{"id":53005,"date":"2024-10-06T19:30:15","date_gmt":"2024-10-06T11:30:15","guid":{"rendered":"https:\/\/swarma.org\/?p=53005"},"modified":"2024-10-06T19:30:15","modified_gmt":"2024-10-06T11:30:15","slug":"nature-%e5%b0%81%e9%9d%a2%e6%8a%a5%e9%81%93%e8%bf%9e%e6%8e%a5%e7%bb%84%e5%ad%a6%e9%87%8c%e7%a8%8b%e7%a2%91%ef%bc%9a%e6%9e%9c%e8%9d%87%e8%84%91%e7%9a%84%e7%ac%ac%e4%b8%80%e4%b8%aa","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=53005","title":{"rendered":"Nature \u5c01\u9762\u62a5\u9053\u201c\u8fde\u63a5\u7ec4\u5b66\u201d\u91cc\u7a0b\u7891\uff1a\u679c\u8747\u8111\u7684\u7b2c\u4e00\u4e2a\u5b8c\u6574\u56fe\u8c31 FlyWire"},"content":{"rendered":"
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Nature<\/span> <\/span>| \u6765\u6e90<\/span><\/strong><\/span><\/p>\n

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\u56fe1. \u8bc6\u522b\u7684\u795e\u7ecf\u5143\u793a\u4f8b\uff0c\u6309\u7167\u7c7b\u578b\u5bf9\u795e\u7ecf\u5143\u8fdb\u884c\u989c\u8272\u7f16\u7801\uff0c\u5e76\u7528\u989c\u8272\u6e32\u67d3\u679c\u8747\u8111\u4e2d\u5bf9\u5e94\u7684\u795e\u7ecf\u5143\u7c7b\u578b\u3002\uff5c\u56fe\u7247\u6765\u6e90\uff1aAmy Sterling, Murthy and Seung Labs, Princeton University<\/span><\/p>\n


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FlyWire \u4e8e2024\u5e7410\u67082\u65e5\u5b8c\u6210\u5e76\u53d1\u5e03\uff0c\u6570\u636e\u96c6\u5305\u62ec14\u4e07\u4e2a\u795e\u7ecf\u5143<\/strong><\/span>\uff08\u5176\u4e2d98%\u5df2\u88ab\u5206\u578b\uff09<\/span>\uff0c\u8d85\u8fc75000\u4e07\u4e2a\u7a81\u89e6<\/strong>\uff0c<\/strong>\u795e\u7ecf\u5143\u5c5e\u6027\u4fe1\u606f\u548c<\/strong> <\/strong>8453 <\/strong>\u79cd\u7c7b\u578b\u7684\u7cbe\u7ec6\u6807\u6ce8<\/strong>\uff0c\u4ee5\u53ca\u8fde\u63a5\u7ec4\u7ed3\u6784\u7684\u7edf\u8ba1\u5206\u6790[1-4]\u3002\u8fd9 8453 \u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u795e\u7ecf\u5143\u4e2d\u6709 4581 \u79cd\u662f\u65b0\u53d1\u73b0\u7684\uff0c\u6bcf\u4e00\u79cd\u7ec6\u80de\u7c7b\u578b\u90fd\u8574\u542b\u7740\u65b0\u7684\u95ee\u9898\uff0c\u6709\u671b\u5f00\u8f9f\u65b0\u7684\u7814\u7a76\u65b9\u5411\u3002\u8111\u795e\u7ecf\u5143\u4e4b\u95f4\u7684\u76f8\u4e92\u8fde\u63a5\u7a0b\u5ea6\u4e5f\u8ba9\u4eba\u611f\u5230\u60ca\u8bb6\u3002\u4f8b\u5982\uff0c\u88ab\u8ba4\u4e3a\u53ea\u53c2\u4e0e\u5355\u4e00\u611f\u89c9\u7ebf\u8def\u56de\u8def\u7684\u795e\u7ecf\u5143<\/span>\uff08\u5982\u89c6\u89c9\u901a\u8def\uff09<\/span>\uff0c\u5f80\u5f80\u4f1a\u4ece\u591a\u79cd\u611f\u89c9\u4e2d\u63a5\u6536\u4fe1\u53f7<\/span>\uff08\u5305\u62ec\u542c\u89c9\u548c\u89e6\u89c9\uff09<\/span>[2]\u3002\u8fd9\u4e5f\u662f\u7b2c\u4e00\u6b21\u5b8c\u6574\u63ed\u793a\u751f\u7269\u89c6\u89c9\u7cfb\u7edf\u7684\u7ec6\u80de\u7c7b\u578b\u548c\u8fde\u63a5\u3002<\/span><\/section>\n

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[1] \u6210\u5e74\u96cc\u6027\u679c\u8747\u8111\u7684\u5b8c\u6574\u56fe\u8c31<\/span><\/section>\n
Dorkenwald, S., Matsliah, A., Sterling, A.R. et al.<\/em> Neuronal wiring diagram of an adult brain. Nature <\/em>634<\/strong>, 124\u2013138 (2024).https:\/\/doi.org\/<\/span>10.1038\/s41586-024-07558-y<\/span><\/section>\n<\/blockquote>\n
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[2] \u795e\u7ecf\u5143\u548c 8,000 \u591a\u79cd\u7ec6\u80de\u7c7b\u578b<\/span><\/section>\n
Schlegel, P., Yin, Y., Bates, A.S. et al.<\/em> Whole-brain annotation and multi-connectome cell typing of Drosophila<\/em>. Nature <\/em>634<\/strong>, 139\u2013152 (2024).https:\/\/doi.org\/<\/span>10.1038\/s41586-024-07686-5<\/span><\/section>\n<\/blockquote>\n
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Lin, A., Yang, R., Dorkenwald, S. et al.<\/em> Network statistics of the whole-brain connectome of Drosophila<\/em>. Nature <\/em>634<\/strong>, 153\u2013165 (2024). https:\/\/doi.org\/<\/span>10.1038\/s41586-024-07968-y<\/span><\/section>\n<\/blockquote>\n
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Matsliah, A., Yu, Sc., Kruk, K. et al.<\/em> Neuronal parts list and wiring diagram for a visual system. Nature<\/em> 634<\/strong>, 166\u2013180 (2024).https:\/\/doi.org\/<\/span>10.1038\/s41586-024-07981-1<\/span><\/section>\n<\/blockquote>\n
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\u56fe2. \u56fe\u7247\u6765\u6e90 : Tyler Sloan for FlyWire and Amy Sterling, Murthy and Seung Labs, Princeton University<\/span><\/p>\n


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\u73b0\u5728\uff0c\u6709\u4e86\u8fde\u63a5\u7ec4\u6570\u636e\uff0c\u4e86\u89e3\u679c\u8747\u795e\u7ecf\u7cfb\u7edf\u884c\u4e3a\u4ea7\u751f\u673a\u5236\u7684\u76ee\u6807\u53d8\u5f97\u66f4\u52a0\u5bb9\u6613\u5b9e\u73b0\u3002\u8bba\u6587\u96c6\u4e2d\u4e5f\u5305\u542b\u5982\u4f55\u4f7f\u7528\u8fd9\u4e9b\u8d44\u6e90\u6765\u6307\u5bfc\u5b9e\u9a8c\u7684\u793a\u4f8b\u3002<\/span><\/section>\n

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\u4e00\u79cd\u601d\u8def\u662f\u5355\u72ec\u4f7f\u7528\u8fde\u63a5\u7ec4\u6570\u636e\u6765\u9884\u6d4b\u5c1a\u672a\u53d1\u73b0\u7684\u73b0\u8c61\u3002Seung \u7684\u7814\u7a76\u5c31\u662f\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\uff0c\u8be5\u8bba\u6587\u4f7f\u7528\u8fde\u63a5\u7ec4\u6570\u636e\u6765\u8bc6\u522b\u65b0\u7684\u795e\u7ecf\u56de\u8def\uff0c\u5e76\u9884\u6d4b\u5176\u5728\u89c6\u89c9\u529f\u80fd\u4e2d\u7684\u4f5c\u7528[5] \u3002<\/span><\/section>\n

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[5] Seung, H.S. Predicting visual function by interpreting a neuronal wiring diagram. Nature <\/em>634<\/strong>, 113\u2013123 (2024). https:\/\/doi.org\/<\/span>10.1038\/s41586-024-07953-5<\/span><\/section>\n<\/blockquote>\n

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\u53e6\u4e00\u79cd\u601d\u8def\u662f\u5728\u56de\u8def\u7684\u4e00\u4e9b\u5173\u952e\u8282\u70b9\u8fdb\u884c\u5b9e\u9a8c\uff0c\u5e76\u6839\u636e\u5b9e\u9a8c\u89c2\u5bdf\u6784\u5efa\u4e00\u4e2a\u5168\u8fde\u63a5\u7684\u795e\u7ecf\u5143\u7f51\u7edc\u3002Sapkal \u7b49\u4eba\u4f7f\u7528\u8fd9\u79cd\u65b9\u6cd5\u6765\u63cf\u8ff0\u505c\u6b62\u884c\u52a8<\/span>\uff08halting\uff09<\/span>\u7684\u795e\u7ecf\u56de\u8def[6] \u3002\u7814\u7a76\u4eba\u5458\u63cf\u8ff0\u4e86\u4e24\u4e2a\u4fe1\u53f7\u56de\u8def\uff0c\u5b83\u4eec\u5411\u679c\u8747\u53d1\u51fa\u505c\u6b62\u884c\u8d70\u7684\u4fe1\u53f7\u3002\u5176\u4e2d\u4e00\u4e2a\u56de\u8def\u5305\u542b\u4e24\u4e2a\u795e\u7ecf\u5143\uff0c\u5f53\u679c\u8747\u60f3\u8981\u505c\u4e0b\u6765\u8fdb\u98df\u65f6\uff0c\u5b83\u4eec\u8d1f\u8d23\u4ece\u8111\u53d1\u51fa\u505c\u6b62\u201c\u884c\u8d70\u201d\u7684\u4fe1\u53f7\u3002\u53e6\u4e00\u4e2a\u56de\u8def\u5305\u62ec\u795e\u7ecf\u7d22\u4e2d\u7684\u795e\u7ecf\u5143\uff0c\u5b83\u4eec\u63a5\u6536\u548c\u5904\u7406\u6765\u81ea\u8111\u7684\u4fe1\u53f7\u3002\u8fd9\u4e9b\u7ec6\u80de\u5728\u679c\u8747\u7684\u817f\u90e8\u5173\u8282\u5904\u4ea7\u751f\u963b\u529b\uff0c\u4f7f\u6606\u866b\u5728\u81ea\u6211\u68b3\u7406\u65f6\u80fd\u591f\u505c\u4e0b\u6765\u3002<\/span><\/section>\n

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[6] Sapkal, N., Mancini, N., Kumar, D.S. et al.<\/em> Neural circuit mechanisms underlying context-specific halting in Drosophila<\/em>. Nature<\/em> 634<\/strong>, 191\u2013200 (2024). https:\/\/doi.org\/<\/span>10.1038\/s41586-024-07854-7<\/span><\/section>\n<\/blockquote>\n

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\u56fe4. FlyWire \u80fd\u591f\u5bf9\u8fd9\u4e9b\u884c\u4e3a\u80cc\u540e\u7684\u795e\u7ecf\u56de\u8def\u63d0\u4f9b\u524d\u6240\u672a\u6709\u7684\u6d1e\u5bdf\u3002\uff5c\u56fe\u7247\u6765\u6e90\uff1aAmy Sterling, Murthy and Seung Labs, Princeton University<\/span><\/p>\n


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Shiu \u7b49\u4eba<\/span>\u57fa\u4e8e\u795e\u7ecf\u5143\u6574\u5408\u4fe1\u606f\u7684\u5408\u7406\u5047\u8bbe\uff0c\u5c06\u6574\u4e2a\u8fde\u63a5\u7ec4\u8f6c\u5316\u4e3a\u4e00\u4e2a\u6a21\u578b\u8109\u51b2\u7f51\u7edc<\/span>\uff08model spiking network\uff09<\/span>\uff0c\u4f7f\u6211\u4eec\u66f4\u63a5\u8fd1\u679c\u8747\u8111\u7684\u6240\u8c13\u201c\u6570\u5b57\u5b6a\u751f\u201d[7]\u3002\u4ed6\u4eec\u901a\u8fc7\u6fc0\u6d3b\u5df2\u77e5\u7684\u611f\u77e5\u751c\u5473\u6216\u82e6\u5473\u7684\u795e\u7ecf\u5143\u6765\u6d4b\u8bd5\u6a21\u578b\u3002\u8fd9\u4e9b\u795e\u7ecf\u5143\u968f\u540e\u5728\u865a\u62df\u679c\u8747\u8111\u4e2d\u5f15\u53d1\u4e00\u8fde\u4e32\u4fe1\u53f7\uff0c\u6700\u7ec8\u89e6\u53d1\u4e0e\u679c\u8747\u53e3\u5668<\/span>\uff08\u76f8\u5f53\u4e8e\u54fa\u4e73\u52a8\u7269\u7684\u820c\u5934\uff09<\/span>\u76f8\u5173\u7684\u8fd0\u52a8\u795e\u7ecf\u5143\u3002\u5f53\u6fc0\u6d3b\u751c\u5473\u56de\u8def\u65f6\uff0c\u4f1a\u4f20\u9012\u51fa\u4f38\u5c55\u53e3\u5668\u7684\u4fe1\u53f7\uff0c\u5c31\u50cf\u6606\u866b\u51c6\u5907\u8fdb\u98df\u4e00\u6837\uff1b\u5f53\u6fc0\u6d3b\u82e6\u5473\u56de\u8def\u65f6\uff0c\u8fd9\u4e2a\u4fe1\u53f7\u4f1a\u88ab\u6291\u5236\u3002\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e9b\u53d1\u73b0\uff0c\u7814\u7a76\u56e2\u961f\u5728\u771f\u5b9e\u7684\u679c\u8747\u4e2d\u6fc0\u6d3b\u4e86\u76f8\u540c\u7684\u795e\u7ecf\u5143\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u8fd9\u4e2a\u6a21\u62df\u5728\u9884\u6d4b\u54ea\u4e9b\u795e\u7ecf\u5143\u4f1a\u54cd\u5e94\u4ee5\u53ca\u679c\u8747\u5c06\u5982\u4f55\u884c\u4e3a\u65b9\u9762\u7684\u51c6\u786e\u5ea6\u8d85\u8fc790%\u3002\u8fd9\u79cd\u65b9\u6cd5\u53ef\u7528\u4e8e\u6a21\u62df\u6270\u52a8\u5bf9\u795e\u7ecf\u5143\u56de\u8def\u7684\u5f71\u54cd\uff0c\u5e76\u9884\u6d4b\u884c\u4e3a\u7684\u6700\u7ec8\u53d8\u5316\u3002<\/span><\/section>\n

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[7] \u57fa\u4e8e\u8fde\u63a5\u7ec4\u6570\u636e\u7684\u6a21\u578b\u8109\u51b2\u7f51\u7edc<\/span><\/span><\/section>\n
Shiu, P.K., Sterne, G.R., Spiller, N. et al.<\/em> A Drosophila<\/em> computational brain model reveals sensorimotor processing. Nature <\/em>634<\/strong>, 210\u2013219 (2024). https:\/\/doi.org\/<\/span>10.1038\/s41586-024-07763-9<\/span><\/section>\n<\/blockquote>\n
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[8] Cowley, B.R., Calhoun, A.J., Rangarajan, N. et al.<\/em> Mapping model units to visual neurons reveals population code for social behaviour. Nature <\/em>629<\/strong>, 1100\u20131108 (2024). https:\/\/doi.org\/<\/span>10.1038\/s41586-024-07451-8<\/span><\/section>\n<\/blockquote>\n

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[9] \u57fa\u4e8e\u8fde\u63a5\u7ec4\u7684\u6548\u5e94\u7ec4\u7684\u63d0\u51fa<\/span><\/span><\/section>\n
Pospisil, D.A., Aragon, M.J., Dorkenwald, S. et al.<\/em> The fly connectome reveals a path to the effectome. Nature<\/em> 634<\/strong>, 201\u2013209 (2024). https:\/\/doi.org\/<\/span>10.1038\/s41586-024-07982-0<\/span><\/section>\n
\u6548\u5e94\u7ec4\uff08effectome\uff09\uff1a\u5728\u795e\u7ecf\u5143\u6216\u795e\u7ecf\u7f51\u7edc\u4e2d\uff0c\u7279\u5b9a\u57fa\u56e0\u6270\u52a8\u5f15\u8d77\u7684\u6240\u6709\u53ef\u89c2\u5bdf\u6548\u5e94\u7684\u96c6\u5408\u3002<\/span><\/section>\n<\/blockquote>\n

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\u56fe5. \u57fa\u4e8e\u795e\u7ecf\u9012\u8d28\u7c7b\u578b\u7f16\u7801\u7684\u795e\u7ecf\u7f51\u7edc\u8bc6\u522b\u793a\u4f8b\uff0cFlyWire \u4f7f\u7814\u7a76\u4eba\u5458\u80fd\u591f\u5efa\u7acb\u5355\u4e2a\u56de\u8def\u751a\u81f3\u6574\u4e2a\u5927\u8111\u7684\u8ba1\u7b97\u6216\u7406\u8bba\u6a21\u578b\u3002\uff5c\u56fe\u7247\u6765\u6e90\uff1aAmy Sterling, Murthy and Seung Labs, Princeton University<\/span><\/p>\n


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\u6b64\u6b21 FlyWire \u9879\u76ee\u7684\u4e00\u4e2a\u5c40\u9650\u662f\uff0c\u65b0\u7684\u8fde\u63a5\u7ec4\u662f\u4ece\u4e00\u53ea\u96cc\u6027\u679c\u8747\u521b\u5efa\u7684\u3002\u5c3d\u7ba1\u679c\u8747\u7684\u8111\u5f7c\u6b64\u76f8\u4f3c\uff0c\u4f46\u5e76\u975e\u5b8c\u5168\u76f8\u540c\u3002\u5982\u679c\u5728\u672a\u6765\u6784\u5efa\u4e00\u4e2a\u96c4\u6027\u679c\u8747\u7684\u8fde\u63a5\u7ec4\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u80fd\u591f\u7814\u7a76\u96c4\u6027\u7279\u6709\u7684\u884c\u4e3a\uff0c\u5982\u9e23\u53eb\u3002<\/span><\/section>\n

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\u56fe6. Codex \u662f\u4e00\u4e2a\u641c\u7d22\u5f15\u64ce\uff0c\u4f7f\u7814\u7a76\u4eba\u5458\u80fd\u591f\u641c\u7d22\u5e26\u6ce8\u91ca\u7684\u795e\u7ecf\u5143\u5e76\u68c0\u7d22\u795e\u7ecf\u9012\u8d28\u7c7b\u578b\u548c\u8fde\u63a5\u6027\u7b49\u4fe1\u606f\u3002\uff5c\u56fe\u7247\u6765\u6e90\uff1aAmy Sterling, Murthy and Seung Labs, Princeton University<\/span><\/p>\n


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FlyWire \u7f51\u7ad9\uff1ahttps:\/\/flywire.ai\/<\/span><\/section>\n
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\u6606\u866b\u667a\u80fd\u4e0eAI\u8bfb\u4e66\u4f1a\u62db\u52df\u4e2d<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u8be6\u60c5\u8bf7\u89c1\uff1a\u6606\u866b\u667a\u80fd\u5982\u4f55\u542f\u53d1\u4eba\u5de5\u667a\u80fd\u4e0e\u4eff\u751f\u673a\u5668\u4eba\uff1f\u6606\u866b\u667a\u80fd\u4e0eAI\u8bfb\u4e66\u4f1a\u542f\u52a8\uff01<\/a><\/span><\/p>\n


<\/section>\n

<\/section>\n
\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/strong>
<\/section>\n
1. <\/strong>\u4ece\u590d\u6742\u795e\u7ecf\u52a8\u529b\u5b66\u5230\u667a\u80fd\u6d8c\u73b0\uff1a\u57fa\u4e8e\u795e\u7ecf\u590d\u6742\u6027\u7684\u7c7b\u8111\u4eba\u5de5\u667a\u80fd<\/a><\/strong><\/span><\/section>\n
2. <\/strong>\u4ece\u57fa\u56e0\u7ec4\u5230\u8fde\u63a5\u7ec4\uff1a\u4f60\u4e0d\u53ea\u662f\u4f60\u7684\u57fa\u56e0\u7ec4\uff0c\u4f60\u662f\u4f60\u7684\u8fde\u63a5\u7ec4<\/a><\/strong><\/span><\/section>\n
3. <\/strong>\u5927\u89c4\u6a21\u8111\u7f51\u7edc\uff1a\u5404\u7c7b\u529f\u80fd\u8fde\u63a5\u7ec4 | \u96c6\u667a\u767e\u79d1<\/a><\/strong><\/span><\/section>\n
4. <\/strong><\/span>\u5f20\u6c5f\uff1a\u7b2c\u4e09\u4ee3\u4eba\u5de5\u667a\u80fd\u6280\u672f\u57fa\u7840\u2014\u2014\u4ece\u53ef\u5fae\u5206\u7f16\u7a0b\u5230\u56e0\u679c\u63a8\u7406 | \u96c6\u667a\u5b66\u56ed\u5168\u65b0\u8bfe\u7a0b<\/a><\/strong><\/strong><\/span><\/section>\n
<\/strong>5.<\/strong> \u9f99\u5e74\u5927\u8fd0\u8d77\uff0c\u5b66\u4e60\u6b63\u5f53\u65f6\uff01\u89e3\u9501\u96c6\u667a\u5168\u7ad9\u5185\u5bb9\uff0c\u5f00\u542f\u65b0\u5e74\u5b66\u4e60\u8ba1\u5212<\/a><\/strong><\/strong><\/strong><\/strong><\/span><\/strong><\/strong><\/section>\n

6. <\/strong>\u52a0\u5165\u96c6\u667a\uff0c\u4e00\u8d77\u590d\u6742\uff01<\/strong><\/span><\/a><\/p>\n


<\/p>\n


<\/p>\n

\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/strong><\/span><\/strong><\/span><\/strong><\/p>\n


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