{"id":51521,"date":"2024-07-17T19:22:57","date_gmt":"2024-07-17T11:22:57","guid":{"rendered":"https:\/\/swarma.org\/?p=51521"},"modified":"2024-07-17T19:22:57","modified_gmt":"2024-07-17T11:22:57","slug":"%e5%89%8d%e6%b2%bf%e8%bf%9b%e5%b1%95%ef%bc%9aatp%e4%b8%8e%e6%b0%b4%e8%a7%a3%e8%87%aa%e7%94%b1%e8%83%bd%e5%af%b9%e7%bb%86%e8%83%9e%e5%86%85%e5%8f%8c%e7%a8%b3%e6%80%81%e5%bc%80%e5%85%b3%e7%9a%84","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=51521","title":{"rendered":"\u524d\u6cbf\u8fdb\u5c55\uff1aATP\u4e0e\u6c34\u89e3\u81ea\u7531\u80fd\u5bf9\u7ec6\u80de\u5185\u53cc\u7a33\u6001\u5f00\u5173\u7684\u8c03\u63a7\u673a\u5236"},"content":{"rendered":"
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\u8bba\u6587\u9898\u76ee\uff1aInterplay between ATP and hydrolysis free energy in promoting and restraining biochemical switches<\/span><\/section>\n
\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/journals.aps.org\/prresearch\/abstract\/10.1103\/PhysRevResearch.6.033050<\/span>
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\u6d3b\u7ec6\u80de\u662f\u8fdc\u79bb\u70ed\u529b\u5b66\u5e73\u8861\u6001\u7684\u5f00\u653e\u7cfb\u7edf\uff0c\u9700\u8981\u4e0d\u65ad\u5730\u4e0e\u5916\u90e8\u73af\u5883\u4ea4\u6362\u7269\u8d28\u3001\u4fe1\u606f\u548c\u80fd\u91cf\uff0c\u6765\u7ef4\u6301\u751f\u547d\u6d3b\u52a8\u7684\u6709\u5e8f\u6027[1, 2]\u3002\u7ec6\u80de\u8c03\u63a7\u7f51\u7edc\u4ea7\u751f\u7684\u591a\u79cd\u52a8\u529b\u5b66\u884c\u4e3a\uff0c\u5728\u7ec6\u80de\u589e\u6b96\u3001\u5206\u5316\u548c\u4ee3\u8c22\u7b49\u751f\u7269\u8fc7\u7a0b\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u5b9e\u73b0\u4e0d\u540c\u751f\u7269\u529f\u80fd[3]\u3002\u540c\u65f6\uff0c\u6d3b\u7ec6\u80de\u9700\u8981\u7ef4\u6301\u5728\u70ed\u529b\u5b66\u975e\u5e73\u8861\u6001\uff0c\u901a\u8fc7\u4e0d\u65ad\u8017\u6563\u80fd\u91cf<\/span>\uff08\u4f8b\u5982ATP\u6c34\u89e3\u81ea\u7531\u80fd\u0394\u03bc<\/em>\uff09<\/span>\u6765\u9a71\u52a8\u751f\u7269\u8fc7\u7a0b\u548c\u751f\u7269\u529f\u80fd[2, 4]\u3002\u524d\u4eba\u7814\u7a76\u5df2\u7ecf\u63ed\u793a\u4e86\u5b9e\u73b0\u4e0d\u540c\u751f\u7269\u529f\u80fd\u6240\u9700\u7684\u57fa\u672c\u7f51\u7edc\uff0c\u4e5f\u53d1\u73b0\u4e86ATP\u6c34\u89e3\u81ea\u7531\u80fd\u0394\u03bc<\/em>\u5bf9\u7279\u5b9a\u751f\u7269\u529f\u80fd\u548c\u52a8\u529b\u5b66\u884c\u4e3a\u7684\u5f71\u54cd[2-4]\u3002\u7136\u800c\uff0c\u5728\u5177\u4f53\u7684\u7ec6\u80de\u8c03\u63a7\u7f51\u7edc\u548c\u751f\u547d\u6d3b\u52a8\u4e2d\uff0c\u4e0d\u540c\u7f51\u7edc\u7ed3\u6784\u662f\u5982\u4f55\u5f71\u54cd\u0394\u03bc<\/em>\u5bf9\u751f\u7269\u529f\u80fd<\/span>\uff08\u52a8\u529b\u5b66\u884c\u4e3a\uff09<\/span>\u7684\u8c03\u63a7\u4f5c\u7528\uff1f<\/span><\/section>\n

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2024\u5e747\u670811\u65e5\uff0c\u5317\u4eac\u5927\u5b66\u7269\u7406\u5b66\u9662\/\u5b9a\u91cf\u751f\u7269\u5b66\u4e2d\u5fc3\u6b27\u9633\u9880\/\u674e\u65b9\u5ef7\u56e2\u961f\u5728\u7f8e\u56fd\u7269\u7406\u5b66\u4f1a<\/span>\uff08APS\uff09<\/span>\u65d7\u4e0b\u671f\u520aPhysical Review Research<\/em>\u53d1\u8868\u4e86\u9898\u4e3a\u201cInterplay between ATP and hydrolysis free energy in promoting and restraining biochemical switches\u201d<\/span>\uff08DOI: 10.1103\/PhysRevResearch.6.033050\uff09<\/span>\u7684\u7814\u7a76\u8bba\u6587\uff0c\u63ed\u793a\u4e86\u7ec6\u80de\u5185\u53cc\u7a33\u6001\u5f00\u5173\u4e2d\uff0c\u8c03\u63a7\u7f51\u7edc\u7ed3\u6784\u5bf9\u7ec6\u80de\u5185ATP\u6c34\u5e73\u548c\u0394\u03bc<\/em>\u8c03\u63a7\u53cc\u7a33\u6001\u6027\u8d28\u7684\u5f71\u54cd\u3002<\/span><\/section>\n

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\uff081\uff09\u5bf9\u4e8e\u5355PdP\u5faa\u73af\u7f51\u7edc\uff0c\u8be5\u7814\u7a76\u901a\u8fc7\u7406\u8bba\u5206\u6790\u548c\u6570\u503c\u6a21\u62df\u8868\u660e\uff0c\u5728\u0394\u03bc <\/em>> 0\u65f6\uff0c\u65e0\u8bba\u7f51\u7edc\u7ed3\u6784\u5982\u4f55\u53d8\u5316\uff0c\u53cc\u7a33\u533a\u8fb9\u754c\u7684\u659c\u7387\u59cb\u7ec8\u4e3a\u8d1f\u503c\uff0c\u8bf4\u660e\u52a8\u529b\u5b66\u53c2\u6570[ATP]\u548c\u70ed\u529b\u5b66\u53c2\u6570\u0394\u03bc<\/em>\u5171\u540c\u6253\u5f00\/\u5173\u95ed\u5355PdP\u5faa\u73af\u7684\u53cc\u7a33\u6001\u5f00\u5173\uff0c\u534f\u540c\u8c03\u63a7\u5355\u7a33\u6001-\u53cc\u7a33\u6001\u8df3\u8f6c\u8fc7\u7a0b\u3002<\/span><\/section>\n

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\uff082\uff09\u5bf9\u4e8e\u53ccPdP\u5faa\u73af\u7f51\u7edc\uff0c\u8be5\u7814\u7a76\u901a\u8fc7\u89e3\u6790\u8ba1\u7b97\u548c\u6a21\u62df\u8bc1\u660e\u4e86\u5bf9\u4e8e\u201c\u540c\u5411\u201d\u7f51\u7edc<\/span>\uff08\u7f51\u7edc\u4e2d\u6240\u6709\u78f7\u9178\u5316\u90fd\u4fc3\u8fdb\u6700\u7ec8\u4ea7\u7269\u751f\u6210\uff0c\u56fe2a\u201cidentical\u201d\uff09<\/span>\uff0c\u53cc\u7a33\u533a\u8fb9\u754c\u7684\u659c\u7387\u90fd\u662f\u8d1f\u6570\uff0c\u0394\u03bc\u4e0e[ATP]\u548c\u603b\u662f\u534f\u540c\u8c03\u63a7\u53cc\u7a33\u6001\u6027\u8d28\u3002\u800c\u5bf9\u4e8e\u201c\u53cd\u5411\u201d\u7f51\u7edc<\/span>\uff08\u7f51\u7edc\u4e2d\u81f3\u5c11\u6709\u4e00\u4e2a\u78f7\u9178\u5316\u53cd\u5e94\u4f7f\u5f97\u76ee\u6807\u5206\u5b50\u51cf\u5c11\uff0c\u56fe2a\u201creversed\u201d\uff09<\/span>\uff0c\u53cc\u7a33\u533a\u8fb9\u754c\u659c\u7387\u6709\u5404\u79cd\u9009\u62e9<\/span>\uff08\u56fe2b\uff09<\/span>\u3002\u5c3d\u7ba1\u201c\u53cd\u5411\u201d\u7f51\u7edc\u4e2d\u78f7\u9178\u5316\u80fd\u91cf\u0394\u03bc<\/em>\u53ea\u90e8\u5206\u7528\u4e8e\u4fc3\u8fdb\u76ee\u6807\u4ea7\u7269\u751f\u6210<\/span>\uff08\u80fd\u91cf\u5229\u7528\u7387\u4f4e\u4e8e\u201c\u540c\u5411\u201d\u7f51\u7edc\uff09<\/span>\uff0c\u4f46\u662f\u7814\u7a76\u4e5f\u53d1\u73b0\u201c\u53cd\u5411\u201d\u7f51\u7edc\u4e2d\u0394\u03bc<\/em>\u4e0e[ATP]\u7684\u7ade\u4e89\u6548\u5e94\u662f\u6709\u5229\u4e8e\u63d0\u9ad8\u53cc\u7a33\u6001\u7684\u9c81\u68d2\u6027\u3002<\/span><\/section>\n

<\/section>\n

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\u56fe2. \u53ccPdP\u5faa\u73af\u7f51\u7edc\u53ca\u4e0d\u540c\u7684\u53cc\u7a33\u533a\u7c7b\u578b\u3002\uff08a\uff09\u5177\u6709\u201c\u540c\u5411\u201d\u548c\u201c\u53cd\u5411\u201d\u7f51\u7edc\u7ed3\u6784\u7684\u53ccPdP\u5faa\u73af\u7f51\u7edc\u3002\u201c\u78f7\u9178\u5316\u8d21\u732e\u201d\uff08Phosphorylation Contribution\uff0cPC\uff09\u662f\u8be5\u7f51\u7edc\u7684\u6240\u6709\u78f7\u9178\u5316\u53cd\u5e94\u4e2d\uff0c\u4fc3\u8fdb\u76ee\u6807\u4ea7\u7269S<\/span>p<\/sub>\u751f\u6210\u7684\u78f7\u9178\u5316\u53cd\u5e94\u5360\u6bd4\u3002\u201c\u53cd\u9988\u201d\uff08Feedback\uff09\u662f\u8868\u5f81\u6240\u6709\u53cd\u9988\u7c7b\u578b\u7684\u6570\u7ec4\uff0c\u5176\u4e2d+1\u548c-1\u5206\u522b\u4ee3\u8868\u6b63\u53cd\u9988\u548c\u8d1f\u53cd\u9988\u3002\uff08b\uff09[ATP]-\u0394<\/span>\u03bc<\/em>\u76f8\u56fe\u4e2d\u56db\u79cd\u53cc\u7a33\u533a\u7c7b\u578b\u7684\u793a\u610f\u56fe\u3002\u5206\u7c7b\u6761\u4ef6\u4e3a\u53cc\u7a33\u6001\u533a\u57df\u8fb9\u754c\u659c\u7387\uff0c\u4f8b\u5982NP\uff08Negative-Positive\uff09\u4ee3\u8868\u4e24\u6761\u8fb9\u754c\u7684\u659c\u7387\u4e00\u6b63\u4e00\u8d1f\uff0cOther\u5219\u5305\u542b\u66f4\u590d\u6742\u7684\u53cc\u7a33\u6001\u533a\u57df\u3002<\/span><\/span><\/p>\n


<\/span><\/section>\n
\u8be5\u7814\u7a76\u8fd8\u53d1\u73b0\u5728\u53ccPdP\u5faa\u73af\u7f51\u7edc\u4e2d\u53ef\u80fd\u5b58\u5728\u4e09\u7a33\u6001\u884c\u4e3a<\/span>\uff08\u56fe3a\u548c3b\uff09<\/span>\uff0c\u4e14\u53ef\u80fd\u5b58\u5728\u0394\u03bc<\/em>\u5bf9\u53cc\u7a33\u6001\u7684\u590d\u6742\u8c03\u63a7<\/span>\uff08\u56fe3d\u548c3e\uff09<\/span>\u3002\u9996\u5148\uff0c\u0394\u03bc<\/em>\u5bf9\u7cfb\u7edf\u7a33\u6001\u6570\u76ee\u7684\u8c03\u63a7\uff0c\u4ea7\u751f\u4e86\u6709\u8da3\u7684[ATP]- \u0394\u03bc<\/em>\u76f8\u56fe\uff0c\u5373\u4e09\u7a33\u6001\u533a\u57df\u5d4c\u5957\u5728\u53cc\u7a33\u6001\u533a\u57df\u5185<\/span>\uff08\u56fe3c\uff09<\/span>\u3002\u5206\u6790\u8868\u660e\u57fa\u4e8e\u76ee\u6807\u5206\u5b50Sp<\/sub>\u53bb\u78f7\u9178\u5316\u7684\u8d1f\u53cd\u9988\u8c03\u63a7\u662f\u53ccPdP\u5faa\u73af\u7f51\u7edc\u4e2d\u4e09\u7a33\u6001\u4ea7\u751f\u7684\u6f5c\u5728\u673a\u5236\u3002\u540c\u65f6\uff0c\u8be5\u7814\u7a76\u8fd8\u53d1\u73b0\u4e86\u0394\u03bc<\/em>\u5bf9\u53cc\u7a33\u6001\u6027\u8d28\u7684\u975e\u4e00\u81f4\u8c03\u63a7\u3002\u901a\u5e38\u800c\u8a00\uff0c\u0394\u03bc<\/em>\u7684\u589e\u52a0\u603b\u662f\u6709\u5229\u4e8e\u53cc\u7a33\u6001\u9c81\u68d2\u6027\u63d0\u9ad8<\/span>\uff08\u5982\u56fe2b\u4e2dNN\u3001NP\u548cPP\uff09<\/span>\u3002\u7136\u800c\uff0c\u5728\u56fe3f\u4e2d\uff0c\u53ea\u6709\u5728\u7279\u5b9a\u0394\u03bc<\/em>\u6c34\u5e73\u4e0b\uff0c\u7cfb\u7edf\u624d\u80fd\u7ef4\u6301\u53cc\u7a33\u6001\u7684\u5b58\u5728\uff0c\u5373\u5728[ATP]- \u0394\u03bc<\/em>\u76f8\u56fe\u4e2d\u5b58\u5728\u4e00\u4e2a\u5c9b\u5c7f\u72b6\u7684\u53cc\u7a33\u6001\u533a\u57df\uff1b\u5f53\u0394\u03bc<\/em>\u4ece\u751f\u7406\u6c34\u5e73<\/span>\uff08\u0394\u03bc <\/em>~ 23 kB<\/sub>T\uff09<\/span>\u5f00\u59cb\u589e\u52a0\u65f6\uff0c\u53cc\u7a33\u6001\u5374\u6d88\u5931\u4e86\u3002<\/span><\/section>\n

<\/span><\/section>\n


<\/span><\/p>\n

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\u56fe3. \u53ccPdP\u5faa\u73af\u7f51\u7edc\u4e2d\u4e09\u7a33\u6001\u6027\u8d28\u548c\u2206\u03bc\u5bf9\u53cc\u7a33\u533a<\/span>\u8fb9\u754c\u7684\u590d\u6742\u8c03\u63a7\u3002\uff08a-c\uff09Network 2\u62bd\u6837\u7ed3\u679c\u4e2d\u7684\u4e09\u7a33\u6001\u73b0\u8c61\u3002\u5f53\u81ea\u7531\u80fd\u5347\u9ad8\u65f6\uff0c\u76f8\u540c[ATP]\u4e0b[Sp<\/sub>]\u7684\u7a33\u6001\u6570\u91cf\u4ece\u4e24\u4e2a\u53d8\u4e3a\u4e09\u4e2a\uff08b\uff09\uff0c\u4f7f\u5f97\u7cfb\u7edf\u4ece\u53cc\u7a33\u6001\u53d8\u6210\u4e09\u7a33\u6001\uff08c\uff09\u3002\uff08d-f\uff09\u5728Network 7\u4e2d\u53d1\u73b0\u7684\u5bf9\u53cc\u7a33\u533a\u975e\u5355\u8c03\u8c03\u63a7\u884c\u4e3a\u3002<\/span><\/p>\n


<\/span><\/section>\n
\u7efc\u4e0a\u6240\u8ff0\uff0c\u8be5\u7814\u7a76\u5173\u6ce8\u7ec6\u80de\u5185ATP\u6c34\u5e73<\/span>\uff08[ATP]\uff09<\/span>\u548c\u7ec6\u80de\u5185ATP\u6c34\u89e3\u81ea\u7531\u80fd<\/span>\uff08\u0394\u03bc<\/em>\uff09<\/span>\u5bf9\u7ec6\u80de\u5185\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u53cc\u7a33\u6001\u6027\u8d28\u7684\u8c03\u63a7\u4f5c\u7528\uff0c\u63ed\u793a\u4e86\u5728\u540c\u5411\u7f51\u7edc\u4e2d\uff0c\u65e0\u8bba\u53cd\u9988\u673a\u5236\u5982\u4f55\uff0c[ATP]\u548c\u2206\u03bc<\/em>\u90fd\u4ee5\u534f\u540c\u7684\u65b9\u5f0f\u6765\u8c03\u63a7\u5355-\u53cc\u7a33\u6001\u7684\u8df3\u8f6c\uff1b\u5728\u53cd\u5411\u7f51\u7edc\u4e2d\uff0c\u5b58\u5728[ATP]\u548c\u2206\u03bc<\/em>\u5bf9\u53cc\u7a33\u6001\u6027\u8d28\u7684\u7ade\u4e89\u8c03\u63a7\uff0c\u8fd9\u79cd\u7ade\u4e89\u6548\u5e94\u53ef\u4ee5\u589e\u5f3a\u53cc\u7a33\u6001\u7684\u9c81\u68d2\u6027\uff1b\u672c\u7814\u7a76\u8fd8\u8ba8\u8bba\u4e86\u5177\u6709\u4e09\u7a33\u6001\u7279\u6027\u548c\u0394\u03bc<\/em>\u975e\u5355\u8c03\u8c03\u63a7\u6548\u5e94\u7684\u7279\u6b8a\u7f51\u7edc\u7ed3\u6784\u3002\u5728\u8bba\u6587\u5ba1\u7a3f\u8fc7\u7a0b\u4e2d\uff0c\u5ba1\u7a3f\u4eba\u5bf9\u8be5\u7814\u7a76\u7684\u7ed3\u679c\u63d0\u51fa\u8f83\u9ad8\u8bc4\u4ef7\uff0c\u90e8\u5206\u5ba1\u7a3f\u610f\u89c1\u5982\u4e0b\uff1a\u201cThe points addressed here are of extreme importance in the study of biochemical switches and add a new dimension in these studies of this area\u201d\u3002<\/span><\/section>\n

<\/span><\/section>\n
\u8bfe\u9898\u7ec4\u4ece2018\u5e74\u5f00\u59cb\uff0c\u7814\u7a76\u4e86\u7ec6\u80de\u5185\u975e\u5e73\u8861\u6001\u70ed\u529b\u5b66\u5bf9\u7ec6\u80de\u5185\u4e0d\u540c\u8c03\u63a7\u7f51\u7edc\u4e2d\u52a8\u529b\u5b66\u884c\u4e3a\u7684\u5f71\u54cd\u5e76\u5b8c\u6210\u4e86\u4e00\u7cfb\u5217\u7684\u5de5\u4f5c[5-7]\uff0c\u4e3b\u8981\u7814\u7a76\u6210\u679c\u5305\u62ec\uff1a\u7406\u8bba\u5206\u6790\u4e86\u975e\u5e73\u8861\u6001\u548c\u968f\u673a\u6027\u5bf9\u82bd\u6b96\u9175\u6bcdDNA\u635f\u4f24\u4fee\u590d\u901a\u8def\u6fc0\u6d3b\u8fc7\u7a0b\u7684\u5f71\u54cd[5]\uff1b\u5728\u88c2\u6b96\u9175\u6bcd\u4e2d\uff0c\u7ed3\u5408\u7406\u8bba\u5206\u6790\u548c\u5b9e\u9a8c\u65b9\u6cd5\uff0c\u63ed\u793a\u4e86ATP\u548c\u0394\u03bc<\/em>\u5bf9\u7ec6\u80de\u5468\u671fG2-M\u8f6c\u6362\u8fc7\u7a0b\u4e2d\u53cc\u7a33\u6001\u5f00\u5173\u7684\u8c03\u63a7\u4f5c\u7528[6]\uff1b\u5728\u80f0\u5c9b\u03b2\u7ec6\u80de\u4e2d\uff0c\u5206\u6790\u4e86\u76f8\u5173\u79bb\u5b50\u901a\u9053\u7684\u70ed\u529b\u5b66\u6027\u8d28\uff0c\u89e3\u6790\u4e86ATP\u548c\u0394\u03bc<\/em>\u5bf9\u9499\u632f\u8361\u884c\u4e3a\u7684\u8c03\u63a7\u673a\u5236\uff0c\u5e76\u5229\u7528ATP-\u0394\u03bc<\/em>\u76f8\u56fe\u89e3\u91ca\u4e86\u4e0d\u540c\u9499\u632f\u8361\u884c\u4e3a\u7684\u4ea7\u751f\u673a\u5236[7]\u3002<\/span><\/section>\n

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\u5317\u4eac\u5927\u5b66\u7269\u7406\u5b66\u9662\u674e\u5178\u6770\u4e3a\u8bba\u6587\u7b2c\u4e00\u4f5c\u8005\uff0c\u5317\u4eac\u5927\u5b66\u7269\u7406\u5b66\u9662\/\u5b9a\u91cf\u751f\u7269\u5b66\u4e2d\u5fc3\u674e\u65b9\u5ef7\u526f\u6559\u6388\u4e3a\u901a\u8baf\u4f5c\u8005\u3002\u8be5\u7814\u7a76\u5f97\u5230\u4e86\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u7b49\u673a\u6784\u7684\u652f\u6301\u3002<\/span><\/section>\n

<\/strong><\/section>\n

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\u53c2\u8003\u6587\u732e\uff1a<\/strong>
<\/section>\n
[1] E. Schr\u00f6dinger, What Is Life? The Physical Aspect of the Living Cell (The University Press, Cambridge, 1944).<\/span><\/section>\n
[2] X. Yang, et al., Physical bioenergetics: Energy fluxes, budgets, and con straints in cells, Proc. Natl. Acad. Sci. USA 118, e2026786118 (2021).<\/span><\/section>\n
[3] U. Alon, An Introduction to Systems Biology: Design Principles of Biological Circuits. (Chapman & Hall\/CRC, Philadelphia, PA, 2023).<\/span><\/section>\n
[4] H. Qian, Phosphorylation energy hypothesis: Open chemical systems and their biological functions, Annu. Rev. Phys. Chem. 58, 113 (2007).<\/span><\/section>\n
[5] C. Jin, X. Yan, and F. Li, Non-equilibrium and stochasticity influence the activation process of the yeast DNA damage pathway, Sci. China Phys. Mech. Astron. 61, 028721 (2018).<\/span><\/section>\n
[6] D. Zhao, et al., Nonequilibrium and Nonlinear Kinetics as Key Determinants for Bistability in Fission Yeast G2-M Transition, Nonequilibrium and nonlinear kinetics as key determinants for bistability in fission yeast G2-M transition [q-bio.MN] arXiv:1610.09637.<\/span><\/section>\n
[7] Y. Sun, et al., ATP hydrolysis kinetics and thermodynamics as determinants of calcium oscillation in pancreatic \ud835\udefd cells, Phys. Rev. Res. 4, 043142 (2022).<\/span><\/section>\n

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\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a<\/strong><\/p>\n

\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/strong>
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\u5728\u751f\u7269\u5b66\u4e2d\u5fc3\u6cd5\u5219\u7684\u8d77\u70b9\uff0c\u57fa\u56e0\u4f5c\u4e3a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u9057\u4f20\u4fe1\u606f\u8f7d\u4f53\uff0c\u5728\u751f\u547d\u5468\u671f\u5185\u7a33\u5b9a\u5b58\u5728\uff1b\u800c\u4f4d\u4e8e\u4e2d\u5fc3\u6cd5\u5219\u672b\u7aef\u7684\u86cb\u767d\u8d28\uff0c\u5176\u7ec4\u7ec7\u6784\u6210\u548c\u65f6\u7a7a\u53d8\u5316\u7684\u590d\u6742\u6027\u5448\u6307\u6570\u5f0f\u589e\u957f\u3002\u968f\u7740\u5206\u5b50\u751f\u7269\u5b66\u6570\u5341\u5e74\u6765\u7684\u7a81\u98de\u731b\u8fdb\uff0c\u5c24\u5176\u662f\u751f\u547d\u7ec4\u5b66\uff08\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7b49\u7684\u96c6\u5408\uff09\u7b49\u9886\u57df\u7684\u65e5\u65b0\u6708\u5f02\uff0c\u5f53\u4ee3\u751f\u547d\u79d1\u5b66\u4e34\u8fd1\u7206\u53d1\u7684\u8fb9\u7f18\u3002\u5982\u6b64\u6d77\u91cf\u7684\u6570\u636e\u5982\u4f55\u5e2e\u52a9\u6211\u4eec\u63ed\u793a\u5b87\u5b99\u4e2d\u6700\u590d\u6742\u7684\u7269\u8d28\u7cfb\u7edf\u2014\u2014\u201c\u4eba\u4f53\u201d\u7684\u6784\u6210\u539f\u7406\u548c\u8bbe\u8ba1\u539f\u7406\uff1f\u9610\u91ca\u4eba\u7c7b\u53d1\u80b2\u3001\u8870\u8001\u548c\u91cd\u5927\u75be\u75c5\u7684\u53d1\u751f\u673a\u5236\uff1f<\/span><\/p>\n


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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/section>\n
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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/strong><\/section>\n
1. <\/strong>\u524d\u6cbf\u8fdb\u5c55\uff1aATP\u6c34\u5e73\u4e0e\u6c34\u89e3\u81ea\u7531\u80fd\u600e\u6837\u5171\u540c\u5f71\u54cd\u7ec6\u80de\u7684\u9499\u4fe1\u53f7\u8c03\u63a7\u7cfb\u7edf\u8d70\u5411\u201c\u5206\u53c9\u201d<\/a><\/strong><\/span><\/section>\n
2. <\/strong>PRX\u751f\u7269\u7269\u7406\u524d\u6cbf\uff1a\u566a\u58f0\u9a71\u52a8\u7684\u7ec6\u80de\u4e0d\u540c\u72b6\u6001\u8df3\u8f6c\u7684\u52a8\u529b\u5b66\u673a\u7406<\/a><\/strong><\/span><\/section>\n
3.<\/strong> \u524d\u6cbf\u8fdb\u5c55\uff1a\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u4e0e\u514d\u75ab\u7cfb\u7edf\u534f\u540c\u54cd\u5e94\u7684\u52a8\u529b\u5b66\u673a\u5236<\/a><\/strong><\/span><\/section>\n
4. <\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
5.<\/strong> \u96c6\u667aVIP\u96c6\u5408\u5566\uff01\u4e91\u5357\u7ebf\u4e0b\u7814\u4fee\u8425\uff0c\u4e0e\u96c6\u667a\u521b\u59cb\u4eba\u4e00\u8d77\u6500\u767b\u201c\u590d\u6742\u6027\u9636\u68af\u201d<\/a><\/strong><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n
6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/section>\n


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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/span><\/strong><\/span><\/strong><\/p>\n

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