{"id":61781,"date":"2025-07-09T17:27:00","date_gmt":"2025-07-09T09:27:00","guid":{"rendered":"https:\/\/swarma.org\/?p=61781"},"modified":"2025-07-09T17:27:00","modified_gmt":"2025-07-09T09:27:00","slug":"cell-%e8%ae%a1%e7%ae%97%e5%8c%bb%e5%ad%a6%e5%89%8d%e6%b2%bf%ef%bc%9a%e5%a5%b3%e5%a8%b2%e6%a8%a1%e5%9e%8b%e8%a7%a3%e7%a0%81%e5%9f%ba%e5%9b%a0%e8%b0%83%e6%8e%a7%e8%af%ad","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=61781","title":{"rendered":"Cell \u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\uff1a\u201c\u5973\u5a32\u6a21\u578b\u201d\u89e3\u7801\u57fa\u56e0\u8c03\u63a7\u201c\u8bed\u6cd5\u201d"},"content":{"rendered":"
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7\u670810\u65e5\uff08\u5468\u56db\uff0919:00-21:00\uff0c\u6211\u4eec\u7279\u522b\u9080\u8bf7\u5230\u90ed\u56fd\u9aa5\u8001\u5e08\u5728\u201c\u8ba1\u7b97\u533b\u5b66\u7814\u8ba8\u4f1a\u201d<\/a>\u7b2c\u4e8c\u671f\u6d3b\u52a8\u4e2d\u5206\u4eab\u8fd9\u4e00\u6700\u65b0\u7814\u7a76\u6210\u679c\u3002\u201cAI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\uff1a\u4ece\u79d1\u5b66\u53d1\u73b0\u5230\u6570\u5b57\u5b6a\u751f\u201d\u7cfb\u5217\u7814\u8ba8\u4f1a\u7531DAMO\u5f00\u53d1\u8005\u77e9\u9635\u4e0e\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u4e3b\u529e\uff0c\u6df1\u5165\u63a2\u8ba8AI\u4e0e\u751f\u7269\u533b\u5b66\u4ea4\u53c9\u7684\u6700\u65b0\u8fdb\u5c55\u3002<\/span><\/span><\/strong><\/p>\n

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\u8bba\u6587\u5730\u5740<\/span>\uff1a<\/span><\/span>https:\/\/doi.org\/10.1016\/j.cell.2025.06.020<\/span><\/span><\/strong><\/span><\/p>\n<\/blockquote>\n


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AI\u6b63\u5728\u6df1\u523b\u5f71\u54cd\u751f\u547d\u79d1\u5b66\uff0c\u5c24\u5176\u5728\u591a\u7ec4\u5b66\u9886\u57df\u3002\u8fc7\u53bb\u51e0\u5e74\uff0cAI\u7b97\u6cd5\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b<\/span>\uff08\u5982AlphaFold\uff09<\/span>\u548c\u57fa\u56e0\u529f\u80fd\u89e3\u6790<\/span>\uff08\u5982Enformer\uff09<\/span>\u7b49\u65b9\u5411\u4e0a\u63a5\u8fde\u53d6\u5f97\u7a81\u7834\u3002\u7136\u800c\uff0c\u7528AI\u5b9e\u73b0\u751f\u547d\u7cfb\u7edf\u7684\u7cbe\u51c6\u5efa\u6a21\uff0c\u4f9d\u8d56\u4e8e\u8986\u76d6\u591a\u7269\u79cd\u3001\u591a\u7ec6\u80de\u7c7b\u578b\u7684\u9ad8\u8d28\u91cf\u6570\u636e\u3002\u5728\u57fa\u56e0\u7ec4\u4e0e\u8868\u89c2\u57fa\u56e0\u7ec4\u9886\u57df\uff0c\u8fd9\u7c7b\u6570\u636e\u7684\u7f3a\u4e4f\u5df2\u6210\u4e3a\u5236\u7ea6AI\u6df1\u5165\u7406\u89e3\u57fa\u56e0\u8c03\u63a7\u673a\u5236\u7684\u74f6\u9888\u3002<\/span><\/span><\/p>\n

\u5176\u4e2d\u6709\u4ee3\u8868\u6027\u7684\u662f\u7ec6\u80de\u67d3\u8272\u8d28\u7684\u5f00\u653e\u72b6\u6001\u6570\u636e\u3002\u67d3\u8272\u8d28\u5f00\u653e\u72b6\u6001\u51b3\u5b9a\u4e86DNA\u5e8f\u5217\u80fd\u5426\u88ab\u8f6c\u5f55\u56e0\u5b50\u7b49\u8c03\u63a7\u86cb\u767d\u6709\u6548\u8bc6\u522b\u548c\u7ed3\u5408\uff0c\u4ece\u800c\u76f4\u63a5\u5f71\u54cd\u57fa\u56e0\u7684\u8868\u8fbe\u4e0e\u8c03\u63a7\u3002\u56e0\u6b64\uff0c\u67d3\u8272\u8d28\u53ef\u53ca\u6027\u5206\u6790<\/span>\uff08\u5982ATAC-seq\uff09<\/span>\u6210\u4e3a\u63ed\u793a\u57fa\u56e0\u7ec4\u529f\u80fd\u7684\u91cd\u8981\u6280\u672f\u624b\u6bb5\uff0c\u80fd\u591f\u5e2e\u52a9\u6211\u4eec\u660e\u786e\u57fa\u56e0\u7ec4\u4e2d\u54ea\u4e9b\u533a\u57df\u5904\u4e8e\u67d3\u8272\u8d28\u5f00\u653e\u72b6\u6001\u3002\u4f46\u76ee\u524d\u5355\u7ec6\u80de\u6c34\u5e73\u7684ATAC-seq<\/span>\uff08\u8f6c\u5ea7\u9176\u53ef\u53ca\u67d3\u8272\u8d28\u6d4b\u5e8f\uff09<\/span>\u6280\u672f\uff0c\u666e\u904d\u5b58\u5728\u901a\u91cf\u4f4e\u3001\u7075\u654f\u5ea6\u4e0d\u8db3\u7b49\u95ee\u9898\uff0c\u96be\u4ee5\u4e3aAI\u6a21\u578b\u63d0\u4f9b\u5145\u8db3\u4e14\u9ad8\u8d28\u91cf\u7684\u8bad\u7ec3\u6570\u636e\u3002<\/span><\/span><\/p>\n

\u6d59\u6c5f\u5927\u5b66\u90ed\u56fd\u9aa5\u56e2\u961f7\u67088\u65e5\u5728\u300aCell\u300b\u6742\u5fd7\u53d1\u8868\u7684\u6700\u65b0\u5de5\u4f5c\uff0c\u56de\u5e94\u4e86\u4e0a\u8ff0\u6311\u6218\u3002\u56e2\u961f\u5f00\u53d1\u4e86UUATAC-seq<\/span>\uff08\u8d85\u9ad8\u901a\u91cf\u5355\u6838ATAC\u6d4b\u5e8f\uff09<\/span>\u6280\u672f\uff0c\u9996\u6b21\u5b9e\u73b0\u5355\u65e5\u5185\u6784\u5efa\u8de8\u7269\u79cd\u7684\u5355\u7ec6\u80de\u67d3\u8272\u8d28\u56fe\u8c31\u3002\u8be5\u7814\u7a76\u57fa\u4e8e\u65b0\u6d4b\u5e8f\u6280\u672f\uff0c\u8fdb\u4e00\u6b65\u63d0\u51fa\u4e86\u6df1\u5ea6\u5b66\u4e60\u6a21\u578bNvwaCE<\/span>\uff08\u5973\u5a32CE\uff09<\/span>\uff0c\u5b9e\u73b0\u4e86\u8de8\u7269\u79cd\u3001\u8de8\u7ec6\u80de\u7c7b\u578b\u7684\u5355\u7ec6\u80de\u8c03\u63a7\u5e8f\u5217\u7cbe\u51c6\u9884\u6d4b\u3002\u8fd9\u9879\u7814\u7a76\u4e0d\u4ec5\u663e\u8457\u63d0\u5347\u4e86AI\u6a21\u578b\u5728\u57fa\u56e0\u8c03\u63a7\u9886\u57df\u7684\u9884\u6d4b\u6027\u80fd\uff0c\u4e5f\u4e3a\u540e\u7eed\u7814\u7a76\u63d0\u4f9b\u4e86\u9ad8\u8d28\u91cf\u7684\u6570\u636e\u57fa\u7840\u4e0e\u5168\u65b0\u601d\u8def\u3002<\/span><\/span><\/p>\n


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\u56fe1\uff08\u539f\u56fe1A\uff09 UUATAC\u2011seq \u7684\u5b9e\u9a8c\u6d41\u7a0b\u4e0e\u201c\u56db\u8f6e\u6c60\u62c6\u6761\u7801\u201d\u8bbe\u8ba1\uff0c\u9ad8\u6548\u5b8c\u6210\u5355\u7ec6\u80de\u67d3\u8272\u8d28\u68c0\u6d4b\u3002\u7b2c\u4e00\u6b65\uff0c\u5229\u7528\u7279\u6b8a\u7684\u9176\u7ed9\u6bcf\u4e2a\u7ec6\u80de\u7684DNA\u6253\u4e0a\u521d\u59cb\u6807\u7b7e\u6761\u7801\uff1b\u7b2c\u4e8c\u6b65\uff0c\u7ec6\u80de\u6df7\u5408\u540e\uff0c\u518d\u7ed9\u6bcf\u4e2a\u7ec6\u80de\u6dfb\u52a0\u4e00\u4e2a\u72ec\u7279\u6807\u7b7e\uff1b\u7b2c\u4e09\u6b65\uff0c\u901a\u8fc7\u6e29\u5ea6\u63a7\u5236\u7684\u65b9\u5f0f\u7cbe\u786e\u52a0\u5165\u7b2c\u4e09\u4e2a\u6807\u7b7e\uff1b\u6700\u540e\u4e00\u6b65\uff0c\u901a\u8fc7DNA\u6269\u589e\u52a0\u5165\u7b2c\u56db\u4e2a\u6807\u7b7e\uff0c\u5b8c\u6210\u5355\u7ec6\u80de\u6c34\u5e73\u7684\u67d3\u8272\u8d28\u5206\u6790\u3002<\/span><\/span><\/p>\n

\u57fa\u4e8e\u8fd9\u4e9b\u6539\u8fdb\uff0cUUATAC-seq\u53ef\u5728\u5355\u65e5\u5185\u5b8c\u6210\u5bf9\u591a\u4e2a\u7269\u79cd\u3001\u6570\u5341\u4e07\u7ec6\u80de\u6838\u7684\u67d3\u8272\u8d28\u53ef\u53ca\u6027\u5206\u6790\uff0c\u6570\u636e\u8d28\u91cf\u548c\u5b9e\u9a8c\u901a\u91cf\u663e\u8457\u4f18\u4e8e\u73b0\u6709\u7684\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\uff0c\u4e3a\u540e\u7eedAI\u6a21\u578b\u7684\u9ad8\u6548\u8bad\u7ec3\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u6570\u636e\u57fa\u7840\u3002<\/span><\/span><\/p>\n


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\u5728\u83b7\u5f97\u9ad8\u8d28\u91cf\u6570\u636e\u57fa\u7840\u4e0a\uff0c\u90ed\u56fd\u9aa5\u56e2\u961f\u8fdb\u4e00\u6b65\u6784\u5efa\u4e86\u4e00\u4e2a\u5f3a\u5927\u7684AI\u6a21\u578b\uff1aNvwaCE<\/span>\uff08\u5973\u5a32CE\uff09<\/span>\u3002\u8be5\u6a21\u578b\u76f4\u63a5\u4ee5DNA\u5e8f\u5217\u4f5c\u4e3a\u8f93\u5165\uff0c\u4ee5\u5355\u7ec6\u80de<\/span>\uff08single-cell\uff09<\/span>\u751a\u81f3\u5355\u6838<\/span>\uff08single-nucleus\uff09<\/span>\u7ea7\u522b\u7684\u5206\u8fa8\u7387\u7cbe\u51c6\u9884\u6d4b\u67d3\u8272\u8d28\u5f00\u653e\u6027\uff0c\u4ece\u800c\u7cfb\u7edf\u5730\u89e3\u8bfb\u9690\u85cf\u4e8e\u57fa\u56e0\u7ec4\u5e8f\u5217\u4e2d\u7684\u8c03\u63a7\u201c\u8bed\u6cd5\u201d\u3002<\/span><\/span><\/p>\n

\u5176\u4e2d\uff0cCE \u6307\u987a\u5f0f\u8c03\u63a7\u5143\u4ef6<\/span>\uff08cis-regulatory element\uff09<\/span>\uff0c\u5373\u57fa\u56e0\u7ec4\u4e2d\u4e0d\u76f4\u63a5\u7f16\u7801\u86cb\u767d\u8d28\u3001\u4f46\u80fd\u8c03\u63a7\u57fa\u56e0\u8868\u8fbe\u7684\u529f\u80fd\u5e8f\u5217\u3002\u8fd9\u4e9b\u8c03\u63a7\u5143\u4ef6\u80fd\u591f\u51b3\u5b9a\u54ea\u4e9b\u57fa\u56e0\u3001\u4f55\u65f6\u4f55\u5730\u88ab\u6fc0\u6d3b\u6216\u5173\u95ed\uff0c\u4ece\u800c\u63a7\u5236\u7ec6\u80de\u7c7b\u578b\u7684\u591a\u6837\u6027\u3002\u4ee5\u5f80\u57fa\u56e0\u7ec4AI\u6a21\u578b\u5927\u591a\u4fa7\u91cd\u4e8e\u4eceDNA\u5e8f\u5217\u7684\u76f8\u4f3c\u6027\u6765\u9884\u6d4b\u529f\u80fd\u3002\u5973\u5a32CE\u5219\u4fa7\u91cd\u4eceDNA\u5e8f\u5217\u4e2d\u76f4\u63a5\u5b66\u4e60\u67d3\u8272\u8d28\u7684\u5f00\u653e\u72b6\u6001\u53ca\u5176\u8c03\u63a7\u6a21\u5f0f\uff0c\u800c\u975e\u7b80\u5355\u57fa\u4e8e\u5e8f\u5217\u5339\u914d\u3002<\/span><\/span><\/p>\n

\u8fd9\u79cd\u7b56\u7565\u4f7f\u5f97\u5973\u5a32CE\u80fd\u591f\u6709\u6548\u8bc6\u522b\u8de8\u7269\u79cd\u7684\u666e\u9002\u7684\u8c03\u63a7\u5e8f\u5217\u8bed\u6cd5\uff0c\u5e76\u7531\u6b64\u63ed\u793a\u810a\u690e\u52a8\u7269\u7ec6\u80de\u529f\u80fd\u8c03\u63a7\u4e2d\u7684\u901a\u7528\u89c4\u5f8b\u3002<\/span><\/span><\/p>\n

\u5177\u4f53\u800c\u8a00\uff0c\u5973\u5a32CE\u6a21\u578b\u91c7\u7528\u4e86\u591a\u4efb\u52a1\u6df1\u5ea6\u5b66\u4e60\u67b6\u6784<\/span>\uff08\u56fe2\uff09<\/span>\uff0c\u5176\u6838\u5fc3\u7ed3\u6784\u7531\u5377\u79ef\u7f51\u7edcCNN\u4e0e\u6b8b\u5dee\u7f51\u7edcResNeXt\u7ec4\u6210\uff0c\u80fd\u591f\u6709\u6548\u6355\u6349DNA\u5e8f\u5217\u4e2d\u590d\u6742\u7684\u6a21\u5f0f\u7279\u5f81\u4e0e\u591a\u5c3a\u5ea6\u4fe1\u606f\u3002\u6a21\u578b\u4ee5\u56fa\u5b9a\u957f\u5ea6<\/span>\uff08500 bp\uff09<\/span>\u7684\u57fa\u56e0\u7ec4\u5e8f\u5217\u4e3a\u8f93\u5165\uff0c\u7ecf\u5377\u79ef\u5c42\u548c\u74f6\u9888\u5c42\u7684\u7279\u5f81\u538b\u7f29\u540e\uff0c\u6700\u7ec8\u8f93\u51fa\u8fd9\u6bb5\u5e8f\u5217\u5728\u6570\u4e07\u4e2a\u5355\u7ec6\u80de\u6838\u5185\u5904\u4e8e\u67d3\u8272\u8d28\u5f00\u653e\u72b6\u6001<\/span>\uff08\u8c03\u63a7\u5143\u4ef6\u6d3b\u8dc3\uff09<\/span>\u7684\u6982\u7387\u3002<\/span><\/span><\/p>\n

<\/section>\n

\u56fe2\uff08\u539f\u56fe5A\uff09\u5973\u5a32 CE \u6a21\u578b\u67b6\u6784\u793a\u610f\u3002<\/span><\/span><\/p>\n

\u5728\u6027\u80fd\u8bc4\u4f30\u4e2d\uff0c\u5973\u5a32CE\u6a21\u578b\u8868\u73b0\u51fa\u5353\u8d8a\u7684\u9884\u6d4b\u80fd\u529b\uff0c\u5728\u4e0d\u540c\u7269\u79cd\u7684\u67d3\u8272\u8d28\u5f00\u653e\u72b6\u6001\u9884\u6d4b\u4efb\u52a1\u4e2d\u5747\u8fbe\u5230\u9ad8\u7cbe\u5ea6<\/span>\uff08AUROC > 0.80\uff0c\u90e8\u5206\u751a\u81f3\u8fbe\u52300.99\uff09<\/span>\uff0c\u660e\u663e\u4f18\u4e8e\u4e3b\u6d41\u6a21\u578b<\/span>\uff08\u5982scBasset\u548cTransformer\uff09<\/span>\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5373\u4fbf\u5bf9\u4e8e\u672a\u7ecf\u8fc7\u8bad\u7ec3\u7684\u7269\u79cd<\/span>\uff08\u5982\u9e21\u3001\u58c1\u864e\u3001\u877e\u8788\u3001\u6591\u9a6c\u9c7c\uff09<\/span>\uff0c\u6a21\u578b\u4f9d\u7136\u5177\u6709\u5f88\u5f3a\u7684\u6cdb\u5316\u9884\u6d4b\u80fd\u529b\u3002<\/span><\/span><\/p>\n

\u8fd9\u8868\u660e\u8c03\u63a7\u5143\u4ef6\u80cc\u540e\u7684\u201c\u5e8f\u5217\u8bed\u6cd5\u201d\u8fdc\u6bd4DNA\u5e8f\u5217\u672c\u8eab\u66f4\u4e3a\u4fdd\u5b88\uff0c\u66f4\u63ed\u793a\u4e86\u810a\u690e\u52a8\u7269\u57fa\u56e0\u8c03\u63a7\u7684\u5171\u6027\u3002\u6b64\u5916\uff0c\u5973\u5a32CE\u8fd8\u80fd\u81ea\u52a8\u8bc6\u522b\u51fa\u4e0e\u795e\u7ecf\u3001\u514d\u75ab\u3001\u8102\u4ee3\u8c22\u7b49\u529f\u80fd\u76f8\u5173\u7684\u5e8f\u5217\u6a21\u5757\uff0c\u4e0d\u4ec5\u63d0\u9ad8\u4e86\u9884\u6d4b\u51c6\u786e\u5ea6\uff0c\u4e5f\u589e\u5f3a\u4e86\u6a21\u578b\u7684\u53ef\u89e3\u91ca\u6027\u3002<\/span><\/span><\/p>\n


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\u529f\u80fd\u9a8c\u8bc1\u4e0e\u7cbe\u51c6\u533b\u5b66\u5e94\u7528<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


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\u8fd9\u9879\u7814\u7a76\u8fdb\u4e00\u6b65\u63a2\u7d22\u4e86\u5973\u5a32CE\u6a21\u578b\u5728\u5b9e\u9645\u751f\u7269\u533b\u5b66\u95ee\u9898\u4e2d\u7684\u5e94\u7528\u6f5c\u529b\uff0c\u7279\u522b\u662f\u5728\u9488\u5bf9\u4eba\u7c7b\u75be\u75c5\u76f8\u5173\u975e\u7f16\u7801\u8c03\u63a7\u5143\u4ef6\u7684\u7a81\u53d8\u6548\u5e94\u9884\u6d4b\u65b9\u9762\uff0c\u8bc4\u4f30\u4e86\u8be5\u6a21\u578b\u7684\u7cbe\u51c6\u533b\u5b66\u4ef7\u503c\u3002<\/span><\/span><\/p>\n

\u56e2\u961f\u9009\u53d6\u4e86361\u4e2a\u5df2\u77e5\u4e0e\u4eba\u7c7b\u75be\u75c5\u5bc6\u5207\u76f8\u5173\u7684\u7cbe\u7ec6\u5b9a\u4f4d\u975e\u7f16\u7801\u4f4d\u70b9\uff0c\u9010\u4e00\u5229\u7528\u5973\u5a32CE\u6a21\u578b\u8fdb\u884c\u7a81\u53d8\u529f\u80fd\u6548\u5e94\u9884\u6d4b\uff0c\u6210\u529f\u9274\u5b9a\u51fa265\u4e2a\u5177\u6709\u660e\u786e\u529f\u80fd\u5f71\u54cd\u7684\u5173\u952e\u53d8\u5f02\u4f4d\u70b9\uff0c\u660e\u663e\u4f18\u4e8e\u4f20\u7edf\u65b9\u6cd5\u3002<\/span><\/span><\/p>\n

\u56e2\u961f\u8fd8\u5229\u7528\u57fa\u56e0\u7f16\u8f91\u5b9e\u9a8c\uff0c\u9996\u6b21\u5728\u4eba\u4f53\u7ec6\u80de\u4e2d\u9a8c\u8bc1\u4e86\u5b8c\u5168\u7531AI\u7cbe\u51c6\u9884\u6d4b\u7684\u75be\u75c5\u6cbb\u7597\u5173\u952e\u4f4d\u70b9<\/span>\uff08\u80ce\u513f\u8840\u7ea2\u86cb\u767d\u57fa\u56e0HBG1-68:A>G\uff09<\/span>\u3002\u8fd9\u4e3aAI\u5728\u4e34\u5e8a\u6cbb\u7597\u9776\u70b9\u8bbe\u8ba1\u4e2d\u7684\u5e94\u7528\u63d0\u4f9b\u4e86\u660e\u786e\u7684\u5b9e\u9a8c\u8bc1\u636e\u3002<\/span><\/span><\/p>\n


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\u8de8\u5c3a\u5ea6\u4e0e\u8de8\u7269\u79cd\u7684\u7814\u7a76\u524d\u666f<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


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\u5728\u8fd9\u9879\u5de5\u4f5c\u4e2d\uff0c\u7814\u7a76\u56e2\u961f\u63ed\u793a\u4e86\u8de8\u7269\u79cd\u7684\u8c03\u63a7\u5e8f\u5217\u5171\u6027\u89c4\u5f8b\u3002\u4ed6\u4eec\u53d1\u73b0\u4e0d\u540c\u810a\u690e\u52a8\u7269\u7684\u57fa\u56e0\u7ec4\u4e2d\uff0c\u8c03\u63a7\u5143\u4ef6\u6570\u91cf\u968f\u7740\u57fa\u56e0\u7ec4\u89c4\u6a21\u7684\u6269\u589e\u800c\u7a33\u5b9a\u589e\u52a0<\/span>\uff08\u56fe3\uff09<\/span>\uff0c\u4f46\u6bcf\u4e2a\u8c03\u63a7\u5143\u4ef6\u81ea\u8eab\u7684\u957f\u5ea6\u5219\u76f8\u5bf9\u7a33\u5b9a\u3002\u8fd9\u610f\u5473\u7740\u5728\u4e0d\u540c\u7269\u79cd\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u67d0\u79cd\u666e\u904d\u7684\u3001\u5185\u5728\u7684\u8c03\u63a7\u8bbe\u8ba1\u539f\u5219\u3002<\/span><\/span><\/p>\n

<\/section>\n

\u56fe3\uff08\u539f\u56fe4F\uff09\u5c55\u793a\u4e86\u810a\u690e\u52a8\u7269\u57fa\u56e0\u7ec4\u89c4\u6a21\uff08Genome size\uff09\u4e0e\u5019\u9009\u987a\u5f0f\u8c03\u63a7\u5143\u4ef6\u6570\u91cf\uff08Number of cCREs\uff09\u4e4b\u95f4\u663e\u8457\u7684\u7ebf\u6027\u5173\u7cfb\uff0c\u63ed\u793a\u4e86\u4e0d\u540c\u7269\u79cd\u57fa\u56e0\u7ec4\u4e2d\uff0c\u8c03\u63a7\u5143\u4ef6\u6570\u91cf\u968f\u57fa\u56e0\u7ec4\u89c4\u6a21\u6269\u589e\u800c\u7a33\u5b9a\u589e\u52a0\u7684\u89c4\u5f8b\u3002<\/span><\/span><\/p>\n

\u5982\u4f55\u5728\u7269\u79cd\u3001\u7ec4\u7ec7\u3001\u7ec6\u80de\u7c7b\u578b\u7b49\u4e0d\u540c\u751f\u547d\u5c3a\u5ea6\u4e4b\u95f4\u53d1\u73b0\u666e\u9002\u89c4\u5f8b\uff0c\u4e00\u76f4\u662f\u751f\u547d\u79d1\u5b66\u7684\u91cd\u8981\u6311\u6218\uff0c\u4e5f\u662f\u7cfb\u7edf\u79d1\u5b66\u7684\u4e3b\u6218\u573a\uff0c\u66f4\u662f\u5f53\u524dAI for Science\u7684\u4e3b\u8981\u9776\u6807\u3002<\/span><\/span><\/p>\n

\u8fd1\u4e24\u5e74\u6765\uff0c\u4e00\u7cfb\u5217\u65b0\u5174AI\u65b9\u6cd5\uff0c\u5747\u5c1d\u8bd5\u4ee5\u4e0d\u540c\u7684\u7b56\u7565\u548c\u5c3a\u5ea6\u6765\u89e3\u7801\u751f\u547d\u7cfb\u7edf\u7684\u529f\u80fd\u4fe1\u606f\u3002\u4f8b\u5982\uff0cEvo 2\u6a21\u578b\u4ece\u57fa\u56e0\u7ec4\u5e8f\u5217\u7684\u5b8f\u89c2\u5c3a\u5ea6\uff0c\u5c1d\u8bd5\u7528\u5927\u89c4\u6a21\u53c2\u6570\u6a21\u578b\u6765\u7edf\u4e00\u4e0d\u540c\u79cd\u7c7b\u7684\u5e8f\u5217\u4fe1\u606f\uff1b\u800cChromBPNet\u5219\u81f4\u529b\u4e8e\u7ec6\u81f4\u523b\u753b\u78b1\u57fa\u5c3a\u5ea6\u4e0a\u7684\u8c03\u63a7\u5e8f\u5217\u4e0e\u67d3\u8272\u8d28\u72b6\u6001\u7684\u5173\u7cfb\u3002\u4f46\u8fd9\u4e9b\u5de5\u4f5c\u666e\u904d\u53d7\u5230\u8bad\u7ec3\u6570\u636e\u5c3a\u5ea6\u4e0e\u7c7b\u578b\u7684\u9650\u5236\uff0c\u96be\u4ee5\u4ece\u6839\u672c\u4e0a\u89e3\u51b3\u201c\u5355\u7ec6\u80de\u2014\u5168\u57fa\u56e0\u7ec4\u201d\u8fd9\u4e00\u4ea4\u53c9\u5c3a\u5ea6\u95ee\u9898\u3002<\/span><\/span><\/p>\n

\u5728\u6b64\u80cc\u666f\u4e0b\uff0c\u5973\u5a32CE\u6a21\u578b\u7684\u7a81\u7834\uff0c\u4e0d\u4f9d\u8d56\u4e8eENCODE<\/span>\uff08DNA\u5143\u4ef6\u767e\u79d1\u5168\u4e66\u8ba1\u5212\uff09<\/span>\u7684\u590d\u6742\u6570\u636e\u4f53\u7cfb\uff0c\u5c31\u80fd\u591f\u5b9e\u73b0\u5355\u7ec6\u80de\u6c34\u5e73\u7684\u5e8f\u5217\u529f\u80fd\u9884\u6d4b\uff0c\u5e76\u4e14\u7406\u89e3\u5927\u91cf\u9690\u85cf\u7684\u7279\u5f02\u6027\u8c03\u63a7\u89c4\u5219\u3002<\/span><\/span><\/p>\n

\u603b\u4e4b\uff0c\u90ed\u56fd\u9aa5\u56e2\u961f\u7684\u6700\u65b0\u5de5\u4f5c\uff0c\u4e3a\u5168\u9762\u89e3\u8bfb\u57fa\u56e0\u7ec4\u8bed\u8a00\u548c\u5efa\u7acb\u6570\u5b57\u751f\u547d\u6a21\u578b\uff0c\u5960\u5b9a\u4e86\u66f4\u5b9e\u7684\u57fa\u7840\u3002\u5c24\u5176\u662f\u5973\u5a32CE\u6a21\u578b\u5728\u8de8\u7269\u79cd\u6cdb\u5316\u9884\u6d4b\u548c\u975e\u7f16\u7801\u53d8\u5f02\u529f\u80fd\u9a8c\u8bc1\u4e2d\u7684\u6210\u529f\uff0c\u6709\u671b\u52a0\u901f\u7cbe\u51c6\u533b\u5b66\u548c\u5408\u6210\u751f\u7269\u5b66\u53d1\u5c55\uff0c\u8fdb\u4e00\u6b65\u6253\u5f00AI for Science\u7684\u60f3\u8c61\u7a7a\u95f4\u3002<\/span><\/span>
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AI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\u7814\u8ba8\u4f1a<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/span><\/span><\/span><\/strong><\/span><\/section>\n

\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u5b66\u9886\u57df\u6b63\u7ecf\u5386\u7740\u6df1\u523b\u7684\u667a\u80fd\u9769\u547d\u3002\u5927\u8bed\u8a00\u6a21\u578b\u4e0e\u591a\u667a\u80fd\u4f53\u6280\u672f\u5feb\u901f\u53d1\u5c55\uff0c\u6b63\u5728\u63a8\u52a8\u5f62\u6210\u8ba1\u7b97\u533b\u5b66\uff08Computational Medicine\uff09\u65b0\u8303\u5f0f\uff0c\u4e3a\u7cbe\u51c6\u533b\u7597\u3001\u75be\u75c5\u8bca\u65ad\u548c\u5065\u5eb7\u7ba1\u7406\u5f00\u8f9f\u5168\u65b0\u8def\u5f84\u3002AI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u5728\u81ea\u4e3b\u63a2\u7d22\u3001\u8de8\u5c3a\u5ea6\u6570\u636e\u878d\u5408\u3001\u4e2a\u4f53\u5efa\u6a21\u4e0e\u6570\u5b57\u5b6a\u751f\u7b49\u65b9\u9762\u5feb\u901f\u53d1\u5c55\uff0c\u7136\u800c\u8de8\u5b66\u79d1\u5408\u4f5c\u4e0e\u65b9\u6cd5\u8bba\u6574\u5408\u4ecd\u662f\u91cd\u8981\u6311\u6218\u3002<\/span><\/p>\n

\u4e3a\u6b64\uff0cDAMO\u5f00\u53d1\u8005\u77e9\u9635\uff08\u7531\u963f\u91cc\u5df4\u5df4\u8fbe\u6469\u9662\u548c\u4e2d\u56fd\u4e92\u8054\u7f51\u534f\u4f1a\u8054\u5408\u53d1\u8d77\uff09\u4e0e\u96c6\u667a\u4ff1\u4e50\u90e8\u5171\u540c\u4e3b\u529e\u201cAI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\uff1a\u4ece\u79d1\u5b66\u53d1\u73b0\u5230\u6570\u5b57\u5b6a\u751f\u201d\u7cfb\u5217\u7814\u8ba8\u4f1a<\/a>\uff0c\u9080\u8bf7\u591a\u4f4d\u56fd\u5185\u5916\u524d\u6cbf\u5b66\u8005\u4e0e\u4e1a\u754c\u4e13\u5bb6\u5206\u4eab\u4ea4\u6d41\u3002\u7cfb\u5217\u7814\u8ba8\u4f1a\u5c06\u7cfb\u7edf\u68b3\u7406\u8ba1\u7b97\u533b\u5b66\u4e0eAI\u4ea4\u53c9\u9886\u57df\u7684\u6700\u65b0\u8fdb\u5c55\uff0c\u81ea2025\u5e747\u67086\u65e5\uff08\u5468\u65e5\uff09\u5f00\u59cb\uff0c\u51715\u5927\u8bae\u9898\u5206\u4eab\u4e0e\u8ba8\u8bba\u3002\u6b22\u8fce\u76f8\u5173\u7814\u7a76\u3001\u5e94\u7528\u9886\u57df\u7684\u670b\u53cb\u62a5\u540d\u53c2\u52a0\uff0c\u5171\u540c\u63a8\u52a8\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u7597\u5065\u5eb7\u7684\u667a\u80fd\u672a\u6765\uff01<\/span><\/p>\n

\u672c\u6d3b\u52a8\u514d\u8d39\u62a5\u540d\uff0c\u5b9e\u884c\u5ba1\u6838\u5165\u7fa4\u5236\uff0c\u8bf7\u586b\u5199\u4fe1\u606f\u540e\u5165\u7fa4\u53c2\u4e0e\u4ea4\u6d41\u5e76\u83b7\u5f97\u6bcf\u671f\u6d3b\u52a8\u4fe1\u606f\u3002<\/span><\/p>\n

\"\u56fe\u7247\"<\/span><\/a><\/p>\n

\u8be6\u60c5\u8bf7\u89c1\uff1aAI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\u7814\u8ba8\u4f1a\u5f00\u542f\u62a5\u540d\uff1a\u4ece\u79d1\u5b66\u53d1\u73b0\u5230\u6570\u5b57\u5b6a\u751f<\/a><\/span><\/span><\/section>\n


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\u63a8\u8350\u9605\u8bfb<\/span><\/span><\/strong><\/strong><\/strong><\/section>\n
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1.\u96c6\u667a\u79d1\u5b66\u5bb6\u5434\u4ee4\u98deNature\u53d1\u6587\uff1a\u5927\u56e2\u961f\u6e10\u8fdb\u53d1\u5c55\uff0c\u5c0f\u56e2\u961f\u98a0\u8986\u5f0f\u521b\u65b0<\/span><\/a><\/span><\/strong>
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2.Nature\u6700\u65b0\uff1a\u8fdc\u7a0b\u5408\u4f5c\u5f80\u5f80\u6ca6\u4e3a\u6253\u5de5\u4eba\uff0c\u98a0\u8986\u5f0f\u521b\u65b0\u8fd8\u5f97\u9760\u9762\u5bf9\u9762\u4ea4\u6d41<\/span><\/a><\/span><\/strong>
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3.\u5fb7\u56fd\u9a6c\u666e\u6240\u4e13\u9898\u7814\u8ba8\u4f1a\uff1a\u591a\u4f4d\u5b66\u8005\u6279\u8bc4\u201cNature\u8fdc\u7a0b\u56e2\u961f\u4e0d\u98a0\u8986\u201d\u65b0\u7814\u7a76<\/span><\/a><\/span><\/strong><\/section>\n
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4. <\/span><\/strong><\/span>\u6d8c\u73b0\u52a8\u529b\u5b66\u5982\u4f55\u7528\u6765\u5206\u6790\u590d\u6742\u7cfb\u7edf\uff1f | \u65b0\u8bfe\u4e0a\u7ebf<\/a><\/span><\/strong><\/strong><\/span><\/section>\n
<\/strong>5. <\/span><\/strong>AI\u65f6\u4ee3\u7684\u5b66\u4e60\uff1a\u5171\u63a2\u4eba\u7c7b\u5b66\u4e60\u7684\u590d\u6742\u6027<\/span><\/a><\/span><\/strong><\/section>\n

6. <\/span><\/strong>\u63a2\u7d22\u8005\u8ba1\u5212 | \u96c6\u667a\u4ff1\u4e50\u90e82025\u5185\u5bb9\u56e2\u961f\u62db\u52df\uff08\u5168\u804c&\u517c\u804c\uff09<\/a><\/span><\/strong><\/span><\/p>\n

7.<\/span><\/span><\/strong><\/strong><\/span> <\/span><\/span><\/strong><\/strong><\/span>\u7cfb\u7edf\u79d1\u5b66\u524d\u6cbf\u5341\u8bb2\uff1a\u7406\u89e3\u81ea\u7136\u3001\u751f\u547d\u4e0e\u793e\u4f1a\u7684\u590d\u6742\u6027<\/span><\/a><\/span><\/strong><\/strong><\/span><\/p>\n


<\/span><\/p>\n


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<\/span><\/a><\/section>\n


<\/span><\/p>\n


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\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c<\/span>\u62a5\u540d\u7cfb\u5217\u7814\u8ba8\u4f1a<\/span><\/span><\/span><\/span><\/strong><\/span><\/span><\/section>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc\u8bed \u9ad8\u8d28\u91cf\u7684\u6570\u636e\u662fAI\u9a71\u52a8\u751f\u547d\u79d1\u5b66\u7684\u91cd\u8981\u74f6\u9888\u3002\u8fd1\u65e5\uff0c\u6d59\u6c5f\u5927\u5b66\u90ed\u56fd\u9aa5\u56e2\u961f\u5728\u300aCell\u300b\u53d1\u8868\u6700\u65b0\u7814\u7a76\uff0c\u5f00\u53d1\u4e86\u8d85\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u67d3\u8272\u8d28\u5f00\u653e\u6d4b\u5e8f\u6280\u672f\uff08UUATAC-seq\uff09\uff0c\u5e76\u6784\u5efa\u8de8\u7269\u79cd\u5355\u7ec6\u80de\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff08\u5973\u5a32CE\uff09\uff0c\u5b9e\u73b0\u4e86\u8c03\u63a7\u5e8f\u5217\u7684\u7cbe\u51c6\u9884\u6d4b\u548c\u75be\u75c5\u76f8\u5173\u7a81\u53d8\u529f\u80fd\u9a8c\u8bc1\uff0c\u53d1\u73b0\u4e86\u8de8\u7269\u79cd\u7684\u57fa\u56e0\u8c03\u63a7\u201c\u8bed\u6cd5\u201d\uff0c\u4e3a\u8ba1\u7b97\u533b\u5b66\u63d0…<\/p>\n","protected":false},"author":0,"featured_media":61771,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/61781"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=61781"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/61781\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/61771"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=61781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=61781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=61781"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=61781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}