{"id":52128,"date":"2024-08-19T16:43:29","date_gmt":"2024-08-19T08:43:29","guid":{"rendered":"https:\/\/swarma.org\/?p=52128"},"modified":"2024-08-19T16:43:29","modified_gmt":"2024-08-19T08:43:29","slug":"%e7%bb%86%e8%83%9e%e8%93%9d%e5%9b%be%e8%ae%a1%e5%88%92%ef%bc%9a%e5%a6%82%e4%bd%95%e5%ae%9a%e4%b9%89%e7%bb%86%e8%83%9e%e7%b1%bb%e5%9e%8b%ef%bc%9f%e7%bb%86%e8%83%9e%e5%91%bd%e8%bf%90%e5%86%b3%e5%ae%9a","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=52128","title":{"rendered":"\u7ec6\u80de\u84dd\u56fe\u8ba1\u5212\uff1a\u5982\u4f55\u5b9a\u4e49\u7ec6\u80de\u7c7b\u578b\uff1f\u7ec6\u80de\u547d\u8fd0\u51b3\u5b9a\u673a\u5236\u662f\u600e\u6837\u7684\uff1f\uff5c\u5468\u4e8c\u76f4\u64ad\u00b7\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a"},"content":{"rendered":"
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    \u7ec6\u80de\u84dd\u56fe cell landscape<\/span><\/p>\n

    \u5355\u7ec6\u80de\u7ec4\u5b66 Single-cell omics<\/span><\/p>\n

    \u6df1\u5ea6\u5b66\u4e60 deep learning<\/span><\/p>\n

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    \u4e2a\u4eba\u4e3b\u9875\uff1ahttps:\/\/person.zju.edu.cn\/ggj<\/span><\/section>\n


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    [1] Han, X., Zhou, Z., Fei, L. et al.<\/em> Construction of a human cell landscape at single-cell level. Nature<\/em> 581, 303\u2013309 (2020). https:\/\/doi.org\/10.1038\/s41586-020-2157-4<\/span><\/p>\n

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    [2] Han, Xiaoping, et al. Mapping the mouse cell atlas by microwell-seq. Cell<\/em> 172.5 (2018): 1091-1107.<\/span><\/p>\n

    \u63a8\u8350\u7406\u7531\uff1a\u9996\u4e2a\u5c0f\u9f20\u7ec6\u80de\u56fe\u8c31\u3002<\/span><\/p>\n

    [3] Li, Jiaqi, et al. Deep learning of cross-species single-cell landscapes identifies conserved regulatory programs underlying cell types. Nature Genetics<\/em> 54.11 (2022): 1711-1720.<\/span><\/p>\n

    \u63a8\u8350\u7406\u7531\uff1a\u9996\u6b21\u5b9e\u73b0\u4ece\u7269\u79cd\u57fa\u56e0\u7ec4\u5230\u7ec6\u80de\u56fe\u8c31\u7684\u4eba\u5de5\u667a\u80fd\u9884\u6d4b\u6a21\u578b\u3002<\/span><\/section>\n

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    Cell\uff1a\u5355\u7ec6\u80de\u5206\u6790\u6280\u672f\u7ed8\u5236\u5c0f\u9f20\u7ec6\u80de\u56fe\u8c31\uff082018\uff09<\/span><\/strong><\/span><\/h3>\n
    \n
    Han, Xiaoping, et al. Mapping the mouse cell atlas by microwell-seq. Cell<\/em> 172.5 (2018): 1091-1107. https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(18)30116-8<\/span><\/section>\n<\/blockquote>\n
    \u5728\u8fd9\u9879\u5de5\u4f5c\u4e2d\uff0c\u6d59\u6c5f\u5927\u5b66\u90ed\u56fd\u9aa5\u6559\u6388\u56e2\u961f\u81ea\u4e3b\u5f00\u53d1\u4e86\u4e00\u5957\u9ad8\u7cbe\u5ea6\u3001\u4f4e\u6210\u672c\u3001\u56fd\u4ea7\u5316\u7684\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u5206\u6790\u6280\u672fMicrowell-seq\uff0c\u5bf9\u6765\u81ea\u5c0f\u9f20\u8fd150\u79cd\u5668\u5b98\u7ec4\u7ec7\u768440\u4f59\u4e07\u4e2a\u7ec6\u80de\u8fdb\u884c\u7cfb\u7edf\u6027\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\uff0c\u6784\u5efa\u4e86\u5f53\u65f6\uff082018\u5e74\uff09\u9996\u4e2a\u54fa\u4e73\u52a8\u7269\u5168\u7ec6\u80de\u8f6c\u5f55\u7ec4\u56fe\u8c31\u3002\u8be5\u7814\u7a76\u57fa\u672c\u6db5\u76d6\u4e86\u54fa\u4e73\u52a8\u7269\u4f53\u5185\u7684\u5404\u79cd\u4e3b\u8981\u7ec6\u80de\u7c7b\u578b\uff0c\u5e76\u5bf9\u6bcf\u4e00\u79cd\u5668\u5b98\u5185\u7684\u7ec4\u7ec7\u7ec6\u80de\u4e9a\u578b\u3001\u57fa\u8d28\u7ec6\u80de\u4e9a\u578b\u3001\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u4e9a\u578b\u548c\u514d\u75ab\u7ec6\u80de\u4e9a\u578b\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u8fdb\u884c\u8be6\u7ec6\u63cf\u8ff0\uff0c\u7ed8\u5236\u6210\u4e00\u5e45\u7cbe\u7f8e\u7684\u201c\u7ec6\u80de\u5730\u56fe\u201d\u3002<\/span><\/section>\n

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    \u6b64\u5916\uff0c\u8fd9\u9879\u7814\u7a76\u8fd8\u53d1\u73b0\u6765\u81ea\u4e0d\u540c\u7ec4\u7ec7\u7684\u57fa\u8d28\u7ec6\u80de\u5177\u6709\u5b8c\u5168\u4e0d\u540c\u7684\u57fa\u56e0\u8868\u8fbe\u7279\u5f81\uff0c\u4e3a\u63a2\u7a76\u7ec4\u7ec7\u5fae\u73af\u5883\u5f02\u8d28\u6027\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u89c1\u89e3\u548c\u5e2e\u52a9\u3002\u6b64\u9879\u5de5\u4f5c\u83b7\u5f97\u7684\u5c0f\u9f20\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u8d44\u6e90\u5df2\u7ecf\u516c\u5f00\u5728\u7ebf\u53ef\u8bbf\u95ee\uff08http:\/\/bis.zju.edu.cn\/MCA\/\uff09\uff0c\u7f51\u7ad9\u8fd8\u63d0\u4f9b\u4e86\u5355\u7ec6\u80de\u6570\u636e\u6bd4\u5bf9\u7cfb\u7edf\uff0c\u4efb\u4f55\u5355\u7ec6\u80de\u8868\u8fbe\u8c31\u6570\u636e\u90fd\u53ef\u4ee5\u901a\u8fc7\u5355\u7ec6\u80de\u6bd4\u5bf9\u5206\u6790\u5bfb\u627e\u5230\u5b83\u6240\u5bf9\u5e94\u7684\u7ec6\u80de\u7c7b\u578b\u548c\u6765\u6e90\u3002<\/span><\/section>\n

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    Nature\uff1a\u5355\u7ec6\u80de\u6c34\u5e73\u6784\u5efa\u4eba\u7c7b\u7ec6\u80de\u84dd\u56fe\uff082020\uff09<\/span><\/strong><\/span><\/h3>\n
    \n
    Han, X., Zhou, Z., Fei, L. et al.<\/em> Construction of a human cell landscape at single-cell level. Nature<\/em> 581, 303\u2013309 (2020). https:\/\/doi.org\/10.1038\/s41586-020-2157-4<\/span><\/section>\n<\/blockquote>\n
    2020\u5e743\u6708\uff0c\u90ed\u56fd\u9aa5\u6559\u6388\u56e2\u961f\u901a\u8fc7\u4f7f\u7528\u8bfe\u9898\u7ec4\u4e4b\u524d\u7814\u53d1\u7684Microwell-seq\u6280\u672f\uff0c\u5bf9\u4e2d\u56fd\u6c49\u65cf\u6350\u8d60\u6837\u672c\u8fdb\u884c\u4e86\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u9996\u6b21\u4ece\u5355\u7ec6\u80de\u6c34\u5e73\u5168\u9762\u5206\u6790\u4e86\u80da\u80ce\u548c\u6210\u5e74\u65f6\u671f\u7684\u4e3b\u8981\u4eba\u4f53\u5668\u5b98\u7ec6\u80de\u7c7b\u578b\uff0c\u5efa\u7acb\u4e86\u4eba\u7c7b\u7ec6\u80de\u56fe\u8c31\u5206\u6790\u6846\u67b6\u3002\u8be5\u7814\u7a76\u6db5\u76d660\u79cd\u4eba\u4f53\u7ec4\u7ec7\u7c7b\u578b\uff0c\u5229\u7528702,968\u4e2a\u5355\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u6570\u636e\uff0c\u7cfb\u7edf\u5efa\u7acb\u4e86\u8de8\u8d8a\u4eba\u7c7b\u80da\u80ce\u548c\u6210\u5e74\u4e24\u4e2a\u65f6\u671f\u7684\u5355\u7ec6\u80de\u56fe\u8c31\uff0c\u9274\u5b9a\u4e86102\u79cd\u7ec6\u80de\u7c07\u548c843\u79cd\u7ec6\u80de\u4e9a\u7c7b\uff0c\u4e3a\u4eba\u7c7b\u751f\u7269\u5b66\u7814\u7a76\u4ee5\u53ca\u5bf9\u4eba\u4f53\u75be\u75c5\u7ec6\u80de\u72b6\u6001\u7684\u9274\u5b9a\u63d0\u4f9b\u4e86\u5b9d\u8d35\u7684\u8d44\u6e90\u3002<\/span><\/section>\n

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    \u540c\u65f6\uff0c\u8be5\u7814\u7a76\u5bf9\u4eba\u7c7b\u548c\u4e4b\u524d\u53d1\u8868\u7684\u5c0f\u9f20\u5355\u7ec6\u80de\u56fe\u8c31\u8fdb\u884c\u4e86\u6bd4\u8f83\u5206\u6790\uff0c\u5e76\u53d1\u73b0\u5e72\u7ec6\u80de\u548c\u7956\u7ec6\u80de\u8868\u73b0\u51fa\u5f88\u5f3a\u7684\u8f6c\u5f55\u7ec4\u968f\u673a\u6027\uff0c\u5206\u5316\u548c\u6210\u719f\u7ec6\u80de\u7684\u8f6c\u5f55\u72b6\u6001\u5374\u5206\u660e\u4e14\u7a33\u5b9a\uff0c\u8be5\u7814\u7a76\u8fd8\u53d1\u73b0\u4e86\u8bb8\u591a\u4eba\u7c7b\u7ec4\u7ec7\u4e2d\u6b64\u524d\u672a\u88ab\u8bc6\u522b\u7684\u7ec6\u80de\u5f02\u8d28\u6027\uff0c\u5b9a\u4e49\u4e8630\u591a\u79cd\u65b0\u7ec6\u80de\u79cd\u7c7b\u3002\u4f8b\u5982\uff0c\u5728\u80ce\u513f\u80be\u810f\u4e2d\u53d1\u73b0\u4e86\u65b0\u7684S\u5f62\u4f53\u7ec6\u80de\u7c7b\u578b\uff1b\u5728\u6210\u4eba\u80be\u810f\u4e2d\u53d1\u73b0\u4e86\u65b0\u7ec6\u80de\u7c7b\u578b\u7b49\u3002\u4e3a\u4e86\u516c\u5f00\u6570\u636e\u8d44\u6e90\uff0c\u7814\u7a76\u56e2\u961f\u642d\u5efa\u4e86\u4eba\u7c7b\u7ec6\u80de\u56fe\u8c31\u7f51\u7ad9 https:\/\/db.cngb.org\/HCL\/\u3002<\/span><\/section>\n

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    \u56fe2. \u4eba\u4f53\u7ec6\u80de\u56fe\u8c31\u7684\u6784\u5efa<\/span><\/section>\n

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    Nature Genetics\uff1a\u8de8\u7269\u79cd\u7ec6\u80de\u56fe\u8c31\u6784\u5efa\u4e0e\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b Nvwa\uff082022\uff09<\/span><\/strong><\/span><\/h3>\n
    \n
    Li, Jiaqi, et al. Deep learning of cross-species single-cell landscapes identifies conserved regulatory programs underlying cell types. Nature Genetics<\/em> 54.11 (2022): 1711-1720.<\/span><\/section>\n<\/blockquote>\n
    2022\u5e7410\u6708\uff0c\u90ed\u56fd\u9aa5\u6559\u6388\u56e2\u961f\u7684\u6587\u7ae0\u5728Nature Genetics\u4e0a\u7ebf\u3002\u7814\u7a76\u4eba\u5458\u9996\u5148\u4f7f\u7528\u81ea\u4e3b\u7814\u53d1\u7684\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u6d4b\u5e8f\u5e73\u53f0Microwell-seq\u7ed8\u5236\u4e86\u6591\u9a6c\u9c7c\u3001\u679c\u8747\u548c\u86af\u8693\u7684\u5168\u8eab\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u56fe\uff0c\u5229\u7528\u8fd9\u4e09\u79cd\u6a21\u5f0f\u52a8\u7269\u7684\u5355\u7ec6\u80de\u56fe\u8c31\uff0c\u5e76\u7ed3\u5408\u5176\u4ed6\u4e94\u79cd\u4ee3\u8868\u6027\u52a8\u7269\u7684\u5355\u7ec6\u80de\u56fe\u8c31\uff08\u4eba\u7c7b\u3001\u5c0f\u9f20\u3001\u6d77\u9798\u3001\u7ebf\u866b\u548c\u6da1\u866b\uff09\uff0c\u6316\u6398\u4e86\u8de8\u7269\u79cd\u7ec6\u80de\u8c31\u7cfb\u7279\u5f02\u6027\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u63a2\u7a76\u4e86\u516b\u79cd\u4ee3\u8868\u6027\u540e\u751f\u52a8\u7269\u7ec6\u80de\u7c7b\u578b\u7684\u8de8\u7269\u79cd\u53ef\u6bd4\u6027\uff0c\u63ed\u793a\u4e86\u810a\u690e\u52a8\u7269\u7ec6\u80de\u7c7b\u578b\u7684\u4fdd\u5b88\u8c03\u8282\u7a0b\u5e8f\u3002<\/span><\/section>\n

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    \u6b64\u5916\uff0c\u57fa\u4e8eDNA\u5e8f\u5217\u7f16\u7801\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\u7684\u5047\u8bbe\uff0c\u8be5\u7814\u7a76\u63d0\u51fa\u4e86\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b Nvwa\uff08\u5973\u5a32\uff09\uff0c\u9996\u6b21\u5b9e\u73b0\u4e86\u5b8c\u5168\u57fa\u4e8e\u57fa\u56e0\u7ec4\u5e8f\u5217\u9884\u6d4b\u5355\u7ec6\u80de\u5206\u8fa8\u7387\u4e0b\u7684\u57fa\u56e0\u8868\u8fbe\uff0c\u4e14\u9884\u6d4b\u51c6\u786e\u5ea6\u4e0e\u5b9e\u9a8c\u6d4b\u91cf\u7cbe\u5ea6\u76f8\u5f53\u3002\u57fa\u4e8e Nvwa \u6a21\u578b\u5b66\u4e60\u884d\u751f\u7684\u8c31\u7cfb\u7279\u5f02\u6027\u57fa\u5e8f\uff0c\u8868\u5f81\u4e86\u8de8\u7269\u79cd\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7684\u8c03\u8282\u7a0b\u5e8f\u3002\u8be5\u5de5\u4f5c\u9996\u6b21\u5efa\u7acb\u4e86\u7269\u79cd\u5c42\u9762\u57fa\u56e0\u7ec4\u7f16\u7801\u7ec6\u80de\u56fe\u8c31\u7684\u6574\u5408\u6a21\u578b\uff0c\u5e76\u4e3a\u89e3\u7801\u591a\u7269\u79cd\u57fa\u56e0\u8c03\u63a7\u7a0b\u5e8f\u63d0\u4f9b\u4e86\u5b9d\u8d35\u8d44\u6e90\u3002<\/span><\/section>\n

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    \u5728\u751f\u7269\u5b66\u4e2d\u5fc3\u6cd5\u5219\u7684\u8d77\u70b9\uff0c\u57fa\u56e0\u4f5c\u4e3a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u9057\u4f20\u4fe1\u606f\u8f7d\u4f53\uff0c\u5728\u751f\u547d\u5468\u671f\u5185\u7a33\u5b9a\u5b58\u5728\uff1b\u800c\u4f4d\u4e8e\u4e2d\u5fc3\u6cd5\u5219\u672b\u7aef\u7684\u86cb\u767d\u8d28\uff0c\u5176\u7ec4\u7ec7\u6784\u6210\u548c\u65f6\u7a7a\u53d8\u5316\u7684\u590d\u6742\u6027\u5448\u6307\u6570\u5f0f\u589e\u957f\u3002\u968f\u7740\u5206\u5b50\u751f\u7269\u5b66\u6570\u5341\u5e74\u6765\u7684\u7a81\u98de\u731b\u8fdb\uff0c\u5c24\u5176\u662f\u751f\u547d\u7ec4\u5b66\uff08\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7b49\u7684\u96c6\u5408\uff09\u7b49\u9886\u57df\u7684\u65e5\u65b0\u6708\u5f02\uff0c\u5f53\u4ee3\u751f\u547d\u79d1\u5b66\u4e34\u8fd1\u7206\u53d1\u7684\u8fb9\u7f18\u3002\u5982\u6b64\u6d77\u91cf\u7684\u6570\u636e\u5982\u4f55\u5e2e\u52a9\u6211\u4eec\u63ed\u793a\u5b87\u5b99\u4e2d\u6700\u590d\u6742\u7684\u7269\u8d28\u7cfb\u7edf\u2014\u2014\u201c\u4eba\u4f53\u201d\u7684\u6784\u6210\u539f\u7406\u548c\u8bbe\u8ba1\u539f\u7406\uff1f\u9610\u91ca\u4eba\u7c7b\u53d1\u80b2\u3001\u8870\u8001\u548c\u91cd\u5927\u75be\u75c5\u7684\u53d1\u751f\u673a\u5236\uff1f<\/span><\/p>\n


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    \u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/section>\n
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