{"id":53055,"date":"2024-10-09T20:54:39","date_gmt":"2024-10-09T12:54:39","guid":{"rendered":"https:\/\/swarma.org\/?p=53055"},"modified":"2024-10-09T20:54:39","modified_gmt":"2024-10-09T12:54:39","slug":"2024%e5%b9%b4%e8%af%ba%e8%b4%9d%e5%b0%94%e5%8c%96%e5%ad%a6%e5%a5%96%e6%8e%88%e4%ba%88-alphafold%ef%bc%9a%e5%bc%80%e5%90%af-aiscience-%e6%96%b0%e7%ba%aa%e5%85%83%ef%bc%81","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=53055","title":{"rendered":"2024\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u6388\u4e88 AlphaFold\uff1a\u5f00\u542f AI+Science \u65b0\u7eaa\u5143\uff01"},"content":{"rendered":"
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\u5317\u4eac\u65f6\u95f410\u67089\u65e5\u4e0b\u53485\u70b945\u5206\u5de6\u53f3\uff0c2024\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u7684\u4e00\u534a\u6388\u4e88 <\/span><\/strong>David Baker<\/span><\/strong>\uff0c\u8868\u5f70\u4ed6\u5728\u8ba1\u7b97\u86cb\u767d\u8d28\u8bbe\u8ba1\u65b9\u9762\u7684\u8d21\u732e\uff0c\u53e6\u4e00\u534a\u5219\u5171\u540c\u6388\u4e88 <\/span><\/strong>Demis Hassabis<\/span><\/strong> \u548c <\/span><\/strong>John M. Jumper<\/span><\/strong>\uff0c\u8868\u5f70\u4ed6\u4eec\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u65b9\u9762\u7684\u6210\u5c31\u3002<\/span><\/strong><\/span><\/strong>\u6628\u5929\u7684\u8bfa\u8d1d\u5c14\u7269\u7406\u5b66\u5956\u6388\u4e88\u4eba\u5de5\u795e\u7ecf\u7f51\u7edc\uff0c\u4eca\u5929\u7684\u5316\u5b66\u5956\u6388\u4e88 AlphaFold \u548c\u8ba1\u7b97\u86cb\u767d\u8d28\u8bbe\u8ba1\uff0c\u5c55\u73b0\u4e86\u4eba\u5de5\u667a\u80fd\u5728\u63a8\u52a8\u79d1\u5b66\u521b\u65b0\u65b9\u9762\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u9884\u793a\u7740 AI+Science<\/a> \u6b63\u5728\u5e26\u6765\u79d1\u5b66\u53d1\u5c55\u7684\u65b0\u7eaa\u5143\u3002<\/span><\/strong><\/span><\/strong><\/section>\n

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\u5982\u4f55\u53d1\u73b0 AI+Science \u4e2d\u7684\u4e0b\u4e00\u4e2a AlphaFold \u548c ChatGPT\uff1f<\/a><\/span><\/strong><\/span><\/strong>\u6587\u672b\u9644\u5e26\u6709\u96c6\u667a\u4ff1\u4e50\u90e8\u5728 AI+Science \u9886\u57df\u7684\u76f8\u5173\u4e3b\u9898\u8bfb\u4e66\u4f1a\u3001\u6587\u7ae0\u7b49\u8d44\u6599\uff0c\u6b22\u8fce\u611f\u5174\u8da3\u7684\u670b\u53cb\u6df1\u5165\u63a2\u7d22\uff01<\/span><\/strong><\/span><\/strong><\/section>\n<\/section>\n
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2024\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u4e0e\u7269\u7406\u5956\u4e00\u6837\uff0c\u5f70\u663e\u4e86\u4eba\u5de5\u667a\u80fd\u5728\u6253\u7834\u5b66\u79d1\u754c\u9650\u3001\u901a\u8fc7\u8de8\u5b66\u79d1\u5408\u4f5c\u63a8\u52a8\u79d1\u5b66\u53d1\u73b0\u4e2d\u7684\u53d8\u9769\u6027\u4f5c\u7528\u3002\u4eca\u5e74\u7684\u5316\u5b66\u5956\u6388\u4e88 John Jumper\u3001Demis Hassabis \u548c David Baker\uff0c\u8868\u5f70\u4ee5 AlphaFold \u4e3a\u4ee3\u8868\u7684AI\u6280\u672f\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u4e0e\u86cb\u767d\u8d28\u8ba1\u7b97\u8bbe\u8ba1\u4e2d\u7684\u9769\u547d\u6027\u5f71\u54cd\u3002AI\u7834\u89e3\u4e86\u957f\u671f\u672a\u89e3\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u96be\u9898\uff0c\u5f7b\u5e95\u6539\u53d8\u4e86\u751f\u7269\u5b66\u7814\u7a76\uff0c\u4f7f\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u83b7\u53d6\u66f4\u52a0\u4fbf\u6377\uff0c\u9ad8\u6548\u63a8\u52a8\u4e86\u836f\u7269\u53d1\u73b0\u7684\u8fdb\u7a0b\uff0c\u5e76\u4e3a\u672a\u6765\u7684\u9ad8\u901a\u91cf\u751f\u547d\u79d1\u5b66\u8ba1\u7b97\u7814\u7a76\u63d0\u4f9b\u4e86\u5f3a\u6709\u529b\u7684\u652f\u6301\u3002David Baker \u5728\u8ba1\u7b97\u86cb\u767d\u8d28\u8bbe\u8ba1\u9886\u57df\u7684\u8d21\u732e\u8fdb\u4e00\u6b65\u62d3\u5c55\u4e86\u4eba\u5de5\u667a\u80fd\u5728\u5b9e\u9645\u5e94\u7528\u4e2d\u521b\u9020\u65b0\u578b\u86cb\u767d\u8d28\u7684\u5e7f\u6cdb\u6f5c\u529b\u3002\u6628\u5929\uff0c\u7269\u7406\u5956\u6388\u4e88 John Hopfield \u548c Geoffrey Hinton\uff0c\u80af\u5b9a\u4e86\u7edf\u8ba1\u7269\u7406\u5b66\u539f\u7406\u5728\u73b0\u4ee3\u4eba\u5de5\u795e\u7ecf\u7f51\u7edc\u53d1\u5c55\u4e2d\u7684\u57fa\u7840\u6027\u4f5c\u7528\uff0c\u5f3a\u8c03\u4e86\u8de8\u5b66\u79d1\u65b9\u6cd5\u5982\u4f55\u63a8\u52a8\u4eba\u5de5\u667a\u80fd\u7684\u4f18\u5316\u4e0e\u5e94\u7528\u53d1\u5c55\u3002<\/span><\/p>\n


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2024\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u662f\u5173\u4e8e\u86cb\u767d\u8d28\uff0c\u751f\u547d\u7684\u975e\u51e1\u5316\u5b66\u5de5\u5177\u3002David Baker \u6210\u529f\u5730\u8bbe\u8ba1\u51fa\u4e86\u5168\u65b0\u7684\u86cb\u767d\u8d28\uff0c\u8fd9\u662f\u4e00\u9879\u51e0\u4e4e\u4e0d\u53ef\u80fd\u5b8c\u6210\u7684\u58ee\u4e3e\u3002Demis Hassabis \u548c John Jumper \u5219\u5f00\u53d1\u4e86\u4e00\u4e2a\u4eba\u5de5\u667a\u80fd\u6a21\u578b\u6765\u89e3\u51b3\u6301\u7eed50\u5e74\u4e4b\u4e45\u7684\u95ee\u9898\uff1a\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u590d\u6742\u7ed3\u6784\u3002\u8fd9\u4e9b\u53d1\u73b0\u8574\u85cf\u7740\u5de8\u5927\u7684\u6f5c\u529b\u3002<\/span><\/section>\n

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\u8bfa\u8d1d\u5c14\u5316\u5b66\u59d4\u5458\u4f1a\u4e3b\u5e2d Heiner Linke \u8bf4\uff1a\u201c\u4eca\u5e74\u83b7\u5956\u7684\u53d1\u73b0\u4e00\u4e2a\u662f\u5173\u4e8e\u5168\u65b0\u86cb\u767d\u8d28\u7684\u6784\u5efa\u3002\u53e6\u4e00\u4e2a\u662f\u5173\u4e8e\u5b9e\u73b0\u4e00\u4e2a50\u5e74\u7684\u68a6\u60f3\uff1a\u4ece\u6c28\u57fa\u9178\u5e8f\u5217\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u8fd9\u4e24\u4e2a\u53d1\u73b0\u90fd\u5f00\u521b\u4e86\u5e7f\u9614\u7684\u53ef\u80fd\u6027\u3002\u201d<\/span><\/section>\n

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\u86cb\u767d\u8d28\u901a\u5e38\u753120\u79cd\u4e0d\u540c\u7684\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u8fd9\u4e9b\u6c28\u57fa\u9178\u53ef\u4ee5\u88ab\u63cf\u8ff0\u4e3a\u751f\u547d\u7684\u57fa\u77f3\u30022003\u5e74\uff0cDavid Baker \u6210\u529f\u5229\u7528\u8fd9\u4e9b\u6a21\u5757\u8bbe\u8ba1\u4e86\u4e00\u79cd\u5168\u65b0\u7684\u86cb\u767d\u8d28\u3002\u4ece\u90a3\u65f6\u8d77\uff0c\u4ed6\u7684\u7814\u7a76\u5c0f\u7ec4\u521b\u9020\u4e86\u4e00\u4e2a\u53c8\u4e00\u4e2a\u5bcc\u6709\u60f3\u8c61\u529b\u7684\u86cb\u767d\u8d28\uff0c\u5305\u62ec\u53ef\u7528\u4e8e\u5236\u836f\u3001\u75ab\u82d7\u3001\u7eb3\u7c73\u6750\u6599\u548c\u5fae\u578b\u4f20\u611f\u5668\u7684\u86cb\u767d\u8d28\u3002<\/span><\/section>\n

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Baker \u5b9e\u9a8c\u5ba4\u7684 Rossetta \u5f00\u53d1\u7684\u5bcc\u6709\u60f3\u8c61\u529b\u7684\u5404\u79cd\u86cb\u767d\u8d28\u3002<\/span><\/p>\n


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2020\u5e74\uff0cDemis Hassabis \u548c John Jumper \u63d0\u51fa\u4e86\u540d\u4e3a AlphaFold2 \u7684 AI \u6a21\u578b\u3002\u7528\u8fd9\u4e2a\u6a21\u578b\u80fd\u591f\u9884\u6d4b\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u7684\u51e0\u4e4e\u6240\u67092\u4ebf\u79cd\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3002\u81ea\u53d6\u5f97\u7a81\u7834\u4ee5\u6765\uff0cAlphaFold2 \u5df2\u7ecf\u88ab\u6765\u81ea190\u4e2a\u56fd\u5bb6\u7684200\u591a\u4e07\u4eba\u4f7f\u7528\u3002\u5728\u4f17\u591a\u7684\u79d1\u5b66\u5e94\u7528\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u73b0\u5728\u53ef\u4ee5\u66f4\u597d\u5730\u4e86\u89e3\u6297\u751f\u7d20\u8010\u836f\u6027\uff0c\u5e76\u521b\u9020\u51fa\u53ef\u4ee5\u5206\u89e3\u5851\u6599\u7684\u9176\u7684\u56fe\u50cf\u3002<\/span><\/section>\n

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\u4f7f\u7528 AlphaFold2 \u786e\u5b9a\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002<\/span><\/p>\n


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David Baker <\/span><\/strong>\u662f\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u86cb\u767d\u8d28\u8bbe\u8ba1\u7814\u7a76\u6240\u7684\u751f\u7269\u5316\u5b66\u6559\u6388\u3001HHMI \u7814\u7a76\u5458\u517c\u4e3b\u4efb\u3002Baker \u5b9e\u9a8c\u5ba4\u5f00\u53d1\u86cb\u767d\u8d28\u8bbe\u8ba1\u8f6f\u4ef6\uff0c\u5e76\u5229\u7528\u8fd9\u4e9b\u8f6f\u4ef6\u521b\u9020\u5206\u5b50\u7528\u4e8e\u89e3\u51b3\u533b\u5b66\u3001\u6280\u672f\u548c\u53ef\u6301\u7eed\u53d1\u5c55\u6311\u6218\u3002\u4ed6\u6700\u8fd1\u7684\u4e00\u9879\u5de5\u4f5c\u662f\u5f00\u53d1\u5f3a\u5927\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u7528\u4e8e\u751f\u6210\u529f\u80fd\u6027\u86cb\u767d\u8d28\u3002\u4ed6\u8fd8\u5728\u534e\u76db\u987f\u5927\u5b66\u62c5\u4efb\u57fa\u56e0\u7ec4\u79d1\u5b66\u3001\u751f\u7269\u5de5\u7a0b\u3001\u5316\u5b66\u5de5\u7a0b\u3001\u8ba1\u7b97\u673a\u79d1\u5b66\u548c\u7269\u7406\u5b66\u7684\u517c\u804c\u6559\u6388\u3002Baker \u662f\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u58eb\uff0c2020\u5e74\u83b7\u5f97\u4e86\u79d1\u5b66\u7a81\u7834\u5956\u751f\u547d\u79d1\u5b66\u5956\u30022024\u5e74\uff0c\u300a\u65f6\u4ee3\u300b\u6742\u5fd7\u5c06\u4ed6\u5217\u5165\u5065\u5eb7\u9886\u57df100\u4f4d\u6700\u5177\u5f71\u54cd\u529b\u4eba\u7269\u3002<\/span><\/span><\/section>\n

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Demis Hassabis <\/span><\/strong>\u662f DeepMind \u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98\u3002Hassabis \u81ea\u5e7c\u70ed\u7231\u8c61\u68cb\uff0c1989\u5e74\u8fbe\u5230\u56fd\u9645\u68cb\u80542300\u5206\u30021992\u5e74\u8fdb\u5165\u5251\u6865\u5927\u5b66\uff0c2005\u5e74\u5728\u4f26\u6566\u5927\u5b66\u5b66\u9662\u653b\u8bfb\u795e\u7ecf\u79d1\u5b66\u535a\u58eb\u5b66\u4f4d\u30022016\u5e74Hassabis \u5e26\u9886\u56e2\u961f\u5f00\u53d1\u7684 AlphaGo \u51fb\u8d25\u4e86\u4e16\u754c\u56f4\u68cb\u51a0\u519b\u674e\u4e16\u77f3\u30022018\u5e74\u5e95\uff0cAlphaGo\u5728\u56f4\u68cb\u3001\u56fd\u9645\u8c61\u68cb\u548c\u5c06\u68cb\u9886\u57df\u53d6\u5f97\u9886\u5148\uff0c\u5e76\u767b\u4e0a\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u5c01\u9762\u3002Hassabis \u83b7\u5f97\u4e86\u591a\u9879\u8363\u8a89\uff0c\u5305\u62ec\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u201c\u5e74\u5ea6\u7a81\u7834\u5956\u201d\u3001\u82f1\u56fd\u7687\u5bb6\u5b66\u4f1a\u201c\u7a46\u62c9\u5fb7\u5956\u201d\u3002\u300a\u65f6\u4ee3\u300b\u6742\u5fd7\u5c06\u4ed6\u5217\u5165\u4eba\u5de5\u667a\u80fd\u9886\u57df100\u4f4d\u6700\u5177\u5f71\u54cd\u529b\u4eba\u7269\u3002<\/span><\/span><\/section>\n

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John Jumper<\/span><\/strong> \u662f DeepMind \u9ad8\u7ea7\u7814\u7a76\u79d1\u5b66\u5bb6\uff0c\u4ed6\u4e0e\u540c\u4e8b Demis Hassabis \u5171\u540c\u5f00\u53d1\u4e86 AlphaFold\u3002Jumper \u5728\u829d\u52a0\u54e5\u5927\u5b66\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\uff0c\u5f00\u53d1\u4e86\u6a21\u62df\u86cb\u767d\u8d28\u6298\u53e0\u548c\u52a8\u529b\u5b66\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u3002Jumper \u8fd8\u5728\u5251\u6865\u5927\u5b66\u5b66\u4e60\u4e86\u7269\u7406\u5b66\uff0c\u5e76\u83b7\u5f97\u4e86\u9a6c\u6b47\u5c14\u5956\u5b66\u91d1\uff0c\u5e76\u62e5\u6709\u8303\u5fb7\u5821\u5927\u5b66\u7269\u7406\u548c\u6570\u5b66\u7406\u5b66\u5b66\u58eb\u5b66\u4f4d\u30022021\u5e74\uff0cJumper \u88abNature\u5217\u4e3a\u5e74\u5ea6\u699c\u5355\u4e2d\u7684\u5341\u5927\u201c\u91cd\u8981\u4eba\u7269\u201d\u4e4b\u4e00\u3002<\/span><\/span><\/section>\n
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AI+Science \u8d44\u6e90\u63a8\u8350<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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AI \u518d\u83b7\u8bfa\u5956\uff0c\u79d1\u5b66\u5bb6\u8fd8\u80fd\u5e72\u4ec0\u4e48\uff1f<\/span><\/span><\/p>\n


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\u8def\u5f84 1\uff1a\u53d1\u73b0 AI+Science \u4e2d\u7684\u4e0b\u4e00\u4e2a AlphaFold \u548c ChatGPT\uff01<\/span><\/strong><\/p>\n


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\u6b22\u8fce\u5173\u6ce8\u201c\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\u201d\u8bfb\u4e66\u4f1a<\/a>\uff0c\u7531\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u52a9\u7406\u6559\u6388\u5434\u6cf0\u9716\u3001\u65af\u5766\u798f\u5927\u5b66\u8ba1\u7b97\u673a\u79d1\u5b66\u7cfb\u535a\u58eb\u540e\u7814\u7a76\u5458\u738b\u701a\u5bb8\u3001\u535a\u58eb\u7814\u7a76\u751f\u9ec4\u67ef\u946b\u3001\u9ec4\u5029\uff0c\u534e\u76db\u987f\u5927\u5b66\u535a\u58eb\u7814\u7a76\u751f\u5c60\u946b\u660e\u5171\u540c\u53d1\u8d77\uff0c\u8bfb\u4e66\u4f1a\u9080\u8bf7\u56fd\u5185\u5916\u4e00\u7ebf\u79d1\u7814\u5de5\u4f5c\u8005\uff0c\u8fdb\u884c\u4e8610\u4f59\u573a\u5b66\u4e60\u548c\u4ea4\u6d41\uff0c\u63a2\u8ba8\u5927\u6a21\u578b\u5728\u4e0d\u540c\u5c3a\u5ea6\u7684\u7ec4\u5b66\u6570\u636e\u4e2d\u5982\u4f55\u53d1\u6325\u4f5c\u7528\u3002<\/span><\/p>\n


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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span>\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/a><\/p>\n


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\u8def\u5f84 2\uff1a\u5982\u679c AI \u8ba9\u79d1\u5b66\u5bb6\u5931\u4e1a\uff0c\u90a3\u79d1\u5b66\u5bb6\u5c31\u53bb\u7814\u7a76 AI\uff01<\/span><\/strong><\/p>\n


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\u4e00\u65b9\u9762\u662f AI for Science\uff0c\u53e6\u4e00\u65b9\u9762\u8fd8\u6709 Science for AI\u3002\u6b22\u8fce\u548c\u6211\u4eec\u4e00\u8d77\u63a2\u7d22\uff5e<\/span><\/p>\n


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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span>\u4eba\u5de5\u667a\u80fd\u548c\u79d1\u5b66\u53d1\u73b0\u76f8\u4e92\u8d4b\u80fd\u7684\u65b0\u8303\u5f0f\uff1aAI+Science \u8bfb\u4e66\u4f1a\u542f\u52a8<\/a>
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\u63a8\u8350\u9605\u8bfb<\/span><\/strong><\/strong><\/strong><\/section>\n