{"id":60351,"date":"2025-06-02T20:02:41","date_gmt":"2025-06-02T12:02:41","guid":{"rendered":"https:\/\/swarma.org\/?p=60351"},"modified":"2025-06-02T20:02:41","modified_gmt":"2025-06-02T12:02:41","slug":"%e8%a1%b0%e8%80%81%e7%9a%84%e7%bb%88%e6%9e%81%e8%b0%9c%e9%a2%98%ef%bc%9a%e6%8f%ad%e5%bc%80%e7%ab%af%e7%b2%92%e4%b8%8erdna%e7%9a%84%e8%b0%83%e6%8e%a7%e9%9d%a2%e7%ba%b1","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=60351","title":{"rendered":"\u8870\u8001\u7684\u7ec8\u6781\u8c1c\u9898\uff1a\u63ed\u5f00\u7aef\u7c92\u4e0erDNA\u7684\u8c03\u63a7\u9762\u7eb1"},"content":{"rendered":"
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\u5173\u952e\u8bcd\uff1a\u8870\u8001\u6807\u5fd7\uff08Aging Hallmarks\uff09\u3001\u56e0\u679c\u5173\u7cfb\uff08Causality\uff09\u3001\u7aef\u7c92\uff08Telomere\uff09\u3001\u6838\u7cd6\u4f53DNA\uff08rDNA\uff09\u3001P53\u901a\u8def\u3001\u7a0b\u5e8f\u5316\u8870\u8001<\/span>
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\u8bba\u6587\u9898\u76ee\uff1aCausality of Aging Hallmarks<\/span><\/span><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.aginganddisease.org\/EN\/10.14336\/AD.2025.0541<\/span><\/span><\/p>\n

\u53d1\u8868\u65f6\u95f4\uff1a2025\u5e745\u670820\u65e5<\/span><\/span><\/p>\n

\u8bba\u6587\u6765\u6e90\uff1aAging and Disease<\/span><\/span><\/p>\n<\/blockquote>\n


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\u4eba\u7c7b\u5bf9\u8870\u8001\u673a\u5236\u7684\u63a2\u7d22\u4ece\u672a\u505c\u6b62\u30022023\u5e74 Cell \u671f\u520a\u63d0\u51fa\u7684\u201c\u8870\u8001\u5341\u4e8c\u5927\u6807\u5fd7\u201d\u6846\u67b6\uff0c\u5c06\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u3001\u7aef\u7c92\u635f\u8017\u3001\u8868\u89c2\u9057\u4f20\u6539\u53d8\u7b49\u73b0\u8c61\u7eb3\u5165\u8870\u8001\u7279\u5f81\uff0c\u4f46\u672a\u80fd\u9610\u660e\u5176\u56e0\u679c\u5173\u7cfb\u30022025\u5e74\u53d1\u8868\u4e8e Aging and Disease \u7684\u8fd9\u9879\u7814\u7a76\u76f4\u51fb\u6838\u5fc3\uff0c\u63d0\u51fa\u7aef\u7c92\uff08Telomere\uff09\u4e0e\u6838\u7cd6\u4f53DNA\uff08rDNA\uff09\u7684\u534f\u540c\u7f29\u77ed\u662f\u9a71\u52a8\u7ec6\u80de\u7a0b\u5e8f\u5316\u8870\u8001\u7684\u6839\u672c\u539f\u56e0\uff0c\u800c\u5176\u4ed6\u8870\u8001\u6807\u5fd7\u5747\u4e3a\u8fd9\u4e00\u8fc7\u7a0b\u7684\u884d\u751f\u7ed3\u679c\u3002\u8fd9\u4e00\u53d1\u73b0\u4e0d\u4ec5\u6311\u6218\u4f20\u7edf\u7406\u8bba\uff0c\u66f4\u4e3a\u6297\u8870\u8001\u5e72\u9884\u63d0\u4f9b\u4e86\u5168\u65b0\u65b9\u5411\u3002<\/span><\/span><\/section>\n

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\u7a0b\u5e8f\u5316\u8870\u8001\u7684\u6838\u5fc3\u5728\u4e8e\u57fa\u56e0\u8868\u8fbe\u7684\u65f6\u5e8f\u5207\u6362\u3002\u4ee5\u809d\u7ec6\u80de\u4e3a\u4f8b\uff0c\u5728\u80da\u80ce\u671f\u8868\u8fbe\u7532\u80ce\u86cb\u767d\uff08AFP\uff09\uff0c\u6210\u5e74\u540e\u8f6c\u4e3a\u767d\u86cb\u767d\uff08Albumin\uff09\uff0c\u8001\u5e74\u671f\u5219\u51fa\u73b0\u529f\u80fd\u7d0a\u4e71\u86cb\u767d\u3002\u8fd9\u79cd\u6a21\u5f0f\u5207\u6362\u7531\u7aef\u7c92\u4e0erDNA\u7ec4\u6210\u7684\u201c\u5206\u5b50\u65f6\u949f\u201d\u9a71\u52a8\u2014\u2014\u4e24\u8005\u5747\u4e3a\u591a\u62f7\u8d1d\u4e32\u8054\u91cd\u590d\u5e8f\u5217\uff0c\u5728\u7ec6\u80de\u5206\u88c2\u4e2d\u4e0d\u53ef\u9006\u7f29\u77ed\uff0c\u901a\u8fc7\u6fc0\u6d3bP53\u4fe1\u53f7\u5f62\u6210\u6d53\u5ea6\u68af\u5ea6\uff0c\u9010\u6b65\u6539\u5199\u57fa\u56e0\u8868\u8fbe\u8c31\uff08\u56fe1\uff09\u3002<\/span><\/span><\/p>\n

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\u56fe 1. \u7ec6\u80de\u8870\u8001\u7684\u7aef\u7c92DNA\u548c\u6838\u7cd6\u4f53DNA\u5171\u8c03\u63a7\u6a21\u578b\u3002<\/span><\/span><\/p>\n

\u5de6\uff1a\u7aef\u7c92\u548crDNA\u957f\u6392\u5217\u7684\u67d3\u8272\u4f53\uff1aP53\u8fc5\u901f\u964d\u89e3\uff0cP53\u6c34\u5e73\u4f4e\uff0c\u7ec6\u80de\u5e74\u8f7b\u3002\u53f3\uff1a\u7aef\u7c92\u548crDNA\u77ed\u6392\u5217\u7684\u67d3\u8272\u4f53\uff1aP53\u7f13\u6162\u964d\u89e3\uff0cP53\u6c34\u5e73\u9ad8\uff0c\u7ec6\u80de\u8001\u5316\u3002<\/span><\/span><\/p>\n


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1. \u53cc\u65f6\u949f\u673a\u5236<\/span><\/span>\uff1a\u7aef\u7c92\u4f4d\u4e8e\u67d3\u8272\u4f53\u672b\u7aef\uff0crDNA\u96c6\u4e2d\u4e8e\u8fd1\u7aef\u7740\u4e1d\u7c92\u67d3\u8272\u4f53\u77ed\u81c2\uff0c\u4e24\u8005\u5747\u901a\u8fc7\u8f6c\u5f55\u635f\u8017\u957f\u5ea6\uff0c\u4e14\u7f29\u77ed\u901f\u7387\u540c\u6b65\uff08\u7ea6\u6bcf\u5e746420bp\uff09\u3002<\/span><\/span><\/p>\n

2. P53\u7684\u4e2d\u4ecb\u4f5c\u7528<\/span><\/span>\uff1a\u5e74\u8f7b\u7ec6\u80de\u4e2d\u957f\u7aef\u7c92\/rDNA\u53ef\u5feb\u901f\u964d\u89e3P53\uff0c\u4fdd\u6301\u4f4e\u6c34\u5e73\uff1b\u968f\u7740\u7f29\u77ed\uff0cP53\u7d2f\u79ef\u5e76\u6291\u5236\u7ec4\u86cb\u767d\u4e59\u9170\u5316\uff0c\u5bfc\u81f4\u67d3\u8272\u8d28\u51dd\u805a\u3001\u8f6c\u5f55\u6548\u7387\u4e0b\u964d\u3002\u6572\u4f4e\u5c0f\u9f20\u5e72\u7ec6\u80de\u4e2d45S rDNA\u62f7\u8d1d\u6570\uff0cP53\/P21\/P16\u7b49\u8870\u8001\u6807\u5fd7\u663e\u8457\u4e0a\u8c03\uff0c\u7ec6\u80de\u5206\u88c2\u80fd\u529b\u9aa4\u964d\u3002<\/span><\/span><\/p>\n

3. \u975e\u5206\u88c2\u7ec6\u80de\u7684\u8870\u8001\u5bc6\u94a5<\/span><\/span>\uff1a\u5728\u7ec8\u672b\u5206\u5316\u7ec6\u80de\u4e2d\uff0crDNA\u5355\u72ec\u627f\u62c5\u201c\u8ba1\u65f6\u201d\u529f\u80fd\u3002\u679c\u874740\u5929\u5bff\u547d\u5185rDNA\u62f7\u8d1d\u6570\u51cf\u534a\uff0c\u5176\u4e32\u8054\u91cd\u590d\u7ed3\u6784\u8bbe\u8ba1\u6070\u4f3c\u4e3a\u8870\u8001\u201c\u91cf\u8eab\u5b9a\u5236\u201d\u3002<\/span><\/span><\/p>\n


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1. \u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\uff08Genomic Instability\uff09<\/span><\/span><\/h4>\n

\u4f20\u7edf\u7406\u8bba\u8ba4\u4e3a\u7aef\u7c92\u8fc7\u77ed\u5f15\u53d1\u67d3\u8272\u4f53\u878d\u5408\uff0c\u4f46\u8001\u5e74\u7ec6\u80de\u4e2d\u6b8b\u7559\u7aef\u7c92\u4ecd\u8fdc\u8d85\u5b89\u5168\u9608\u503c\u3002\u771f\u76f8\u5728\u4e8e\uff1aP53\u6291\u5236\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\uff08HDAC\uff09\u548cDNA\u7532\u57fa\u8f6c\u79fb\u9176\uff08DNMT1\uff09\uff0c\u5bfc\u81f4\u5f02\u67d3\u8272\u8d28\u533a\u7a33\u5b9a\u6027\u4e27\u5931\u3002\u4f8b\u5982\uff0c\u6572\u9664rDNA\u7684\u5c0f\u9f20\u9020\u8840\u5e72\u7ec6\u80de\u4e2d\uff0c\u7740\u4e1d\u7c92\u86cb\u767dCENP-A\u8868\u8fbe\u4e0b\u8c03\uff0c\u67d3\u8272\u4f53\u5206\u79bb\u9519\u8bef\u7387\u6fc0\u589e\u3002<\/span><\/span><\/h4>\n


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2. \u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\uff08Mitochondrial Dysfunction\uff09<\/span><\/span><\/h4>\n

P53\u901a\u8fc7\u6291\u5236SIRT1-PGC1\u03b1\u8f74\uff0c\u5173\u95ed\u7ebf\u7c92\u4f53\u751f\u7269\u5408\u6210\u3002\u5b9e\u9a8c\u663e\u793a\uff0c\u7aef\u7c92\u5ef6\u957f\u7684\u5c0f\u9f20\u7ebf\u7c92\u4f53DNA\u635f\u4f24\u51cf\u5c1150%\uff0c\u800c\u6297\u6c27\u5316\u5242\u7ef4\u751f\u7d20C\u867d\u63d0\u5347\u7ebf\u7c92\u4f53\u6d3b\u6027\uff0c\u5374\u56e0\u52a0\u901f\u201c\u5206\u5b50\u65f6\u949f\u201d\u7f29\u77ed\u5bff\u547d\u3002<\/span><\/span><\/h4>\n


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3. \u6162\u6027\u708e\u75c7\uff08Chronic Inflammation\uff09<\/span><\/span><\/h4>\n

\u8870\u8001\u7ec6\u80de\u91ca\u653e\u7684mtDNA\u7247\u6bb5\u6fc0\u6d3bcGAS-STING\u901a\u8def\uff0c\u5f15\u53d1\u201c\u65e0\u83cc\u6027\u708e\u75c7\u201d\u3002\u4f46\u6e05\u9664\u8870\u8001\u7ec6\u80de\u7684\u836f\u7269\u8fbe\u6c99\u66ff\u5c3c\uff08Dasatinib\uff09\u53cd\u800c\u52a0\u901f\u5375\u5de2\u8870\u8001\u2014\u2014\u708e\u75c7\u662f\u8870\u8001\u7684\u7ed3\u679c\u800c\u975e\u539f\u56e0\uff0c\u5173\u952e\u4ecd\u5728\u4e8e\u9006\u8f6c\u5e72\u7ec6\u80de\u7aef\u7c92\/rDNA\u635f\u8017\u3002<\/span><\/span><\/h4>\n
<\/section>\n

\u56fe2. \u7531\u7aef\u7c92\u548crDNA\u901a\u8fc7P53\u4ecb\u5bfc\u7684\u8870\u8001\u768411\u4e2a\u4e3b\u8981\u6807\u5fd7\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

<\/span><\/section>\n

\n
\n
\n
\n
\n

<\/span><\/section>\n

<\/span><\/section>\n
\n
<\/section>\n<\/section>\n<\/section>\n
\n

\u6297\u8870\u8001\u7684\u672a\u6765\uff1a\u91cd\u7f16\u7a0b\u201c\u5206\u5b50\u6c99\u6f0f\u201d<\/span><\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/span><\/p>\n


<\/span><\/h3>\n

\u5f53\u524d\u6297\u8870\u8001\u7b56\u7565\u591a\u805a\u7126\u4e8e\u8868\u89c2\u9057\u4f20\u4fee\u9970\u6216\u6e05\u9664\u8870\u8001\u7ec6\u80de\uff0c\u4f46\u7814\u7a76\u8868\u660e\uff1a<\/span><\/span><\/p>\n

1. \u8868\u89c2\u9057\u4f20\u65f6\u949f\u7684\u5c40\u9650\u6027<\/span><\/span>\uff1a\u751f\u957f\u6fc0\u7d20\u53ef\u9006\u8f6cDNA\u7532\u57fa\u5316\u5e74\u9f84\uff0c\u5374\u900f\u652f\u7aef\u7c92\u50a8\u5907\uff0c\u52a0\u901f\u5b9e\u9645\u8870\u8001\u3002<\/span><\/span><\/p>\n

2. \u5e72\u7ec6\u80de\u79fb\u690d\u7684\u56f0\u5c40<\/span><\/span>\uff1a\u81ea\u4f53\u5e72\u7ec6\u80de\u4f53\u5916\u6269\u589e\u5f15\u53d1\u590d\u5236\u8870\u8001\uff0c\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSC\uff09\u5219\u9762\u4e34\u9ad8\u7a81\u53d8\u7387\u3002<\/span><\/span><\/p>\n

\u771f\u6b63\u7a81\u7834\u5728\u4e8e\u76f4\u63a5\u5ef6\u957f\u7ec4\u7ec7\u5e72\u7ec6\u80de\u4e2d\u7684\u7aef\u7c92\u4e0erDNA\u9635\u5217\u3002\u5b9e\u9a8c\u8bc1\u5b9e\uff0c\u7aef\u7c92\u9176\u6fc0\u6d3b\u53ef\u4f7f\u5c0f\u9f20\u5bff\u547d\u5ef6\u957f40%\uff0c\u6bdb\u8272\u6062\u590d\u5e74\u8f7b\u6001\u3002\u672a\u6765\uff0c\u9488\u5bf9300\u4f59\u79cd\u7ec4\u7ec7\u5e72\u7ec6\u80de\u7684\u201c\u5206\u5b50\u6c99\u6f0f\u201d\u4fee\u590d\uff0c\u6216\u5c06\u6210\u4e3a\u9006\u8f6c\u8870\u8001\u7684\u7ec8\u6781\u7b54\u6848\u3002<\/span><\/span><\/p>\n

\u5f6d\u6668\uff5c\u7f16\u8bd1<\/span><\/span><\/p>\n

\n
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\n
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\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a<\/span><\/strong><\/p>\n

\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/span><\/strong>
<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/span><\/section>\n

\u5728\u751f\u7269\u5b66\u4e2d\u5fc3\u6cd5\u5219\u7684\u8d77\u70b9\uff0c\u57fa\u56e0\u4f5c\u4e3a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u9057\u4f20\u4fe1\u606f\u8f7d\u4f53\uff0c\u5728\u751f\u547d\u5468\u671f\u5185\u7a33\u5b9a\u5b58\u5728\uff1b\u800c\u4f4d\u4e8e\u4e2d\u5fc3\u6cd5\u5219\u672b\u7aef\u7684\u86cb\u767d\u8d28\uff0c\u5176\u7ec4\u7ec7\u6784\u6210\u548c\u65f6\u7a7a\u53d8\u5316\u7684\u590d\u6742\u6027\u5448\u6307\u6570\u5f0f\u589e\u957f\u3002\u968f\u7740\u5206\u5b50\u751f\u7269\u5b66\u6570\u5341\u5e74\u6765\u7684\u7a81\u98de\u731b\u8fdb\uff0c\u5c24\u5176\u662f\u751f\u547d\u7ec4\u5b66\uff08\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7b49\u7684\u96c6\u5408\uff09\u7b49\u9886\u57df\u7684\u65e5\u65b0\u6708\u5f02\uff0c\u5f53\u4ee3\u751f\u547d\u79d1\u5b66\u4e34\u8fd1\u7206\u53d1\u7684\u8fb9\u7f18\u3002\u5982\u6b64\u6d77\u91cf\u7684\u6570\u636e\u5982\u4f55\u5e2e\u52a9\u6211\u4eec\u63ed\u793a\u5b87\u5b99\u4e2d\u6700\u590d\u6742\u7684\u7269\u8d28\u7cfb\u7edf\u2014\u2014\u201c\u4eba\u4f53\u201d\u7684\u6784\u6210\u539f\u7406\u548c\u8bbe\u8ba1\u539f\u7406\uff1f\u9610\u91ca\u4eba\u7c7b\u53d1\u80b2\u3001\u8870\u8001\u548c\u91cd\u5927\u75be\u75c5\u7684\u53d1\u751f\u673a\u5236\uff1f<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u7406\u5b66\u9662\u53ca\u4ea4\u53c9\u79d1\u5b66\u4e2d\u5fc3\u8bb2\u5e2d\u6559\u6388\u6c64\u96f7\u7ff0\uff0c\u56fd\u5bb6\u86cb\u767d\u8d28\u79d1\u5b66<\/span><\/span>\u4e2d\u5fc3\uff08\u5317\u4eac\uff09\u526f\u7814\u7a76\u5458\u5e38\u4e58\u3001\u674e\u6768\uff0c\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\u52a9\u7406\u6559\u6388\u5510\u4e7e\u5143\uff0c\u5317\u4eac\u5927\u5b66\u524d\u6cbf\u4ea4\u53c9\u5b66\u79d1\u7814\u7a76\u9662\u7814\u7a76\u5458\u6797\u4e00\u701a\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5206\u5b50\u7ec6\u80de\u79d1\u5b66\u5353\u8d8a\u521b\u65b0\u4e2d\u5fc3\u535a\u58eb\u540e\u5510\u8bd7\u5a55\uff0c\u5171\u540c\u53d1\u8d77<\/span><\/span>\u300c\u751f\u547d\u590d\u6742\u6027\uff1a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406\u300d\u8bfb\u4e66\u4f1a<\/a><\/span>\uff0c\u4ece\u5fae\u89c2\u7ec6\u80de\u5c3a\u5ea6\u3001\u4ecb\u89c2\u7ec4\u7ec7\u5668\u5b98\u5c3a\u5ea6\u5230\u5b8f\u89c2\u4eba\u4f53\u5c3a\u5ea6\uff0c\u68b3\u7406\u751f\u547d\u79d1\u5b66\u9886\u57df\u4e2d\u7684\u91cd\u8981\u95ee\u9898\u53ca\u91cd\u8981\u6570\u636e\uff0c\u7531\u751f\u7269\u5b66\u5bb6\u63d0\u95ee\uff0c\u5e0c\u671b\u4fc3\u8fdb\u7edf\u8ba1\u7269\u7406\u3001\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u7814\u7a76\u8005\u548c\u751f\u547d\u79d1\u5b66\u7814\u7a76\u8005\u4e4b\u95f4\u7684\u6df1\u5ea6\u4ea4\u6d41\uff0c\u5efa\u7acb\u8de8\u5b66\u79d1\u5408\u4f5c\u5173\u7cfb\uff0c\u6fc0\u53d1\u65b0\u7684\u7814\u7a76\u601d\u8def\u548c\u5408\u4f5c\u9879\u76ee\u3002\u8bfb\u4e66\u4f1a\u76ee\u524d\u5171\u8fdb\u884c10\u671f\uff0c\u73b0\u5728\u62a5\u540d\u53c2\u4e0e\u8bfb\u4e66\u4f1a\u53ef\u4ee5\u52a0\u5165\u8bfb\u4e66\u4f1a\u793e\u7fa4\uff0c\u89c2\u770b\u89c6\u9891\u56de\u653e\uff0c\u89e3\u9501\u5b8c\u6574\u8bfb\u4e66\u4f1a\u6743\u9650\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/section>\n
\"\u56fe\u7247\"<\/span><\/a><\/span><\/strong><\/span><\/section>\n

<\/span><\/span><\/section>\n
\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/span><\/section>\n
\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a\u4ece\u5fae\u89c2\u5230\u5b8f\u89c2\uff0c\u591a\u5c3a\u5ea6\u89c6\u89d2\u63a2\u7d22\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/a><\/span><\/span><\/section>\n


<\/span><\/p>\n

\u63a8\u8350\u9605\u8bfb<\/span><\/span><\/strong><\/span><\/strong><\/strong><\/p>\n

Cell \u901f\u9012\uff1a\u8870\u8001\u768412\u4e2a\u6807\u5fd7<\/span><\/a><\/span><\/strong><\/span><\/strong><\/strong><\/p>\n

\u8870\u8001\u662f\u4e00\u79cd\u6d8c\u73b0\u7279\u5f81\u2014\u2014\u4ece\u590d\u6742\u7cfb\u7edf\u89c6\u89d2\u770b\u8870\u8001<\/span><\/a><\/span><\/strong><\/strong><\/strong><\/p>\n

Cell\u901f\u9012\uff1a\u4fe1\u606f\u8bba\u89c6\u89d2\u4e0b\u7684\u8870\u8001\uff1a\u8868\u89c2\u9057\u4f20\u4fe1\u606f\u4e22\u5931\u662f\u54fa\u4e73\u52a8\u7269\u8870\u8001\u7684\u539f\u56e0\u4e4b\u4e00<\/span><\/a><\/span><\/strong><\/strong><\/strong><\/p>\n


<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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