u4e86\u63a2\u7d22\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u6211\u539f\u4ee5\u4e3a<\/span>\uff08AlphaFold2\uff09<\/span>\u4f1a\u5931\u8d25\uff0c\u201dThornton\u8bf4\u3002\u201c\u4f46\u5b9e\u9645\u4e0a\u5b83\u5374\u53d6\u5f97\u4e86\u5de8\u5927\u7684\u6210\u529f\u3002\u201d<\/span><\/p>\n<\/section>\n

\n
\n
<\/span><\/section>\n
\u8377\u5170\u764c\u75c7\u7814\u7a76\u6240\u548c\u4e4c\u7279\u52d2\u652f\u5927\u5b66\u7684\u7ed3\u6784\u751f\u7269\u5b66\u5bb6Anastassis Perrakis\u5f00\u73a9\u7b11\u8bf4\uff1a\u201c\u6211\u5f88\u559c\u6b22\u770b\u5230\u4ed6\u4eec\u5931\u8d25\u3002\u201d\u4ed6\u66fe\u5c06\u5b9e\u9a8c\u9a8c\u8bc1\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u63d0\u4f9b\u7ed9CASP\u7ec4\u7ec7\u8005\u4f5c\u4e3a\u6bd4\u8d5b\u53c2\u8003\u3002\u201c\u8fd9\u4e0d\u662f\u8f83\u52b2\uff0c\u6211\u4eec\u53ea\u662f\u559c\u6b22\u5c31\u79d1\u5b66\u95ee\u9898\u6349\u5f04\u5f7c\u6b64\u3002\u201d\u56fe\u6e90\uff1aAnastassis Perrakis<\/span><\/section>\n<\/section>\n<\/section>\n
\n

Anastassis Perrakis\u5411CASP\u8d21\u732e\u4e86\u5b9e\u9a8c\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\u5728\u5176\u4e0a\u6d4b\u8bd5\u4e86\u4ed6\u4eec\u7684\u65b9\u6cd5\u3002\u201c\u6211\u5f88\u9ad8\u5174\u770b\u5230[\u8fd9\u4e9b\u65b9\u6cd5]\u5931\u8d25\uff0c\u201d\u4ed6\u5f00\u73a9\u7b11\u8bf4\u3002\u201c\u8fd9\u4e0d\u662f\u7ade\u4e89\uff0c\u4f46\u6211\u4eec\u559c\u6b22\u5728\u79d1\u5b66\u4e0a\u4e92\u76f8\u53d6\u7b11\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u9010\u6e10\u610f\u8bc6\u5230\uff0cAlphaFold2\u53ef\u80fd\u5e76\u4e0d\u4f1a\u5a01\u80c1\u5230\u4ed6\u4eec\u7684\u5de5\u4f5c\uff0c\u800c\u662f\u52a0\u901f\u7814\u7a76\u7684\u50ac\u5316\u5242\u3002\u5b83\u4e0d\u4ec5\u6ca1\u6709\u4f7f\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\u5931\u4e1a\uff0c\u53cd\u800c\u4e3a\u4ed6\u4eec\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u5de5\u5177\uff0c\u4f7f\u4ed6\u4eec\u7684\u5de5\u4f5c\u66f4\u52a0\u51fa\u8272\u3002\u201c\u5982\u679c\u4f60\u8ba4\u4e3a\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\u53ea\u662f\u6280\u672f\u4e13\u5bb6\uff0c\u4ed6\u4eec\u7684\u5de5\u4f5c\u4ec5\u4ec5\u662f\u5f04\u6e05\u86cb\u767d\u8d28\u7684\u7ed3\u6784\uff0c\u90a3\u4e48\u4ed6\u4eec\u5f53\u7136\u4f1a\u5931\u4e1a\uff0c\u201dWalden\u8bf4\u9053\u3002\u4f46\u8fd9\u5c31\u50cf\u8bf4\u56e0\u4e3a\u6709\u4e86\u4eba\u7c7b\u57fa\u56e0\u7ec4\u8ba1\u5212\uff0c\u57fa\u56e0\u7ec4\u5b66\u5bb6\u4e0d\u80fd\u518d\u53d1\u8868\u63cf\u8ff0\u5355\u4e2a\u57fa\u56e0\u5e8f\u5217\u7684\u8bba\u6587\uff0c\u6240\u4ee5\u4ed6\u4eec\u4f1a\u5931\u4e1a\u4e00\u6837\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\uff0c\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\u7684\u76ee\u6807\u5176\u5b9e\u662f\u63a2\u7d22\u86cb\u767d\u8d28\u7684\u529f\u80fd\u3002\u6709\u4e86AlphaFold2\uff0c\u4ed6\u4eec\u53ef\u4ee5\u5728\u51e0\u5206\u949f\u5185\u63d0\u51fa\u5047\u8bbe\uff0c\u800c\u4e0d\u662f\u7b49\u5f85\u6570\u6708\u751a\u81f3\u6570\u5e74\u6765\u901a\u8fc7\u5b9e\u9a8c\u5f04\u6e05\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002<\/span><\/p>\n


<\/p>\n

Adams\u8ba4\u4e3a\uff1a\u201c\u8fd9\u7ed9\u7ed3\u6784\u751f\u7269\u5b66\u5e26\u6765\u4e86\u8bb8\u591a\u6709\u76ca\u7684\u6539\u53d8\uff0c\u800c\u975e\u574f\u5904\uff0c\u8ba9\u8fd9\u4e2a\u9886\u57df\u66f4\u52a0\u4ee4\u4eba\u5174\u594b\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u7136\u800c\uff0c\u5b83\u5e76\u6ca1\u6709\u7acb\u5373\u50cf\u4e00\u4e9b\u4eba\u9884\u6d4b\u7684\u90a3\u6837\u52a0\u901f\u5404\u79cd\u65b0\u836f\u7684\u7814\u53d1\uff0c\u56e0\u4e3a\u7814\u7a76\u4eba\u5458\u5f88\u5feb\u53d1\u73b0\u8fd9\u4e2a\u5de5\u5177\u4e5f\u6709\u5176\u5c40\u9650\u6027\u3002Perrakis\u8868\u793a\uff0cAlphaFold2\u7684\u9884\u6d4b\u5e76\u4e0d\u5b8c\u7f8e\uff0c\u9700\u8981\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u4f46\u201c\u4f60\u53ef\u4ee5\u66f4\u5feb\u5730\u8fdb\u5165\u5b9e\u9645\u7684\u7ed3\u6784\u7814\u7a76\u201d\u3002\u73b0\u5728\uff0c\u5f53\u4ed6\u7684\u5b66\u751f\u5f00\u59cb\u4e00\u4e2a\u65b0\u9879\u76ee\u65f6\uff0c\u4ed6\u4eec\u4f1a\u9996\u5148\u4f7f\u7528AlphaFold2\u9884\u6d4b\u7279\u5b9a\u86cb\u767d\u8d28\u7684\u7ed3\u6784\uff0c\u7136\u540e\u8fdb\u884c\u5b9e\u9a8c\u9a8c\u8bc1\u3002<\/span><\/p>\n


<\/p>\n

Perrakis\u8ba4\u4e3a\u81ea\u5df1\u548c\u5176\u4ed6\u7814\u7a76\u4eba\u5458\u53ef\u80fd\u4ecd\u4f1a\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u7528\u5230X\u5c04\u7ebf\u6676\u4f53\u5b66\u3002\u4f46\u662f\uff0c\u4e3a\u4e86\u521d\u6b65\u6784\u5efa\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u8bb8\u591a\u4eba\u5f00\u59cb\u5c06\u6df1\u5ea6\u5b66\u4e60\u9884\u6d4b\u4e0e\u5148\u8fdb\u7684\u7535\u5b50\u663e\u5fae\u955c\u6280\u672f\u5982\u51b7\u51bb\u7535\u955c<\/span>\uff08cryo-EM\uff09<\/span>\u76f8\u7ed3\u5408\uff0c\u8fd9\u9879\u6280\u672f\u7684\u6838\u5fc3\u662f\u5feb\u901f\u51b7\u51bb\u751f\u7269\u6837\u672c\u5e76\u7528\u7535\u5b50\u8f70\u51fb\u5b83\u4eec\u3002\u89e3\u6790\u4e86\u7ed3\u6784\u4e4b\u540e\uff0c\u4ed6\u4eec\u4fbf\u53ef\u4ee5\u7740\u624b\u7814\u7a76\u86cb\u767d\u8d28\u7684\u529f\u80fd\u95ee\u9898\u3002AlQuraishi\u8868\u793a\uff0cAlphaFold2\u7684\u51fa\u73b0\u52a0\u901f\u4e86\u51b7\u51bb\u7535\u955c\u7684\u5e94\u7528\u3002<\/span><\/p>\n<\/section>\n

\n
\n

<\/span><\/p>\n

\u51b7\u51bb\u7535\u955c\uff08Cryo-EM\uff09\u7684\u5de5\u4f5c\u539f\u7406\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

\n

\u8fd9\u79cd\u8f6c\u53d8\u5df2\u7ecf\u5f00\u59cb\u30022022\u5e746\u6708\uff0c\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u7684\u4e00\u671f\u7279\u520a\u63ed\u793a\u4e86\u4eba\u7c7b\u6838\u5b54\u590d\u5408\u4f53\u7684\u8fd1\u539f\u5b50\u7ed3\u6784\u3002\u8fd9\u4e2a\u753130\u79cd\u4e0d\u540c\u86cb\u767d\u8d28\u6784\u6210\u7684\u5e9e\u5927\u800c\u590d\u6742\u7684\u7ed3\u6784\u51e0\u5341\u5e74\u6765\u4e00\u76f4\u662f\u751f\u7269\u5b66\u4e0a\u7684\u96be\u9898\u3002\u79d1\u5b66\u5bb6\u4eec\u4f7f\u7528AlphaFold2\u7684\u9884\u6d4b\u7ed3\u679c\u6765\u5f25\u8865\u51b7\u51bb\u7535\u955c\u672a\u80fd\u89e3\u51b3\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u95ee\u9898\u3002<\/span><\/p>\n


<\/p>\n

Jumper\u8868\u793a\uff0c\u770b\u5230\u8fd9\u7bc7\u8bba\u6587\u4e2d\u7684\u5176\u4ed6\u79d1\u5b66\u5bb6\u4f7f\u7528AlphaFold2\u53d6\u5f97\u4e86\u751f\u7269\u5b66\u4e0a\u7684\u7a81\u7834\uff0c\u4ed6\u5728\u90a3\u4e00\u523b\u610f\u8bc6\u5230\u201c<\/span>\uff08AlphaFold\uff09<\/span>\u786e\u5b9e\u975e\u5e38\u3001\u975e\u5e38\u91cd\u8981\u201d\u3002<\/span><\/p>\n


<\/p>\n

\u5728\u8fc7\u53bb\u4e09\u5e74\u91cc\uff0c\u50cf\u6838\u5b54\u590d\u5408\u4f53\u8fd9\u6837\u7684\u7a81\u7834\u6807\u5fd7\u7740\u86cb\u767d\u8d28\u79d1\u5b66\u9886\u57df\u7684\u4e00\u4e2a\u53c8\u4e00\u4e2a\u91cc\u7a0b\u7891\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0cAlphaFold2\u9884\u6d4b\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u5df2\u88ab\u7528\u4e8e\u7814\u7a76\u75be\u75c5\u548c\u5f00\u53d1\u65b0\u7684\u836f\u7269\u8f93\u9001\u5de5\u5177\u3002\u201c\u5bf9\u6211\u4eec\u6765\u8bf4\uff0c\u8fd9\u975e\u5e38\u6709\u5e2e\u52a9\uff0c\u201d\u535a\u5fb7\u7814\u7a76\u6240\u7684\u5206\u5b50\u751f\u7269\u5b66\u5bb6Feng Zhang\u8868\u793a\u3002\u4ed6\u4f7f\u7528AlphaFold2\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5c06\u836f\u7269\u8f93\u9001\u5230\u4eba\u4f53\u7ec6\u80de\u5185\u7684\u5206\u5b50\u6ce8\u5c04\u5668\u3002\u4e86\u89e3\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u8fd8\u53ef\u4ee5\u8f85\u52a9\u836f\u7269\u5f00\u53d1\uff0c\u4f8b\u5982\uff0c\u5b83\u80fd\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u5224\u65ad\u54ea\u4e9b\u5206\u5b50\u80fd\u591f\u9644\u7740\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u4e0a\uff0c\u5e76\u6539\u53d8\u5176\u884c\u4e3a\u3002\u5c3d\u7ba1\u6709\u4e9b\u7814\u7a76\u8868\u660e\uff0cAlphaFold2\u7684\u9884\u6d4b\u7ed3\u679c\u5728\u836f\u7269\u7814\u53d1\u9886\u57df\u4e0d\u5982\u5b9e\u9a8c\u6240\u5f97\u6709\u7528\uff0c\u4f46\u4e5f\u6709\u7814\u7a76\u8bc1\u660e\u5b83\u53ef\u4ee5\u53d1\u6325\u76f8\u540c\u7684\u4f5c\u7528\u3002\u4eba\u4eec\u8fd8\u5728\u63a2\u7d22\u4eba\u5de5\u667a\u80fd\u5de5\u5177\u5bf9\u836f\u7269\u5f00\u53d1\u7684\u7efc\u5408\u5f71\u54cd\u3002<\/span><\/p>\n


<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u4e00\u4e9b\u751f\u7269\u5b66\u5bb6\u5df2\u7ecf\u4e0d\u6ee1\u8db3\u4e8eAlphaFold2\u5728\u8bc6\u522b\u5df2\u77e5\u86cb\u767d\u8d28\u7ed3\u6784\u548c\u529f\u80fd\u65b9\u9762\u7684\u5e94\u7528\uff0c\u8f6c\u5411\u8bbe\u8ba1\u81ea\u7136\u754c\u4e2d\u4e0d\u5b58\u5728\u7684\u86cb\u767d\u8d28\uff0c\u8fd9\u79cd\u6280\u672f\u5bf9\u521b\u65b0\u836f\u7269\u7814\u53d1\u6765\u8bf4\u5341\u5206\u5173\u952e\u3002<\/span><\/p>\n<\/section>\n

\n

\uff082\uff09\u65b0\u524d\u6cbf<\/span><\/strong><\/span><\/p>\n<\/section>\n

\n

\u770b\u5230Jumper\u57282020\u5e74CASP\u4f1a\u8bae\u4e0a\u7684\u6f14\u8bb2\u540e\uff0cBaker\u7acb\u523b\u56de\u5230\u4e86\u4ed6\u7684Rosetta\u7b97\u6cd5\u7684\u5de5\u4f5c\u4e0a\u3002\u5f53\u65f6\u8c37\u6b4c\u5c1a\u672a\u5206\u4eabAlphaFold2\u7684\u5e95\u5c42\u6e90\u4ee3\u7801\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u201c\u6211\u4eec\u5f00\u59cb\u5c1d\u8bd5\u4ed6\u4eec\u5206\u4eab\u7684\u4e00\u4e9b\u60f3\u6cd5\uff0c\u201dBaker\u8bf4\u3002\u8c37\u6b4cDeepMind\u56e2\u961f\u5728\u300a\u81ea\u7136\u300b\u671f\u520a\u4e0a\u53d1\u8868AlphaFold2\u7684\u5f53\u5929\uff0cBaker\u548c\u4ed6\u7684\u56e2\u961f\u5ba3\u5e03\u4e86RoseTTAFold\uff0c\u8fd9\u662f\u4e00\u79cd\u4e0e\u51c6\u786e\u5ea6\u80fd\u4e0eAlphaFold\u5ab2\u7f8e\u7684\u9884\u6d4b\u6a21\u578b\u3002RoseTTAFold\u540c\u6837\u4f7f\u7528\u6df1\u5ea6\u5b66\u4e60\u6765\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u4f46\u5176\u5e95\u5c42\u67b6\u6784\u4e0eAlphaFold2\u5927\u76f8\u5f84\u5ead\u3002<\/span><\/p>\n


<\/p>\n

Tosatto\u8868\u793a\uff1a\u201c\u79d1\u5b66\u7406\u5ff5\u4e00\u65e6\u88ab\u63d0\u51fa\uff0c\u5176\u4ed6\u4eba\u5c31\u53ef\u4ee5\u9006\u5411\u5de5\u7a0b\u5e76\u5728\u6b64\u57fa\u7840\u4e0a\u8fdb\u884c\u6784\u5efa\uff0c\u81f3\u5c11\u90a3\u4e9b\u6709\u8db3\u591f\u591a\u8d44\u6e90\u7684\u4eba\u53ef\u4ee5\u505a\u5230\u3002\u201d<\/span><\/p>\n


<\/p>\n

RoseTTAFold\u5e76\u4e0d\u662fAlphaFold\u552f\u4e00\u7684\u7ade\u4e89\u8005\u3002Meta\u4e5f\u5f00\u53d1\u4e86\u81ea\u5df1\u7684\u7b97\u6cd5\u6765\u89e3\u51b3\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u6216\u76f8\u5173\u95ee\u9898\u3002\u4e00\u4e9b\u516c\u53f8\uff0c\u5df2\u7ecf\u4e0d\u5c40\u9650\u4e8e\u86cb\u767d\u8d28\u9886\u57df\uff0c\u800c\u662f\u4f7f\u7528\u6df1\u5ea6\u5b66\u4e60\u6765\u89e3\u6790RNA\u7ed3\u6784\uff0c\u8fd9\u5176\u4e2d\u5c31\u6709Townshend\u7684\u751f\u7269\u79d1\u6280\u521d\u521b\u516c\u53f8Atomic AI\uff0c\u3002\u7136\u800c\uff0c\u5728\u5355\u4e00\u7ed3\u6784\u9884\u6d4b\u9886\u57df\uff0c\u8fc4\u4eca\u4e3a\u6b62\u8fd8\u6ca1\u6709\u4eba\u80fd\u591f\u8fbe\u5230AlphaFold\u7684\u7cbe\u786e\u5ea6\uff0cThornton\u8868\u793a\uff1a\u201c\u6211\u76f8\u4fe1\u6709\u4e9b\u516c\u53f8\u4e5f\u53ef\u4ee5\u505a\u5230\uff0c\u4f46\u6211\u8ba4\u4e3a\u5f88\u96be\u518d\u73b0AlphaFold\u5f53\u521d\u5e26\u6765\u7684\u9707\u64bc\u3002\u201d<\/span><\/p>\n<\/section>\n

\n
\n
<\/span><\/section>\n
\u53bb\u5e74\uff0c David Baker\uff08\u5982\u56fe\uff09\u4e0eJohn Jumper\u548cDemis Hassabi\u56e0\u5176\u5728\u4f7f\u7528\u4eba\u5de5\u667a\u80fd\u7814\u7a76\u548c\u8bbe\u8ba1\u86cb\u767d\u8d28\u65b9\u9762\u7684\u9769\u547d\u6027\u5de5\u4f5c\uff0c\u5171\u540c\u83b7\u5f97\u4e86\u751f\u7269\u5b66\u548c\u751f\u7269\u533b\u5b66\u9886\u57df\u7684\u77e5\u8bc6\u524d\u6cbf\u5956\u3002\u56fe\u6e90\uff1aBBVA Foundation<\/span><\/section>\n<\/section>\n<\/section>\n
\n

\u81f3\u5c11\u5bf9\u5916\u800c\u8a00\uff0cBaker\u548cJumper\u7ee7\u7eed\u5ef6\u7eed\u7740CASP\u7684\u826f\u6027\u7ade\u4e89\u4f20\u7edf\u3002\u201c\u4ed6\u4eec\u53ef\u80fd\u89c9\u5f97\u6211\u5728\u4e0e\u4ed6\u4eec\u7ade\u4e89\uff0c\u4f46\u6211\u89c9\u5f97\u6211\u4eec\u53ea\u662f\u4ece\u4ed6\u4eec\u7684\u5de5\u4f5c\u4e2d\u83b7\u53d6\u7075\u611f\uff0c\u201dBaker\u8bf4\u9053\u3002<\/span><\/p>\n


<\/p>\n

Jumper\u5bf9\u6b64\u8868\u793a\u6b22\u8fce\uff0c\u4ed6\u8bf4\uff1a\u201c\u5927\u5bb6\u5171\u540c\u63a8\u52a8\u8fd9\u95e8\u79d1\u5b66\u7684\u53d1\u5c55\u771f\u7684\u5f88\u91cd\u8981\u3002\u5982\u679cAlphaFold\u7684\u667a\u6167\u7ed3\u6676\u540e\u7ee7\u65e0\u4eba\uff0c\u6211\u89c9\u5f97\u662f\u4ef6\u5f88\u60b2\u54c0\u7684\u4e8b\u60c5\u3002\u201d<\/span><\/p>\n


<\/p>\n

Baker\u5df2\u7ecf\u625b\u8d77\u4e86\u8fd9\u4efd\u4f20\u627f\u7684\u91cd\u4efb\uff0c\u5e76\u5728\u5c1d\u8bd5\u5c06\u4e4b\u8fd0\u7528\u5230\u86cb\u767d\u8d28\u79d1\u5b66\u7684\u65b0\u524d\u6cbf\u4e2d\uff1a\u86cb\u767d\u8d28\u8bbe\u8ba1\u3002\u7531\u4e8e\u751f\u7269\u5b66\u5bb6\u73b0\u5728\u53ea\u80fd\u7814\u7a76\u81ea\u7136\u754c\u5df2\u7ecf\u5b58\u5728\u7684\u86cb\u767d\u8d28\uff0c\u6240\u4ee5Baker\u8bbe\u60f3\u4e86\u4e00\u95e8\u79d1\u5b66\uff0c\u80fd\u591f\u8bbe\u8ba1\u51fa\u65b0\u7684\u86cb\u767d\u8d28\uff0c\u4e13\u95e8\u7528\u6765\u63a7\u5236\u9633\u5149\u3001\u5206\u89e3\u5851\u6599\u6216\u7814\u53d1\u65b0\u836f\u6216\u75ab\u82d7\u3002<\/span><\/p>\n


<\/p>\n

\u8377\u5170\u80e1\u5e03\u52d2\u652f\u7814\u7a76\u6240\u7684\u7ed3\u6784\u751f\u7269\u5b66\u5bb6Danny Sahtoe\u66fe\u5728Baker\u6307\u5bfc\u4e0b\u505a\u535a\u58eb\u540e\u7814\u7a76\uff0c\u4ed6\u8868\u793a\uff1a\u201c\u76ee\u524d\u81ea\u7136\u754c\u4e2d\u4e0d\u540c\u7c7b\u578b\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u6216\u5f62\u72b6\u7684\u6570\u91cf\u662f\u76f8\u5f53\u6709\u9650\u7684\u3002\u7406\u8bba\u4e0a\uff0c\u5e94\u8be5\u6709\u66f4\u591a\u53ef\u80fd\u7684\u5f62\u72b6\uff0c\u800c\u5982\u679c\u4f60\u80fd\u751f\u6210\u66f4\u591a\u5f62\u72b6\u7684\u86cb\u767d\u8d28\uff0c\u90a3\u4e48\u5c31\u610f\u5473\u7740\u4f60\u80fd\u62e5\u6709\u66f4\u591a\u4e0d\u540c\u529f\u80fd\u7684\u86cb\u767d\u8d28\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u4f5c\u4e3a\u534e\u76db\u987f\u5927\u5b66\u86cb\u767d\u8d28\u8bbe\u8ba1\u7814\u7a76\u6240\u7684\u4e3b\u4efb\uff0cBaker\u8ba4\u4e3a\u86cb\u767d\u8d28\u8bbe\u8ba1\u672c\u8d28\u4e0a\u662f\u201c\u9006\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u201d\u3002\u4e0e\u5176\u5c06\u6c28\u57fa\u9178\u5e8f\u5217\u8f93\u5165\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5\u5e76\u8ba9\u5b83\u8f93\u51fa\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u86cb\u767d\u8d28\u8bbe\u8ba1\u8005\u5e94\u8be5\u505a\u7684\u662f\u5c06\u4e00\u4e2a\u7ed3\u6784\u8f93\u5165\u7b97\u6cd5\u5e76\u8ba9\u5b83\u8f93\u51fa\u4e00\u4e2a\u5e8f\u5217\uff0c\u7136\u540e\u5229\u7528\u8fd9\u4e2a\u5e8f\u5217\u5728\u5b9e\u9a8c\u5ba4\u91cc\u751f\u6210\u86cb\u767d\u8d28\u3002<\/span><\/p>\n


<\/p>\n

AlphaFold\u548cRoseTTAFold\u672c\u8eab\u4e0d\u80fd\u8f93\u51fa\u8fd9\u4e9b\u5e8f\u5217\uff0c\u5b83\u4eec\u7684\u7f16\u7a0b\u903b\u8f91\u662f\u76f8\u53cd\u7684\u3002\u4f46Baker\u521b\u5efa\u4e86RoseTTAFold\u7684\u8bbe\u8ba1\u4e13\u7528\u8fed\u4ee3\u7248\uff0c\u57fa\u4e8e\u5176\u795e\u7ecf\u67b6\u6784\uff0c\u88ab\u79f0\u4e3aRoseTTAFold diffusion\u6216RF diffusion\u3002<\/span><\/p>\n


<\/p>\n

Sahtoe\u8bf4\uff0c\u86cb\u767d\u8d28\u8bbe\u8ba1\u7531\u6765\u5df2\u4e45\uff0c\u4f46\u6df1\u5ea6\u5b66\u4e60\u52a0\u901f\u4e86\u8fd9\u4e00\u9886\u57df\u7684\u53d1\u5c55\uff0c\u8ba9\u8bbe\u8ba1\u7b26\u5408\u73b0\u5b9e\u7684\u86cb\u767d\u8d28\u8ba1\u7b97\u673a\u6a21\u578b\u53d8\u5f97\u201c\u6781\u5176\u5feb\u901f\u201d\u3002\u4ee5\u524d\uff0c\u63a5\u53d7\u8fc7\u4e13\u4e1a\u57f9\u8bad\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u5e08\u9700\u8981\u51e0\u5468\u6216\u51e0\u4e2a\u6708\u7684\u65f6\u95f4\u6765\u521b\u5efa\u65b0\u86cb\u767d\u8d28\u7684\u9aa8\u67b6\uff0c\u4f46\u73b0\u5728\u4ed6\u4eec\u53ef\u4ee5\u5728\u51e0\u5929\u5185\uff0c\u751a\u81f3\u4e00\u591c\u4e4b\u95f4\u5b8c\u6210\u3002<\/span><\/p>\n


<\/p>\n<\/section>\n

\n
\n

<\/span><\/p>\n

Foldit\u662f\u7531Baker\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u7684\u5728\u7ebf\u6e38\u620f\uff0c\u73a9\u5bb6\u53ef\u4ee5\u501f\u6b64\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

\n

Baker\u8fd8\u66f4\u65b0\u4e86Foldit\uff0c\u5c06\u86cb\u767d\u8d28\u8bbe\u8ba1\u878d\u5165\u5176\u4e2d\u3002\u73a9\u5bb6\u4e0d\u4ec5\u53ef\u4ee5\u6784\u5efa\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u8fd8\u53ef\u4ee5\u52a8\u624b\u8bbe\u8ba1\u86cb\u767d\u8d28\u3002\u8fd9\u4e2a\u6539\u53d8\u9887\u5177\u6210\u6548\uff0cBaker\u7684\u5b9e\u9a8c\u5ba4\u5df2\u7ecf\u53d1\u8868\u4e86\u51e0\u7bc7\u5173\u4e8e\u73a9\u5bb6\u8bbe\u8ba1\u7684\u86cb\u767d\u8d28\u7684\u8bba\u6587\u3002Baker\u5728\u534e\u76db\u987f\u5927\u5b66\u7684\u540c\u4e8b\u6307\u5bfc\u7684\u4e00\u540d\u7814\u7a76\u751f\u5c31\u662f\u4e16\u754c\u4e0a\u6700\u9876\u5c16\u7684Foldit\u73a9\u5bb6\u4e4b\u4e00\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u6211\u4eec\u771f\u7684\u7406\u89e3\u86cb\u767d\u8d28\u6298\u53e0\u5417\uff1f\u5982\u679c\u6211\u4eec\u80fd\u591f\u8bbe\u8ba1\u51fa\u65b0\u7684\u5e8f\u5217\uff0c\u5e76\u4f7f\u5176\u6298\u53e0\u6210\u65b0\u7684\u7ed3\u6784\uff0c\u90a3\u4e48\u8fd9\u8868\u660e\u6211\u4eec\u5bf9\u86cb\u767d\u8d28\u6298\u53e0\u6709\u7740\u76f8\u5f53\u4e30\u5bcc\u7684\u4e86\u89e3\uff0c\u201dBaker\u8bf4\u3002\u201c\u4ece\u67d0\u79cd\u610f\u4e49\u4e0a\u8bf4\uff0c\u8fd9\u4e5f\u53ef\u4ee5\u88ab\u89c6\u4e3a\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u7684\u89e3\u51b3\u65b9\u6848\u3002\u201d<\/span><\/p>\n<\/section>\n

\n

\uff083\uff09\u4fe1\u4efb\u7ec3\u4e60<\/span><\/strong><\/span><\/p>\n<\/section>\n

\n

AlphaFold2\u7684\u6210\u529f\u65e0\u7591\u6539\u53d8\u4e86\u751f\u7269\u5b66\u5bb6\u5bf9\u4eba\u5de5\u667a\u80fd\u7684\u6001\u5ea6\u3002\u957f\u671f\u4ee5\u6765\uff0c\u8bb8\u591a\u5b9e\u9a8c\u751f\u7269\u5b66\u5bb6\u4e0d\u4fe1\u4efb\u8ba1\u7b97\u65b9\u6cd5\uff0c\u56e0\u4e3a\u4ed6\u4eec\u77e5\u9053\u67d0\u4e9b\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u53ef\u4ee5\u4f7f\u6570\u636e\u770b\u8d77\u6765\u6bd4\u5b9e\u9645\u66f4\u597d\u3002\u4f46\u662f\uff0c\u8c37\u6b4cDeepMind\u56e2\u961f\u201c\u660e\u786e\u5730\u8bc1\u660e\u4e86\u4f60\u53ef\u4ee5\u628a\u5b83\u7528\u5728\u4e25\u8083\u7684\u79d1\u7814\u5de5\u4f5c\u4e2d\uff0c\u201dAlQuraishi\u8bf4\u9053\u3002\u73b0\u5728\u5982\u679c\u8fd8\u6709\u4eba\u5bf9\u6b64\u6301\u6000\u7591\u6001\u5ea6\uff0c\u5176\u4ed6\u4eba\u4fbf\u4f1a\u53cd\u9a73\u9053\uff1a\u201c\u597d\u5427\uff0c\u90a3\u4f60\u600e\u4e48\u770bAlphaFold\u5462\uff1f\u201d<\/span><\/p>\n


<\/p>\n

\u63a8\u52a8\u4e86\u5377\u79ef\u7f51\u7edc\u53d1\u5c55\u7684\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\u8bb8\u9526\u6ce2\u8bf4\uff1a\u201c\u73b0\u5728\u751f\u7269\u5b66\u5bb6\u76f8\u4fe1\u6211\u4eec\u7684\u9884\u6d4b\u7ed3\u679c\u4e86\uff0c\u4ed6\u4eec\u4ee5\u524d\u603b\u662f\u6000\u7591\u6211\u4eec\u7684\u9884\u6d4b\u662f\u5426\u53ef\u9760\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u8fd9\u79cd\u4fe1\u4efb\u90e8\u5206\u6e90\u4e8eAlphaFold2\u5e73\u53f0\u7684\u4e00\u4e2a\u7279\u6027\uff1a\u5b83\u4e0d\u4ec5\u751f\u6210\u86cb\u767d\u8d28\u76843D\u6a21\u578b\uff0c\u8fd8\u6309\u7167\u4ece0\u5230100\u7684\u4fe1\u5fc3\u7b49\u7ea7\u5bf9\u7ed3\u6784\u7684\u4e0d\u540c\u90e8\u5206\u8fdb\u884c\u8bc4\u5206\uff0c\u4ee5\u6b64\u6765\u81ea\u6211\u8bc4\u4f30\u9884\u6d4b\u7684\u51c6\u786e\u6027\u3002<\/span><\/p>\n


<\/p>\n

2022\u5e747\u6708\uff0c\u5728\u8c37\u6b4cDeepMind\u53d1\u5e032180\u4e07\u79cd\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u9884\u6d4b\u540e<\/span>\uff08\u51e0\u4e4e\u6db5\u76d6\u4e86\u5df2\u77e5\u7684\u6240\u6709\u86cb\u767d\u8d28\uff09<\/span>\u2014\u2014Adams\u51b3\u5b9a\u5206\u6790AlphaFold2\u7684\u81ea\u6211\u62a5\u544a\u3002\u4ed6\u5c06\u9884\u6d4b\u7ed3\u679c\u4e0e\u8fd9\u4e9b\u86cb\u767d\u8d28\u7684\u5df2\u89e3\u7ed3\u6784\u8fdb\u884c\u6bd4\u8f83\uff0c\u5e76\u72ec\u7acb\u8bc4\u4f30\u5176\u51c6\u786e\u6027\u3002<\/span><\/p>\n


<\/p>\n

\u201c\u597d\u6d88\u606f\u662f\uff0c\u5f53AlphaFold\u8ba4\u4e3a\u81ea\u5df1\u662f\u6b63\u786e\u7684\u65f6\u5019\uff0c\u5b83\u5f80\u5f80\u786e\u5b9e\u662f\u5bf9\u7684\uff0c\u201dAdams\u8bf4\u9053\u3002\u201c\u5f53\u5b83\u8ba4\u4e3a\u81ea\u5df1\u4e0d\u5bf9\u65f6\uff0c\u73b0\u5b9e\u60c5\u51b5\u5f80\u5f80\u4e5f\u662f\u5982\u6b64\u3002\u201d\u4f46\u662f\uff0c\u5728\u5927\u7ea610%\u7684\u60c5\u51b5\u4e0b\uff0c\u5f53AlphaFold2\u5bf9\u5176\u9884\u6d4b\u201c\u975e\u5e38\u81ea\u4fe1\u201d<\/span>\uff08\u4fe1\u5fc3\u7b49\u7ea7\u5f97\u5206\u81f3\u5c1190\u5206\uff09<\/span>\u65f6\uff0c\u5176\u9884\u6d4b\u7ed3\u679c\u5176\u5b9e\u4e0e\u5b9e\u9a8c\u6240\u5f97\u6709\u51fa\u5165\uff0c\u6240\u4ee5\u5b83\u81ea\u4fe1\u8fc7\u5934\u4e86\u3002<\/span><\/p>\n


<\/p>\n

AI\u7cfb\u7edf\u4f3c\u4e4e\u6709\u67d0\u79cd\u81ea\u6211\u6000\u7591\u7684\u80fd\u529b\uff0c\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4eba\u4eec\u8fc7\u5ea6\u4f9d\u8d56\u5176\u7ed3\u8bba\u3002\u5927\u591a\u6570\u751f\u7269\u5b66\u5bb6\u4ec5\u4ec5\u5c06AlphaFold2\u89c6\u4e3a\u4e00\u79cd\u9884\u6d4b\u5de5\u5177\uff0c\u4f46\u6709\u4e9b\u4eba\u6b65\u5b50\u8fc8\u5f97\u592a\u5927\u4e86\u3002\u4e00\u4e9b\u4ee5\u524d\u4e0e\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\u5408\u4f5c\u7684\u7ec6\u80de\u751f\u7269\u5b66\u5bb6\u548c\u751f\u7269\u5316\u5b66\u5bb6\u5df2\u7ecf\u7528AlphaFold2\u5b8c\u5168\u53d6\u4ee3\u4e86\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\uff0c\u5e76\u5c06\u5176\u9884\u6d4b\u7ed3\u679c\u5949\u4e3a\u572d\u81ec\u3002Perrakis\u8bf4\uff0c\u6709\u65f6\u79d1\u5b66\u5bb6\u53d1\u8868\u7684\u8bba\u6587\u4e2d\u5305\u542b\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u5728\u4efb\u4f55\u7ed3\u6784\u751f\u7269\u5b66\u5bb6\u770b\u6765\u90fd\u663e\u7136\u662f\u9519\u8bef\u7684\u3002\u201c\u800c\u4ed6\u4eec\u5374\u8bf4\uff1a\u2018\u8fd9\u53ef\u662fAlphaFold\u9884\u6d4b\u7684\u7ed3\u679c\u3002\u2019\u201d<\/span><\/p>\n<\/section>\n

\n
\n
<\/span><\/section>\n
\u5728\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff0cLauren Porter\u7814\u7a76\u4e86\u53ef\u4ee5\u6539\u53d8\u6784\u8c61\u7684\u86cb\u767d\u8d28\uff0c\u79f0\u4e3a\u6298\u53e0\u8f6c\u6362\u86cb\u767d\u8d28\u3002\u4ed6\u4eec\u201c\u6311\u6218\u4e86\u5e8f\u5217\u7f16\u7801\u4e00\u79cd\u7ed3\u6784\u7684\u8303\u5f0f\uff0c\u201d\u5979\u8bf4\uff0c\u201c\u56e0\u4e3a\u663e\u7136\u5b83\u4eec\u4e0d\u7f16\u7801\u4e00\u79cd\u7ed3\u6784\u3002\u201d\u56fe\u6e90\uff1aLauren Porter<\/span><\/section>\n<\/section>\n<\/section>\n
\n

\u201c\u6709\u4e9b\u4eba\u5bf9\u8fd9\u4e9b\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u7684\u80fd\u529b\u8fc7\u4e8e\u81ea\u4fe1\uff0c\u5b9e\u5728\u592a\u8fc7\u81ea\u4fe1\u4e86\uff0c\u201d\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684\u7814\u7a76\u5458Lauren Porter\u8fd9\u6837\u8ba4\u4e3a\u3002\u201c\u6211\u4eec\u5e94\u8be5\u5c3d\u53ef\u80fd\u591a\u5730\u4f7f\u7528\u8fd9\u4e9b\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff0c\u4f46\u6211\u4eec\u4e5f\u9700\u8981\u4ee5\u8c28\u614e\u548c\u8c26\u900a\u7684\u6001\u5ea6\u5bf9\u5f85\u5b83\u4eec\u3002\u201d<\/span><\/p>\n


<\/p>\n

Jones\u542c\u8bf4\u6709\u79d1\u5b66\u5bb6\u60f3\u901a\u8fc7\u8ba1\u7b97\u65b9\u6cd5\u786e\u5b9a\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u4f46\u5728\u7533\u8bf7\u8d44\u91d1\u65f6\u5374\u9047\u5230\u4e86\u56f0\u96be\u3002Jones\u8bf4\uff1a\u201c\u666e\u904d\u7684\u770b\u6cd5\u662fDeepMind\u5df2\u7ecf\u505a\u5230\u4e86\uff0c\u4e3a\u4ec0\u4e48\u4f60\u8fd8\u8981\u7ee7\u7eed\u505a\uff1f\u201d\u4f46\u4ed6\u8ba4\u4e3a\u8fd9\u9879\u5de5\u4f5c\u4ecd\u6709\u5fc5\u8981\u7ee7\u7eed\u4e0b\u53bb\uff0c\u56e0\u4e3aAlphaFold2\u5e76\u975e\u5b8c\u7f8e\u65e0\u7f3a\u3002<\/span><\/p>\n


<\/p>\n

\u4ed6\u8868\u793a\uff1a\u201c<\/span>\uff08AlphaFold2\uff09<\/span>\u4e0e\u5b9e\u9645\u79d1\u7814\u8981\u6c42\u8fd8\u5b58\u5728\u975e\u5e38\u5927\u7684\u5dee\u8ddd\uff0c\u6709\u4e9b\u4e8b\u60c5\u5b83\u663e\u7136\u65e0\u6cd5\u505a\u5230\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u867d\u7136AlphaFold2\u5728\u9884\u6d4b\u5c0f\u800c\u7b80\u5355\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u65b9\u9762\u8868\u73b0\u51fa\u8272\uff0c\u4f46\u5728\u9884\u6d4b\u5305\u542b\u591a\u4e2a\u90e8\u5206\u7684\u86cb\u767d\u8d28\u65f6\u5176\u51c6\u786e\u6027\u8f83\u4f4e\u3002\u5b83\u4e5f\u65e0\u6cd5\u517c\u987e\u86cb\u767d\u8d28\u7684\u73af\u5883\u6216\u4e0e\u5176\u4ed6\u5206\u5b50\u7684\u7ed3\u5408\uff0c\u800c\u8fd9\u4e9b\u56e0\u7d20\u4f1a\u5728\u81ea\u7136\u72b6\u6001\u4e0b\u6539\u53d8\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002\u6709\u65f6\uff0c\u86cb\u767d\u8d28\u9700\u8981\u88ab\u67d0\u4e9b\u79bb\u5b50\u3001\u76d0\u7c7b\u7269\u8d28\u6216\u91d1\u5c5e\u7c7b\u7269\u8d28\u5305\u56f4\u624d\u80fd\u6b63\u786e\u6298\u53e0\u3002<\/span><\/p>\n


<\/p>\n

Walden\u8bf4\uff1a\u201c\u76ee\u524d\uff0cAlphaFold\u8fd8\u65e0\u6cd5\u786e\u5b9a\u86cb\u767d\u8d28\u6240\u5904\u7684\u73af\u5883\u3002\u201d\u5979\u7684\u5c0f\u7ec4\u5df2\u7ecf\u901a\u8fc7\u5b9e\u9a8c\u786e\u5b9a\u4e86\u51e0\u79cdAlphaFold2\u65e0\u6cd5\u9884\u6d4b\u7684\u7ed3\u6784\u3002<\/span><\/p>\n


<\/p>\n

AlphaFold2\u5bf9\u96c6\u4e2d\u52a8\u6001\u86cb\u767d\u8d28\u7684\u9884\u6d4b\u7ed3\u679c\u4e5f\u4e0d\u662f\u5f88\u597d\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u7684\u529f\u80fd\u4e5f\u975e\u5e38\u91cd\u8981\u3002\u6709\u4e9b\u86cb\u767d\u8d28\u7684\u5f62\u72b6\u4f1a\u53d1\u751f\u6539\u53d8\uff0c\u56e0\u6b64\u88ab\u79f0\u4e3a\u6298\u53e0\u8f6c\u6362\u86cb\u767d\u8d28<\/span>\uff08fold-switching protein\uff09<\/span>\u3002\u6b64\u7c7b\u86cb\u767d\u8d28\u4e0d\u662f\u9759\u6001\u7684\uff0c\u5b83\u4eec\u7684\u5f62\u72b6\u968f\u7740\u4e0e\u5176\u4ed6\u5206\u5b50\u7684\u76f8\u4e92\u4f5c\u7528\u800c\u53d1\u751f\u53d8\u5316\u3002\u6709\u4e9b\u5373\u4f7f\u5177\u6709\u76f8\u540c\u7684\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u4e5f\u4f1a\u6298\u53e0\u6210\u622a\u7136\u4e0d\u540c\u7684\u5f62\u72b6\u3002Porter\u8ba4\u4e3a\uff0c\u6298\u53e0\u8f6c\u6362\u86cb\u767d\u8d28\u201c\u53cd\u9a73\u4e86\u5e8f\u5217\u7f16\u7801\u5355\u4e00\u7ed3\u6784\u7684\u4f20\u7edf\u89c2\u70b9\uff0c\u56e0\u4e3a\u8fd9\u663e\u7136\u4e0e\u73b0\u5b9e\u4e0d\u7b26\u201d\u3002<\/span><\/p>\n<\/section>\n

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