{"id":60275,"date":"2025-06-01T15:08:10","date_gmt":"2025-06-01T07:08:10","guid":{"rendered":"https:\/\/swarma.org\/?p=60275"},"modified":"2025-06-01T15:08:10","modified_gmt":"2025-06-01T07:08:10","slug":"%e7%8b%ac%e8%be%9f%e8%b9%8a%e5%be%84-%e5%b1%82%e6%ac%a1%e5%8f%a0%e5%8a%a0%e8%8d%af%e6%95%88%e6%a8%a1%e5%9e%8b%e7%a0%b4%e8%a7%a3%e8%8d%af%e7%89%a9%e7%bb%84%e5%90%88%e5%a5%a5%e7%a7%98","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=60275","title":{"rendered":"\u72ec\u8f9f\u8e4a\u5f84\u2014\u2014\u5c42\u6b21\u53e0\u52a0\u836f\u6548\u6a21\u578b\u7834\u89e3\u836f\u7269\u7ec4\u5408\u5965\u79d8"},"content":{"rendered":"
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\u8bba\u6587\u9898\u76ee\uff1aHierarchical Superposition Framework Reveals the Complex Effects of Natural Medicine Formulas<\/span><\/p>\n

\u8bba\u6587\u5730\u5740\uff1ahttps:\/\/doi.org\/10.1002\/aisy.202500060<\/span><\/p>\n<\/blockquote>\n


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\u6784\u5efa<\/span><\/span><\/span>\u4e00\u4e2a\u771f\u5b9e<\/span><\/span><\/span>\u3001\u6e05\u6670\u4e14\u5b9e\u7528\u7684\u836f\u7269\u7ec4\u5408\u6548\u5e94\u7f51\u7edc\u662f\u4e00\u9879\u91cd\u5927\u6311\u6218<\/span><\/span><\/span>\u3002<\/span><\/span><\/span>\u56e0\u4e3a\u836f\u7406\u4f5c\u7528\u53ef\u80fd\u6cbf\u7740\u591a\u6761\u76f8\u4e92\u4ea4\u7ec7\u7684\u901a\u8def\u6f14\u5316\uff0c\u5f62\u6210\u4e00\u4e2a\u590d\u6742\u7684\u7f51\u7edc\u3002\u8fd9\u79cd\u590d\u6742\u6027\u963b\u788d\u4e86\u6211\u4eec\u9884\u6d4b\u540c\u65f6\u4f5c\u7528\u4e8e\u591a\u4e2a\u9776\u70b9\u53ef\u80fd\u4ea7\u751f\u7684\u751f\u7269\u5b66\u6548\u5e94\u7684\u80fd\u529b\u3002\u7136\u800c\uff0c\u8fd9\u5e76\u4e0d\u610f\u5473\u7740\u6211\u4eec\u65e0\u6cd5\u63a2\u7d22\u836f\u7269\u7ec4\u5408\u7684\u6f5c\u5728\u76f8\u4e92\u4f5c\u7528\u7a7a\u95f4\u3002\u76ee\u524d\uff0c\u836f\u7269\u7ec4\u5408\u4ea7\u751f\u7684\u534f\u540c\u6548\u5e94\u7814\u7a76\u4e25\u91cd\u4f9d\u8d56\u4e8e\u4ece\u5404\u79cd\u771f\u5b9e\u4e16\u754c\u6a21\u578b<\/span>\uff08\u4f8b\u5982\u7ec6\u80de\u3001\u7ec4\u7ec7\u3001\u52a8\u7269\u751a\u81f3\u7c7b\u5668\u5b98\uff09<\/span>\u6536\u96c6\u7684\u5b9e\u9a8c\u6570\u636e\u3002\u901a\u8fc7\u7f51\u7edc\u836f\u7406\u5b66\uff0c\u6211\u4eec\u53ef\u4ee5\u5efa\u7acb\u9776\u70b9\u72b6\u6001\u548c\u63a7\u5236\u6761\u4ef6\uff0c\u4ece\u800c\u786e\u5b9a\u6700\u7ec8\u7684\u7597\u6548\u9014\u5f84<\/span><\/span><\/span>[1<\/span><\/span><\/span>1<\/span><\/span><\/span>]<\/span><\/span><\/span>\u3002<\/span><\/span><\/span><\/section>\n

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\u7136\u800c\uff0c\u7406\u89e3\u836f\u7269\u6548\u5e94\u53e0\u52a0\u7684\u89c4\u5f8b\u9519\u7efc\u590d\u6742\uff0c\u56e0\u4e3a\u5b83\u6d89\u53ca\u4e2a\u4f53\u5316\u8c03\u63a7\u7684\u5fae\u5999\u6027\u548c\u5916\u90e8\u5f71\u54cd\u7684\u4e0d\u53ef\u8ba1\u7b97\u6027\uff0c\u5bfc\u81f4\u5de5\u4f5c\u91cf\u5de8\u5927\u3002\u6b64\u5916\uff0c\u53d8\u91cf\u6570\u91cf\u4e4b\u591a\u4f7f\u5f97\u4efb\u4f55\u5efa\u6a21\u65b9\u6cd5\u53ea\u6709\u5728\u6781\u5176\u7406\u60f3\u5316\u7684\u6761\u4ef6\u4e0b\u624d\u5177\u6709\u8ba1\u7b97\u53ef\u884c\u6027\u3002\u8fc7\u53bb\u7528\u4e8e\u7814\u7a76\u5929\u7136\u836f\u7269\u5236\u5242\u7684\u7f51\u7edc\u836f\u7406\u5b66\u65b9\u6cd5\u4e3b\u8981\u4fa7\u91cd\u4e8e\u836f\u7406\u6548\u5e94\u7684\u7b80\u5355\u53e0\u52a0\uff0c\u8ba1\u7b97\u5176\u52a0\u6027\u6216\u51cf\u6027\u7ed3\u679c<\/span><\/span><\/span>[1<\/span><\/span><\/span>2<\/span><\/span><\/span>]<\/span><\/span><\/span>\uff0c\u800c\u6ca1\u6709\u8003\u8651\u5c42\u7ea7\u89c4\u5219\u7684\u53d8\u5316\u4ee5\u53ca\u5c42\u7ea7\u8f6c\u6362\u5e26\u6765\u7684\u8870\u51cf\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u4ecd\u7136\u57fa\u4e8e\u904d\u5386\uff0c\u672a\u80fd\u8003\u8651\u8def\u5f84\u9009\u62e9\u540e\u5c42\u7ea7\u6240\u627f\u8f7d\u7684\u5386\u53f2\u4fe1\u606f\u6240\u5e26\u6765\u7684\u975e\u904d\u5386\u7ea6\u675f\u3002<\/span><\/span><\/span><\/section>\n

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\u672c\u7814\u7a76\u5f15\u5165\u4e86\u836f\u7406\u6548\u5e94\u7684\u5c42\u7ea7\u53e0\u52a0\u548c\u6f14\u5316\u6982\u5ff5\uff0c\u5e76\u81f4\u529b\u4e8e\u6784\u5efa\u57fa\u4e8e\u6b64\u6982\u5ff5\u7684\u836f\u6548\u6a21\u578b\uff0c\u5229\u7528\u4eba\u7c7b\u86cb\u767d\u8d28<\/span><\/span><\/span>–<\/span><\/span><\/span>\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u6765\u91cf\u5316\u836f\u7269\u6216\u836f\u7269\u7ec4\u5408\u5bf9\u75be\u75c5\u7684\u5f71\u54cd\u3002\u7406\u60f3\u7684\u836f\u6548\u6a21\u578b\u5e94\u8be5\u5305\u542b\u5c42\u7ea7\u5173\u7cfb\u548c\u5c42\u7ea7\u95f4\u89c4\u5219\uff0c\u4f46\u5f71\u54cd\u8fd9\u4e9b\u89c4\u5219\u7684\u4f17\u591a\u53d8\u91cf\u6240\u5e26\u6765\u7684\u590d\u6742\u6027\u4f7f\u5176\u8ba1\u7b97\u5177\u6709\u6311\u6218\u6027\uff1b\u56e0\u6b64\uff0c<\/span><\/span><\/span>\u7814\u7a76<\/span><\/span><\/span>\u76ee\u524d\u4e13\u6ce8\u4e8e\u57fa\u4e8e\u836f\u7406\u9014\u5f84\u9009\u62e9\u7684\u7406\u60f3\u5316\u6a21\u578b\u3002\u8be5\u6a21\u578b\u7684\u6838\u5fc3\u5728\u4e8e\u89e3\u6790\u75be\u75c5\u76f8\u5173\u86cb\u767d\u4e0e\u836f\u7269\u9776\u70b9\u4e4b\u95f4\u7684\u5c42\u7ea7\u5173\u8054\uff0c\u4ee5\u53ca\u836f\u7406\u4f5c\u7528\u5982\u4f55\u5728\u8fd9\u4e9b\u5c42\u7ea7\u4e4b\u95f4\u4f20\u9012\u3002\u901a\u8fc7\u5b9e\u8bc1\u6570\u636e<\/span><\/span><\/span>\u7684<\/span><\/span><\/span>\u9a8c\u8bc1<\/span><\/span><\/span>\uff0c\u5c55\u793a\u4e86<\/span><\/span><\/span>\u8be5\u6a21\u578b\u7684\u6709\u6548\u6027\uff0c\u5e76\u5c1d\u8bd5\u4ece\u6a21\u578b\u89c6\u89d2\u9610\u91ca\u836f\u7269\u7ec4\u5408\u524d\u540e\u836f\u6548\u7684\u590d\u6742\u53d8\u5316\uff0c\u5e76\u4ee5\u4e2d\u533b\u836f\u7684\u5b9e\u8df5\u7ecf\u9a8c\u4e3a\u4f50\u8bc1\u3002\u6b64\u5916\uff0c<\/span><\/span><\/span>\u672c\u7814\u7a76<\/span><\/span><\/span>\u81f4\u529b\u4e8e\u5229\u7528\u8be5\u6a21\u578b\u8ba1\u7b97\u65b0\u7684\u836f\u7269\u7ec4\u5408\uff0c\u5e76\u901a\u8fc7\u7ec6\u80de\u5b9e\u9a8c\u8fdb\u884c\u9a8c\u8bc1\uff0c\u4ece\u800c\u68c0\u9a8c\u8be5\u6a21\u578b\u6307\u5bfc\u836f\u7269\u7ec4\u5408\u53d1\u73b0\u7684\u53ef\u884c\u6027\u3002<\/span><\/span><\/span><\/section>\n

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\u521b\u65b0\u6a21\u578b\u6784\u5efa\uff0c\u5f15\u5165\u5c42\u6b21\u53e0\u52a0\u65b0\u89c6\u89d2<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/span><\/p>\n

Hierarchical Superposition Pharmacodynamic Model<\/span><\/span><\/span><\/span>\uff08<\/span><\/span><\/span>HSPM<\/span><\/span><\/span>\uff0c<\/span><\/span><\/span>\u5c42\u6b21\u53e0\u52a0\u836f\u6548\u6a21\u578b<\/span><\/span><\/span>\uff09<\/span><\/span><\/span>\u7684\u6838\u5fc3\u601d\u60f3\u662f\u786e\u5b9a\u75be\u75c5\u9776\u70b9\u4e0e\u836f\u7269\u9776\u70b9\u4e4b\u95f4\u7684\u5c42\u7ea7\u5173\u7cfb\uff0c\u5e76\u901a\u8fc7\u8ba1\u7b97\u836f\u7269\u6cbf\u9009\u5b9a\u901a\u8def\u7684\u5c42\u7ea7\u4f20\u9012\u6765\u8bc4\u4f30\u836f\u7269\u7684\u836f\u6548<\/span><\/span><\/span>\u3002\u8be5\u65b9\u6cd5\u5229\u7528<\/span><\/span><\/span>\u86cb\u767d\u8d28\u4e92\u4f5c\u7f51\u7edc<\/span>\uff08<\/span><\/span><\/span>Protein-Protein Interaction Networks<\/span><\/span><\/span>\uff0c<\/span><\/span><\/span>PPI<\/span><\/span><\/span>\uff09<\/span><\/span><\/span><\/span>\u7f51\u7edc\uff0c\u91cf\u5316\u836f\u7269\u9776\u70b9\u4e0e\u75be\u75c5\u9776\u70b9\u95f4\u7684\u7f51\u7edc\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u8bc4\u4f30\u5355\u4e00\u836f\u7269\u6216\u836f\u7269\u7ec4\u5408\u5bf9\u75be\u75c5\u7684\u5f71\u54cd\u3002\u8ba1\u7b97\u836f\u6548\u4f5c\u7528\u8bc4\u5206\u7684\u7b2c\u4e00\u6b65\u662f\u786e\u5b9a\u75be\u75c5\u9776\u70b9\u4e0e\u836f\u7269\u9776\u70b9\u7684\u5c42\u6b21\u5173\u7cfb\uff0c\u5373\u5b83\u4eec\u5728\u7f51\u7edc\u4e2d\u7684\u8ddd\u79bb\u3002\u7531\u4e8e\u836f\u6548\u53ef\u901a\u8fc7\u591a\u6761\u8def\u5f84\u4ece\u836f\u7269\u9776\u70b9\u4f20\u9012\u5230\u75be\u75c5\u9776\u70b9\uff0c<\/span><\/span><\/span>\u7814\u7a76\u56e2\u961f\u81f4\u529b\u4e8e\u627e\u51fa\u627f\u8f7d\u5c42\u7ea7\u95f4\u4f20\u9012\u6700\u5927<\/span><\/span><\/span>\u6743\u91cd<\/span><\/span><\/span>\u7684\u4ee3\u8868\u6027\u6700\u77ed\u8def\u5f84\u3002\u5177\u4f53\u800c\u8a00\uff0c\u5c31\u662f\u5bfb\u627e\u8def\u5f84\u957f\u5ea6\uff08\u5373\u5c42\u7ea7\u8ddd\u79bb\uff09\u6700\u77ed\u4e14\u8def\u5f84\u4e0a\u8282\u70b9\u5ea6\u4e58\u79ef\u6700\u5c0f\u7684\u8def\u5f84\u3002<\/span><\/span><\/span>\uff08\u56fe<\/span><\/span><\/span>1<\/span><\/span><\/span>\uff09<\/span><\/span><\/span><\/section>\n
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\u56fe<\/span><\/span><\/span>1 <\/span><\/span><\/span>\u5c42\u7ea7\u53e0\u52a0\u836f\u7406\u5b66\u6846\u67b6\u6982\u5ff5\u56fe<\/span><\/span><\/span><\/section>\n
(A) (B) <\/span><\/span><\/span>\u5206\u522b\u4e3a\u5c42\u7ea7\u53e0\u52a0\u836f\u6548\u5b66\u6846\u67b6\u7684\u5168\u666f\u56fe\u548c\u5c42\u95f4\u56fe\u3002\u4e0d\u540c\u989c\u8272\u7684\u5757\u8868\u793a\u540c\u4e00\u7f51\u7edc\u5185\u4e0d\u540c\u5c42\u7ea7\u8282\u70b9\u7c07\u7684\u53e0\u52a0\u3002\u8282\u70b9\u95f4\u7684\u8fde\u63a5\u7ebf\u8868\u793a\u76f8\u4e92\u4f5c\u7528\u901a\u8def\u3002\u7ea2\u8272\u5b9e\u7ebf\u8868\u793a\u7279\u5b9a\u836f\u7269\u7684\u836f\u7406\u4f5c\u7528\u8def\u5f84\u3002<\/span><\/span><\/span><\/section>\n

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\u5728\u8ba1\u7b97\u836f\u6548\u4f5c\u7528\u8bc4\u5206\u65f6\uff0c\u7814\u7a76\u56e2\u961f\u5047\u8bbe\u836f\u6548\u5728\u4e0d\u540c\u5c42\u7ea7\u95f4\u4f20\u9012\u65f6\u4f1a\u7ecf\u5386\u8870\u51cf\u3002\u6bcf\u6b21\u4f20\u9012\u6b65\u9aa4\u90fd\u4f1a\u5bfc\u81f4\u836f\u7269\u6548\u80fd\u964d\u4f4e\uff0c\u8870\u51cf\u7a0b\u5ea6\u7531\u5c42\u7ea7\u95f4\u8ddd\u79bb<\/span>\uff08\u5373\u4e24\u8282\u70b9\u95f4\u8def\u5f84\u7684\u5c42\u7ea7\u8ddd\u79bb\uff09<\/span>\u51b3\u5b9a\u3002\u540c\u65f6\uff0c\u540c\u5c42\u7ea7\u5185\u836f\u6548\u4f20\u9012\u53d7\u86cb\u767d\u8d28\u8282\u70b9\u5ea6\u5f71\u54cd\u3002\u8282<\/span><\/span><\/span>\u70b9\u5ea6\u8f83\u4f4e\u7684\u86cb\u767d\u8d28\u503e\u5411\u4e8e\u5c06\u6548\u5e94\u4f20\u9012\u5230\u5176\u4ed6\u5c42\u7ea7\uff0c\u800c\u8282\u70b9\u5ea6\u8f83\u9ad8\u7684\u86cb\u767d\u8d28\u5219\u66f4\u591a\u5730\u4fdd\u7559\u836f\u6548\uff0c\u5bfc\u81f4\u6548\u5e94\u4e3b\u8981\u5728\u540c\u5c42\u7ea7\u5185\u4f20\u9012\u3002<\/span><\/span><\/span><\/section>\n

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\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u51c6\u786e\u8861\u91cf\u836f\u7269\u9776\u70b9\u4e0e\u75be\u75c5\u9776\u70b9\u76f8\u4e92\u4f5c\u7528\u5bf9\u836f\u6548\u7684\u5f71\u54cd\uff0c\u540c\u65f6\u8003\u8651\u4e0d\u540c\u5c42\u7ea7\u548c\u8282\u70b9\u7279\u6027\u5bf9\u836f\u6548\u4f20\u9012\u7684\u5f71\u54cd\u3002\u5728\u786e\u5b9a\u4e86\u75be\u75c5\u9776\u70b9\u4e0e\u836f\u7269\u9776\u70b9\u95f4\u7684\u5c42\u6b21\u5173\u7cfb\u540e\uff0c\u7814\u7a76\u56e2\u961f\u8fdb\u4e00\u6b65\u8ba1\u7b97\u836f\u6548\u6cbf\u8def\u5f84\u7684\u5c42\u7ea7\u4f20\u9012\uff0c\u4ece\u800c\u91cf\u5316\u836f\u7269\u5bf9\u75be\u75c5\u7684\u6cbb\u7597\u6548\u679c\u3002<\/span><\/span><\/span>\u57fa\u4e8e\u8fd9\u4e00\u65b9\u6cd5\uff0c\u7814\u7a76\u56e2\u961f\u6784\u5efa\u4e86\u836f\u7269\u4e0e\u75be\u75c5\u7684\u5173\u7cfb\u6a21\u578b\uff0c\u5e76\u901a\u8fc7\u5927\u91cf\u6570\u636e\u9a8c\u8bc1\u5176\u6709\u6548\u6027\u3002\u5728\u6784\u5efa\u7684\u836f\u7269<\/span><\/span><\/span> – <\/span><\/span><\/span>\u75be\u75c5\u6570\u636e\u96c6\u548c\u836f\u7269\u7ec4\u5408<\/span><\/span><\/span> – <\/span><\/span><\/span>\u75be\u75c5\u6570\u636e\u96c6\u4e2d\uff0c\u7814\u7a76\u53d1\u73b0\u5df2\u77e5\u6709\u6548\u836f\u7269<\/span><\/span><\/span> – <\/span><\/span><\/span>\u75be\u75c5\u5bf9\u7684\u836f\u6548\u4f5c\u7528\u8bc4\u5206\u663e\u8457\u9ad8\u4e8e\u672a\u77e5<\/span><\/span><\/span> \/ <\/span><\/span><\/span>\u65e0\u6548\u5bf9\u3002\u8fd9\u8868\u660e<\/span><\/span><\/span> HSPM <\/span><\/span><\/span>\u80fd\u591f\u6709\u6548\u533a\u5206\u836f\u7269\u5bf9\u75be\u75c5\u7684\u6f5c\u5728\u7597\u6548\uff0c\u4e3a\u836f\u7269\u7ec4\u5408\u7684\u9884\u6d4b\u4e0e\u53d1\u73b0\u63d0\u4f9b\u4e86\u53ef\u9760\u7684\u7406\u8bba\u57fa\u7840\u3002<\/span><\/span><\/span>\uff08\u56fe<\/span><\/span><\/span>2<\/span><\/span><\/span>\uff09<\/span><\/span><\/span><\/section>\n

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<\/span><\/span><\/section>\n
\u56fe<\/span><\/span><\/span>2 <\/span><\/span><\/span>\u6784\u5efa\u5206\u5c42\u53e0\u52a0\u836f\u6548\u52a8\u529b\u5b66\u6a21\u578b\u7684\u836f\u6548\u4f5c\u7528<\/span><\/span><\/span>\u5206\u6570<\/span><\/span><\/span>\u65b9\u6cd5\u53ca\u9a8c\u8bc1<\/span><\/span><\/span><\/section>\n
\uff08<\/span><\/span><\/span>A<\/span><\/span><\/span>\uff09\u57fa\u4e8e\u4eba\u7c7b\u86cb\u767d\u8d28<\/span><\/span><\/span>–<\/span><\/span><\/span>\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\uff08<\/span><\/span><\/span>PPI<\/span><\/span><\/span>\uff09\u7f51\u7edc\u7684<\/span><\/span><\/span>\u836f\u6548\u4f5c\u7528\u5206\u6570\u65b9\u6cd5<\/span><\/span><\/span>\u8ba1\u7b97\u793a\u610f\u56fe\u3002\u836f\u7269\u9776\u70b9\u4e0e\u75be\u75c5\u9776\u70b9\u4e4b\u95f4\u7684\u8bc4\u5206\u901a\u8fc7\u786e\u5b9a\u8def\u5f84\u4e0a\u8282\u70b9\u5ea6\u79ef\u6700\u5c0f\u7684\u6700\u77ed\u8def\u5f84\u6765\u8ba1\u7b97\u3002\uff08<\/span><\/span><\/span>B<\/span><\/span><\/span>\uff09<\/span><\/span><\/span>\u836f\u6548\u4f5c\u7528\u5206\u6570\u65b9\u6cd5<\/span><\/span><\/span>\u8bc4\u4ef7\u5929\u7136\u836f\u7269\u5bf9\u75be\u75c5\u7684\u836f\u6548\u4f5c\u7528\u3002\uff08<\/span><\/span><\/span>C<\/span><\/span><\/span>\uff09\u836f\u6548\u4f5c\u7528<\/span><\/span><\/span>\u5206\u6570\u65b9\u6cd5<\/span><\/span><\/span>\u8bc4\u4ef7\u7ec4\u65b9\u5bf9\u75be\u75c5\u7684\u836f\u6548\u5173\u7cfb\u3002\uff08<\/span><\/span><\/span>D<\/span><\/span><\/span>\uff09\u548c\uff08<\/span><\/span><\/span>E<\/span><\/span><\/span>\uff09\u5929\u7136\u836f\u7269<\/span><\/span><\/span>\/<\/span><\/span><\/span>\u7ec4\u65b9<\/span><\/span><\/span>–<\/span><\/span><\/span>\u75be\u75c5\u5bf9\u7684<\/span><\/span><\/span>\u836f\u6548\u4f5c\u7528\u5206\u6570<\/span><\/span><\/span>\u5206\u5e03\u3002\u6709\u6548\u5bf9\u7684\u8bc4\u5206\u663e\u8457\u5347\u9ad8\uff0c\u63d0\u793a\u5176\u836f\u6548\u4f5c\u7528\u66f4\u5f3a\u3002\u4f7f\u7528<\/span><\/span><\/span>Mann-Whitney U<\/span><\/span><\/span>\u68c0\u9a8c\u8bc4\u4f30\u5df2\u77e5\u6709\u6548\u5bf9\u548c\u672a\u77e5\u6709\u6548\u5bf9<\/span><\/span><\/span>\u4e4b\u95f4<\/span><\/span><\/span>\u5206\u6570<\/span><\/span><\/span>\u5206\u5e03\u5dee\u5f02\u7684\u663e\u8457\u6027\u3002<\/span><\/span><\/span> (F) ROC <\/span><\/span><\/span>\u66f2\u7ebf\u548c\u76f8\u5e94\u7684\u66f2\u7ebf\u4e0b\u9762\u79ef<\/span><\/span><\/span> (AUC) <\/span><\/span><\/span>\u6bd4\u8f83\u836f\u6548<\/span><\/span><\/span>\u4f5c\u7528\u5206\u6570\u65b9\u6cd5<\/span><\/span><\/span>\u548c\u90bb\u8fd1\u5ea6\u6cd5\u5728\u533a\u5206\u5df2\u77e5\u6709\u6548\u548c\u672a\u77e5\u7597\u6548\u7684\u5929\u7136\u836f\u7269<\/span><\/span><\/span>\/<\/span><\/span><\/span>\u914d\u65b9<\/span><\/span><\/span>–<\/span><\/span><\/span>\u75be\u75c5\u5bf9\u65b9\u9762\u7684\u9884\u6d4b\u6027\u80fd\u3002<\/span><\/span><\/span><\/section>\n

<\/span><\/section>\n

<\/span><\/span><\/section>\n

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<\/section>\n<\/section>\n<\/section>\n
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\u63ed\u79d8\u836f\u7269\u7ec4\u5408\u534f\u540c\u589e\u6548\uff0c\u6316\u6398\u6f5c\u5728\u65b0\u7ec4\u5408<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/span><\/p>\n

HSPM <\/span><\/span><\/span>\u5728\u4e2d\u836f\u7814\u7a76\u4e2d\u7684\u5e94\u7528\uff0c\u5145\u5206\u5c55\u73b0\u4e86\u5176<\/span><\/span><\/span>\u72ec\u7279<\/span><\/span><\/span>\u7684<\/span><\/span><\/span>\u4f18\u52bf<\/span><\/span><\/span>\u3002\u4ee5<\/span><\/span><\/span> \u201c<\/span><\/span><\/span>\u54b3\u55fd<\/span><\/span><\/span>\u201d <\/span><\/span><\/span>\u4e3a\u4f8b\uff0c\u6a21\u578b\u8ba1\u7b97\u663e\u793a\uff0c\u6854\u6897\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>D,S<\/span><\/span><\/sub><\/span> = 1.86\u00d710\u207b\u2074<\/span><\/span><\/span>\uff09\u548c\u9ebb\u9ec4\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>D,S<\/span><\/span><\/sub><\/span>=1.47\u00d710\u207b\u2074<\/span><\/span><\/span>\uff09\u5bf9\u54b3\u55fd\u7597\u6548\u663e\u8457\u3002\u800c\u77f3\u51b3\u660e\u5bf9\u54b3\u55fd\u4f5c\u7528\u8f83\u5f31\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>D,S<\/span><\/span><\/sub><\/span> = 2.46\u00d710\u207b\u2075<\/span><\/span><\/span>\uff09\uff0c\u5374\u5bf9\u89c6\u529b\u6a21\u7cca\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>D,S<\/span><\/span><\/sub><\/span> = 1.16\u00d710\u207b\u2074<\/span><\/span><\/span>\uff09\u6548\u679c\u826f\u597d\uff0c\u4e0e\u4e34\u5e8a\u7ecf\u9a8c\u9ad8\u5ea6\u543b\u5408\u3002\u5728\u836f\u7269\u7ec4\u5408\u65b9\u9762\uff0c\u767e\u5408\u56fa\u91d1\u6c64\u5bf9\u54b3\u55fd\u836f\u6548\u663e\u8457\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>C,S<\/span><\/span><\/sub><\/span> = 1.74\u00d710\u207b\u2074<\/span><\/span><\/span>\uff09\uff0c\u76f8\u5173\u7814\u7a76\u8868\u660e\u5176\u5177\u6709\u6297\u83cc\u3001\u6297\u708e\u548c\u9000\u70ed\u6548\u679c\uff0c\u80fd\u663e\u8457\u6539\u5584\u611f\u67d3\u5f15\u8d77\u7684\u54b3\u55fd\u75c7\u72b6\u3002\u800c\u91d1\u94c3\u5b50\u6563\u5bf9\u54b3\u55fd\u7597\u6548\u8f83\u5f31\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>C,S<\/span><\/span><\/sub><\/span> = 7.5\u00d710\u207b\u2075<\/span><\/span><\/span>\uff09\uff0c\u5374\u5bf9\u80c6\u56ca\u708e\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>C,S<\/span><\/span><\/sub><\/span> = 1.43\u00d710\u207b\u2074<\/span><\/span><\/span>\uff09\u6548\u679c\u660e\u663e\uff0c\u540c\u6837\u5951\u5408\u4e34\u5e8a\u5b9e\u8df5\u3002<\/span><\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n
HSPM <\/span><\/span><\/span>\u4e0d\u4ec5\u80fd\u8bc4\u4f30\u5df2\u77e5\u836f\u7269\u548c\u590d\u65b9\u7684\u7597\u6548\uff0c\u8fd8\u80fd\u9884\u6d4b\u672a\u77e5\u836f\u7269<\/span><\/span><\/span> – <\/span><\/span><\/span>\u75be\u75c5\u5bf9\u7684\u6f5c\u5728\u7597\u6548\u3002\u4f8b\u5982\uff0c\u828d\u836f\u6c64\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>C,S<\/span><\/span><\/sub><\/span> = 1.17\u00d710\u207b\u2074<\/span><\/span><\/span>\uff09\u548c\u75db\u6cfb\u65b9\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>C,S<\/span><\/span><\/sub><\/span> =1.36\u00d710\u207b\u2074<\/span><\/span><\/span>\uff09\u5bf9\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u663e\u793a\u51fa\u8f83\u5f3a\u7597\u6548\u3002\u5c3d\u7ba1\u5f53\u524d\u516c\u5f00\u6570\u636e\u96c6\u672a\u8bb0\u5f55\u5176\u5bf9\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u6709\u6548\u6027\uff0c\u4f46\u591a\u9879\u7814\u7a76\u4ece\u7ec6\u80de\u6c34\u5e73\u5230\u4e34\u5e8a\u8bd5\u9a8c\u5747\u8868\u660e\u5b83\u4eec\u80fd\u6709\u6548\u5e72\u9884\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u3002\u6b64\u5916\uff0c\u91d1\u94c3\u5b50\u6563\u5bf9\u80c3\u6e83\u75a1\u7684\u6f5c\u5728\u7597\u6548\u4e5f\u5f97\u5230\u6a21\u578b\u9884\u6d4b\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>C,S<\/span><\/span><\/sub><\/span> = 1.161\u00d710\u207b\u2074<\/span><\/span><\/span>\uff09\uff0c\u5c3d\u7ba1\u6570\u636e\u5e93\u4e2d\u6ca1\u6709\u76f8\u5173\u8bb0\u5f55\uff0c\u4f46\u4e34\u5e8a\u7814\u7a76\u663e\u793a\u5176\u5bf9\u80c3\u6e83\u75a1\u7684\u6cbb\u7597\u6548\u679c\u663e\u8457\u3002<\/span><\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n
\u5728\u836f\u7269\u7ec4\u5408\u6548\u5e94\u5206\u6790\u65b9\u9762\uff0c<\/span><\/span><\/span>HSPM <\/span><\/span><\/span>\u63ed\u793a\u4e86\u836f\u7269\u7ec4\u5408\u53ef\u80fd\u51fa\u73b0\u7684\u4e09\u79cd\u7597\u6548\u53d8\u5316\uff1a\u65b0\u7597\u6548\u6d8c\u73b0\u3001\u7597\u6548\u589e\u5f3a\u4e0e\u7597\u6548\u964d\u4f4e\u6216\u65e0\u6548\u3002\u4f8b\u5982\uff0c<\/span><\/span><\/span>\u75db\u6cfb\u8981\u65b9<\/span><\/span><\/span>\u5728\u6cbb\u7597<\/span><\/span><\/span>\u80a0\u6613\u6fc0\u7efc\u5408\u5f81<\/span><\/span><\/span>\u65f6\uff0c\u5355\u4e2a\u6210\u5206\u5728\u5df2\u77e5\u6570\u636e\u5e93\u4e2d\u672a\u663e\u793a\u7597\u6548\uff0c\u4f46\u7ec4\u5408\u540e\u7684\u65b9\u5242\u836f\u6548\u4f5c\u7528\u8bc4\u5206\u589e\u5f3a\uff0c\u8d85\u8fc7\u9608\u503c\uff0c\u8868\u73b0\u51fa\u5bf9\u6162\u6027\u809d\u708e\u7684\u65b0\u7597\u6548\u3002\u800c<\/span><\/span><\/span>\u900d\u9065\u6563<\/span><\/span><\/span>\u5728\u6cbb\u7597<\/span><\/span><\/span>\u6162\u6027\u809d\u708e<\/span><\/span><\/span>\u65f6\uff0c\u7ec4\u5408\u540e\u836f\u6548\u4f5c\u7528\u8bc4\u5206\u589e\u5f3a\uff0c\u8d85\u8fc7\u4e2a\u4f53\u6210\u5206\u8bc4\u5206\uff0c\u5c55\u73b0\u51fa\u6cbb\u7597\u6548\u679c\u7684\u589e\u5f3a\u3002<\/span><\/span><\/span>\uff08\u56fe<\/span><\/span><\/span>3<\/span><\/span><\/span>\uff09<\/span><\/span><\/span><\/section>\n

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<\/p>\n
<\/section>\n

<\/span><\/section>\n

\u56fe<\/span><\/span><\/span>3<\/span><\/span><\/span>. HSPM<\/span><\/span><\/span>\u63ed\u793a\u836f\u7269\u7ec4\u5408\u4e2d\u7597\u6548\u7684\u589e\u5f3a\u3001\u51cf\u5f31\u548c\u65b0\u836f\u6548\u7684\u51fa\u73b0<\/span><\/span><\/span><\/section>\n
(A) 9<\/span><\/span><\/span>\u79cd\u5929\u7136\u836f\u7269\u5bf9\u75be\u75c5<\/span><\/span><\/span>A<\/span><\/span><\/span>\u7684<\/span><\/span><\/span>\u836f\u6548\u4f5c\u7528\u5206\u6570<\/span><\/span><\/span>\u3002\u56fe\u4e2d\u663e\u793a\u4e86<\/span><\/span><\/span>9<\/span><\/span><\/span>\u79cd\u5929\u7136\u836f\u7269\u5bf9\u75be\u75c5<\/span><\/span><\/span>A<\/span><\/span><\/span>\u7684\u836f\u6548\u5b66\u4f5c\u7528\u8bc4\u5206\uff0c\u5176\u4e2d\u6709\u6548\u836f\u7269<\/span><\/span><\/span>4<\/span><\/span><\/span>\u79cd\uff0c\u7597\u6548\u672a\u77e5\u836f\u7269<\/span><\/span><\/span>5<\/span><\/span><\/span>\u79cd\u3002\u8fd9\u4e9b\u836f\u7269\u88ab\u7ec4\u5408\u6210<\/span><\/span><\/span>5<\/span><\/span><\/span>\u79cd\u4e0d\u540c\u7684\u7ec4\u5408\u3002<\/span><\/span><\/span>(B) <\/span><\/span><\/span>\u5404\u5929\u7136\u836f\u7269\u53ca\u5176\u914d\u65b9\u5bf9\u75be\u75c5<\/span><\/span><\/span>A<\/span><\/span><\/span>\u7684<\/span><\/span><\/span>\u836f\u6548\u4f5c\u7528\u5206\u6570<\/span><\/span><\/span>\u6bd4\u8f83\u3002\u5176\u4e2d\uff0c\u7ec4\u5408<\/span><\/span><\/span>2<\/span><\/span><\/span>\u8868\u793a\u51fa\u73b0\u4e86\u65b0\u836f\u6548\uff0c\u7ec4\u5408<\/span><\/span><\/span>4<\/span><\/span><\/span>\u8868\u793a\u8be5\u836f\u7269\u7ec4\u5408\u589e\u5f3a\u4e86\u7597\u6548\uff0c\u7ec4\u5408<\/span><\/span><\/span>5<\/span><\/span><\/span>\u8868\u793a\u7597\u6548\u51cf\u5f31\uff0c\u5bfc\u81f4\u914d\u65b9\u65e0\u6548\u3002<\/span><\/span><\/span> (C)<\/span><\/span><\/span>\u548c<\/span><\/span><\/span>(D) <\/span><\/span><\/span>\u5c42\u6b21\u53e0\u52a0\u836f\u7406\u6a21\u578b\u5728\u5b9e\u9645\u7ec4\u65b9\u53ca\u5176\u5929\u7136\u836f\u7269\u7684\u5b9e\u9645\u5e94\u7528\uff1a<\/span><\/span><\/span>(C) <\/span><\/span><\/span>\u900d\u9065\u6563\uff08\u7531\u832f\u82d3\u3001\u7518\u8349\u3001\u767d\u828d\u3001\u767d\u672f\u3001\u5f53\u5f52\u3001\u67f4\u80e1\u7ec4\u6210\u7684\u7ec4\u65b9\uff09\u4e0e\u5176\u7ec4\u65b9\u836f\u7269\u7684<\/span><\/span><\/span>\u836f\u6548\u4f5c\u7528\u5206\u6570<\/span><\/span><\/span>\u6bd4\u8f83\u3002\u900d\u9065\u6563\u6cbb\u7597\u5341\u4e8c\u6307\u80a0\u6e83\u75a1\u548c\u80c6\u56ca\u708e\u7684\u7597\u6548\u663e\u8457\u589e\u5f3a\uff0c\u8868\u660e\u51fa\u73b0\u4e86\u65b0\u7684\u6cbb\u7597\u6548\u679c\u3002<\/span><\/span><\/span>(D) <\/span><\/span><\/span>\u75db\u6cfb<\/span><\/span><\/span>\u8981<\/span><\/span><\/span>\u65b9\uff08\u7531\u767d\u828d\u3001\u767d\u672f\u3001\u9648\u76ae\u3001\u9632\u98ce\u7ec4\u6210\u7684\u7ec4\u65b9\uff09\u4e0e\u5176\u7ec4\u65b9\u836f\u7269\u7684\u836f\u6548\u5b66\u4f5c\u7528\u8bc4\u5206\u6bd4\u8f83\u3002\u75db\u6cfb<\/span><\/span><\/span>\u8981<\/span><\/span><\/span>\u65b9\u6cbb\u7597\u6025\u6027\u80a0\u708e\u548c\u80a0\u6613\u6fc0\u7efc\u5408\u5f81\u7684\u7597\u6548\u540c\u6837\u589e\u5f3a\uff0c\u8868\u660e\u836f\u7269\u7ec4\u5408\u65f6\u51fa\u73b0\u4e86\u65b0\u7684\u6cbb\u7597\u6548\u679c\u3002<\/span><\/span><\/span><\/section>\n

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\u5728\u836f\u7269\u5f00\u53d1\u7684\u5e94\u7528\u65b9\u9762\uff0c<\/span><\/span><\/span>HSPM <\/span><\/span><\/span>\u8fd8\u80fd\u53d1\u73b0\u836f\u7269\u7ec4\u5408\u7684\u65b0\u6cbb\u7597\u6548\u679c\u3002\u4f8b\u5982\uff0c\u7d2b\u8349\u7d20\u4e0e\u6c34\u98de\u84df\u7d20\u8054\u5408\u5bf9\u809d\u7ec6\u80de\u764c<\/span>\uff08<\/span><\/span><\/span>HCC<\/span><\/span><\/span>\uff09<\/span>\u7684\u6291\u5236\u4f5c\u7528\u6b64\u524d\u672a\u6709\u7814\u7a76\u6216\u4e34\u5e8a\u8bc1\u636e\u8868\u660e\u5b58\u5728\u534f\u540c\u6548\u5e94\u3002<\/span><\/span><\/span>HSPM <\/span><\/span><\/span>\u8ba1\u7b97\u663e\u793a\uff0c\u7d2b\u8349\u7d20\u4e0e\u6c34\u98de\u84df\u7d20\u7ec4\u5408\u5bf9<\/span><\/span><\/span> HCC <\/span><\/span><\/span>\u7684\u836f<\/span><\/span><\/span>\u6548\u4f5c\u7528\u8bc4\u5206\uff08<\/span><\/span><\/span>T<\/span><\/span><\/span>C,S<\/span><\/span><\/sub><\/span> = 1.591\u00d710\u207b\u2074<\/span><\/span><\/span>\uff09\u9ad8\u4e8e\u5355\u4e00\u836f\u7269\uff0c\u4e14\u8d85\u8fc7\u836f\u6548\u4f5c\u7528\u9608\u503c\u3002\u7ec6\u80de\u5b9e\u9a8c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u8fd9\u4e00\u8ba1\u7b97\u7ed3\u679c\uff0c\u8868\u660e\u8be5\u7ec4\u5408\u80fd\u663e\u8457\u6291\u5236<\/span><\/span><\/span> HCC <\/span><\/span><\/span>\u7ec6\u80de\u589e\u6b96\u3002\u6b64\u5916\uff0c<\/span><\/span><\/span>HSPM <\/span><\/span><\/span>\u8fd8\u9884\u6d4b\u8335\u6800\u9ec4\u6ce8\u5c04\u6db2\u548c\u53cc\u9ec4\u8fde\u6ce8\u5c04\u6db2\u5bf9<\/span><\/span><\/span> HCC <\/span><\/span><\/span>\u5177\u6709\u6291\u5236\u6548\u679c\uff0c\u5b9e\u9a8c\u7ed3\u679c\u4e0e\u6a21\u578b\u9884\u6d4b\u9ad8\u5ea6\u4e00\u81f4\uff0c\u8bc1\u5b9e\u4e86\u6a21\u578b\u7684\u51c6\u786e\u6027\u3002<\/span><\/span><\/span>\uff08\u56fe<\/span><\/span><\/span>4<\/span><\/span><\/span>\uff09<\/span><\/span><\/span><\/section>\n

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<\/p>\n
<\/section>\n

<\/span><\/section>\n

\u56fe<\/span><\/span><\/span>4<\/span><\/span><\/span>\u5c42\u6b21\u53e0\u52a0\u836f\u6548\u52a8\u529b\u5b66\u6a21\u578b\u63ed\u793a\u7d2b\u8349\u7d20\u4e0e\u6c34\u98de\u84df\u5bbe\u3001\u53cc\u9ec4\u8fde\u3001\u8335\u6800\u9ec4\u5408\u7528\u5bf9<\/span><\/span><\/span>HCC<\/span><\/span><\/span>\u7684\u6291\u5236\u4f5c\u7528<\/span><\/span><\/span><\/span><\/section>\n
\u4eba\u4f53\u86cb\u767d\u8d28<\/span><\/span><\/span>–<\/span><\/span><\/span>\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528<\/span><\/span><\/span>(PPI)<\/span><\/span><\/span>\u7f51\u7edc\u4e2d\u90e8\u5206\u836f\u7269\u9776\u70b9\u4e0e<\/span><\/span><\/span>HCC<\/span><\/span><\/span>\u5f62\u6210\u7684\u5c40\u90e8\u8fde\u63a5\u7f51\u7edc\u63ed\u793a\u4e86\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\u6a21\u5f0f\u3002\u57fa\u4e8e\u8be5\u7f51\u7edc\u8ba1\u7b97\u836f\u7269\u53ca\u836f\u7269\u7ec4\u5408\u5bf9<\/span><\/span><\/span>HCC<\/span><\/span><\/span>\u7684\u836f\u6548\u52a8\u529b\u5b66\u4f5c\u7528\uff1a<\/span><\/span><\/span>(A) <\/span><\/span><\/span>\u7d2b\u8349\u7d20\u3001\u6c34\u98de\u84df\u5bbe\u53ca\u7d2b\u8349\u7d20\u4e0e\u6c34\u98de\u84df\u5bbe\u5408\u7528\u3002<\/span><\/span><\/span>(B) <\/span><\/span><\/span>\u836f\u7269\u7ec4\u5408<\/span><\/span><\/span>–<\/span><\/span><\/span>\u53cc\u9ec4\u8fde\u3002<\/span><\/span><\/span>(C) <\/span><\/span><\/span>\u836f\u7269\u7ec4\u5408<\/span><\/span><\/span>–<\/span><\/span><\/span>\u8335\u6800\u9ec4\u3002<\/span><\/span><\/span>(D) <\/span><\/span><\/span>\u4e0d\u540c\u6d53\u5ea6\u4e0b\u7d2b\u8349\u7d20\u3001\u6c34\u98de\u84df\u5bbe\u53ca\u7d2b\u8349\u7d20\u4e0e\u6c34\u98de\u84df\u5bbe\u5408\u7528\u5bf9<\/span><\/span><\/span>HepG2<\/span><\/span><\/span>\u548c<\/span><\/span><\/span>Huh7<\/span><\/span><\/span>\u7ec6\u80de\u589e\u6b96\u7684\u5f71\u54cd\uff08\u6a2a\u8f74\uff1a<\/span><\/span><\/span>log[M]<\/span><\/span><\/span>\uff09\u3002<\/span><\/span><\/span> (E) SHLI<\/span><\/span><\/span>\uff08\u53cc\u9ec4\u8fde\u6ce8\u5c04\u6db2\uff09\u548c<\/span><\/span><\/span>YZHI<\/span><\/span><\/span>\uff08\u8335\u6800\u9ec4\u6ce8\u5c04\u6db2\uff09\u5728\u4e0d\u540c\u6d53\u5ea6\u4e0b\u5bf9<\/span><\/span><\/span>HepG2<\/span><\/span><\/span>\u548c<\/span><\/span><\/span>Huh7<\/span><\/span><\/span>\u7ec6\u80de\u589e\u6b96\u7684\u5f71\u54cd\uff08<\/span><\/span><\/span>x<\/span><\/span><\/span>\u8f74\uff1a<\/span><\/span><\/span>log[g\/mL]<\/span><\/span><\/span>\uff09\u3002<\/span><\/span><\/span><\/section>\n

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<\/span><\/section>\n

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<\/section>\n<\/section>\n<\/section>\n
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\u603b\u7ed3\uff1a<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n

\u590d\u6742\u79d1\u5b66\u89c6\u89d2\u770b\u836f\u7406\uff0c\u62d3\u5c55\u5e94\u7528\u524d\u666f\u5e7f\u9614<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/span><\/p>\n

\u8fd9\u9879\u5de5\u4f5c<\/span><\/span><\/span>\u7531\u6df1\u5733\u6e05\u534e\u5927\u5b66\u7814\u7a76\u9662<\/span><\/span><\/span>\/<\/span><\/span><\/span>\u6e05\u534e\u5927\u5b66\u6df1\u5733\u56fd\u9645\u7814\u7a76\u751f\u9662<\/span><\/span><\/span>\u9ec4\u5609\u9a8f<\/span><\/span><\/span>\u3001<\/span><\/span><\/span>\u5f25\u80dc\u5229\u56e2\u961f\u5b8c\u6210\u5e76\u53d1\u8868\u3002<\/span><\/span><\/span>\u7814\u7a76\u65e8\u5728\u5efa\u7acb\u548c\u9610\u660e\u5206\u5c42\u53e0\u52a0\u6846\u67b6\u5728\u836f\u7406\u5b66\u4e2d\u7684\u5e94\u7528\uff0c\u5e76<\/span><\/span><\/span>\u9a8c\u8bc1\u5176\u5e7f\u6cdb\u7684\u9002\u7528\u6027\u548c\u8de8\u9886\u57df\u7684\u53ef\u8fc1\u79fb\u6027\u3002\u4f5c\u4e3a\u8be5\u6982\u5ff5\u7684\u5b9e\u9645\u4f53\u73b0\uff0c<\/span><\/span><\/span>HSPM <\/span><\/span><\/span>\u5728\u5176\u65e9\u671f<\/span><\/span><\/span>\u5f00\u53d1<\/span><\/span><\/span>\u4e2d\u9762\u4e34\u7740\u56e0\u4e3a\u5c42\u7ea7\u95f4\u89c4\u5219\u7684\u590d\u6742\u6027\u4ee5\u53ca\u7531\u4e8e\u53d8\u91cf\u4f17\u591a\u800c\u96be\u4ee5\u8ba1\u7b97<\/span><\/span><\/span>\u7684<\/span><\/span><\/span>\u6311\u6218\u3002\u56e0\u6b64\uff0c\u5373\u4f7f\u6709\u4e86\u65b0\u7684\u7406\u8bba\u89c1\u89e3\uff0c\u6211\u4eec\u4e5f\u4e0d\u5f97\u4e0d\u7b80\u5316\u6a21\u578b\u6784\u5efa\u4e2d\u7684\u590d\u6742\u6027\uff0c\u4ec5\u6355\u6349\u5c42\u7ea7\u95f4\u836f\u7406\u9014\u5f84\u7684\u4e0d\u53ef\u7ea6\u6027\u3002\u5c3d\u7ba1<\/span><\/span><\/span> HSPM <\/span><\/span><\/span>\u4e3a\u8bc4\u4f30\u548c\u7406\u89e3\u836f\u7269\u7ec4\u5408\u7684\u590d\u6742\u6548\u5e94\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6709\u524d\u666f\u7684\u6846\u67b6\uff0c\u4f46\u5b83\u4e5f\u5b58\u5728\u5c40\u9650\u6027\u3002\u6a21\u578b\u7684\u51c6\u786e\u6027\u53ef\u80fd\u53d7\u5230\u6570\u636e\u8d28\u91cf\u548c\u7f51\u7edc\u5b8c\u6574\u6027\u7684\u9650\u5236\u3002\u6b64\u5916\uff0c\u6539\u8fdb\u6a21\u578b\u4ee5\u66f4\u6709\u6548\u5730\u5904\u7406\u5c42\u7ea7\u7ed3\u6784\u7684\u590d\u6742\u6027\u4e5f\u662f\u4e00\u4e2a\u6311\u6218\u3002\u672a\u6765\u7684\u7814\u7a76\u5c06\u63a2\u7d22\u6574\u5408\u66f4\u591a\u751f\u7269\u4fe1\u606f\u5b66\u6570\u636e\uff0c\u4f8b\u5982\u591a\u7ef4\u6570\u636e\u548c\u8d2f\u7a7f\u6574\u4e2a\u75be\u75c5\u8f68\u8ff9\u7684\u52a8\u6001\u9776\u70b9\u7f51\u7edc\uff0c\u4ee5\u6784\u5efa\u66f4\u5168\u9762\u7684\u836f\u7406\u5b66\u6216\u75c5\u7406\u5b66\u6a21\u578b\u3002<\/span><\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n
HSPM <\/span><\/span><\/span>\u7684\u5e94\u7528<\/span><\/span><\/span>\u662f<\/span><\/span><\/span>\u590d\u6742\u7cfb\u7edf\u7406\u8bba\u5411\u836f\u7406\u5b66\u7684\u8de8\u5b66\u79d1\u62d3\u5c55<\/span><\/span><\/span>\u7684\u65b0\u5c1d\u8bd5<\/span><\/span><\/span>\u3002<\/span><\/span><\/span>\u5c24\u5176<\/span><\/span><\/span>\u5728\u4e2d\u836f\u7814\u7a76\u4e2d\uff0c\u4e2d\u836f\u590d\u65b9\u591a\u7ec4\u5206\u3001\u591a\u9776\u70b9\u7279\u6027\u4e0e<\/span><\/span><\/span> HSPM <\/span><\/span><\/span>\u591a\u5c42\u6b21\u5206\u6790\u6846\u67b6\u9ad8\u5ea6\u5951\u5408\uff0c\u4f7f\u5176\u80fd\u6df1\u5165\u89e3\u6790\u4e2d\u836f\u590d\u65b9\u6574\u4f53\u7597\u6548\u4e0e\u534f\u540c\u589e\u6548\u673a\u5236\uff0c\u4e3a<\/span><\/span><\/span>\u4f20\u7edf\u4e2d\u836f\u590d\u65b9\u7684\u79d1\u5b66\u89e3\u6790\u63d0\u4f9b<\/span><\/span><\/span>\u7406\u8bba<\/span><\/span><\/span>\u652f\u6301\u3002\u5728\u672a\u6765\uff0c\u968f\u7740\u66f4\u591a\u751f\u7269\u4fe1\u606f\u6570\u636e\u7684\u6574\u5408\uff0c\u4ee5\u53ca\u4eba\u5de5\u667a\u80fd\u7b49\u524d\u6cbf\u6280\u672f\u7684\u5f15\u5165\uff0c<\/span><\/span><\/span>HSPM <\/span><\/span><\/span>\u6709\u671b\u8fdb\u4e00\u6b65\u5b8c\u5584\uff0c\u66f4\u7cbe\u51c6\u5730\u5e94\u5bf9\u590d\u6742\u75be\u75c5\u6311\u6218\u3002<\/span><\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n
\u8be5\u7814\u7a76<\/span><\/span><\/span>\u6700\u521d\u7684\u7075\u611f\u6765\u81ea\u4e8e\u4e00\u4e2a<\/span><\/span><\/span>\u5947\u602a<\/span><\/span><\/span>\u7684<\/span><\/span><\/span>\u60f3\u6cd5<\/span><\/span><\/span>\uff1a\u201c<\/span><\/span><\/span>\u6211\u4eec\u80fd\u5426\u5c06\u836f\u7269\u9776\u70b9\u89c6\u4f5c\u8f93\u5165\u8282\u70b9\uff0c\u501f\u52a9\u8ba1\u7b97\u2018\u9690\u85cf\u5c42\u2019\u7684\u903b\u8f91\uff0c\u63a8\u5bfc\u51fa\u53e0\u52a0\u836f\u6548\u4f5c\u4e3a\u8f93\u51fa\u7ed3\u679c\uff1f<\/span><\/span><\/span>\u5c31\u50cf<\/span><\/span><\/span>\u6784\u5efa<\/span><\/span><\/span>\u4e00\u4e2a<\/span><\/span><\/span>\u6df1\u5ea6\u5b66\u4e60\u795e\u7ecf\u7f51\u7edc\u7684\u67b6\u6784<\/span><\/span><\/span>\u4e00\u6837\u3002<\/span><\/span><\/span>\u201d\u6211\u60f3\uff0c\u8fd9\u9879\u5de5\u4f5c<\/span><\/span><\/span>\u505a<\/span><\/span><\/span>\u51fa\u4e86\u4e00\u4e2a<\/span><\/span><\/span>\u5c1d\u8bd5<\/span><\/span><\/span>\u3002<\/span><\/span><\/span><\/section>\n

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\u53c2\u8003\u6587\u732e\uff1a<\/span><\/span><\/span><\/section>\n
[<\/span><\/span><\/span>1]<\/span><\/span><\/span><\/span>Anderson PW. More Is Different: Broken symmetry and the nature of the hierarchical structure of science. Science <\/span><\/span><\/span>1972;177:393<\/span><\/span><\/span>\u20136.<\/span><\/span><\/span><\/section>\n
[2]<\/span><\/span><\/span><\/span>H\u00e9bert-Dufresne L, Allard A, Garland J, Hobson EA, Zaman L. The path of complexity. <\/span><\/span><\/span>Npj<\/span><\/span><\/span> Complexity <\/span><\/span><\/span>2024;1:4<\/span><\/span><\/span>. https:\/\/doi.org\/10.1038\/s44260-024-00004-0.<\/span><\/span><\/span><\/section>\n
[3]<\/span><\/span><\/span><\/span>Sharma A, <\/span><\/span><\/span>Cz\u00e9gel<\/span><\/span><\/span> D, <\/span><\/span><\/span>Lachmann<\/span><\/span><\/span> M, <\/span><\/span><\/span>Kempes<\/span><\/span><\/span> CP, Walker SI, Cronin L. Assembly theory explains and quantifies selection and evolution. Nature <\/span><\/span><\/span>2023;622:321<\/span><\/span><\/span>\u20138. https:\/\/doi.org\/10.1038\/s41586-023-06600-9.<\/span><\/span><\/span><\/section>\n
[<\/span><\/span><\/span>4<\/span><\/span><\/span>]<\/span><\/span><\/span><\/span>Archibald JM. Endosymbiosis and eukaryotic cell evolution. Current Biology 2015;<\/span><\/span><\/span>25:R<\/span><\/span><\/span>911\u201321.<\/span><\/span><\/span><\/section>\n
[<\/span><\/span><\/span>5<\/span><\/span><\/span>]<\/span><\/span><\/span><\/span>Duval MX. The inadequacy of the reductionist approach in discovering new therapeutic agents against complex diseases. Experimental Biology and Medicine <\/span><\/span><\/span>2018;243:1004<\/span><\/span><\/span>\u201313.<\/span><\/span><\/span><\/section>\n
[<\/span><\/span><\/span>6<\/span><\/span><\/span>]<\/span><\/span><\/span><\/span>Sutherland JJ, <\/span><\/span><\/span>Yonchev<\/span><\/span><\/span> D, Fekete A, Urban L. A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs. Nature Communications <\/span><\/span><\/span>2023;14:4323<\/span><\/span><\/span>.<\/span><\/span><\/span><\/section>\n
[<\/span><\/span><\/span>7<\/span><\/span><\/span>]<\/span><\/span><\/span><\/span>Goldstein I, Burnett AL, Rosen RC, Park PW, Stecher VJ. The serendipitous story of sildenafil: an unexpected oral therapy for erectile dysfunction. Sexual Medicine Reviews <\/span><\/span><\/span>2019;7:115<\/span><\/span><\/span>\u201328.<\/span><\/span><\/span><\/section>\n
[<\/span><\/span><\/span>8<\/span><\/span><\/span>]<\/span><\/span><\/span><\/span>Culpepper L, Wingertzahn MA. Over-the-counter agents for the treatment of occasional disturbed sleep or transient insomnia: a systematic review of efficacy and safety. The Primary Care Companion for CNS Disorders <\/span><\/span><\/span>2015;17:26162<\/span><\/span><\/span>.<\/span><\/span><\/span><\/section>\n
[<\/span><\/span><\/span>9<\/span><\/span><\/span>]<\/span><\/span><\/span><\/span>Wang S, Chen L, Leng J, Chen P, Fan X, Cheng Y. Fragment ion diagnostic strategies for the comprehensive identification of chemical profile of Gui-Zhi-Tang by integrating high-resolution MS, multiple-stage MS and UV information. Journal of Pharmaceutical and Biomedical Analysis <\/span><\/span><\/span>2014;98:22<\/span><\/span><\/span>\u201335.<\/span><\/span><\/span><\/section>\n
[1<\/span><\/span><\/span>0<\/span><\/span><\/span>]<\/span><\/span><\/span><\/span>Wang Y, Liu B, Fu X, Tong T, Yu Z. Efficacy and safety of Si-Jun-Zi-Tang-based therapies for functional (non-ulcer) dyspepsia: a meta-analysis of randomized controlled trials. BMC Complementary Medicine and Therapies <\/span><\/span><\/span>2021;21:1<\/span><\/span><\/span>\u201311.<\/span><\/span><\/span><\/section>\n
[1<\/span><\/span><\/span>1<\/span><\/span><\/span>]<\/span><\/span><\/span><\/span>Dagar N, Kale A, Jadhav HR, Gaikwad AB. Nutraceuticals and network pharmacology approach for acute kidney injury: A review from the drug discovery aspect. <\/span><\/span><\/span>Fitoterapia<\/span><\/span><\/span><\/span>2023;168:105563<\/span><\/span><\/span>. https:\/\/doi.org\/10.1016\/j.fitote.2023.105563.<\/span><\/span><\/span><\/section>\n
[1<\/span><\/span><\/span>2<\/span><\/span><\/span>]<\/span><\/span><\/span><\/span><\/span>Padhy<\/span><\/span><\/span> I, Mahapatra A, Banerjee B, Sharma T. Computational approaches in drug discovery from phytochemicals. Phytochemistry, Computational Tools and Databases in Drug<\/span><\/span><\/span><\/section>\n

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\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1a<\/span><\/strong><\/p>\n

AI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u751f\u7269\u533b\u5b66\u662f\u4e00\u4e2a\u590d\u6742\u4e14\u5bcc\u6709\u6311\u6218\u6027\u7684\u9886\u57df\uff0c\u6d89\u53ca\u5230\u5927\u91cf\u7684\u6570\u636e\u5904\u7406\u3001\u6a21\u5f0f\u8bc6\u522b\u3001\u7406\u8bba\u6a21\u578b\u5efa\u6784\u548c\u5b9e\u9a8c\u9a8c\u8bc1\u7b49\u95ee\u9898\u3002AI\u57fa\u7840\u6a21\u578b\u7684\u5f15\u5165\uff0c\u4f7f\u5f97\u6211\u4eec\u80fd\u591f\u4ece\u524d\u6240\u672a\u6709\u7684\u89d2\u5ea6\u53bb\u89c2\u5bdf\u548c\u7406\u89e3\u8fd9\u4e2a\u9886\u57df\u7684\u95ee\u9898\uff0c\u52a0\u901f\u79d1\u5b66\u7814\u7a76\u7684\u6b65\u4f10\uff0c\u63d0\u9ad8\u533b\u7597\u670d\u52a1\u7684\u6548\u7387\u548c\u6548\u679c\u3002\u8fd9\u79cd\u4ea4\u53c9\u9886\u57df\u7684\u5408\u4f5c\uff0c\u6807\u5fd7\u7740\u6211\u4eec\u6b63\u5728\u5411\u79d1\u6280\u4e0e\u751f\u7269\u533b\u5b66\u6df1\u5ea6\u878d\u5408\u7684\u65b0\u65f6\u4ee3\u8fc8\u8fdb\uff0c\u5bf9\u4e8e\u63a8\u52a8\u79d1\u5b66\u7814\u7a76\u3001\u4f18\u5316\u533b\u7597\u670d\u52a1\u3001\u4fc3\u8fdb\u4eba\u7c7b\u5065\u5eb7\u6709\u7740\u6df1\u8fdc\u7684\u5f71\u54cd\u3002<\/span><\/span><\/section>\n

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\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u52a9\u7406\u6559\u6388\u5434\u6cf0\u9716\u3001\u65af\u5766\u798f\u5927\u5b66\u8ba1\u7b97\u673a\u79d1\u5b66\u7cfb\u535a\u58eb\u540e\u7814\u7a76\u5458\u738b\u701a\u5bb8\u3001\u535a\u58eb\u7814\u7a76\u751f\u9ec4\u67ef\u946b\u3001\u9ec4\u5029\uff0c\u534e\u76db\u987f\u5927\u5b66\u535a\u58eb\u7814\u7a76\u751f\u5c60\u946b\u660e\uff0c\u5171\u540c\u53d1\u8d77\u4ee5\u201c\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\u201d\u4e3a\u4e3b\u9898\u7684\u8bfb\u4e66\u4f1a\uff0c<\/span>\u5171\u5b66\u5171\u7814\u76f8\u5173\u6587\u732e\uff0c<\/span><\/span><\/span>\u63a2\u8ba8\u57fa\u7840\u6a21\u578b\u5728\u751f\u7269\u533b\u5b66\u7b49\u79d1\u5b66\u9886\u57df\u7684\u5e94\u7528\u3001\u5f71\u54cd\u548c\u5c55\u671b\u3002<\/span><\/span><\/span><\/span>\u8bfb\u4e66\u4f1a\u5df2\u5b8c\u7ed3\uff0c\u73b0\u5728\u62a5\u540d\u53ef\u52a0\u5165\u793e\u7fa4\u5e76\u89e3\u9501<\/span><\/span>\u56de\u653e<\/span><\/span>\u89c6\u9891\u6743\u9650\u3002<\/span><\/span><\/span><\/section>\n

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\"\u56fe\u7247\"<\/span><\/a><\/section>\n

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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/span><\/span><\/p>\n

\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/a><\/span><\/span>
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\u63a8\u8350\u9605\u8bfb<\/span><\/span><\/strong><\/strong><\/strong><\/section>\n
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1. AI for \u836f\u7269\u53d1\u73b0\u95ee\u9898\u8bf7\u6559\uff1a\u80fd\u5426\u7528AI\u8ba1\u7b97\u83b7\u5f97\u5355\u5206\u5b50\u632f-\u8f6c\u8fd0\u52a8\u7684\u65f6\u7a7a\u56fe\u50cf\u53ca\u53c2\u6570\uff1f<\/span><\/a><\/span><\/strong>
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2. Nat. Mach. Intell. \u901f\u9012\uff1a\u57fa\u4e8e\u529f\u80fd\u63d0\u793a\u7684\u77e5\u8bc6\u56fe\u8c31\u53d1\u73b0\u65b0\u836f\u7269<\/span><\/a><\/span>
<\/span><\/strong><\/strong><\/section>\n
3. \u7814\u7a76\u901f\u9012\uff1aGNN\u80fd\u5426\u5b66\u4e60\u66f4\u597d\u7684\u5206\u5b50\u8868\u5f81\u7528\u4e8e\u836f\u7269\u53d1\u73b0\uff1f<\/span><\/a><\/span>
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4. <\/span><\/strong><\/span>\u6e38\u620f\u5316\u79d1\u7814\u2014\u2014\u8ba9\u6211\u4eec\u7a81\u7834\u5185\u5377\u3001\u5171\u7814\u6d8c\u73b0<\/a><\/span><\/strong><\/strong><\/span><\/section>\n
<\/strong>5.  <\/span><\/strong>\u63a2\u7d22\u8005\u8ba1\u5212 | \u96c6\u667a\u4ff1\u4e50\u90e82025\u5185\u5bb9\u56e2\u961f\u62db\u52df\uff08\u5168\u804c&\u517c\u804c\uff09<\/a><\/span><\/strong><\/span><\/section>\n

6. \u52a0\u5165\u96c6\u667a\uff0c\u73a9\u8f6c\u590d\u6742\uff0c\u5171\u521b\u6591\u56fe\uff01\u96c6\u667a\u4ff1\u4e50\u90e8\u7ebf\u4e0b\u5fd7\u613f\u8005\u62db\u52df<\/span><\/a><\/span><\/strong>
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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/span><\/span><\/section>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc\u8bed \u7269\u8d28\u95f4\u76f8\u4e92\u4f5c\u7528\u5e38\u4ee5\u5c42\u6b21\u7ed3\u6784\u5448\u73b0\uff0c\u5404\u5c42\u6b21\u6709\u72ec\u7279\u7684\u76f8\u4e92\u4f5c\u7528\u89c4\u5219\u800c\u5e76\u975e\u8f83\u4f4e\u5c42\u6b21\u89c4\u5219\u7684\u7b80\u5355\u53e0\u52a0\uff0c\u6574\u4f53\u6d8c\u73b0\u7279\u6027\u5e38\u5e38\u96be\u4ee5\u4ece\u4e2a\u4f53\u6027\u8d28\u76f4\u63a5\u63a8\u65ad\u3002\u751f\u7269\u7cfb\u7edf\u7684\u590d\u6742\u6027\u53d7\u5c42\u7ea7\u89c4\u5219\u548c\u6f14\u5316\u8def\u5f84\u8282\u70b9\u6240\u643a\u5e26\u7684\u5386\u53f2\u652f\u914d\uff0c\u4f1a\u4ea7\u751f\u6700\u521d\u5e76\u4e0d\u5b58\u5728\u4e14\u770b\u4f3c\u4e0d\u53ef\u80fd\u51fa\u73b0\u7684\u6027\u72b6\uff0c\u5e76\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u901a\u8fc7\u56e0\u679c\u94fe\u4e0d\u65ad\u6f14\u5316\u3002\u8fd9\u4f53\u73b0\u5728\u591a\u4e2a\u5c3a\u5ea6\u7684\u751f\u7269\u7cfb\u7edf\u4e2d\uff0c…<\/p>\n","protected":false},"author":0,"featured_media":60265,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/60275"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=60275"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/60275\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/60265"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=60275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=60275"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=60275"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=60275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}