{"id":60373,"date":"2025-06-03T21:29:30","date_gmt":"2025-06-03T13:29:30","guid":{"rendered":"https:\/\/swarma.org\/?p=60373"},"modified":"2025-06-03T21:29:30","modified_gmt":"2025-06-03T13:29:30","slug":"science%ef%bc%9a%e5%a4%a7%e8%af%ad%e8%a8%80%e6%a8%a1%e5%9e%8b%e6%a8%a1%e6%8b%9f5%e4%ba%bf%e5%b9%b4%e8%bf%9b%e5%8c%96%ef%bc%8c%e5%bc%80%e5%90%af%e8%9b%8b%e7%99%bd%e8%b4%a8%e8%ae%be%e8%ae%a1%e6%96%b0","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=60373","title":{"rendered":"Science\uff1a\u5927\u8bed\u8a00\u6a21\u578b\u6a21\u62df5\u4ebf\u5e74\u8fdb\u5316\uff0c\u5f00\u542f\u86cb\u767d\u8d28\u8bbe\u8ba1\u65b0\u7eaa\u5143"},"content":{"rendered":"
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\u8d85\u8fc7 30 \u4ebf\u5e74\u7684\u8fdb\u5316\u5728\u5929\u7136\u86cb\u767d\u8d28\u7684\u7a7a\u95f4\u4e2d\u5f62\u6210\u4e86\u751f\u7269\u5b66\u7684\u56fe\u666f\u3002\u5728\u6b64\uff0c\u6211\u4eec\u5c55\u793a\u4e86\u5927\u89c4\u6a21\u8bad\u7ec3\u7684\u57fa\u4e8e\u8fdb\u5316\u6570\u636e\u7684\u8bed\u8a00\u6a21\u578b\u80fd\u591f\u751f\u6210\u4e0e\u5df2\u77e5\u86cb\u767d\u8d28\u76f8\u53bb\u751a\u8fdc\u7684\u529f\u80fd\u6027\u86cb\u767d\u8d28\u3002\u6211\u4eec\u63a8\u51fa\u4e86 ESM3\uff0c\u8fd9\u662f\u4e00\u79cd\u524d\u6cbf\u7684\u591a\u6a21\u6001\u751f\u6210\u8bed\u8a00\u6a21\u578b\uff0c\u80fd\u591f\u5bf9\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u8fdb\u884c\u63a8\u7406\u3002ESM3 \u80fd\u591f\u9075\u5faa\u7ed3\u5408\u5176\u6a21\u6001\u7684\u590d\u6742\u63d0\u793a\uff0c\u5e76\u4e14\u5bf9\u9f50\u5ea6\u7684\u63d0\u9ad8\u80fd\u663e\u8457\u63d0\u5347\u5176\u51c6\u786e\u6027\u3002\u6211\u4eec\u63d0\u793a ESM3 \u751f\u6210\u8367\u5149\u86cb\u767d\u3002\u5728\u6211\u4eec\u5408\u6210\u7684\u751f\u6210\u7269\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0\u4e86\u4e00\u79cd\u4e0e\u5df2\u77e5\u8367\u5149\u86cb\u767d\u76f8\u8ddd\u751a\u8fdc\uff08\u5e8f\u5217\u540c\u6e90\u6027\u4e3a 58%\uff09\u7684\u660e\u4eae\u8367\u5149\u86cb\u767d\uff0c\u636e\u4f30\u8ba1\u8fd9\u76f8\u5f53\u4e8e\u6a21\u62df\u4e86 5 \u4ebf\u5e74\u7684\u8fdb\u5316\u3002<\/span><\/span><\/span><\/strong><\/p>\n


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\u5173\u952e\u8bcd\uff1a\u86cb\u767d\u8d28\u8bbe\u8ba1\uff08Protein Design\uff09\u3001\u8bed\u8a00\u6a21\u578b\uff08Language Model\uff09\u3001\u8fdb\u5316\u6a21\u62df\uff08Evolution Simulation\uff09\u3001ESM3\u3001\u8367\u5149\u86cb\u767d\uff08Fluorescent Protein\uff09\u3001\u591a\u6a21\u6001\u751f\u6210\uff08Multimodal Generation\uff09<\/span><\/span><\/span><\/strong><\/p>\n<\/section>\n

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\u8bba\u6587\u9898\u76ee\uff1aSimulating 500 million years of evolution with a language model<\/span><\/span><\/p>\n

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\u8bba\u6587\u5730\u5740\uff1ahttps:\/\/www.science.org\/doi\/10.1126\/science.ads0018<\/span><\/span><\/p>\n

\u671f\u520a\u540d\u79f0\uff1a<\/span><\/span>Science<\/span><\/span><\/em><\/p>\n<\/blockquote>\n


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\u86cb\u767d\u8d28\u662f\u751f\u547d\u6d3b\u52a8\u7684\u6838\u5fc3\u6267\u884c\u8005\uff0c\u5176\u8bbe\u8ba1\u4e00\u76f4\u662f\u5408\u6210\u751f\u7269\u5b66\u548c\u836f\u7269\u5f00\u53d1\u7684\u201c\u5723\u676f\u201d\u3002\u7136\u800c\uff0c\u81ea\u7136\u8fdb\u5316\u9700\u8981\u6570\u4ebf\u5e74\u624d\u80fd\u4ea7\u751f\u529f\u80fd\u6027\u86cb\u767d\uff0c\u800c\u4f20\u7edf\u8bbe\u8ba1\u65b9\u6cd5\u5f80\u5f80\u5c40\u9650\u4e8e\u5bf9\u5df2\u77e5\u86cb\u767d\u7684\u5fae\u5c0f\u4fee\u9970\u3002\u8fd1\u65e5\uff0c\u53d1\u8868\u4e8e<\/span><\/span>Science<\/span><\/span><\/em>\u671f\u520a\u7684\u4e00\u9879\u7814\u7a76\uff0c\u63d0\u51fa\u4e86\u4e00\u79cd\u591a\u6a21\u6001\u751f\u6210\u8bed\u8a00\u6a21\u578bESM3\uff0c\u6210\u529f\u8bbe\u8ba1\u51fa\u4e0e\u5929\u7136\u8367\u5149\u86cb\u767d\u5e8f\u5217\u5dee\u5f02\u8fbe58%\u7684\u65b0\u578b\u8367\u5149\u86cb\u767desmGFP\uff0c\u76f8\u5f53\u4e8e\u6a21\u62df\u4e86\u8d85\u8fc75\u4ebf\u5e74\u7684\u81ea\u7136\u8fdb\u5316\u3002\u8fd9\u4e00\u7a81\u7834\u6807\u5fd7\u7740\u4eba\u5de5\u667a\u80fd\u5728\u86cb\u767d\u8d28\u8bbe\u8ba1\u9886\u57df\u8fc8\u5165\u5168\u65b0\u9636\u6bb5\u3002<\/span><\/span><\/p>\n


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\u7ed3\u6784\u7f16\u7801<\/span><\/span><\/strong>\u662f\u6280\u672f\u96be\u70b9\u4e4b\u4e00\uff1aESM3\u5c06\u4e09\u7ef4\u539f\u5b50\u5750\u6807\u538b\u7f29\u4e3a\u79bb\u6563\u7684\u7ed3\u6784\u4ee4\u724c\uff0c\u901a\u8fc7\u51e0\u4f55\u81ea\u6ce8\u610f\u529b\u673a\u5236<\/span>\uff08Geometric Attention\uff09<\/span>\u6355\u6349\u5c40\u90e8\u4e0e\u5168\u5c40\u7a7a\u95f4\u5173\u7cfb\uff0c\u91cd\u5efa\u8bef\u5dee\u4f4e\u81f30.5 \u00c5<\/span>\uff08RMSD\uff09<\/span>\u3002\u529f\u80fd\u5c42\u9762\uff0c\u6a21\u578b\u6574\u5408\u4e86\u57fa\u56e0\u672c\u4f53\u8bba<\/span>\uff08Gene Ontology\uff09<\/span>\u5173\u952e\u8bcd\u548c\u4e8c\u7ea7\u7ed3\u6784<\/span>\uff08Secondary Structure\uff09<\/span>\u7b49\u8bed\u4e49\u4fe1\u606f\uff0c\u5b9e\u73b0\u4ece\u539f\u5b50\u7ec6\u8282\u5230\u529f\u80fd\u63cf\u8ff0\u7684\u591a\u5c42\u6b21\u63a7\u5236\u3002<\/span><\/span><\/p>\n


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\u7814\u7a76\u56e2\u961f\u8bad\u7ec3\u4e86\u4e09\u4e2a\u89c4\u6a21\u7684\u6a21\u578b<\/span>\uff081.4B\/7B\/98B\u53c2\u6570\uff09<\/span>\uff0c\u53d1\u73b0\u6a21\u578b\u80fd\u529b\u968f\u89c4\u6a21\u663e\u8457\u63d0\u5347\u3002\u6700\u5927\u768498B\u6a21\u578b\u5728\u7ed3\u6784\u9884\u6d4b\u4efb\u52a1\u4e2d\u8d85\u8d8a\u524d\u4ee3ESMFold<\/span>\uff08\u5e73\u5747LDDT 0.88 vs. 0.86\uff09<\/span>\uff0c\u751f\u6210\u7684\u86cb\u767d\u7ed3\u6784\u591a\u6837\u6027\u8986\u76d6\u5929\u7136\u86cb\u767d\u8d28\u5206\u5e03<\/span>\uff08\u56fe1E\uff09<\/span>\uff0c\u4e14\u9884\u6d4b\u7f6e\u4fe1\u5ea6<\/span>\uff08pTM\uff09<\/span>\u9ad8\u8fbe0.84\u3002<\/span><\/span><\/p>\n


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\u56fe 1. ESM3 \u662f\u4e00\u79cd\u751f\u6210\u5f0f\u8bed\u8a00\u6a21\u578b\uff0c\u80fd\u591f\u5bf9\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u8fdb\u884c\u63a8\u7406\u3002\uff08A\uff09ESM3 \u7684\u8fed\u4ee3\u91c7\u6837\u3002\u751f\u6210\u4e00\u79cd\u03b1\/\u03b2\u6c34\u89e3\u9176\u3002\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u90fd\u53ef\u4ee5\u7528\u4f5c\u63d0\u793a\u6a21\u578b\u3002\u5728\u6bcf\u4e2a\u65f6\u95f4\u6b65 t\uff0c\u5bf9\u90e8\u5206\u63a9\u7801\u4f4d\u7f6e\u8fdb\u884c\u91c7\u6837\uff0c\u76f4\u5230\u6240\u6709\u4f4d\u7f6e\u90fd\u672a\u88ab\u63a9\u7801\u3002\uff08B\uff09ESM3 \u67b6\u6784\u3002\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u5728\u8f93\u5165\u548c\u8f93\u51fa\u7aef\u5747\u8868\u793a\u4e3a\u79bb\u6563\u6807\u8bb0\u7684\u8f68\u9053\u3002\u8be5\u6a21\u578b\u7531\u4e00\u7cfb\u5217\u7684 Transformer \u5757\u7ec4\u6210\uff0c\u6240\u6709\u8f68\u9053\u90fd\u5728\u4e00\u4e2a\u5355\u4e00\u7684\u6f5c\u5728\u7a7a\u95f4\u4e2d\u878d\u5408\uff1b\u7b2c\u4e00\u4e2a\u5757\u4e2d\u7684\u51e0\u4f55\u6ce8\u610f\u529b\u5141\u8bb8\u57fa\u4e8e\u539f\u5b50\u5750\u6807\u8fdb\u884c\u6761\u4ef6\u8bbe\u7f6e\u3002ESM3 \u901a\u8fc7\u9884\u6d4b\u63a9\u7801\u6807\u8bb0\u8fdb\u884c\u76d1\u7763\u8bad\u7ec3\u3002\uff08C\uff09\u7ed3\u6784\u6807\u8bb0\u5316\u3002\u6bcf\u4e2a\u6c28\u57fa\u9178\u5468\u56f4\u7684\u5c40\u90e8\u539f\u5b50\u7ed3\u6784\u88ab\u7f16\u7801\u4e3a\u6807\u8bb0\u3002\uff08D\uff09\u6a21\u578b\u5728\u4e09\u4e2a\u89c4\u6a21\u4e0a\u8fdb\u884c\u8bad\u7ec3\uff1a14 \u4ebf\u300170 \u4ebf\u548c 980 \u4ebf\u53c2\u6570\u3002\u6d4b\u8bd5\u96c6\u4e0a\u8d1f\u5bf9\u6570\u4f3c\u7136\uff08\u5e73\u5747\u4e8e\u63a9\u7801\u7387\uff09\u4f5c\u4e3a\u8bad\u7ec3 FLOPs \u7684\u51fd\u6570\u663e\u793a\u4e86\u5bf9\u6bcf\u4e2a\u8f93\u5165\u8f68\u9053\u8fdb\u884c\u6761\u4ef6\u8bbe\u7f6e\u7684\u54cd\u5e94\uff0c\u968f\u7740 FLOPs \u7684\u589e\u52a0\u800c\u63d0\u9ad8\uff0895%\u7f6e\u4fe1\u533a\u95f4\uff09\u3002\uff08E\uff09ESM3 980 \u4ebf\u53c2\u6570\u6a21\u578b\u7684\u65e0\u6761\u4ef6\u751f\u6210\uff08\u6309\u989c\u8272\u533a\u5206\uff09\u4e0e\u8bad\u7ec3\u96c6\u4e2d\u6700\u63a5\u8fd1\u5e8f\u5217\u7684\u5e8f\u5217\u4e00\u81f4\u6027\uff0c\u901a\u8fc7 ESM3 \u5d4c\u5165\uff0c\u5e76\u901a\u8fc7 UMAP \u6295\u5f71\uff0c\u540c\u65f6\u8fd8\u6709\u4ece UniProt \u4e2d\u968f\u673a\u62bd\u53d6\u7684\u5e8f\u5217\uff08\u4ee5\u7070\u8272\u663e\u793a\uff09\u3002\u751f\u6210\u7684\u5e8f\u5217\u591a\u6837\u3001\u8d28\u91cf\u9ad8\uff0c\u5e76\u6db5\u76d6\u4e86\u5929\u7136\u5e8f\u5217\u7684\u5206\u5e03\u3002<\/span><\/span><\/p>\n


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ESM3\u7684\u98a0\u8986\u6027\u5728\u4e8e\u5176\u53ef\u7f16\u7a0b\u6027\uff0c\u7528\u6237\u53ef\u901a\u8fc7\u7ec4\u5408\u4e0d\u540c\u6a21\u6001\u7684\u63d0\u793a\uff08Prompt\uff09\u6307\u5bfc\u751f\u6210\u3002\u4f8b\u5982\uff0c\u6307\u5b9a\u5173\u952e\u50ac\u5316\u6b8b\u57fa\u7684\u539f\u5b50\u5750\u6807\uff0c\u540c\u65f6\u7528\u5173\u952e\u8bcd\u63cf\u8ff0\u9176\u529f\u80fd\uff0c\u6a21\u578b\u5373\u53ef\u751f\u6210\u6ee1\u8db3\u6761\u4ef6\u7684\u5168\u65b0\u86cb\u767d\u3002\u5b9e\u9a8c\u663e\u793a\uff0cESM3\u80fd\u751f\u6210\u8fdc\u79bb\u81ea\u7136\u5206\u5e03\u7684\u86cb\u767d\uff1a\u5f53\u8f93\u5165\u975e\u5929\u7136\u5bf9\u79f0\u7ed3\u6784\u6216\u529f\u80fd\u5173\u952e\u8bcd\u65f6\uff0c\u6a21\u578b\u8f93\u51fa\u5e8f\u5217\u4e0e\u5929\u7136\u86cb\u767d\u7684\u76f8\u4f3c\u5ea6\u4f4e\u4e8e20%\uff0c\u7ed3\u6784\u5dee\u5f02\u663e\u8457\uff08TM Score <0.5\uff09\u3002<\/span><\/span><\/p>\n


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\u66f4\u4ee4\u4eba\u60ca\u53f9\u7684\u662f\u5176\u521b\u9020\u6027\u89e3\u51b3\u80fd\u529b\u3002\u4f8b\u5982\uff0cESM3\u5c06\u4e1d\u6c28\u9178\u86cb\u767d\u9176<\/span>\uff08Serine Protease\uff09<\/span>\u7684\u6d3b\u6027\u4f4d\u70b9\u79fb\u690d\u5230\u5b8c\u5168\u4e0d\u540c\u7684\u6298\u53e0\u67b6\u6784\u4e2d\uff0c\u5e76\u538b\u7f29\u5e8f\u5217\u957f\u5ea633%\uff0c\u4ecd\u4fdd\u6301\u50ac\u5316\u529f\u80fd\u3002\u8fd9\u79cd\u201c\u539f\u5b50\u7ea7\u5ac1\u63a5\u201d\u5728\u81ea\u7136\u8fdb\u5316\u4e2d\u51e0\u4e4e\u4e0d\u53ef\u80fd\u5b9e\u73b0\uff0c\u5374\u901a\u8fc7\u591a\u6a21\u6001\u63d0\u793a\u8f7b\u677e\u8fbe\u6210\u3002<\/span><\/span><\/p>\n


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\u5bf9\u9f50\u8bad\u7ec3\uff1a\u89e3\u9501\u5927\u6a21\u578b\u7684\u201c\u9690\u85cf\u6280\u80fd\u201d<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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\u7814\u7a76\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u901a\u8fc7\u504f\u597d\u4f18\u5316<\/span>\uff08Preference Optimization\uff09<\/span>\u5bf9\u9f50\u6a21\u578b\uff0c\u53ef\u5927\u5e45\u63d0\u5347\u590d\u6742\u4efb\u52a1\u89e3\u51b3\u80fd\u529b\u3002\u4f8b\u5982\uff0c\u5728\u201c\u4e09\u7ea7\u7ed3\u6784\u57fa\u5e8f\u652f\u67b6<\/span>\uff08Tertiary Motif Scaffolding\uff09<\/span>\u201d\u4efb\u52a1\u4e2d\uff0c98B\u6a21\u578b\u7ecf\u5bf9\u9f50\u540e\u6210\u529f\u7387\u4ece26.8%\u8dc3\u5347\u81f365.5%\uff0c\u4e14\u80fd\u751f\u6210\u591a\u4e2a\u7ed3\u6784\u8fe5\u5f02\u7684\u89e3\u51b3\u65b9\u6848\u3002\u8fd9\u8868\u660e\u5927\u6a21\u578b\u5185\u90e8\u5f62\u6210\u4e86\u5bf9\u86cb\u767d\u8d28\u7269\u7406\u548c\u8fdb\u5316\u89c4\u5f8b\u7684\u6df1\u523b\u8868\u5f81\uff0c\u800c\u5bf9\u9f50\u6280\u672f\u80fd\u6709\u6548\u63d0\u53d6\u8fd9\u79cd\u201c\u9690\u6027\u77e5\u8bc6\u201d\u3002<\/span><\/span><\/p>\n


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\u8de8\u8d8a5\u4ebf\u5e74\u7684\u8367\u5149\u5947\u8ff9\uff1aesmGFP\u8bde\u751f\u8bb0<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


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\u4e3a\u9a8c\u8bc1ESM3\u7684\u751f\u7269\u5b66\u4fdd\u771f\u5ea6\uff0c\u56e2\u961f\u6311\u6218\u4e86\u9ad8\u96be\u5ea6\u76ee\u6807\u2014\u2014\u8bbe\u8ba1\u8fdc\u8ddd\u79bb\u8367\u5149\u86cb\u767d\u3002\u8367\u5149\u529f\u80fd\u4f9d\u8d56\u7cbe\u5bc6\u6392\u5217\u7684\u8272\u6c28\u9178\u6b8b\u57fa\uff08Chromophore\uff09\uff0c\u4f20\u7edf\u65b9\u6cd5\u4ec5\u80fd\u5f15\u5165\u6570\u5341\u4e2a\u7a81\u53d8\uff0c\u800cESM3\u901a\u8fc7\u94fe\u5f0f\u601d\u7ef4\uff08Chain-of-Thought\uff09\u751f\u6210\u7b56\u7565\uff0c\u9010\u6b65\u4f18\u5316\u5e8f\u5217\u4e0e\u7ed3\u6784\u3002\u6700\u7ec8\u5408\u6210\u7684esmGFP\u4e0e\u6700\u8fd1\u5929\u7136\u8367\u5149\u86cb\u767d\uff08tagRFP\uff09\u4ec5\u670958%\u5e8f\u5217\u76f8\u4f3c\u6027\uff0c\u76f8\u5dee96\u4e2a\u7a81\u53d8\uff0c\u76f8\u5f53\u4e8e\u81ea\u7136\u8fdb\u5316\u8d85\u8fc75\u4ebf\u5e74\u7684\u5206\u6b67\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u5b9e\u9a8c\u8bc1\u5b9e\uff0cesmGFP\u7684\u8367\u5149\u5f3a\u5ea6\u4e0e\u5929\u7136\u86cb\u767d\u76f8\u5f53\uff0c\u5149\u8c31\u7279\u6027\u63a5\u8fd1\u3002\u5176\u7ed3\u6784\u9884\u6d4b\u663e\u793a\uff0c22\u4e2a\u7a81\u53d8\u4f4d\u4e8e\u8272\u6c28\u9178\u5468\u56f4\u7684\u654f\u611f\u533a\u57df\uff0c\u4f46ESM3\u4ecd\u6210\u529f\u7ef4\u6301\u4e86\u529f\u80fd\u6240\u9700\u7684\u7a7a\u95f4\u914d\u7f6e\uff08\u56fe4E\uff09\u3002\u8fd9\u4e00\u6210\u679c\u4e0d\u4ec5\u6253\u7834\u4e86\u86cb\u767d\u8d28\u5de5\u7a0b\u7684\u6781\u9650\uff0c\u66f4\u63ed\u793a\u4e86AI\u63a2\u7d22\u201c\u8fdb\u5316\u672a\u8fbe\u4e4b\u5730\u201d\u7684\u6f5c\u529b\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

<\/section>\n

\u56fe 2. \u901a\u8fc7\u4e00\u7cfb\u5217\u7684\u601d\u8003\u751f\u6210\u4e00\u79cd\u8fdc\u8ddd\u79bb\u8367\u5149\u86cb\u767d\u3002\uff08A\uff09\u6211\u4eec\u7528\u5f62\u6210\u548c\u50ac\u5316\u53d1\u8272\u56e2\u53cd\u5e94\u6240\u9700\u7684\u6b8b\u57fa\u5e8f\u5217\u548c\u7ed3\u6784\u4ee5\u53ca\u5929\u7136\u7eff\u8272\u8367\u5149\u86cb\u767d\uff08GFP\uff09\u90e8\u5206\u4e2d\u592e\u03b1\u87ba\u65cb\u7684\u7ed3\u6784\u6765\u63d0\u793a ESM3\uff08\u5de6\uff09\u3002\u901a\u8fc7\u4e00\u7cfb\u5217\u7684\u601d\u8003\uff0cESM3 \u751f\u6210\u8bbe\u8ba1\u5019\u9009\uff08\u53f3\uff09\u3002\uff08B\uff09\u5728\u4e24\u6b21\u5b9e\u9a8c\u4e2d\uff0cESM3 \u627e\u5230\u4e86\u4e00\u79cd\u8fdc\u79bb\u5176\u4ed6\u5df2\u77e5 GFP \u7684\u660e\u4eae GFP\u3002\u6211\u4eec\u5728\u5927\u80a0\u6746\u83cc\u88c2\u89e3\u6db2\u4e2d\u6d4b\u91cf\u4e86\u8367\u5149\u3002\u4e0a\u6392\uff0c\u5e73\u677f\u7167\u7247\u3002\u4e0b\u6392\uff0c\u5e73\u677f\u8bfb\u53d6\u5668\u8367\u5149\u5b9a\u91cf\u3002\u5df2\u77e5 GFP \u7684\u9633\u6027\u5bf9\u7167\u7528\u7d2b\u8272\u5706\u5708\u6807\u8bb0\uff0c\u6ca1\u6709 GFP \u5e8f\u5217\u6216\u6ca1\u6709\u5927\u80a0\u6746\u83cc\u7684\u9634\u6027\u5bf9\u7167\u7528\u7ea2\u8272\u5706\u5708\u6807\u8bb0\u3002\u5728\u7b2c\u4e00\u6b21\u5b9e\u9a8c\uff08\u5de6\uff09\u4e2d\uff0c\u6211\u4eec\u8868\u8fbe\u4e86\u5177\u6709\u4e0d\u540c\u5e8f\u5217\u540c\u6e90\u6027\u7684\u8bbe\u8ba1\u3002\u5728 B8 \u5b54\uff08\u5e95\u90e8\u9ed1\u8272\u5706\u5708\uff0c\u9876\u90e8\u767d\u8272\u5706\u5708\u7a81\u51fa\u663e\u793a\uff09\u4e2d\u51fa\u73b0\u4e86\u4e00\u4e2a\u503c\u5f97\u6ce8\u610f\u7684\u8bbe\u8ba1\uff0c\u5176\u4e0e\u5df2\u77e5\u8367\u5149\u86cb\u767d\u7684\u5e8f\u5217\u540c\u6e90\u6027\u8f83\u4f4e\uff0857%\uff09\u3002\u6211\u4eec\u4ece B8 \u5b54\u4e2d\u7684\u86cb\u767d\u8d28\u7ee7\u7eed\u8fdb\u884c\u7b2c\u4e8c\u6b21\u5b9e\u9a8c\uff08\u53f3\uff09\u3002\u5728 C10 \u5b54\uff08\u4e0e\u5df2\u77e5\u8367\u5149\u86cb\u767d\u7684\u5e8f\u5217\u540c\u6e90\u6027\u4e3a 58%\uff0c\u9ed1\u8272\u5706\u5708\uff09\u4e2d\u51fa\u73b0\u4e86\u4e00\u4e2a\u660e\u4eae\u7684\u8bbe\u8ba1\u3002\uff08B\uff09\u6211\u4eec\u5c06\u5176\u547d\u540d\u4e3a esmGFP \u7684\u662f\u5e95\u90e8\u4e3a\u767d\u8272\u5706\u5708\u9876\u90e8\u4e3a\u7eff\u8272\u8367\u5149\u86cb\u767d\u7684\u7ed3\u6784\u3002\uff08C\uff09esmGFP \u7684\u8367\u5149\u5f3a\u5ea6\u4e0e\u5e38\u89c1\u7684 GFP \u76f8\u4f3c\u3002\u5b9e\u9a8c 2 \u4e2d\u90e8\u5206\u86cb\u767d\u8d28\u7684\u5f52\u4e00\u5316\u8367\u5149\u5f3a\u5ea6\u5982\u56fe\u6240\u793a\u3002\uff08D\uff09esmGFP \u7684\u6fc0\u53d1\u548c\u53d1\u5c04\u5149\u8c31\u4e0e EGFP \u7684\u5149\u8c31\u91cd\u53e0\u3002\uff08E\uff09esmGFP \u9884\u6d4b\u7ed3\u6784\u4e2d\u4e2d\u592e\u03b1\u87ba\u65cb\u548c\u03b2\u6876\u5185\u90e8\u7684\u4e24\u4e2a\u622a\u9762\u56fe\u3002esmGFP \u76f8\u5bf9\u4e8e\u5176\u6700\u8fd1\u7684\u90bb\u5c45 tagRFP \u7684 96 \u4e2a\u7a81\u53d8\u4ee5\u84dd\u8272\u663e\u793a\u3002\uff08F\uff09\u4e0d\u540c\u5206\u7c7b\u7fa4\u4e2d\u8367\u5149\u86cb\u767d\u4e4b\u95f4\u7684\u5e8f\u5217\u540c\u6e90\u6027\u7d2f\u79ef\u5bc6\u5ea6\u3002esmGFP \u4e0e\u5176\u4ed6\u6240\u6709 FP \u7684\u76f8\u4f3c\u7a0b\u5ea6\u901a\u5e38\u5728\u6bd4\u8f83\u4e0d\u540c\u76ee\u4f46\u540c\u5c5e\u7684\u5e8f\u5217\u65f6\u624d\u4f1a\u51fa\u73b0\u3002\uff08G\uff09\u4e09\u79cd\u5178\u578b\u73ca\u745a\u7eb2 GFP \u548c esmGFP \u7684\u8fdb\u5316\u8ddd\u79bb\uff08\u4ee5\u767e\u4e07\u5e74\u4e3a\u5355\u4f4d\uff09\u548c\u5e8f\u5217\u540c\u6e90\u6027\u3002\uff08H\uff09\u6839\u636e GFP \u5e8f\u5217\u540c\u6e90\u6027\u4f30\u7b97\u7684\u8fdb\u5316\u8ddd\u79bb\uff08\u4ee5\u767e\u4e07\u5e74\u4e3a\u5355\u4f4d\uff09\u3002\u6211\u4eec\u4f30\u8ba1 esmGFP \u4e0e\u5df2\u77e5\u6700\u8fd1\u7684\u86cb\u767d\u8d28\u5728\u81ea\u7136\u8fdb\u5316\u4e2d\u76f8\u9694\u8d85\u8fc7 5 \u4ebf\u5e74\u3002<\/span><\/span><\/p>\n


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ESM3\u7684\u7a81\u7834\u6027\u5728\u4e8e\u5176\u9690\u5f0f\u5efa\u6a21\u8fdb\u5316\u8def\u5f84\u7684\u80fd\u529b\u3002\u86cb\u767d\u8d28\u53ef\u89c6\u4e3a\u7531\u7a81\u53d8\u8fde\u63a5\u7684\u201c\u8fdb\u5316\u7f51\u7edc\u201d\uff0c\u800c\u8bed\u8a00\u6a21\u578b\u901a\u8fc7\u9884\u6d4b\u8fdb\u5316\u53ef\u80fd\u7684\u65b9\u5411\uff0c\u6784\u5efa\u51fa\u8d85\u8d8a\u81ea\u7136\u5386\u53f2\u7684\u201c\u865a\u62df\u8fdb\u5316\u7a7a\u95f4\u201d\u3002esmGFP\u7684\u6848\u4f8b\u8868\u660e\uff0c\u8fd9\u79cd\u7a7a\u95f4\u5185\u5b58\u5728\u5927\u91cf\u529f\u80fd\u86cb\u767d\u7684\u201c\u5c9b\u5c7f\u201d\uff0c\u5b83\u4eec\u867d\u672a\u88ab\u81ea\u7136\u9009\u62e9\u9752\u7750\uff0c\u5374\u53ef\u901a\u8fc7AI\u76f4\u63a5\u6316\u6398\u3002\u672a\u6765\uff0c\u968f\u7740\u6a21\u578b\u89c4\u6a21\u6269\u5927\uff0cESM3\u6709\u671b\u6210\u4e3a\u201c\u86cb\u767d\u8d28\u5b87\u5b99\u201d\u7684\u901a\u7528\u6a21\u62df\u5668\uff0c\u52a0\u901f\u836f\u7269\u8bbe\u8ba1\u3001\u9176\u5de5\u7a0b\u7b49\u9886\u57df\u7684\u7a81\u7834\u3002<\/span><\/span><\/p>\n


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<\/span><\/p>\n

\u5f6d\u6668<\/span><\/span> <\/span><\/span>| \u7f16\u8bd1<\/span><\/span><\/strong><\/span><\/strong><\/p>\n


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\u5173\u4e8e\u96c6\u667a\u4ff1\u4e50\u90e8<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u96c6\u667a\u4ff1\u4e50\u90e8\u6210\u7acb\u4e8e 2003 \u5e74\uff0c\u662f\u4e00\u4e2a\u4ece\u4e8b\u5b66\u672f\u7814\u7a76\u3001\u4eab\u53d7\u79d1\u5b66\u4e50\u8da3\u7684\u63a2\u7d22\u8005\u7684\u56e2\u4f53\uff0c\u4e5f\u662f<\/span><\/span>\u56fd\u5185\u6700\u65e9\u7684\u7814\u7a76\u4eba\u5de5\u667a\u80fd\u3001\u590d\u6742\u7cfb\u7edf\u7684\u79d1\u5b66\u793e\u533a<\/span><\/span><\/strong>\u3002\u5b83\u5021\u5bfc\u4ee5\u5e73\u7b49\u5f00\u653e\u7684\u6001\u5ea6\u3001\u79d1\u5b66\u5b9e\u8bc1\u7684\u7cbe\u795e\uff0c\u8fdb\u884c\u8de8\u5b66\u79d1\u7684\u7814\u7a76\u4e0e\u4ea4\u6d41\uff0c\u529b\u56fe\u642d\u5efa\u4e00\u4e2a\u4e2d\u56fd\u7684 \u201c \u6ca1\u6709\u56f4\u5899\u7684\u7814\u7a76\u6240 \u201d\u3002\u96c6\u667a\u79d1\u5b66\u7814\u7a76\u4e2d\u5fc3\uff08<\/span><\/span>\u6c11\u95f4\u975e\u76c8\u5229\u4f01\u4e1a\uff09\u662f\u96c6\u667a\u4ff1\u4e50\u90e8\u7684\u8fd0\u8425\u4e3b\u4f53\uff0c\u957f\u671f\u8fd0\u8425\u793e\u533a\u751f\u6001\uff0c\u50ac\u5316\u7406\u8bba\u521b\u65b0\u3002<\/span><\/span><\/span>\u4f7f\u547d\uff1a\u8425\u9020\u8de8\u5b66\u79d1\u63a2\u7d22\u5c0f\u751f\u5883\uff0c\u50ac\u5316\u590d\u6742\u6027\u79d1\u5b66\u65b0\u7406\u8bba<\/span><\/span><\/strong>\u3002<\/span><\/span><\/span><\/p>\n

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-\u76f4\u64ad\u9884\u544a-<\/span><\/span><\/section>\n
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\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a<\/span><\/strong><\/p>\n

\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/span><\/strong>
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\u5728\u751f\u7269\u5b66\u4e2d\u5fc3\u6cd5\u5219\u7684\u8d77\u70b9\uff0c\u57fa\u56e0\u4f5c\u4e3a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u9057\u4f20\u4fe1\u606f\u8f7d\u4f53\uff0c\u5728\u751f\u547d\u5468\u671f\u5185\u7a33\u5b9a\u5b58\u5728\uff1b\u800c\u4f4d\u4e8e\u4e2d\u5fc3\u6cd5\u5219\u672b\u7aef\u7684\u86cb\u767d\u8d28\uff0c\u5176\u7ec4\u7ec7\u6784\u6210\u548c\u65f6\u7a7a\u53d8\u5316\u7684\u590d\u6742\u6027\u5448\u6307\u6570\u5f0f\u589e\u957f\u3002\u968f\u7740\u5206\u5b50\u751f\u7269\u5b66\u6570\u5341\u5e74\u6765\u7684\u7a81\u98de\u731b\u8fdb\uff0c\u5c24\u5176\u662f\u751f\u547d\u7ec4\u5b66\uff08\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7b49\u7684\u96c6\u5408\uff09\u7b49\u9886\u57df\u7684\u65e5\u65b0\u6708\u5f02\uff0c\u5f53\u4ee3\u751f\u547d\u79d1\u5b66\u4e34\u8fd1\u7206\u53d1\u7684\u8fb9\u7f18\u3002\u5982\u6b64\u6d77\u91cf\u7684\u6570\u636e\u5982\u4f55\u5e2e\u52a9\u6211\u4eec\u63ed\u793a\u5b87\u5b99\u4e2d\u6700\u590d\u6742\u7684\u7269\u8d28\u7cfb\u7edf\u2014\u2014\u201c\u4eba\u4f53\u201d\u7684\u6784\u6210\u539f\u7406\u548c\u8bbe\u8ba1\u539f\u7406\uff1f\u9610\u91ca\u4eba\u7c7b\u53d1\u80b2\u3001\u8870\u8001\u548c\u91cd\u5927\u75be\u75c5\u7684\u53d1\u751f\u673a\u5236\uff1f<\/span><\/span><\/p>\n


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\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u7406\u5b66\u9662\u53ca\u4ea4\u53c9\u79d1\u5b66\u4e2d\u5fc3\u8bb2\u5e2d\u6559\u6388\u6c64\u96f7\u7ff0\uff0c\u56fd\u5bb6\u86cb\u767d\u8d28\u79d1\u5b66<\/span><\/span>\u4e2d\u5fc3\uff08\u5317\u4eac\uff09\u526f\u7814\u7a76\u5458\u5e38\u4e58\u3001\u674e\u6768\uff0c\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\u52a9\u7406\u6559\u6388\u5510\u4e7e\u5143\uff0c\u5317\u4eac\u5927\u5b66\u524d\u6cbf\u4ea4\u53c9\u5b66\u79d1\u7814\u7a76\u9662\u7814\u7a76\u5458\u6797\u4e00\u701a\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5206\u5b50\u7ec6\u80de\u79d1\u5b66\u5353\u8d8a\u521b\u65b0\u4e2d\u5fc3\u535a\u58eb\u540e\u5510\u8bd7\u5a55\uff0c\u5171\u540c\u53d1\u8d77<\/span><\/span>\u300c\u751f\u547d\u590d\u6742\u6027\uff1a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406\u300d\u8bfb\u4e66\u4f1a<\/a><\/span>\uff0c\u4ece\u5fae\u89c2\u7ec6\u80de\u5c3a\u5ea6\u3001\u4ecb\u89c2\u7ec4\u7ec7\u5668\u5b98\u5c3a\u5ea6\u5230\u5b8f\u89c2\u4eba\u4f53\u5c3a\u5ea6\uff0c\u68b3\u7406\u751f\u547d\u79d1\u5b66\u9886\u57df\u4e2d\u7684\u91cd\u8981\u95ee\u9898\u53ca\u91cd\u8981\u6570\u636e\uff0c\u7531\u751f\u7269\u5b66\u5bb6\u63d0\u95ee\uff0c\u5e0c\u671b\u4fc3\u8fdb\u7edf\u8ba1\u7269\u7406\u3001\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u7814\u7a76\u8005\u548c\u751f\u547d\u79d1\u5b66\u7814\u7a76\u8005\u4e4b\u95f4\u7684\u6df1\u5ea6\u4ea4\u6d41\uff0c\u5efa\u7acb\u8de8\u5b66\u79d1\u5408\u4f5c\u5173\u7cfb\uff0c\u6fc0\u53d1\u65b0\u7684\u7814\u7a76\u601d\u8def\u548c\u5408\u4f5c\u9879\u76ee\u3002\u8bfb\u4e66\u4f1a\u76ee\u524d\u5171\u8fdb\u884c10\u671f\uff0c\u73b0\u5728\u62a5\u540d\u53c2\u4e0e\u8bfb\u4e66\u4f1a\u53ef\u4ee5\u52a0\u5165\u8bfb\u4e66\u4f1a\u793e\u7fa4\uff0c\u89c2\u770b\u89c6\u9891\u56de\u653e\uff0c\u89e3\u9501\u5b8c\u6574\u8bfb\u4e66\u4f1a\u6743\u9650\u3002<\/span><\/span><\/p>\n


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\"\u56fe\u7247\"<\/span><\/a><\/span><\/strong><\/span><\/section>\n

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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/span><\/section>\n
\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a\u4ece\u5fae\u89c2\u5230\u5b8f\u89c2\uff0c\u591a\u5c3a\u5ea6\u89c6\u89d2\u63a2\u7d22\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/a><\/span><\/span>
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\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1a<\/span><\/strong><\/p>\n

AI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u751f\u7269\u533b\u5b66\u662f\u4e00\u4e2a\u590d\u6742\u4e14\u5bcc\u6709\u6311\u6218\u6027\u7684\u9886\u57df\uff0c\u6d89\u53ca\u5230\u5927\u91cf\u7684\u6570\u636e\u5904\u7406\u3001\u6a21\u5f0f\u8bc6\u522b\u3001\u7406\u8bba\u6a21\u578b\u5efa\u6784\u548c\u5b9e\u9a8c\u9a8c\u8bc1\u7b49\u95ee\u9898\u3002AI\u57fa\u7840\u6a21\u578b\u7684\u5f15\u5165\uff0c\u4f7f\u5f97\u6211\u4eec\u80fd\u591f\u4ece\u524d\u6240\u672a\u6709\u7684\u89d2\u5ea6\u53bb\u89c2\u5bdf\u548c\u7406\u89e3\u8fd9\u4e2a\u9886\u57df\u7684\u95ee\u9898\uff0c\u52a0\u901f\u79d1\u5b66\u7814\u7a76\u7684\u6b65\u4f10\uff0c\u63d0\u9ad8\u533b\u7597\u670d\u52a1\u7684\u6548\u7387\u548c\u6548\u679c\u3002\u8fd9\u79cd\u4ea4\u53c9\u9886\u57df\u7684\u5408\u4f5c\uff0c\u6807\u5fd7\u7740\u6211\u4eec\u6b63\u5728\u5411\u79d1\u6280\u4e0e\u751f\u7269\u533b\u5b66\u6df1\u5ea6\u878d\u5408\u7684\u65b0\u65f6\u4ee3\u8fc8\u8fdb\uff0c\u5bf9\u4e8e\u63a8\u52a8\u79d1\u5b66\u7814\u7a76\u3001\u4f18\u5316\u533b\u7597\u670d\u52a1\u3001\u4fc3\u8fdb\u4eba\u7c7b\u5065\u5eb7\u6709\u7740\u6df1\u8fdc\u7684\u5f71\u54cd\u3002<\/span><\/span><\/section>\n

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\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u52a9\u7406\u6559\u6388\u5434\u6cf0\u9716\u3001\u65af\u5766\u798f\u5927\u5b66\u8ba1\u7b97\u673a\u79d1\u5b66\u7cfb\u535a\u58eb\u540e\u7814\u7a76\u5458\u738b\u701a\u5bb8\u3001\u535a\u58eb\u7814\u7a76\u751f\u9ec4\u67ef\u946b\u3001\u9ec4\u5029\uff0c\u534e\u76db\u987f\u5927\u5b66\u535a\u58eb\u7814\u7a76\u751f\u5c60\u946b\u660e\uff0c\u5171\u540c\u53d1\u8d77\u4ee5\u201c\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\u201d\u4e3a\u4e3b\u9898\u7684\u8bfb\u4e66\u4f1a\uff0c<\/span>\u5171\u5b66\u5171\u7814\u76f8\u5173\u6587\u732e\uff0c<\/span><\/span><\/span>\u63a2\u8ba8\u57fa\u7840\u6a21\u578b\u5728\u751f\u7269\u533b\u5b66\u7b49\u79d1\u5b66\u9886\u57df\u7684\u5e94\u7528\u3001\u5f71\u54cd\u548c\u5c55\u671b\u3002<\/span><\/span><\/span><\/span>\u8bfb\u4e66\u4f1a\u5df2\u5b8c\u7ed3\uff0c\u73b0\u5728\u62a5\u540d\u53ef\u52a0\u5165\u793e\u7fa4\u5e76\u89e3\u9501<\/span><\/span>\u56de\u653e<\/span><\/span>\u89c6\u9891\u6743\u9650\u3002<\/span><\/span><\/span><\/section>\n

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\"\u56fe\u7247\"<\/span><\/a><\/section>\n

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\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/span><\/span><\/p>\n

\u5927\u6a21\u578b\u4e0e\u751f\u7269\u533b\u5b66\uff1aAI + Science\u7b2c\u4e8c\u5b63\u8bfb\u4e66\u4f1a\u542f\u52a8<\/a><\/span><\/span><\/p>\n


<\/span><\/section>\n
\u63a8\u8350\u9605\u8bfb<\/span><\/span><\/strong><\/strong><\/strong><\/section>\n
<\/strong><\/section>\n
1.\u8de8\u8d8a5\u4ebf\u5e74\u7684\u751f\u547d\u8bbe\u8ba1\u9769\u547d\uff1aScience\u53d1\u5e03\u5927\u8bed\u8a00\u6a21\u578b\u751f\u6210\u5168\u65b0\u8367\u5149\u86cb\u767d<\/span><\/a><\/span><\/strong>
<\/span><\/strong><\/span><\/section>\n
2.Science \u901f\u9012\uff1a\u5f3a\u5316\u5b66\u4e60\u81ea\u4e0a\u800c\u4e0b\u8bbe\u8ba1\u86cb\u767d\u8d28\u7ed3\u6784<\/span><\/a><\/span><\/strong>
<\/span><\/strong><\/span><\/section>\n
3.<\/span>Nat. Commun. \u901f\u9012\uff1a\u86cb\u767d\u8d28\u6298\u53e0\u8f6c\u6362\u7f51\u7edc\u7684\u8bbe\u8ba1\u548c\u89d2\u8272\u5851\u9020<\/span><\/a><\/span><\/strong><\/section>\n
<\/strong><\/section>\n
4. <\/span><\/strong><\/span>\u6d8c\u73b0\u52a8\u529b\u5b66\u5982\u4f55\u7528\u6765\u5206\u6790\u590d\u6742\u7cfb\u7edf\uff1f | \u65b0\u8bfe\u4e0a\u7ebf<\/a><\/span><\/strong><\/strong><\/span><\/section>\n
<\/strong>5. <\/span><\/strong>AI\u65f6\u4ee3\u7684\u5b66\u4e60\uff1a\u5171\u63a2\u4eba\u7c7b\u5b66\u4e60\u7684\u590d\u6742\u6027<\/span><\/a><\/span><\/strong><\/section>\n

6. <\/span><\/strong>\u63a2\u7d22\u8005\u8ba1\u5212 | \u96c6\u667a\u4ff1\u4e50\u90e82025\u5185\u5bb9\u56e2\u961f\u62db\u52df\uff08\u5168\u804c&\u517c\u804c\uff09<\/a><\/span><\/strong><\/span><\/p>\n


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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/span><\/span><\/section>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6458\u8981 \u8d85\u8fc7 30 \u4ebf\u5e74\u7684\u8fdb\u5316\u5728\u5929\u7136\u86cb\u767d\u8d28\u7684\u7a7a\u95f4\u4e2d\u5f62\u6210\u4e86\u751f\u7269\u5b66\u7684\u56fe\u666f\u3002\u5728\u6b64\uff0c\u6211\u4eec\u5c55\u793a\u4e86\u5927\u89c4\u6a21\u8bad\u7ec3\u7684\u57fa\u4e8e\u8fdb\u5316\u6570\u636e\u7684\u8bed\u8a00\u6a21\u578b\u80fd\u591f\u751f\u6210\u4e0e\u5df2\u77e5\u86cb\u767d\u8d28\u76f8\u53bb\u751a\u8fdc\u7684\u529f\u80fd\u6027\u86cb\u767d\u8d28\u3002\u6211\u4eec\u63a8\u51fa\u4e86 ESM3\uff0c\u8fd9\u662f\u4e00\u79cd\u524d\u6cbf\u7684\u591a\u6a21\u6001\u751f\u6210\u8bed\u8a00\u6a21\u578b\uff0c\u80fd\u591f\u5bf9\u86cb\u767d\u8d28\u7684\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u8fdb\u884c\u63a8\u7406\u3002ESM3 \u80fd\u591f\u9075\u5faa\u7ed3\u5408\u5176\u6a21\u6001\u7684\u590d\u6742\u63d0\u793a\uff0c\u5e76…<\/p>\n","protected":false},"author":0,"featured_media":60364,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/60373"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=60373"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/60373\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/60364"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=60373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=60373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=60373"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=60373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}