{"id":52048,"date":"2024-08-15T21:56:40","date_gmt":"2024-08-15T13:56:40","guid":{"rendered":"https:\/\/swarma.org\/?p=52048"},"modified":"2024-08-15T21:56:40","modified_gmt":"2024-08-15T13:56:40","slug":"nat-methods-%e9%80%9f%e9%80%92%ef%bc%9a%e8%80%83%e8%99%91%e7%94%9f%e7%89%a9%e8%83%8c%e6%99%af%e4%bf%a1%e6%81%af%e7%9a%84%e5%8d%95%e7%bb%86%e8%83%9e%e8%9b%8b%e7%99%bd%e8%b4%a8%e8%ae%a1%e7%ae%97","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=52048","title":{"rendered":"Nat. Methods. \u901f\u9012\uff1a\u8003\u8651\u751f\u7269\u80cc\u666f\u4fe1\u606f\u7684\u5355\u7ec6\u80de\u86cb\u767d\u8d28\u8ba1\u7b97\u6a21\u578b"},"content":{"rendered":"
\n
\n
\n
\n
\n

<\/p>\n


<\/p>\n<\/section>\n

\n
\n
\n
\n
<\/strong><\/section>\n
\u6765\u81ea\u54c8\u4f5b\u5927\u5b66\u7684Marinka Zitnik\u6559\u6388\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u8003\u8651\u751f\u7269\u80cc\u666f\u4fe1\u606f\u7684\u5355\u7ec6\u80de\u86cb\u767d\u8d28\u8ba1\u7b97\u6a21\u578b\u2014\u2014PINNACLE\uff0c\u4e3a\u6bcf\u4e2a\u86cb\u767d\u8d28\u751f\u6210\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u7684\u4f4e\u7ef4\u8868\u793a\uff0c\u8fdb\u800c\u5b8c\u6210\u8bf8\u5982\u53d1\u73b0\u9776\u70b9\u3001\u5206\u6790\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u7684\u836f\u7269\u53cd\u5e94\u7b49\u4e0b\u6e38\u4efb\u52a1\u3002<\/span><\/strong><\/section>\n

<\/span><\/strong><\/section>\n
\u5173\u952e\u8bcd\uff1a\u5355\u7ec6\u80de\u86cb\u767d\u8d28\uff0c \u751f\u7269\u80cc\u666f\u4fe1\u606f\uff0c \u51e0\u4f55\u6df1\u5ea6\u5b66\u4e60\uff0c \u8868\u793a\u5b66\u4e60<\/span><\/strong><\/span><\/strong><\/strong><\/section>\n<\/section>\n
\n
<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

<\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n

<\/section>\n
\n
\u8bba\u6587\u9898\u76ee\uff1aContextual AI models for single-cell protein biology<\/span><\/section>\n
\u8bba\u6587\u6765\u6e90\uff1aNature Methods<\/em><\/span><\/section>\n
\u8bba\u6587\u94fe\u63a5\uff1a<\/span>https:\/\/doi.org\/10.1038\/s41592-024-02341-3<\/span><\/section>\n<\/blockquote>\n

<\/section>\n
\u86cb\u767d\u8d28\u662f\u751f\u547d\u8fc7\u7a0b\u7684\u6267\u884c\u8005\u3002\u5728\u6f2b\u957f\u7684\u7814\u7a76\u8fc7\u7a0b\u4e2d\uff0c\u4eba\u4eec\u5bf9\u86cb\u767d\u8d28\u4ece\u7ed3\u6784\u5230\u529f\u80fd\u90fd\u6709\u4e86\u5168\u65b9\u4f4d\u7684\u4e86\u89e3\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740AlphaFold\u7b49\u5de5\u5177\u7684\u5174\u8d77\uff0c\u79d1\u5b66\u5bb6\u4eec\u5f00\u59cb\u4f7f\u7528\u4eba\u5de5\u667a\u80fd\u6a21\u578b\u5bf9\u86cb\u767d\u8d28\u8fdb\u884c\u7814\u7a76\u3002\u5177\u4f53\u800c\u8a00\uff0c\u8ba1\u7b97\u751f\u7269\u5b66\u8005\u5e7f\u6cdb\u4f7f\u7528\u8868\u5f81\u5b66\u4e60<\/span>\uff08Representation Learning\uff09<\/span>\u7684\u624b\u6bb5\u5bf9\u86cb\u767d\u8d28\u8fdb\u884c\u5efa\u6a21\uff0c\u5e76\u5b8c\u6210\u8bf8\u5982\u7ed3\u6784\u9884\u6d4b\u3001\u9776\u70b9\u53d1\u73b0\u3001\u4eb2\u548c\u529b\u9884\u6d4b\u7b49\u4e0b\u6e38\u4efb\u52a1\u3002\u7136\u800c\uff0c\u5df2\u6709\u7684\u4eba\u5de5\u667a\u80fd\u6a21\u578b\u901a\u5e38\u4e3a\u6bcf\u4e2a\u86cb\u767d\u8d28\u90fd\u751f\u6210\u7edf\u4e00\u7684\u8868\u793a\u3002\u968f\u7740\u7cbe\u51c6\u533b\u5b66\u7684\u53d1\u5c55\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u5f00\u59cb\u5173\u6ce8\u751f\u7269\u7ec4\u7ec7\u7ec6\u80de\u4e4b\u95f4\u7684\u5f02\u8d28\u6027\uff0c\u6316\u6398\u86cb\u767d\u8d28\u5728\u4e0d\u540c\u7684\u751f\u7269\u73af\u5883\u548c\u7ec6\u80de\u72b6\u6001\u4e0b\u6240\u53d1\u6325\u7684\u591a\u6837\u4f5c\u7528\u3002<\/span><\/section>\n

<\/section>\n
<\/span><\/section>\n
\n
\n
\u8868\u5f81\u5b66\u4e60\u662f\u4e00\u79cd\u673a\u5668\u5b66\u4e60\u6280\u672f\uff0c\u6307\u4ece\u539f\u59cb\u7684\u8f93\u5165\u6570\u636e\uff08\u8fd9\u91cc\u4e3a\u86cb\u767d\u8d28\uff09\u4e2d\u63d0\u53d6\u663e\u8457\u7279\u5f81\uff0c\u5e76\u4f7f\u7528\u63d0\u53d6\u51fa\u6765\u7684\u7279\u5f81\uff0c\u4e00\u822c\u4e3a\u4e00\u4e32\u5411\u91cf\uff0c\u5bf9\u86cb\u767d\u8d28\u8fdb\u884c\u8868\u793a\uff0c\u8fdb\u800c\u8f93\u5165\u540e\u7eed\u4eba\u5de5\u667a\u80fd\u6a21\u578b\u4e2d\u5b8c\u6210\u4e0b\u6e38\u4efb\u52a1\uff08\u5982\u5206\u7c7b\u3001\u9884\u6d4b\u3001\u56de\u5f52\u7b49\uff09\u3002<\/span><\/section>\n<\/section>\n<\/blockquote>\n

<\/section>\n
\u9274\u4e8e\u6b64\uff0c\u6765\u81ea\u54c8\u4f5b\u5927\u5b66\u7684Marinka Zitnik\u6559\u6388\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u8003\u8651\u751f\u7269\u80cc\u666f\u4fe1\u606f\u7684\u5355\u7ec6\u80de\u86cb\u767d\u8d28\u8ba1\u7b97\u6a21\u578b\u2014\u2014 PINNACLE\uff0c<\/span>\u901a\u8fc7\u7ed3\u5408\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u3001\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528<\/span>\uff08PPI\uff09<\/span>\u7f51\u7edc\u3001\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u548c\u7ec4\u7ec7\u5c42\u6b21\u6570\u636e\uff0c\u4e3a\u6bcf\u4e2a\u86cb\u767d\u8d28\u751f\u6210\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u7684\u4f4e\u7ef4\u8868\u793a\uff0c\u8be5\u6a21\u578b\u751f\u6210\u7684\u7ed3\u679c\u80fd\u591f\u663e\u8457\u589e\u5f3a\u4e4b\u524d\u4ec5\u901a\u8fc7\u86cb\u767d\u4e09\u7ef4\u7ed3\u6784\u5f97\u5230\u7684\u901a\u7528\u8868\u793a\uff0c\u8fdb\u800c\u5b8c\u6210\u8bf8\u5982\u53d1\u73b0\u9776\u70b9\u3001\u5206\u6790\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u7684\u836f\u7269\u53cd\u5e94\u7b49\u4e0b\u6e38\u4efb\u52a1<\/span><\/strong>\u3002<\/span><\/section>\n

<\/section>\n
PINNACLE\u6a21\u578b\u67b6\u6784\u5206\u4e3a\u4ee5\u4e0b\u90e8\u5206<\/span>\uff08\u56fe1\uff09<\/span>\uff1a<\/span><\/section>\n

<\/section>\n
1\uff09\u6784\u5efa\u5c42\u6b21\u5f02\u8d28\u7f51\u7edc<\/span>\uff08\u56fe1 a-b\uff09<\/span>\uff1a<\/span>
<\/section>\n

<\/section>\n
\u901a\u8fc7\u4f7f\u7528\u8f6c\u5f55\u7ec4\u5b66\u56fe\u8c31\u6570\u636e\u4e0e\u53c2\u8003\u57fa\u56e0\u7ec4\u8fdb\u884c\u6bd4\u8f83\uff0c\u9274\u5b9a\u6bcf\u4e2a\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u9ad8\u8868\u8fbe\u57fa\u56e0\uff0c\u5bfb\u627e\u5176\u5bf9\u5e94\u7684\u86cb\u767d\u8d28\uff0c\u4ea7\u751f\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u7684\u86cb\u767d\u4e92\u4f5c\u7f51\u7edc\uff1b\u901a\u8fc7\u5bf9\u914d\u53d7\u4f53\u5173\u7cfb\u548c\u7ec4\u7ec7\u5c42\u6b21\u8fdb\u884c\u6316\u6398\uff0c\u5f97\u5230\u7ec6\u80de-\u7ec4\u7ec7\u5173\u7cfb\u56fe<\/span>\uff08MetaGraph\uff09<\/span>\u3002\u5c06\u4e0a\u8ff0\u4e24\u56fe\u7ed3\u5408\uff0c\u53ef\u5f97\u5230\u4e00\u4e2a\u5c42\u6b21\u5f02\u8d28\u6027\u7f51\u7edc\uff0c\u8282\u70b9\u4e3a\u86cb\u767d\u8d28\u3001\u7ec6\u80de\u7c7b\u578b\u3001\u7ec4\u7ec7\u7c7b\u578b\uff0c\u8fb9\u4e3a\u4e0d\u540c\u7c7b\u578b\u8282\u70b9\u4e4b\u95f4\u7684\u5173\u7cfb<\/span>\uff08\u5982\u86cb\u767d\u4e92\u4f5c\u5173\u7cfb\uff0c\u7ec6\u80de\u914d\u53d7\u4f53\u5173\u7cfb\uff0c\u7ec4\u7ec7\u5c42\u6b21\u7b49\uff09<\/span>\u3002<\/span><\/section>\n

<\/span><\/section>\n
2\uff09\u9884\u8bad\u7ec3<\/span>\uff08\u56fe1 c-d\uff09<\/span>\uff1a<\/span>
<\/section>\n

<\/span><\/section>\n
\u91c7\u7528\u5bf9\u6bd4\u5b66\u4e60\u7684\u601d\u8def\uff0c\u5bf9\u56fe\u8fdb\u884c\u81ea\u76d1\u7763\u9884\u8bad\u7ec3\uff0c\u91c7\u7528\u5c42\u6b21\u6d88\u606f\u4f20\u9012\u7684\u65b9\u5f0f\u5bf9\u8282\u70b9\u8fdb\u884c\u6d88\u606f\u805a\u5408\uff0c\u6709\u8fb9\u7684\u8282\u70b9\u4e4b\u95f4\u589e\u52a0\u7279\u5f81\u8868\u793a\u76f8\u4f3c\u6027\uff0c\u65e0\u8fb9\u7684\u8282\u70b9\u4e4b\u95f4\u51cf\u5c11\u7279\u5f81\u8868\u793a\u76f8\u4f3c\u6027\uff0c\u6700\u7ec8\u5f97\u5230\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u7684\u86cb\u767d\u8868\u793a\uff0c\u7ec6\u80de\u7c7b\u578b\u8868\u793a\uff0c\u7ec4\u7ec7\u8868\u793a\u3002<\/span><\/section>\n

<\/section>\n
<\/section>\n
\u56fe1 PINNACLE\u7684\u6a21\u578b\u67b6\u6784\u56fe<\/span><\/section>\n

<\/section>\n
\u9996\u5148\uff0c\u7814\u7a76\u8005\u4eec\u5bf9\u6a21\u578b\u5f97\u5230\u7684\u8868\u793a\u7a7a\u95f4<\/strong>\u8fdb\u884c\u4e86\u8be6\u7ec6\u800c\u53c8\u6df1\u5165\u7684\u63a2\u7a76\u3002\u4ece\u86cb\u767d\u5c42\u9762\uff0c\u5c06\u6240\u6709\u7684\u86cb\u767d\u8868\u793a<\/span>\uff08394760\u4e2a\uff09<\/span>\u964d\u7ef4\u6295\u5f71\u5230\u4e8c\u7ef4UMAP\u56fe\u4e0a\u8fdb\u884c\u5b9a\u6027\u5206\u6790<\/span>\uff08\u56fe2a-f\uff09<\/span>\uff0c\u53d1\u73b0\u6765\u81ea\u76f8\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u86cb\u767d\u5728\u7a7a\u95f4\u4e2d\u4e5f\u5448\u73b0\u805a\u96c6\u5206\u5e03\u8d8b\u52bf\u3002\u6b64\u5916\uff0c\u6587\u7ae0\u91c7\u7528\u5b9a\u91cf\u7edf\u8ba1\u5b66\u8ba1\u7b97\u65b9\u6cd5\u8868\u660e\uff0c\u6a21\u578b\u8003\u8651\u7ec6\u80de\u7c7b\u578b\u4fe1\u606f\u540e\uff0c\u7684\u786e\u4f1a\u8ba9\u6765\u81ea\u76f8\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u86cb\u767d\u8868\u793a\u76f8\u4f3c\u5ea6\u66f4\u9ad8\uff0c\u53cd\u4e4b\u4ea6\u7136<\/span>\uff08\u56fe3a-b\uff09<\/span>\u3002\u4ece\u7ec4\u7ec7\u5c42\u9762\uff0c\u6587\u7ae0\u53d1\u73b0\u6a21\u578b\u751f\u6210\u7684\u7ec4\u7ec7\u5c42\u6b21\u8868\u793a\u4e5f\u662f\u5408\u7406\u7684<\/span>\uff08\u56fe3c\uff09<\/span>\u3002<\/span><\/section>\n

<\/section>\n
\u5176\u6b21\uff0c\u7814\u7a76\u8005\u4eec\u9009\u53d6\u4e86\u5178\u578b\u53ef\u7ed3\u5408\u86cb\u767d\u5bf9<\/strong>\uff1aPD-1\/ PD-L1\u548cB7-1\/ CTLA-4\uff0c\u901a\u8fc7\u6d88\u878d\u5b9e\u9a8c\u8bc1\u5b9e\u52a0\u5165\u751f\u7269\u80cc\u666f\u4fe1\u606f<\/span>\uff08\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u4fe1\u606f\uff09<\/span>\uff0c\u80fd\u591f\u66f4\u597d\u5730\u533a\u5206\u4e24\u4e2a\u86cb\u767d\u662f\u5426\u80fd\u591f\u7ed3\u5408\uff0c\u4ece\u800c\u5f97\u51fa\u7ed3\u8bba\uff1aPINNACLE\u80fd\u591f\u6709\u6548\u589e\u5f3a\u86cb\u767d-\u86cb\u767d\u4e92\u4f5c\u7f51\u7edc\u76843D\u7ed3\u6784\u8868\u793a<\/strong><\/span>\uff08\u56fe3 d-f\uff09<\/span>\u3002<\/span><\/section>\n

<\/section>\n
<\/section>\n
\u56fe2 \u5bf9PINNACLE\u5f97\u5230\u7684\u8868\u793a\u8fdb\u884c\u5b9a\u6027\u5c55\u793a\u548c\u5bcc\u96c6\u5206\u6790<\/span><\/section>\n

<\/span><\/section>\n
<\/section>\n
\u56fe3 \u5bf9PINNACLE\u5f97\u5230\u7684\u8868\u793a\u8fdb\u884c\u5b9a\u91cf\u8bc4\u4f30<\/span><\/section>\n

<\/section>\n
\u7136\u540e\uff0c\u7814\u7a76\u8005\u4eec\u4e3b\u8981\u9488\u5bf9\u4e24\u79cd\u75be\u75c5\uff1a\u7c7b\u98ce\u6e7f\u5173\u8282\u708e<\/span> (RA) <\/span>\u548c\u708e\u75c7\u6027\u80a0\u75c5<\/span> (IBD) <\/span>\u8fdb\u884c\u4e86\u63a2\u7a76\uff0c\u5f00\u5c55\u4e86\u4e00\u7cfb\u5217\u4e0b\u6e38\u4efb\u52a1\u3002<\/span><\/section>\n

<\/section>\n
\u5c06\u9884\u8bad\u7ec3\u8fc7\u540e\u7684\u6a21\u578b\u8fdb\u884c\u5fae\u8c03\uff0c\u5e76\u68c0\u67e5\u5176\u662f\u5426\u80fd\u8bc6\u522b\u73b0\u5728\u5df2\u6709\u7684\u6cbb\u7597\u9776\u70b9\u3002\u5206\u7c7b\u7ed3\u679c<\/span>\uff08\u56fe4\uff09<\/span>\u8868\u660ePINNACLE\u6a21\u578b\u6548\u679c\u8fdc\u8d85\u5176\u4ed6\u672a\u8003\u8651\u751f\u7269\u80cc\u666f\u7684\u6a21\u578b<\/span>\uff08\u5982\u968f\u673a\u6e38\u8d70\u3001GAT\u7b49\uff09<\/span>\u3002<\/span><\/section>\n

<\/section>\n
<\/section>\n
\u56fe4 \u5bf9PINNACLE\u8fdb\u884c\u5fae\u8c03\uff0c\u68c0\u9a8c\u9776\u70b9\u8bc6\u522b\u6027\u80fd<\/span><\/section>\n

<\/section>\n
\u73b0\u6709\u7814\u7a76\u8868\u660e\uff0c\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u5bf9\u540c\u4e00\u836f\u7269\u7684\u54cd\u5e94\u4e0d\u5c3d\u76f8\u540c\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u8005\u4eec\u63a2\u7a76\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u9776\u70b9\u8bc6\u522b\u6027\u80fd\u662f\u5426\u6709\u663e\u8457\u5dee\u5f02\u3002\u7ed3\u679c\u5982\u56fe5a\u3001\u56fe5d\u6240\u793a\uff0c\u7814\u7a76\u8005\u4eec\u53d1\u73b0\u4e86\u67d0\u4e9b\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u9776\u70b9\u8bc6\u522b\u6027\u80fd\u8f83\u597d\uff0c\u63d0\u793a\u8fd9\u7c7b\u7ec6\u80de\u5bf9\u836f\u7269\u54cd\u5e94\u53ef\u80fd\u8f83\u5f3a\uff0c\u5b58\u5728\u53d1\u73b0\u65b0\u9776\u70b9\u7684\u53ef\u80fd\u3002\u56fe5 bc\u3001ef\u5206\u522b\u4ee5\u5177\u4f53\u5b9e\u4f8b\u5f62\u5f0f\u5c55\u793a\u4e86\u76f8\u5e94\u60c5\u51b5\uff0c\u4e3a\u4e34\u5e8a\u9776\u5411\u6cbb\u7597\u3001\u7cbe\u51c6\u6cbb\u7597\u63d0\u4f9b\u4e86\u6307\u5bfc\u3002<\/span><\/section>\n

<\/section>\n

<\/p>\n

\u56fe5 \u63a2\u7a76\u4e0d\u540c\u7c7b\u578b\u7684\u7ec6\u80de\u7684\u9776\u70b9\u8bc6\u522b\u6548\u679c<\/span><\/section>\n

<\/section>\n
\u603b\u4e4b\uff0c\u5728\u8fd9\u9879\u5de5\u4f5c\u4e2d\uff0c\u7814\u7a76\u8005\u4eec\u91c7\u7528\u51e0\u4f55\u6df1\u5ea6\u5b66\u4e60\u7684\u7b56\u7565\uff0c\u8bbe\u8ba1\u4e86\u4e00\u4e2a\u8003\u8651\u751f\u7269\u80cc\u666f\u4fe1\u606f\u7684\u5355\u7ec6\u80de\u86cb\u767d\u8d28\u8ba1\u7b97\u6a21\u578b\u2014\u2014PINNACLE\uff0c\u901a\u8fc7\u4e30\u5bcc\u7684\u5b9a\u6027\u5b9a\u91cf\u5b9e\u9a8c\uff0c\u4e0d\u4ec5\u9a8c\u8bc1\u4e86\u6a21\u578b\u7684\u5408\u7406\u6027\uff0c\u66f4\u63ed\u793a\u4e86\u6a21\u578b\u7684\u751f\u7269\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n

\n
\n
\n
\n
\n

<\/section>\n

<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n

\u7814\u7a76\u5e26\u6765\u7684\u542f\u793a<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/p>\n

\u4f17\u6240\u5468\u77e5\uff0c\u86cb\u767d\u8d28\u53ef\u4ee5\u5f88\u65b9\u4fbf\u5730\u8f6c\u5316\u4e3a\u4e00\u4e2a\u8ba1\u7b97\u6a21\u578b\uff0c\u901a\u8fc7\u56fe\u795e\u7ecf\u7f51\u7edc\u7b49\u624b\u6bb5\u8fdb\u884c\u4e00\u7cfb\u5217\u7684\u4e0b\u6e38\u4efb\u52a1\uff0c\u5982\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\uff0c\u86cb\u767d\u4e92\u4f5c\u7b49\u3002\u968f\u7740\u5927\u6a21\u578b\u7684\u7206\u706b\uff0c\u6d8c\u73b0\u51fa\u4e86\u5f88\u591a\u4f18\u79c0\u7684\u5de5\u4f5c\u5c06\u86cb\u767d\u6a21\u578b\u505a\u5927\uff0c\u91c7\u7528\u5927\u6570\u636e\u3001\u5927\u7b97\u529b\uff0c\u671f\u671b\u80fd\u591f\u201c\u6d8c\u73b0\u201d\u51fa\u751f\u7269\u5b66\u7684\u5e95\u5c42\u89c4\u5f8b\uff0c\u5982AlphaFold3\u3001ROSETTA – All Atom\u7b49\u3002\u8fd9\u7bc7\u6587\u7ae0\u53d1\u73b0\u4e86\u4e00\u4e2a\u6838\u5fc3\u7684\u95ee\u9898\uff0c\u86cb\u767d\u8d28\u8868\u5f81\u6a21\u578b\u90fd\u4ea7\u751f\u4e00\u4e2a\u7edf\u4e00\u7684\u8868\u793a\uff0c\u5e76\u672a\u8003\u8651\u5230\u5f88\u591a\u751f\u7269\u5b66\u80cc\u666f\u4fe1\u606f\uff0c\u56e0\u6b64\uff0c\u56f4\u7ed5\u7740\u8fd9\u4e2a\u95ee\u9898\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u63a2\u7d22\uff0c\u901a\u8fc7\u8be6\u7ec6\u7684\u5206\u6790\u548c\u5b9e\u9a8c\u8bc1\u5b9e\u4e86\u878d\u5408\u751f\u7269\u5b66\u80cc\u666f\u4fe1\u606f\uff0c\u80fd\u591f\u5f88\u597d\u7684\u89e3\u51b3\u56f0\u6270\u5df2\u4e45\u7684\u96be\u9898\uff0c\u6b63\u5982\u4e00\u540d\u5ba1\u7a3f\u4eba\u6240\u8bf4\uff0cThe paper is very timely, is technically interesting and addresses an important and challenging problem. \u8fd9\u7bc7\u6587\u7ae0\u5bf9\u505a\u7b97\u6cd5\u5f00\u53d1\u7684\u7814\u7a76\u4eba\u5458\u6765\u8bf4\u662f\u4e00\u4e2a\u5f88\u597d\u7684\u6307\u5f15\uff0c\u5f15\u5bfc\u5927\u5bb6\u5c06\u6ce8\u610f\u529b\u653e\u5728\u6316\u6398\u597d\u7684\u79d1\u5b66\u95ee\u9898\uff0c\u800c\u975e\u8fc7\u591a\u6267\u7740\u4e8e\u7b97\u6cd5\u7684\u9ad8\u6df1\u548c\u8270\u96be<\/strong>\u3002<\/span><\/section>\n

<\/section>\n
\u5176\u6b21\uff0c\u5c06\u7ec6\u80de\u7c7b\u578b\u4f5c\u4e3a\u6709\u610f\u4e49\u7684\u751f\u7269\u80cc\u666f\u4fe1\u606f\u4ece\u800c\u6ce8\u5165\u6a21\u578b\u662f\u4e00\u4e2a\u5f88\u597d\u7684\u60f3\u6cd5\uff0c\u5e76\u4e14\u8fd9\u4e0d\u662f\u7b2c\u4e00\u6b21\u5728\u9876\u520a\u4e2d\u4f53\u73b0\u3002\u5982\u4eca\u5e741\u6708\u5728Nature Methods\u4e2d\u520a\u767b\u7684CytoCommunity[1]\uff0c\u4f7f\u7528\u7ec6\u80de\u8868\u578b\u4f5c\u4e3a\u7279\u5f81\u5b66\u4e60\u7ec4\u7ec7\u7ec6\u80de\u90bb\u57df<\/span> (TCN) <\/span>\u7684\u5212\u5206\uff0c\u80fd\u591f\u5728\u53ef\u53d8\u7a7a\u95f4\u5c3a\u5ea6\u4e0a\u53d1\u73b0\u6761\u4ef6\u7279\u5f02\u6027\u7684\u7ec6\u80de\u90bb\u57df\u534f\u4f5c\u6a21\u5f0f\uff0c\u4e3a\u89e3\u6790\u80bf\u7624-\u514d\u75ab\u4e92\u4f5c\u673a\u5236\u63d0\u4f9b\u5206\u6790\u5de5\u5177\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u5c06\u751f\u7269\u5b66\u80cc\u666f\u4fe1\u606f\u9ad8\u6548\u878d\u5165\u5230\u8ba1\u7b97\u6a21\u578b\uff0c\u662f\u672a\u6765\u503c\u5f97\u63a2\u7a76\u7684\u95ee\u9898\u3002<\/span><\/section>\n

<\/section>\n
\u603b\u4f53\u800c\u8a00\uff0c\u8fd9\u7bc7\u6587\u7ae0\u662f\u4e00\u4e2a\u975e\u5e38\u6f02\u4eae\u7684\u5de5\u4f5c\u3002\u4ece\u7cbe\u51c6\u533b\u5b66\u7684\u89d2\u5ea6\u51fa\u53d1\uff0c\u4ee5\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u86cb\u767d\u8868\u793a<\/span>\uff08Cell type-specific protein representation\uff09<\/span>\u4e3a\u7ebf\u7d22\uff0c\u7ed9\u8bfb\u8005\u5c55\u73b0\u4e86\u5355\u7ec6\u80de\u548c\u86cb\u767d\u4e92\u4f5c\u7f51\u7edc\u662f\u5982\u4f55\u7ed3\u5408\u7684\uff0c\u4ece\u800c\u80fd\u591f\u89e3\u51b3\u751f\u7269\u95ee\u9898\uff0c\u63d0\u4f9b\u4e34\u5e8a\u6307\u5bfc\u3002<\/span><\/section>\n

<\/section>\n

<\/section>\n
\u53c2\u8003\u6587\u732e<\/strong><\/span><\/section>\n

1. Hu, Y., Rong, J., Xu, Y. et al. Unsupervised and supervised discovery of tissue cellular neighborhoods from cell phenotypes. Nat Methods 21, 267\u2013278 (2024). <\/span>https:\/\/doi.org\/10.1038\/s41592-023-02124-2<\/span><\/p>\n


<\/section>\n

<\/section>\n
\u4f5c\u8005<\/span> <\/span><\/span>| <\/span><\/strong><\/strong>\u8463\u5f18\u79b9<\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n
\n
\n
\n
\n

\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a<\/strong><\/p>\n

\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/strong>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n

\u5728\u751f\u7269\u5b66\u4e2d\u5fc3\u6cd5\u5219\u7684\u8d77\u70b9\uff0c\u57fa\u56e0\u4f5c\u4e3a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u9057\u4f20\u4fe1\u606f\u8f7d\u4f53\uff0c\u5728\u751f\u547d\u5468\u671f\u5185\u7a33\u5b9a\u5b58\u5728\uff1b\u800c\u4f4d\u4e8e\u4e2d\u5fc3\u6cd5\u5219\u672b\u7aef\u7684\u86cb\u767d\u8d28\uff0c\u5176\u7ec4\u7ec7\u6784\u6210\u548c\u65f6\u7a7a\u53d8\u5316\u7684\u590d\u6742\u6027\u5448\u6307\u6570\u5f0f\u589e\u957f\u3002\u968f\u7740\u5206\u5b50\u751f\u7269\u5b66\u6570\u5341\u5e74\u6765\u7684\u7a81\u98de\u731b\u8fdb\uff0c\u5c24\u5176\u662f\u751f\u547d\u7ec4\u5b66\uff08\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7b49\u7684\u96c6\u5408\uff09\u7b49\u9886\u57df\u7684\u65e5\u65b0\u6708\u5f02\uff0c\u5f53\u4ee3\u751f\u547d\u79d1\u5b66\u4e34\u8fd1\u7206\u53d1\u7684\u8fb9\u7f18\u3002\u5982\u6b64\u6d77\u91cf\u7684\u6570\u636e\u5982\u4f55\u5e2e\u52a9\u6211\u4eec\u63ed\u793a\u5b87\u5b99\u4e2d\u6700\u590d\u6742\u7684\u7269\u8d28\u7cfb\u7edf\u2014\u2014\u201c\u4eba\u4f53\u201d\u7684\u6784\u6210\u539f\u7406\u548c\u8bbe\u8ba1\u539f\u7406\uff1f\u9610\u91ca\u4eba\u7c7b\u53d1\u80b2\u3001\u8870\u8001\u548c\u91cd\u5927\u75be\u75c5\u7684\u53d1\u751f\u673a\u5236\uff1f<\/span><\/p>\n


<\/span><\/p>\n

\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u7406\u5b66\u9662\u53ca\u4ea4\u53c9\u79d1\u5b66\u4e2d\u5fc3\u8bb2\u5e2d\u6559\u6388\u6c64\u96f7\u7ff0\uff0c\u56fd\u5bb6\u86cb\u767d\u8d28\u79d1\u5b66\u4e2d\u5fc3\uff08\u5317\u4eac\uff09\u526f\u7814\u7a76\u5458\u5e38\u4e58\u3001\u674e\u6768\uff0c\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\u52a9\u7406\u6559\u6388\u5510\u4e7e\u5143\uff0c\u5317\u4eac\u5927\u5b66\u524d\u6cbf\u4ea4\u53c9\u5b66\u79d1\u7814\u7a76\u9662\u7814\u7a76\u5458\u6797\u4e00\u701a\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5206\u5b50\u7ec6\u80de\u79d1\u5b66\u5353\u8d8a\u521b\u65b0\u4e2d\u5fc3\u535a\u58eb\u540e\u5510\u8bd7\u5a55\uff0c\u5171\u540c\u53d1\u8d77\u300c\u751f\u547d\u590d\u6742\u6027\uff1a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/a>\u300d\u8bfb\u4e66\u4f1a\uff0c\u4ece\u5fae\u89c2\u7ec6\u80de\u5c3a\u5ea6\u3001\u4ecb\u89c2\u7ec4\u7ec7\u5668\u5b98\u5c3a\u5ea6\u5230\u5b8f\u89c2\u4eba\u4f53\u5c3a\u5ea6\uff0c\u68b3\u7406\u751f\u547d\u79d1\u5b66\u9886\u57df\u4e2d\u7684\u91cd\u8981\u95ee\u9898\u53ca\u91cd\u8981\u6570\u636e\uff0c\u7531\u751f\u7269\u5b66\u5bb6\u63d0\u95ee\uff0c\u5e0c\u671b\u4fc3\u8fdb\u7edf\u8ba1\u7269\u7406\u3001\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u7814\u7a76\u8005\u548c\u751f\u547d\u79d1\u5b66\u7814\u7a76\u8005\u4e4b\u95f4\u7684\u6df1\u5ea6\u4ea4\u6d41\uff0c\u5efa\u7acb\u8de8\u5b66\u79d1\u5408\u4f5c\u5173\u7cfb\uff0c\u6fc0\u53d1\u65b0\u7684\u7814\u7a76\u601d\u8def\u548c\u5408\u4f5c\u9879\u76ee\u3002\u8bfb\u4e66\u4f1a\u4ece2024\u5e748\u67086\u65e5\u5f00\u59cb\uff0c\u6bcf\u5468\u4e8c\u665a19:00-21:00\u8fdb\u884c\uff0c\u6301\u7eed\u65f6\u95f4\u9884\u8ba110-12\u5468\u3002\u6b22\u8fce\u5bf9\u8fd9\u4e2a\u751f\u547d\u79d1\u5b66\u3001\u7269\u7406\u5b66\u3001\u8ba1\u7b97\u673a\u79d1\u5b66\u3001\u590d\u6742\u7cfb\u7edf\u79d1\u5b66\u6df1\u5ea6\u4ea4\u53c9\u7684\u524d\u6cbf\u9886\u57df\u611f\u5174\u8da3\u7684\u670b\u53cb\u52a0\u5165\uff01<\/span><\/p>\n


<\/p>\n

<\/span><\/a><\/span><\/strong><\/span><\/section>\n

<\/span><\/section>\n
\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/section>\n
\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a\u4ece\u5fae\u89c2\u5230\u5b8f\u89c2\uff0c\u591a\u5c3a\u5ea6\u89c6\u89d2\u63a2\u7d22\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/span><\/a><\/section>\n

<\/span><\/span><\/section>\n

<\/section>\n
\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/strong><\/section>\n
1. <\/strong>Nat. Commun.\u901f\u9012\uff1a\u5229\u7528\u6df1\u5ea6\u751f\u6210\u6a21\u578bSpatialScope\u6574\u5408\u7a7a\u95f4\u548c\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e<\/a><\/strong><\/span><\/section>\n
2. <\/strong>\u7528\u751f\u6210\u6a21\u578b\u73a9\u8f6c\u5355\u7ec6\u80de\u8f6c\u5f55\u6570\u636e\uff1ainclust\u901a\u7528\u6846\u67b6\uff5c\u96c6\u667a\u79d1\u5b66\u5bb6Cell\u5b50\u520a\u6700\u65b0\u8bba\u6587<\/a><\/strong><\/span><\/section>\n
3. <\/strong>Nat. Commun. \u901f\u9012\uff1a\u57fa\u4e8e\u5f02\u8d28\u56fe transformer \u7684\u5355\u7ec6\u80de\u751f\u7269\u7f51\u7edc\u63a8\u7406<\/a><\/strong><\/span><\/section>\n
4. <\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
<\/strong>5.<\/strong> \u9f99\u5e74\u5927\u8fd0\u8d77\uff0c\u5b66\u4e60\u6b63\u5f53\u65f6\uff01\u89e3\u9501\u96c6\u667a\u5168\u7ad9\u5185\u5bb9\uff0c\u5f00\u542f\u65b0\u5e74\u5b66\u4e60\u8ba1\u5212<\/a><\/strong><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n

6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/p>\n


<\/p>\n


<\/span><\/p>\n

\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/span><\/section>\n

<\/mp-style-type><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6765\u81ea\u54c8\u4f5b\u5927\u5b66\u7684Marinka Zitnik\u6559\u6388\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u79cd\u8003\u8651\u751f\u7269\u80cc\u666f\u4fe1\u606f\u7684\u5355\u7ec6\u80de\u86cb\u767d\u8d28\u8ba1\u7b97\u6a21\u578b\u2014\u2014PINNACLE\uff0c\u4e3a\u6bcf\u4e2a\u86cb\u767d\u8d28\u751f\u6210\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u7684\u4f4e\u7ef4\u8868\u793a\uff0c\u8fdb\u800c\u5b8c\u6210\u8bf8\u5982\u53d1\u73b0\u9776\u70b9\u3001\u5206\u6790\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u7684\u836f\u7269\u53cd\u5e94\u7b49\u4e0b\u6e38\u4efb\u52a1\u3002 \u5173\u952e\u8bcd\uff1a\u5355\u7ec6\u80de\u86cb\u767d\u8d28\uff0c \u751f\u7269\u80cc\u666f\u4fe1\u606f\uff0c \u51e0\u4f55\u6df1\u5ea6\u5b66\u4e60\uff0c \u8868\u793a\u5b66\u4e60 \u8bba\u6587\u9898\u76ee\uff1aC…<\/p>\n","protected":false},"author":0,"featured_media":52039,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/52048"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=52048"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/52048\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/52039"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=52048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=52048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=52048"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=52048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}