{"id":52200,"date":"2024-08-24T22:32:11","date_gmt":"2024-08-24T14:32:11","guid":{"rendered":"https:\/\/swarma.org\/?p=52200"},"modified":"2024-08-24T22:32:11","modified_gmt":"2024-08-24T14:32:11","slug":"nature-methods%e7%89%b9%e5%88%8a%e8%af%84%e8%ae%ba%ef%bc%9a%e7%94%a8%e4%ba%ba%e5%b7%a5%e6%99%ba%e8%83%bd%e4%b9%8b%e9%92%a5%ef%bc%8c%e5%bc%80%e7%a9%ba%e9%97%b4%e7%bb%84%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=52200","title":{"rendered":"Nature Methods\u7279\u520a\u8bc4\u8bba\uff1a\u7528\u4eba\u5de5\u667a\u80fd\u4e4b\u201c\u94a5\u201d\uff0c\u5f00\u7a7a\u95f4\u7ec4\u5b66\u4e4b\u201c\u9501\u201d"},"content":{"rendered":"
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\u5bfc\u8bed\uff1a2024\u5e748\u6708\uff0cNature Methods<\/em> \u53d1\u8868\u4e3b\u9898\u7279\u520a\uff0c\u63a2\u8ba8\u4eba\u5de5\u667a\u80fd\u5982\u4f55\u5728\u751f\u7269\u5b66\u4e2d\u5e7f\u6cdb\u4f7f\u7528\u5e76\u4e3a\u751f\u7269\u5b66\u5bb6\u5e26\u6765\u5de8\u5927\u5e2e\u52a9\uff08\u300aNature Methods\u4e3b\u9898\u7279\u520a\uff1a\u5173\u6ce8 AI \u5728\u751f\u7269\u5b66\u4e2d\u7684\u5e94\u7528<\/a>\u300b\uff09\u3002\u4eca\u5929\u7684\u6587\u7ae0\u91cd\u70b9\u5bf9\u8bc4\u8bba\u6587\u7ae0\u201cUnlocking the power of spatial omics with AI\u201d\u8fdb\u884c\u89e3\u8bfb\u3002<\/span><\/strong><\/span><\/strong><\/span><\/section>\n


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\u5173\u952e\u8bcd\uff1aAI for Biology\uff0c\u4eba\u5de5\u667a\u80fd\uff0c\u57fa\u56e0\u7ec4\u5b66\uff0c\u86cb\u767d\u8d28\u7ec4\u5b66\uff0c\u7a7a\u95f4\u7ec4\u5b66<\/strong><\/strong><\/span><\/strong><\/span><\/strong><\/section>\n<\/section>\n
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\u6587\u7ae0\u6807\u9898\uff1aUnlocking the power of spatial omics with AI<\/span><\/p>\n

\u6587\u7ae0\u6765\u6e90\uff1aNature Methods<\/span><\/p>\n

\u6587\u7ae0\u94fe\u63a5\uff1a<\/span>https:\/\/www.nature.com\/articles\/s41592-024-02363-x<\/span><\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n


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CeLEry \uff1a\u7528\u4e8e\u914d\u5bf9\u5355\u7ec6\u80de\u548c\u7a7a\u95f4\u7ec4\u6570\u636e\u7684\u6a21\u578b<\/span><\/section>\n
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\u4fc3\u8fdb\u7a7a\u95f4\u591a\u7ec4\u5b66\u6570\u636e\u7684\u751f\u6210<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


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\u6700\u8fd1\u5728\u7a7a\u95f4\u591a\u7ec4\u5b66\u6280\u672f\u65b9\u9762\u7684\u8fdb\u6b65\u4f7f\u5f97\u80fd\u591f\u4ece\u5355\u4e00\u7ec4\u7ec7\u5207\u7247\u4e2d\u83b7\u53d6\u591a\u79cd\u7a7a\u95f4\u89e3\u6790\u7684\u7ec4\u5b66\u6a21\u5f0f\uff0c\u63d0\u4f9b\u5206\u5b50\u7ec4\u6210\u548c\u7ec4\u7ec7\u7ed3\u6784\u7684\u5168\u9762\u89c6\u56fe[6-8]\u3002\u7136\u800c\uff0c\u63d0\u53d6\u4e00\u79cd\u6a21\u6001\u7684\u6570\u636e\u53ef\u80fd\u4f1a\u635f\u5bb3\u5176\u4ed6\u6a21\u6001\u6240\u9700\u7684\u5206\u5b50\u5b8c\u6574\u6027\uff0c\u4ece\u800c\u5728\u540e\u7eed\u7684\u5206\u5b50\u6d4b\u5e8f\u6216\u6210\u50cf\u8fc7\u7a0b\u4e2d\u964d\u4f4e\u654f\u611f\u5ea6\u3002\u4f8b\u5982\uff0c\u53ef\u4ee5\u901a\u8fc7\u5148\u8fdb\u884cMALDI-MSI\u518d\u8fdb\u884cVisium\u6765\u540c\u65f6\u751f\u6210\u540c\u4e00\u7ec4\u7ec7\u5207\u7247\u7684\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u6570\u636e[8]\u3002\u7136\u800c\uff0c\u7528\u4e8e\u4ee3\u8c22\u7269\u5b9a\u4f4d\u7684MALDI-MSI\u53ef\u80fd\u5bfc\u81f4\u7ec4\u7ec7\u964d\u89e3\uff0c\u51cf\u5c11\u53ef\u7528\u4e8e\u6d4b\u5e8f\u7684RNA\u5206\u5b50\u6570\u91cf\u3002\u6b64\u5916\uff0c\u8fde\u7eed\u5e94\u7528\u9488\u5bf9\u540c\u4e00\u79cd\u5206\u5b50\u7c7b\u578b\u7684\u591a\u79cd\u6d4b\u5e8f\u6280\u672f<\/span>\uff08\u5982CUT&Tag-seq\u548cATAC-seq\uff0c\u4e24\u8005\u90fd\u9776\u5411DNA\uff09<\/span>\u53ef\u80fd\u4f1a\u635f\u5bb3\u6700\u540e\u6d4b\u91cf\u6a21\u6001\u7684\u76ee\u6807\u5206\u5b50\u7684\u53ef\u7528\u6027\u3002<\/span><\/p>\n


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\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u5c40\u9650\u6027\uff0c\u6211\u4eec\u8ba4\u4e3a\u53ef\u4ee5\u5229\u7528AI\u5728\u8ba1\u7b97\u673a\u4e0a\u751f\u6210\u7a7a\u95f4\u591a\u7ec4\u5b66\u6570\u636e<\/strong>\uff0c\u6bd4\u5b9e\u9a8c\u4e0a\u7684\u505a\u6cd5\u53ef\u884c\u6027\u66f4\u5e7f\u6cdb\u3002\u8fd9\u6d89\u53ca\u4ece\u540c\u4e00\u5757\u7ec4\u7ec7\u4e2d\u63d0\u53d6\u591a\u4e2a\u76f8\u90bb\u7684\u7ec4\u7ec7\u5207\u7247\uff0c\u4f7f\u7528\u4e0d\u540c\u7684\u7a7a\u95f4\u7ec4\u5b66\u6280\u672f\u5bf9\u6bcf\u4e00\u5207\u7247\u8fdb\u884c\u5206\u5b50\u63d0\u53d6\u8bc6\u522b\uff0c\u540c\u65f6\u786e\u4fdd\u81f3\u5c11\u6709\u4e00\u79cd\u951a\u5b9a\u6a21\u6001<\/span>\uff08\u5982\u82cf\u6728\u7cbe-\u4f0a\u7ea2\u67d3\u8272\u7684\u7ec4\u7ec7\u5b66\u56fe\u50cf\uff09<\/span>\u8d2f\u7a7f\u6240\u6709\u5207\u7247\u3002\u7136\u540e\uff0c\u5bf9\u4e8e\u6bcf\u4e00\u7ec4\u7ec7\u5207\u7247\uff0c\u53ef\u4ee5\u8bad\u7ec3\u4e00\u4e2aAI\u6a21\u578b\u6765\u8fa8\u8ba4\u951a\u5b9a\u6a21\u6001\u4e0e\u8be5\u5207\u7247\u4f7f\u7528\u7684\u7279\u5b9a\u6a21\u6001\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u5229\u7528\u8fd9\u4e9b\u89c1\u89e3\uff0c\u6a21\u578b\u53ef\u4ee5\u6839\u636e\u951a\u5b9a\u6a21\u6001\u5efa\u7acb\u7684\u6a21\u5f0f\u63a8\u65ad\u6bcf\u4e00\u7ec4\u7ec7\u5207\u7247\u4e2d\u672a\u89c2\u5bdf\u5230\u7684\u7ec4\u5b66\u6a21\u6001\u3002\u6b64\u5916\uff0c\u5229\u7528\u82cf\u6728\u7cbe-\u4f0a\u7ea2\u67d3\u8272\u7ec4\u7ec7\u5b66\u56fe\u50cf\uff0c\u53ef\u4ee5\u4f7f\u7528\u5f31\u76d1\u7763\u6846\u67b6\u5c06\u7ec4\u7ec7\u5b66\u7279\u5f81\u4e0e\u5206\u5b50\u6570\u636e\u7ed3\u5408\u8d77\u6765\uff0c\u4ece\u800c\u63d0\u9ad8\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u7684\u5206\u8fa8\u7387[9]\u3002\u968f\u540e\uff0c\u7ec4\u7ec7\u5207\u7247\u7684\u5bf9\u9f50\u5c06\u5f62\u6210\u4e00\u4e2a\u4f2a\u4e09\u7ef4\u8d85\u5206\u8fa8\u7387\u7a7a\u95f4\u591a\u7ec4\u5b66\u6570\u636e\u96c6\uff0c\u5927\u5e45\u51cf\u5c11\u4e86\u5b9e\u9a8c\u751f\u6210\u6b64\u7c7b\u6570\u636e\u96c6\u7684\u6210\u672c\u548c\u590d\u6742\u6027\u3002<\/span><\/p>\n


<\/p>\n

<\/p>\n

iStar\uff1a\u901a\u8fc7\u878d\u5408\u7a7a\u95f4\u7ec4\u6570\u636e\u548c\u7ec4\u7ec7\u5b66\u56fe\u50cf\u8fdb\u800c\u589e\u52a0\u7ec4\u7ec7\u5206\u8fa8\u7387<\/span><\/section>\n
https:\/\/www.nature.com\/articles\/s41587-023-02019-9<\/span><\/section>\n


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\u7136\u800c\uff0c\u5b9e\u65bd\u8fd9\u4e9bAI\u9a71\u52a8\u7684\u65b9\u6cd5\u9762\u4e34\u7740\u4e00\u4e9b\u6311\u6218\u3002\u9996\u5148\uff0c\u5373\u4f7f\u5207\u7247\u6765\u81ea\u540c\u4e00\u7ec4\u7ec7\u5757\uff0c\u7ec4\u7ec7\u5b66\u56fe\u50cf\u4e4b\u95f4\u5f80\u5f80\u5b58\u5728\u5f3a\u70c8\u7684\u6279\u6b21\u6548\u5e94\uff0c\u8fd9\u4f1a\u59a8\u788d\u7ec4\u5b66\u9884\u6d4b\u6a21\u578b\u5728\u65b0\u7ec4\u7ec7\u5207\u7247\u4e0a\u7684\u6709\u6548\u63a8\u5e7f\u3002\u6b64\u5916\uff0c\u5e76\u975e\u6240\u6709\u5206\u5b50\u8868\u8fbe\u6a21\u5f0f\u90fd\u4e0e\u7ec4\u7ec7\u5b66\u7279\u5f81\u76f8\u5173\u8054\uff0c\u8fd9\u9650\u5236\u4e86\u8fd9\u4e9b\u65b9\u6cd5\u53ea\u80fd\u63a8\u65ad\u5206\u5b50\u7279\u5f81\u7684\u4e00\u5c0f\u90e8\u5206\u3002\u800c\u4e14\uff0c\u7a7a\u95f4\u591a\u7ec4\u5b66\u6280\u672f\u76f8\u8f83\u4e8e\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u6280\u672f\u8fd8\u8f83\u4e3a\u4e0d\u6210\u719f\u3002\u7136\u800c\uff0c\u968f\u7740\u9886\u57df\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u6211\u4eec\u9884\u8ba1\u6280\u672f\u7a81\u7834\u5c06\u7f13\u89e3\u8fd9\u4e9b\u6311\u6218\uff0c\u6700\u7ec8\u901a\u8fc7AI\u9a71\u52a8\u7684\u65b9\u6cd5\u4f7f\u6570\u636e\u66f4\u5bb9\u6613\u4e3a\u79d1\u7814\u754c\u6240\u7528\u3002<\/span><\/p>\n


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\u7ec4\u7ec7\u7ed3\u6784\u7684\u4e09\u7ef4\u91cd\u5efa<\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


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\u5927\u591a\u6570\u7a7a\u95f4\u7ec4\u5b66\u6280\u672f\u5728\u7ea65\u5fae\u7c73\u539a\u7684\u5355\u4e2a\u7ec4\u7ec7\u5207\u7247\u7684\u4e8c\u7ef4\u7a7a\u95f4\u5750\u6807\u4e2d\u6355\u83b7\u5206\u5b50\u6d4b\u91cf\u503c\u3002\u867d\u7136\u8fd9\u5bf9\u4e8e\u7406\u89e3\u5355\u4e2a\u7ec4\u7ec7\u5207\u7247\u7684\u5206\u5b50\u7279\u6027\u5f88\u6709\u4ef7\u503c\uff0c\u4f46\u5728z\u8f74\u65b9\u5411\u4e0a\u7684\u7f3a\u5931\u9650\u5236\u4e86\u4ece\u5207\u7247\u7684\u8f83\u5927\u7ec4\u7ec7\u5757\u4e2d\u8fdb\u884c\u751f\u7269\u5b66\u53d1\u73b0\u7684\u80fd\u529b\u3002\u8fd9\u79cd\u9650\u5236\u5728\u7814\u7a76\u75be\u75c5\u65f6\u5c24\u4e3a\u91cd\u8981\u3002\u4f8b\u5982\uff0c\u5728\u764c\u75c7\u4e2d\uff0c\u4ece\u80bf\u7624\u6d3b\u68c0\u83b7\u5f97\u76845\u5fae\u7c73\u5207\u7247\u4ec5\u5360\u6574\u4e2a\u80bf\u7624\u4f53\u79ef\u7684\u6781\u5c0f\u90e8\u5206\u3002\u8fd9\u4e3a\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u548c\u80bf\u7624\u7ed3\u6784\u63d0\u4f9b\u4e86\u975e\u5e38\u6709\u9650\u7684\u89c6\u89d2\u3002\u6b64\u5916\uff0c\u56e0\u4e3a\u7a7a\u95f4\u7ec4\u5b66\u6280\u672f\u53ea\u80fd\u5728\u56fa\u5b9a\u7684\u65f6\u95f4\u70b9\u6d4b\u91cf\u8868\u8fbe\uff0c\u7814\u7a76\u8005\u65e0\u6cd5\u76f4\u63a5\u8ddf\u8e2a\u80bf\u7624\u7684\u53d1\u5c55\u3002\u56e0\u6b64\uff0c\u4ed6\u4eec\u5fc5\u987b\u6839\u636e\u73b0\u6709\u6570\u636e\u63a8\u65ad\u80bf\u7624\u5982\u4f55\u751f\u957f\u548c\u8f6c\u79fb\u3002\u4f7f\u7528\u5355\u4e2a\u4e8c\u7ef4\u7ec4\u7ec7\u5207\u7247\u7684\u7a7a\u95f4\u5206\u5b50\u6570\u636e\u8fdb\u884c\u51c6\u786e\u9884\u6d4b\u51e0\u4e4e\u662f\u4e0d\u53ef\u80fd\u7684\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u8ba4\u4e3a\u4e09\u7ef4\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u5bf9\u4e8e\u5168\u9762\u7406\u89e3\u80bf\u7624\u5fae\u73af\u5883\u7684\u590d\u6742\u6027\u548c\u51c6\u786e\u9884\u6d4b\u80bf\u7624\u8fdb\u5c55\u81f3\u5173\u91cd\u8981<\/strong>\u3002<\/span><\/p>\n


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\u5df2\u7ecf\u6709\u6a21\u578b\u7528\u4e8e\u6570\u5b57\u5316\u91cd\u5efa\u4e09\u7ef4\u7ec4\u7ec7\u5757\uff0c\u5e76\u628a\u8fde\u7eed\u7ec4\u7ec7\u5207\u7247\u5bf9\u9f50\u5230\u7edf\u4e00\u7684\u5750\u6807\u7a7a\u95f4\u4e2d[10]\u3002\u7136\u800c\uff0c\u8003\u8651\u5230\u6709\u4e9b\u7ec4\u7ec7\u5757\u7531\u6570\u5341\u4e07\u4efd\u5207\u7247\u7ec4\u6210\uff0c\u5168\u9762\u7684\u7a7a\u95f4\u5206\u5b50\u5206\u6790\u6240\u9700\u7684\u5de8\u5927\u6210\u672c\u548c\u65f6\u95f4\u610f\u5473\u7740\u901a\u5e38\u53ea\u76f4\u63a5\u5206\u6790\u5176\u4e2d\u4e00\u5c0f\u90e8\u5206\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u8ba4\u4e3a\u9700\u8981AI\u65b9\u6cd5\u6765\u6784\u5efa\u7ec4\u7ec7\u5757\u7684\u5b8c\u6574\u4e09\u7ef4\u7a7a\u95f4\u5206\u5b50\u5730\u56fe\u3002\u4e00\u79cd\u6f5c\u5728\u7684\u65b9\u6cd5\u4e3a\u9009\u5b9a\u7684\u7ec4\u7ec7\u5207\u7247\u751f\u6210\u7a7a\u95f4\u7ec4\u5b66\u548c\u82cf\u6728\u7cbe-\u4f0a\u7ea2<\/span>\uff08H&E\uff09<\/span>\u6210\u50cf\u6570\u636e\uff0c\u8fd9\u4e9b\u5207\u7247\u5171\u540c\u6355\u6349\u6cbfz\u8f74\u65b9\u5411\u5b58\u5728\u7684\u7ed3\u6784\u591a\u6837\u6027\u3002\u5982\u679c\u53ef\u4ee5\u83b7\u5f97\u5269\u4f59\u7ec4\u7ec7\u5207\u7247\u7684H&E\u56fe\u50cf\uff0c\u5219\u53ef\u4ee5\u4f7f\u7528AI\u65b9\u6cd5\u6355\u6349\u5206\u5b50\u548c\u7ec4\u7ec7\u5b66\u7279\u5f81\u4e4b\u95f4\u5173\u7cfb,\u8fdb\u800c\u6765\u63a8\u65ad\u672a\u6d4b\u91cf\u5207\u7247\u7684\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e[9]\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6709\u5fc5\u8981\u786e\u5b9a\u7528\u4e8e\u5206\u6790\u7ec4\u7ec7\u5207\u7247\u7684\u6700\u4f73\u6570\u91cf\u548c\u9009\u62e9\u6807\u51c6\uff0c\u8003\u8651\u7ecf\u6d4e\u7ea6\u675f\u548c\u7ec4\u7ec7\u5757\u7684\u591a\u6837\u6027\u3002<\/span><\/p>\n


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\u591a\u6a21\u6001\u5927\u578b\u8bed\u8a00\u6a21\u578b<\/span>\uff08MM-LLMs\uff09<\/span>\uff0c\u5373\u5728\u5927\u91cf\u6570\u636e\u4e0a\u8bad\u7ec3\u4ee5\u7406\u89e3\u4e0d\u540c\u6a21\u6001\u4e4b\u95f4\u5173\u7cfb\u7684\u6a21\u578b\uff0c\u5728\u89e3\u51b3\u76ee\u524d\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u751f\u6210\u548c\u5206\u6790\u4e2d\u9762\u4e34\u7684\u8bb8\u591a\u6311\u6218\u65b9\u9762\u5c55\u73b0\u51fa\u524d\u666f\u3002LLMs\u548cMM-LLMs\u5df2\u7ecf\u5728\u75c5\u7406\u6210\u50cf[11-12]\u3001\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09[13-14]\u548c\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66[15]\u7b49\u76f8\u5173\u4efb\u52a1\u4e2d\u5c55\u793a\u4e86\u663e\u8457\u7684\u6f5c\u529b\u3002<\/strong>\u901a\u8fc7\u5229\u7528\u5927\u91cf\u7684\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u96c6\uff0c\u6211\u4eec\u9884\u8ba1MM-LLMs\u53ef\u7528\u4e8e\u6267\u884c\u5404\u79cd\u4efb\u52a1\uff0c\u5982\u7a7a\u95f4\u57df\u68c0\u6d4b\u3001\u7a7a\u95f4\u53ef\u53d8\u57fa\u56e0\u68c0\u6d4b\u548c\u7ec6\u80de\u95f4\u901a\u8baf\u5206\u6790\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u6a21\u578b\u80fd\u591f\u7ed3\u5408\u591a\u79cd\u7ec4\u5b66\u548c\u533b\u5b66\u6210\u50cf\u6a21\u6001\uff0c\u4ece\u800c\u63d0\u9ad8\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u7684\u5206\u8fa8\u7387\u548c\u8986\u76d6\u5ea6\uff0c\u5e76\u63a8\u65ad\u672a\u6d4b\u91cf\u7684\u7ec4\u5b66\u6a21\u6001\uff0c\u4e3a\u672c\u6587\u8ba8\u8bba\u7684\u8bb8\u591a\u6311\u6218\u63d0\u4f9b\u89e3\u51b3\u65b9\u6848\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8ba4\u4e3aMM-LLMs\u5728\u7cbe\u51c6\u533b\u5b66\u9886\u57df\u5177\u6709\u91cd\u8981\u5e94\u7528\u524d\u666f\u3002\u5177\u4f53\u6765\u8bf4\uff0c\u7a7a\u95f4\u7ec4\u5b66\u6280\u672f\u80fd\u591f\u4ee5\u524d\u6240\u672a\u6709\u7684\u89c6\u89d2\u63ed\u793a\u75be\u75c5\u76f8\u5173\u7ed3\u6784\u7684\u7ec6\u80de\u548c\u5206\u5b50\u7ec4\u7ec7\u3002\u8fd9\u4e9b\u7ed3\u6784\u53ca\u5176\u5f62\u6210\u65b9\u5f0f\u5bf9\u75be\u75c5\u8bca\u65ad\u3001\u6cbb\u7597\u6548\u679c\u3001\u60a3\u8005\u9884\u540e\u4ee5\u53ca\u65b0\u578b\u6cbb\u7597\u65b9\u6cd5\u7684\u5f00\u53d1\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u901a\u8fc7\u5173\u8054\u7a7a\u95f4\u5206\u5b50\u6a21\u5f0f\u3001\u75c5\u7406\u6210\u50cf\u7279\u5f81\u4e0e\u4e34\u5e8a\u7ed3\u679c\uff0c\u6cbb\u7597\u65b9\u6848\u53ef\u4ee5\u88ab\u5b9a\u5236\u4ee5\u6ee1\u8db3\u4e2a\u4f53\u60a3\u8005\u7684\u72ec\u7279\u9700\u6c42\u3002<\/span><\/p>\n


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Nicheformer: \u7a7a\u95f4\u7ec4\u5b66\u5927\u6a21\u578b<\/span><\/section>\n
https:\/\/www.biorxiv.org\/content\/10.1101\/2024.04.15.589472v1.full.pdf<\/span><\/section>\n


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\u5c55\u671b\u672a\u6765\uff0c\u6211\u4eec\u9884\u8ba1\u53ef\u4ee5\u5f00\u53d1\u51fa\u4e00\u79cdMM-LLM\uff0c\u5b83\u5c06\u7a7a\u95f4\u7ec4\u5b66\u3001\u533b\u5b66\u6210\u50cf\u548c\u4e34\u5e8a\u6587\u672c\u6570\u636e\u6574\u5408\u5230\u4e00\u4e2a\u8fde\u8d2f\u7684\u6a21\u578b\u4e2d<\/strong>\u3002\u8be5\u6a21\u578b\u6700\u521d\u5c06\u5728\u6db5\u76d6\u8fd9\u4e9b\u6a21\u6001\u7684\u5e9e\u5927\u8bed\u6599\u5e93\u4e0a\u8fdb\u884c\u9884\u8bad\u7ec3\u3002\u7136\u540e\uff0c\u5b83\u5c06\u4f7f\u7528\u66f4\u4e3a\u4e13\u4e1a\u7684\u6570\u636e\u96c6\u8fdb\u884c\u5fae\u8c03\uff0c\u4ee5\u9884\u6d4b\u7279\u5b9a\u7ed3\u679c\u6216\u6839\u636e\u6210\u50cf\u751f\u7269\u6807\u5fd7\u7269\u548c\u65e2\u5f80\u75c5\u53f2\u63a8\u8350\u4e2a\u6027\u5316\u7684\u6cbb\u7597\u8ba1\u5212\u3002\u8bf8\u5982Owkin Inc.\u7684MOSAIC\u9879\u76ee\u7b49\u4e3e\u63aa\uff0c\u65e8\u5728\u8de8\u4e03\u79cd\u764c\u75c7\u5b9e\u4f8b\u751f\u6210\u6570\u5343\u4efd\u7a7a\u95f4\u591a\u7ec4\u5b66\u6570\u636e\u96c6\uff0c\u4ee5\u8bc6\u522b\u65b0\u7684\u7a7a\u95f4\u751f\u7269\u6807\u5fd7\u7269\u548c\u60a3\u8005\u7279\u5f02\u6027\u836f\u7269\u9776\u6807\uff0c\u8fd9\u6837\u7684\u6a21\u578b\u81f3\u5173\u91cd\u8981\u3002\u968f\u7740\u66f4\u591a\u7c7b\u4f3cMOSAIC\u7684\u9879\u76ee\u5b8c\u6210\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u96c6\u5c06\u53ef\u7528\u4e8eMM-LLM\u7684\u9884\u8bad\u7ec3\uff0c\u800c\u66f4\u4e13\u4e1a\u7684\u6570\u636e\u96c6\u53ef\u7528\u4e8e\u5fae\u8c03\u3002<\/span><\/p>\n


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\u5c3d\u7ba1\u8fd1\u5e74\u6765\u5728\u7a7a\u95f4\u7ec4\u5b66\u6280\u672f\u65b9\u9762\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u4f46\u6211\u4eec\u8ba4\u4e3a\u6301\u7eed\u5b58\u5728\u7684\u5c40\u9650\u6027\u51f8\u663e\u4e86AI\u5728\u63a8\u8fdb\u8fd9\u4e00\u9886\u57df\u4e2d\u7684\u6838\u5fc3\u4f5c\u7528\u3002AI\u53ef\u4ee5\u4fc3\u8fdb\u7a7a\u95f4\u8f6c\u5f55\u7ec4\u5b66\u4e0escRNA-seq\u7684\u6574\u5408\uff0c\u4f7f\u6211\u4eec\u80fd\u591f\u5728\u5355\u7ec6\u80de\u6c34\u5e73\u4e0a\u6d4b\u91cf\u8f6c\u5f55\u7ec4\u8303\u56f4\u5185\u7684\u7a7a\u95f4\u57fa\u56e0\u8868\u8fbe\u8c31\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u6574\u5408\u7a7a\u95f4\u7ec4\u5b66\u4e0e\u7ec4\u7ec7\u5b66\u6210\u50cf\u6570\u636e\uff0cAI\u53ef\u4ee5\u6784\u5efa\u9ad8\u5206\u8fa8\u7387\u3001\u5168\u9762\u7684\u4e09\u7ef4\u7a7a\u95f4\u7ec4\u7ec7\u56fe\u8c31\uff0c\u8986\u76d6\u5e7f\u6cdb\u7684\u7ec4\u5b66\u6a21\u6001\u3002\u968f\u7740\u53ef\u7528\u6570\u636e\u96c6\u6570\u91cf\u7684\u589e\u957f\uff0cMM-LLMs\u53ef\u4ee5\u5728\u7a7a\u95f4\u7ec4\u5b66\u3001\u533b\u5b66\u6210\u50cf\u548c\u4e34\u5e8a\u6587\u672c\u6570\u636e\u4e0a\u8fdb\u884c\u8bad\u7ec3\uff0c\u7528\u4e8e\u751f\u7269\u533b\u5b66\u7814\u7a76\u548c\u7cbe\u51c6\u533b\u5b66\u4e2d\u7684\u4efb\u52a1\u3002\u8fd9\u4e9b\u6a21\u578b\u5c06\u52a0\u901f\u751f\u7269\u5b66\u53d1\u73b0\u5e76\u4fc3\u8fdb\u4e2a\u6027\u5316\u6cbb\u7597\u7684\u53d1\u5c55\u3002\u901a\u8fc7\u5229\u7528AI\u7684\u529b\u91cf\uff0c\u6211\u4eec\u9884\u8ba1\u7814\u7a76\u4eba\u5458\u5c06\u89e3\u9501\u7a7a\u95f4\u7ec4\u5b66\u7684\u65b0\u7ef4\u5ea6\uff0c\u5e26\u6765\u5f00\u521b\u6027\u7684\u53d1\u73b0\u3002<\/span><\/p>\n


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\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1a<\/strong><\/p>\n

AI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u751f\u7269\u533b\u5b66\u662f\u4e00\u4e2a\u590d\u6742\u4e14\u5bcc\u6709\u6311\u6218\u6027\u7684\u9886\u57df\uff0c\u6d89\u53ca\u5230\u5927\u91cf\u7684\u6570\u636e\u5904\u7406\u3001\u6a21\u5f0f\u8bc6\u522b\u3001\u7406\u8bba\u6a21\u578b\u5efa\u6784\u548c\u5b9e\u9a8c\u9a8c\u8bc1\u7b49\u95ee\u9898\u3002AI\u57fa\u7840\u6a21\u578b\u7684\u5f15\u5165\uff0c\u4f7f\u5f97\u6211\u4eec\u80fd\u591f\u4ece\u524d\u6240\u672a\u6709\u7684\u89d2\u5ea6\u53bb\u89c2\u5bdf\u548c\u7406\u89e3\u8fd9\u4e2a\u9886\u57df\u7684\u95ee\u9898\uff0c\u52a0\u901f\u79d1\u5b66\u7814\u7a76\u7684\u6b65\u4f10\uff0c\u63d0\u9ad8\u533b\u7597\u670d\u52a1\u7684\u6548\u7387\u548c\u6548\u679c\u3002\u8fd9\u79cd\u4ea4\u53c9\u9886\u57df\u7684\u5408\u4f5c\uff0c\u6807\u5fd7\u7740\u6211\u4eec\u6b63\u5728\u5411\u79d1\u6280\u4e0e\u751f\u7269\u533b\u5b66\u6df1\u5ea6\u878d\u5408\u7684\u65b0\u65f6\u4ee3\u8fc8\u8fdb\uff0c\u5bf9\u4e8e\u63a8\u52a8\u79d1\u5b66\u7814\u7a76\u3001\u4f18\u5316\u533b\u7597\u670d\u52a1\u3001\u4fc3\u8fdb\u4eba\u7c7b\u5065\u5eb7\u6709\u7740\u6df1\u8fdc\u7684\u5f71\u54cd\u3002<\/span><\/section>\n

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\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u52a9\u7406\u6559\u6388\u5434\u6cf0\u9716\u3001\u65af\u5766\u798f\u5927\u5b66\u8ba1\u7b97\u673a\u79d1\u5b66\u7cfb\u535a\u58eb\u540e\u7814\u7a76\u5458\u738b\u701a\u5bb8\u3001\u535a\u58eb\u7814\u7a76\u751f\u9ec4\u67ef\u946b\u3001\u9ec4\u5029\uff0c\u534e\u76db\u987f\u5927\u5b66\u535a\u58eb\u7814\u7a76\u751f\u5c60\u946b\u660e\uff0c\u5171\u540c\u53d1\u8d77\u4ee5\u201c\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\u201d\u4e3a\u4e3b\u9898\u7684\u8bfb\u4e66\u4f1a\uff0c\u5171\u5b66\u5171\u7814\u76f8\u5173\u6587\u732e\uff0c<\/span>\u63a2\u8ba8\u57fa\u7840\u6a21\u578b\u5728\u751f\u7269\u533b\u5b66\u7b49\u79d1\u5b66\u9886\u57df\u7684\u5e94\u7528\u3001\u5f71\u54cd\u548c\u5c55\u671b\u3002<\/span>\u8bfb\u4e66\u4f1a\u5df2\u5b8c\u7ed3\uff0c\u73b0\u5728\u62a5\u540d\u53ef\u52a0\u5165\u793e\u7fa4\u5e76\u89e3\u9501\u56de\u653e\u89c6\u9891\u6743\u9650\u3002<\/span><\/section>\n

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\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/a><\/span><\/p>\n


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\u5728\u751f\u7269\u5b66\u4e2d\u5fc3\u6cd5\u5219\u7684\u8d77\u70b9\uff0c\u57fa\u56e0\u4f5c\u4e3a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u9057\u4f20\u4fe1\u606f\u8f7d\u4f53\uff0c\u5728\u751f\u547d\u5468\u671f\u5185\u7a33\u5b9a\u5b58\u5728\uff1b\u800c\u4f4d\u4e8e\u4e2d\u5fc3\u6cd5\u5219\u672b\u7aef\u7684\u86cb\u767d\u8d28\uff0c\u5176\u7ec4\u7ec7\u6784\u6210\u548c\u65f6\u7a7a\u53d8\u5316\u7684\u590d\u6742\u6027\u5448\u6307\u6570\u5f0f\u589e\u957f\u3002\u968f\u7740\u5206\u5b50\u751f\u7269\u5b66\u6570\u5341\u5e74\u6765\u7684\u7a81\u98de\u731b\u8fdb\uff0c\u5c24\u5176\u662f\u751f\u547d\u7ec4\u5b66\uff08\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7b49\u7684\u96c6\u5408\uff09\u7b49\u9886\u57df\u7684\u65e5\u65b0\u6708\u5f02\uff0c\u5f53\u4ee3\u751f\u547d\u79d1\u5b66\u4e34\u8fd1\u7206\u53d1\u7684\u8fb9\u7f18\u3002\u5982\u6b64\u6d77\u91cf\u7684\u6570\u636e\u5982\u4f55\u5e2e\u52a9\u6211\u4eec\u63ed\u793a\u5b87\u5b99\u4e2d\u6700\u590d\u6742\u7684\u7269\u8d28\u7cfb\u7edf\u2014\u2014\u201c\u4eba\u4f53\u201d\u7684\u6784\u6210\u539f\u7406\u548c\u8bbe\u8ba1\u539f\u7406\uff1f\u9610\u91ca\u4eba\u7c7b\u53d1\u80b2\u3001\u8870\u8001\u548c\u91cd\u5927\u75be\u75c5\u7684\u53d1\u751f\u673a\u5236\uff1f<\/span><\/p>\n


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\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u7406\u5b66\u9662\u53ca\u4ea4\u53c9\u79d1\u5b66\u4e2d\u5fc3\u8bb2\u5e2d\u6559\u6388\u6c64\u96f7\u7ff0\uff0c\u56fd\u5bb6\u86cb\u767d\u8d28\u79d1\u5b66\u4e2d\u5fc3\uff08\u5317\u4eac\uff09\u526f\u7814\u7a76\u5458\u5e38\u4e58\u3001\u674e\u6768\uff0c\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\u52a9\u7406\u6559\u6388\u5510\u4e7e\u5143\uff0c\u5317\u4eac\u5927\u5b66\u524d\u6cbf\u4ea4\u53c9\u5b66\u79d1\u7814\u7a76\u9662\u7814\u7a76\u5458\u6797\u4e00\u701a\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5206\u5b50\u7ec6\u80de\u79d1\u5b66\u5353\u8d8a\u521b\u65b0\u4e2d\u5fc3\u535a\u58eb\u540e\u5510\u8bd7\u5a55\uff0c\u5171\u540c\u53d1\u8d77\u300c\u751f\u547d\u590d\u6742\u6027\uff1a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/a>\u300d\u8bfb\u4e66\u4f1a\uff0c\u4ece\u5fae\u89c2\u7ec6\u80de\u5c3a\u5ea6\u3001\u4ecb\u89c2\u7ec4\u7ec7\u5668\u5b98\u5c3a\u5ea6\u5230\u5b8f\u89c2\u4eba\u4f53\u5c3a\u5ea6\uff0c\u68b3\u7406\u751f\u547d\u79d1\u5b66\u9886\u57df\u4e2d\u7684\u91cd\u8981\u95ee\u9898\u53ca\u91cd\u8981\u6570\u636e\uff0c\u7531\u751f\u7269\u5b66\u5bb6\u63d0\u95ee\uff0c\u5e0c\u671b\u4fc3\u8fdb\u7edf\u8ba1\u7269\u7406\u3001\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u7814\u7a76\u8005\u548c\u751f\u547d\u79d1\u5b66\u7814\u7a76\u8005\u4e4b\u95f4\u7684\u6df1\u5ea6\u4ea4\u6d41\uff0c\u5efa\u7acb\u8de8\u5b66\u79d1\u5408\u4f5c\u5173\u7cfb\uff0c\u6fc0\u53d1\u65b0\u7684\u7814\u7a76\u601d\u8def\u548c\u5408\u4f5c\u9879\u76ee\u3002\u8bfb\u4e66\u4f1a\u4ece2024\u5e748\u67086\u65e5\u5f00\u59cb\uff0c\u6bcf\u5468\u4e8c\u665a19:00-21:00\u8fdb\u884c\uff0c\u6301\u7eed\u65f6\u95f4\u9884\u8ba110-12\u5468\u3002\u6b22\u8fce\u5bf9\u8fd9\u4e2a\u751f\u547d\u79d1\u5b66\u3001\u7269\u7406\u5b66\u3001\u8ba1\u7b97\u673a\u79d1\u5b66\u3001\u590d\u6742\u7cfb\u7edf\u79d1\u5b66\u6df1\u5ea6\u4ea4\u53c9\u7684\u524d\u6cbf\u9886\u57df\u611f\u5174\u8da3\u7684\u670b\u53cb\u52a0\u5165\uff01<\/span><\/p>\n


<\/p>\n

<\/span><\/a><\/span><\/strong><\/span><\/section>\n

<\/section>\n
\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/section>\n
\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a\u4ece\u5fae\u89c2\u5230\u5b8f\u89c2\uff0c\u591a\u5c3a\u5ea6\u89c6\u89d2\u63a2\u7d22\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/a><\/section>\n

<\/section>\n

<\/section>\n
\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/strong><\/section>\n
1. <\/strong>Nature Methods\u4e3b\u9898\u7279\u520a\uff1a\u5173\u6ce8 AI \u5728\u751f\u7269\u5b66\u4e2d\u7684\u5e94\u7528<\/a><\/strong><\/span><\/section>\n
2. <\/strong>\u65af\u5766\u798f\u5927\u5b66\u6559\u6388 Jure Leskovec\uff1a\u57fa\u7840\u6a21\u578b\u5728\u5168\u79d1\u533b\u5b66\u4eba\u5de5\u667a\u80fd\u4e2d\u7684\u5e94\u7528\u6f5c\u529b\uff5c\u96c6\u667a\u4ff1\u4e50\u90e820\u5468\u5e74\u5e74\u4f1a\u56de\u987e<\/a><\/strong><\/span><\/section>\n
<\/strong><\/section>\n
3. <\/strong>Yoshua Bengio\u9886\u8854\u8de8\u5b66\u79d1\u56e2\u961f\uff0cNature\u520a\u6587\u7efc\u8ff0\u4eba\u5de5\u667a\u80fd\u65f6\u4ee3\u7684\u79d1\u5b66\u53d1\u73b0<\/strong><\/a><\/section>\n
<\/strong><\/section>\n
4. <\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
<\/strong>5.<\/strong> \u9f99\u5e74\u5927\u8fd0\u8d77\uff0c\u5b66\u4e60\u6b63\u5f53\u65f6\uff01\u89e3\u9501\u96c6\u667a\u5168\u7ad9\u5185\u5bb9\uff0c\u5f00\u542f\u65b0\u5e74\u5b66\u4e60\u8ba1\u5212<\/a><\/strong><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n

6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/p>\n


<\/p>\n


<\/span><\/p>\n

\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/span><\/section>\n

<\/mp-style-type><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\uff08\u6b64\u56fe\u7531DALLE3\u751f\u6210\uff1aAI\u4f5c\u4e3a\u94a5\u5319\uff0c\u6b63\u5728\u89e3\u5f00\u8111\u7ec4\u7ec7\u7684\u79d8\u5bc6\uff0c\u7ed8\u5236\u51fa\u8111\u7684\u7a7a\u95f4\u56fe\u8c31\u4f5c\u4e3a\u201c\u751f\u547d\u5730\u56fe\u201d\uff0c\u4e3a\u7814\u7a76\u5e26\u6765\u6307\u5f15\u548c\u5e2e\u52a9\uff09 \u5bfc\u8bed\uff1a2024\u5e748\u6708\uff0cNature Methods \u53d1\u8868\u4e3b\u9898\u7279\u520a\uff0c\u63a2\u8ba8\u4eba\u5de5\u667a\u80fd\u5982\u4f55\u5728\u751f\u7269\u5b66\u4e2d\u5e7f\u6cdb\u4f7f\u7528\u5e76\u4e3a\u751f\u7269\u5b66\u5bb6\u5e26\u6765\u5de8\u5927\u5e2e\u52a9\uff08\u300aNature Methods\u4e3b\u9898\u7279\u520a\uff1a\u5173…<\/p>\n","protected":false},"author":0,"featured_media":52193,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/52200"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=52200"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/52200\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/52193"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=52200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=52200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=52200"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=52200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}