{"id":61802,"date":"2025-07-09T17:27:00","date_gmt":"2025-07-09T09:27:00","guid":{"rendered":"https:\/\/swarma.org\/?p=61802"},"modified":"2025-07-09T17:27:00","modified_gmt":"2025-07-09T09:27:00","slug":"ai%e8%a7%a3%e7%a0%81%e5%9f%ba%e5%9b%a0-rna%e8%b0%83%e6%8e%a7%ef%bc%9a%e6%9e%84%e5%bb%ba%e7%b2%be%e5%87%86%e5%8c%bb%e5%ad%a6%e7%9a%84%e5%88%86%e5%ad%90%e5%ba%95%e5%ba%a7-%e5%91%a8%e5%9b%9b%e7%9b%b4","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=61802","title":{"rendered":"AI\u89e3\u7801\u57fa\u56e0-RNA\u8c03\u63a7\uff1a\u6784\u5efa\u7cbe\u51c6\u533b\u5b66\u7684\u5206\u5b50\u5e95\u5ea7 | \u5468\u56db\u76f4\u64ad\u00b7\u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\u7814\u8ba8\u4f1a\u7b2c\u4e8c\u671f"},"content":{"rendered":"<div class='wxsyncmain'>\n<section data-mpa-powered-by=\"yiban.io\" data-pm-slice=\"0 0 []\" style=\"margin: 0px;padding: 0px;max-width: 100%;font-style: normal;font-weight: 400;letter-spacing: 0.544px;text-align: justify;text-indent: 0px;text-transform: 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style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><span style=\"margin: 0px;padding: 0px;max-width: 100%;font-size: 13px;letter-spacing: 0.544px\"><span style=\"margin: 0px;padding: 0px;max-width: 100%\"><br \/><\/span><\/span><\/strong><\/section>\n<section style=\"margin: 0px;padding: 0px 8px;max-width: 100%;font-size: 13px;line-height: 2;letter-spacing: 0.544px\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><span style=\"margin: 0px;padding: 0px;max-width: 100%;font-size: 13px;letter-spacing: 0.544px\"><span style=\"margin: 0px;padding: 0px;max-width: 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0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><\/strong><\/section>\n<section style=\"margin: 0px;padding: 0px 8px;max-width: 100%;font-size: 13px;line-height: 2;letter-spacing: 0.544px\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><\/strong><\/section>\n<\/section>\n<section style=\"margin: 5px 0px;padding: 0px;max-width: 100%\">\n<section style=\"margin: 0px;padding: 0px 8px;max-width: 100%;font-size: 13px;line-height: 2;letter-spacing: 0.544px\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><\/strong><\/section>\n<section style=\"margin: 0px;padding: 0px 8px;max-width: 100%;font-size: 13px;line-height: 2;letter-spacing: 0.544px\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><\/strong><\/section>\n<section style=\"margin: 0px;padding: 0px 8px;max-width: 100%;font-size: 13px;line-height: 2;letter-spacing: 0.544px\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><\/strong><\/section>\n<\/section>\n<section style=\"margin: 5px 0px;padding: 0px;max-width: 100%\">\n<section style=\"margin: 0px;padding: 0px 8px;max-width: 100%;font-size: 13px;line-height: 2;letter-spacing: 0.544px\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><\/strong><\/section>\n<section style=\"margin: 0px;padding: 0px 8px;max-width: 100%;font-size: 13px;line-height: 2;letter-spacing: 0.544px\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><\/strong><\/section>\n<\/section>\n<section style=\"margin: 5px 0px;padding: 0px;max-width: 100%\">\n<section style=\"margin: 0px;padding: 0px 8px;max-width: 100%;font-size: 13px;line-height: 2;letter-spacing: 0.544px\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><\/strong><\/section>\n<\/section>\n<section style=\"margin: 5px 0px;padding: 0px;max-width: 100%\">\n<section style=\"margin: 0px;padding: 0px 8px;max-width: 100%;font-size: 13px;line-height: 2;letter-spacing: 0.544px;text-align: right\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.578px;text-indent: 0em;font-size: 15px\"><\/strong><\/section>\n<\/section>\n<section style=\"margin: 5px 0px;padding: 0px;max-width: 100%\">\n<section style=\"margin: 0px;padding: 0px 8px;max-width: 100%;font-size: 13px;line-height: 2;letter-spacing: 0.544px\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%;letter-spacing: 0.544px\"><strong style=\"margin: 0px;padding: 0px;max-width: 100%\"><\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 10px 0px 0px;padding: 0px;max-width: 100%\">\n<section style=\"margin: 0px;padding: 0px;max-width: 100%;width: 661px\">\n<section style=\"margin: 0px;padding: 0px;max-width: 100%;clear: both;line-height: 0\">\n<section style=\"margin: 0px;padding: 0px;max-width: 100%;line-height: 0;width: 0px\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin: 10px 0px;padding: 0px;max-width: 100%;font-style: normal;font-weight: 400;letter-spacing: 0.544px;text-indent: 0px;text-transform: none;font-family: PingFangSC-light;font-size: 15px;text-align: center\">\n<section style=\"margin: 0px;padding: 0px;max-width: 100%;vertical-align: middle;line-height: 0\"><img alt=\"\u56fe\u7247\" class=\"rich_pages wxw-img\" data-ratio=\"0.07314814814814814\" data-type=\"png\" data-w=\"1080\" style=\"margin: 0px;padding: 0px;max-width: 100%;vertical-align: middle;height: auto !important;width: 677px !important\" data-fileid=\"100098753\" data-imgfileid=\"100226453\" src=\"\" 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style=\"float: left;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"float: right;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;, Arial, sans-serif;letter-spacing: 0.578px;line-height: 1.75em\"><span><br \/><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u533b\u7597\u7684\u7cbe\u51c6\u5316\u3001\u4e2a\u4f53\u5316\u65f6\u4ee3\u5df2\u7ecf\u5230\u6765\uff0c\u4f46\u5728\u771f\u6b63\u5b9e\u73b0\u4e34\u5e8a\u7cbe\u51c6\u533b\u7597\u4e4b\u524d\uff0c\u5982\u4f55\u4ece\u6d77\u91cf\u590d\u6742\u7684\u57fa\u56e0\u7ec4\u3001\u8f6c\u5f55\u7ec4\u3001\u86cb\u767d\u7ec4\u3001\u4ee3\u8c22\u7ec4\u7b49\u591a\u7ec4\u5b66\u6570\u636e\u4e2d\u9ad8\u6548\u6316\u6398\u51fa\u75be\u75c5\u8868\u578b\u7684\u6df1\u5c42\u89c4\u5f8b\uff0c\u4ecd\u7136\u662f\u5f53\u524d\u751f\u547d\u79d1\u5b66\u4e0eAI\u4ea4\u53c9\u9886\u57df\u7684\u91cd\u8981\u6311\u6218\u3002AI\u9a71\u52a8\u7684\u591a\u6a21\u6001\u751f\u7269\u533b\u5b66\u6a21\u578b\uff0c\u9010\u6e10\u5728\u4e0d\u540c\u5c3a\u5ea6\u7684\u7ec4\u5b66\u6570\u636e\u95f4\u5efa\u7acb\u9ad8\u6548\u8fde\u63a5\uff0c\u4ece\u800c\u4e3a\u75be\u75c5\u7684\u7cbe\u51c6\u5206\u7c7b\u3001\u8bca\u65ad\u3001\u7597\u6548\u76d1\u6d4b\u548c\u9776\u5411\u6cbb\u7597\u63d0\u4f9b\u4e86\u524d\u6240\u672a\u6709\u7684\u53ef\u80fd\u3002<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><br \/><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><span>\u8ba1\u7b97\u533b\u5b66\u7cfb\u5217\u7814\u8ba8\u4f1a\u5c06\u901a\u8fc7\u4e24\u671f\u5185\u5bb9\uff0c\u5206\u522b\u805a\u7126\u4e8e<\/span><\/span><strong><span><span>AI\u57fa\u56e0-RNA\u8c03\u63a7\u7814\u7a76<\/span><\/span><\/strong><span><span>\u4ee5\u53ca<\/span><\/span><strong><span><span>AI\u86cb\u767d\u8d28\u79d1\u5b66\u4e0e\u591a\u7ec4\u5b66\u7814\u7a76<\/span><\/span><\/strong><span><span>\uff0c\u6df1\u5165\u63a2\u8ba8AI\u5982\u4f55\u63a8\u52a8\u751f\u7269\u533b\u5b66\u6570\u636e\u4e0e\u7cbe\u51c6\u533b\u7597\u7684\u6df1\u5ea6\u878d\u5408\u3002\u672c\u671f\u5c06\u91cd\u70b9\u89e3\u6790AI\u9a71\u52a8\u7684\u57fa\u56e0\u7ec4\u4e0e\u8f6c\u5f55\u7ec4\u7814\u7a76\u5982\u4f55\u63ed\u793a\u590d\u6742\u75be\u75c5\u80cc\u540e\u7684\u8c03\u63a7\u7f51\u7edc\u4e0e\u5206\u5b50\u673a\u5236\uff0c\u63a2\u8ba8\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u5982\u4f55\u5b9e\u73b0\u4eceDNA\u5e8f\u5217\u4e0eRNA\u8c03\u63a7\u5230\u4e34\u5e8a\u75be\u75c5\u8868\u578b\u7684\u6709\u6548\u8d2f\u901a\uff0c\u4e3a\u7cbe\u51c6\u533b\u5b66\u7684\u4e34\u5e8a\u843d\u5730\u63d0\u4f9b\u5206\u5b50\u5c42\u9762\u7684\u79d1\u5b66\u57fa\u7840\u3002\u672c\u671f\u5c06\u63a2\u8ba8\uff1a<\/span><\/span><\/span><\/p>\n<ul style=\"margin-left: 8px;margin-right: 8px\" class=\"list-paddingleft-1\">\n<li style=\"text-align: left\">\n<p style=\"margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>AI\u5982\u4f55\u5e2e\u52a9\u7834\u8bd1\u57fa\u56e0\u7ec4\u8c03\u63a7\u5bc6\u7801\uff0c\u53d1\u73b0\u65b0\u7684\u75be\u75c5\u76f8\u5173\u5206\u5b50\u673a\u5236\uff1f<\/span><\/span><\/p>\n<\/li>\n<li style=\"text-align: left\">\n<p style=\"margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u5982\u4f55\u63ed\u793aRNA\u7ffb\u8bd1\u53ca\u8f6c\u5f55\u540e\u8c03\u63a7\u5728\u590d\u6742\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\uff1f<\/span><\/span><\/p>\n<\/li>\n<li style=\"text-align: left\">\n<p style=\"margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u5982\u4f55\u5c06AI\u9a71\u52a8\u7684\u57fa\u56e0-RNA\u8c03\u63a7\u6a21\u578b\u9ad8\u6548\u8f6c\u5316\u4e3a\u7cbe\u51c6\u533b\u5b66\u7684\u5b9e\u9645\u5e94\u7528\uff1f<\/span><\/span><\/p>\n<\/li>\n<li style=\"text-align: left\">\n<p style=\"margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u5728\u63a8\u8fdb\u4e0a\u8ff0\u7814\u7a76\u4e0e\u4e34\u5e8a\u8f6c\u5316\u8fc7\u7a0b\u4e2d\uff0c\u4e0d\u540c\u5730\u533a\u548c\u56fd\u5bb6\u5728\u6570\u636e\u6807\u51c6\u3001\u7814\u7a76\u6a21\u5f0f\u3001\u4f26\u7406\u6cbb\u7406\u4e0e\u4e34\u5e8a\u5b9e\u65bd\u4e0a\u7684\u5dee\u5f02\u4e0e\u6311\u6218<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<h2 style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span><br \/><\/span><\/h2>\n<h2 style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><br \/><\/span><\/h2>\n<h3 style=\", Arial, sans-serif;letter-spacing: 0.544px\">\n<section style=\"letter-spacing: 0.544px;text-align: right;font-size: 13px\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;letter-spacing: 0.544px;text-align: center\">\n<section style=\"vertical-align: middle\">\n<section style=\"margin-bottom: -2px;, Arial, sans-serif\">\n<section style=\"float: left;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"float: right;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"clear: both;line-height: 0\">\n<section style=\"line-height: 0;width: 0px\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;font-size: 16px;line-height: 1.4\">\n<p><strong><strong style=\"text-align: left;letter-spacing: 0.544px\"><span style=\", Arial, sans-serif\"><strong style=\"letter-spacing: 0.578px\"><span>\u5206\u4eab\u7b80\u4ecb<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;, Arial, sans-serif\">\n<section style=\"float: left;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"float: right;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;, Arial, sans-serif;letter-spacing: 0.578px;line-height: 1.75em\"><span><br \/><\/span><\/p>\n<h3 style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span style=\"font-weight: bold\">\u62a5\u544a\u4e00\uff1a\u5229\u7528AI\u89e3\u8bfb\u57fa\u56e0\u7ec4\u8f6c\u5f55\u8c03\u63a7\u8bed\u6cd5\uff08\u90ed\u56fd\u9aa5\uff09<\/span><\/span><\/h3>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u810a\u690e\u52a8\u7269\u57fa\u56e0\u7ec4\u7684\u8c03\u63a7\u5e8f\u5217\u8bed\u6cd5\u4ecd\u672a\u88ab\u5b8c\u5168\u89e3\u6790\u3002\u4e3a\u6b64\uff0c\u6d59\u6c5f\u5927\u5b66\u90ed\u56fd\u9aa5\u56e2\u961f\u5efa\u7acb\u4e86\u8d85\u9ad8\u901a\u91cf\u8d85\u7075\u654f\u5355\u6838ATAC\u6d4b\u5e8f\u6280\u672f\uff08UUATAC-seq\uff09\uff0c\u53ef\u5728\u5355\u65e5\u5185\u9ad8\u6548\u7387\u9ad8\u8d28\u91cf\u7684\u5b8c\u6210\u4e00\u4e2a\u7269\u79cd\u7684\u67d3\u8272\u8d28\u53ef\u53ca\u6027\u56fe\u8c31\u3002\u57fa\u4e8e\u8be5\u6280\u672f\uff0c\u56e2\u961f\u4e3a\u4e94\u5927\u4ee3\u8868\u6027\u810a\u690e\u52a8\u7269\u4e2d\u7ed8\u5236\u5019\u9009\u987a\u5f0f\u8c03\u63a7\u5143\u4ef6\u56fe\u8c31\uff0c\u5f00\u53d1\u591a\u4efb\u52a1\u6df1\u5ea6\u5b66\u4e60\u6a21\u578bNvwaCE\uff08\u5973\u5a32CE\uff09\uff0c\u5e76\u5b9e\u73b0\u4e86\u4ece\u57fa\u56e0\u7ec4\u5e8f\u5217\u5230\u5355\u7ec6\u80de\u6c34\u5e73\u8c03\u63a7\u5143\u4ef6\u56fe\u8c31\u7684\u76f4\u63a5\u9884\u6d4b\u3002\u56e2\u961f\u53d1\u73b0\uff0c\u810a\u690e\u52a8\u7269\u8c03\u63a7\u8bed\u6cd5\u7684\u4fdd\u5b88\u6027\u660e\u663e\u5f3a\u4e8e\u6838\u82f7\u9178\u5e8f\u5217\u672c\u8eab\uff0c\u4e14\u8be5\u8bed\u6cd5\u5c06\u810a\u690e\u52a8\u7269\u8c03\u63a7\u539f\u4ef6\u5e8f\u5217\u5728\u9ad8\u7ef4\u5206\u7c7b\u4e3a\u4e0d\u540c\u7684\u529f\u80fd\u6a21\u5757\uff0c\u7531\u6b64\u63ed\u793a\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u57fa\u56e0\u8868\u8fbe\u7684\u5e8f\u5217\u57fa\u7840\u3002\u53e6\u5916\uff0c\u5973\u5a32CE\u6a21\u578b\u5728\u591a\u9879\u6307\u6807\u4e0a\uff0c\u8d85\u8d8a\u73b0\u6709\u7684\u57fa\u56e0\u7ec4AI\u6a21\u578b\uff0c\u5e76\u80fd\u7cbe\u51c6\u9884\u6d4b\u5408\u6210\u7a81\u53d8\u5bf9\u8c31\u7cfb\u7279\u5f02\u6027\u8c03\u63a7\u5143\u4ef6\u529f\u80fd\u7684\u5f71\u54cd\u3002\u6700\u540e\uff0c\u56e2\u961f\u5229\u7528\u57fa\u56e0\u7f16\u8f91\u5b9e\u9a8c\uff0c\u9996\u6b21\u9a8c\u8bc1\u4e86\u5b8c\u5168\u7531\u4eba\u5de5\u667a\u80fd\u8bbe\u8ba1\u7684\u4eba\u7c7b\u75be\u75c5\u6cbb\u6108\u6027\u4f4d\u70b9\u3002\u8fd9\u9879\u5de5\u4f5c\u4e3a\u5168\u9762\u89e3\u8bfb\u57fa\u56e0\u7ec4\u8bed\u8a00\u548c\u5efa\u7acb\u6570\u5b57\u751f\u547d\u6a21\u578b\u5960\u5b9a\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><br \/><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em;text-align: left\"><span style=\"font-size: 15px\"><span>\u53c2\u8003\u6587\u732e\uff1a<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em;text-align: left\"><span style=\"font-size: 15px\"><span style=\"font-size: 14px\"><span>Modeling the vertebrate regulatory sequence landscape by UUATAC-seq and deep learning<\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em;text-align: left\"><span style=\"font-size: 15px\"><span style=\"font-size: 14px\"><span>https:\/\/doi.org\/10.1016\/j.cell.2025.06.020<\/span><\/span><\/span><\/p>\n<h3 style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><br \/><\/span><\/h3>\n<h3 style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span style=\"font-weight: bold\">\u62a5\u544a\u4e8c\uff1a\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684RNA\u8c03\u63a7\u53ca\u75be\u75c5\u89e3\u6790\uff08\u718a\u65ed\u6df1\uff09<\/span><\/span><\/h3>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u591a\u57fa\u56e0\u75be\u75c5\u7684\u9057\u4f20\u98ce\u9669\u53d8\u5f02\u5927\u591a\u4f4d\u4e8e\u975e\u7f16\u7801\u533a\u57df\uff0c\u5176\u4f5c\u7528\u673a\u5236\u5c1a\u4e0d\u660e\u786e\uff0c\u963b\u788d\u4e86\u75be\u75c5\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u3002\u6211\u4eec\u6b64\u524d\u4ece\u591a\u4e2a\u5c42\u9762\u63a2\u8ba8\u4e86\u8fd9\u4e9b\u53d8\u5f02\u7684\u8c03\u63a7\u4f5c\u7528\uff0c\u5305\u62ec\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u4e0e\u5355\u7ec6\u80deATAC\u6d4b\u5e8f\uff08Cell 2023\uff09\u3001m6A RNA\u7532\u57fa\u5316\uff08Nat Genet 2021\uff09\u4ee5\u53caH3K27ac\u7ec4\u86cb\u767d\u4fee\u9970\uff08Nat Genet 2023\uff09\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u6211\u4eec\u8fdb\u4e00\u6b65\u5229\u7528\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\uff0c\u805a\u7126\u4e8e\u4ee5RNA\u4e3a\u4e2d\u5fc3\u7684\u75be\u75c5\u9057\u4f20\u5b66\u673a\u5236\u3002<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u7b2c\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u63d0\u51fa\u4e86\u591a\u6a21\u6001 Transformer \u6846\u67b6 Translatomer\uff0c\u53ef\u6839\u636e RNA-seq \u548c\u57fa\u56e0\u5e8f\u5217\u9884\u6d4b\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7684\u6838\u7cd6\u4f53\u8c31\uff08ribosome profiling\uff09\u3002\u5728\u6765\u81ea 33 \u79cd\u7ec4\u7ec7\u548c\u7ec6\u80de\u7cfb\u7684\u6570\u636e\u4e0a\u8bad\u7ec3\u540e\uff0cTranslatomer \u901a\u8fc7\u7eb3\u5165\u5e8f\u5217\u7279\u5f81\uff0c\u5927\u5e45\u63d0\u5347\u4e86\u6838\u7cd6\u4f53\u8c31\u7684\u9884\u6d4b\u80fd\u529b\uff0c\u6355\u83b7\u4e86\u5e8f\u5217\u4f9d\u8d56\u7684\u7ffb\u8bd1\u8c03\u63a7\u7279\u5f81\u3002\u5728\u5168\u65b0\uff08de novo\uff09\u9884\u6d4b\u4efb\u52a1\u4e2d\uff0c\u5176\u9884\u6d4b\u7cbe\u5ea6\u8fbe\u5230 0.72\u20130.80 \u7684\u76ae\u5c14\u900a\u76f8\u5173\u7cfb\u6570\uff08PCC\uff09\u3002\u6211\u4eec\u8fdb\u4e00\u6b65\u5f00\u53d1\u4e86\u4f53\u5916\u6a21\u62df\u7a81\u53d8\uff08in silico mutagenesis\uff09\u5de5\u5177\uff0c\u7528\u4e8e\u8bc4\u4f30\u7a81\u53d8\u5bf9\u7ffb\u8bd1\u7684\u5f71\u54cd\uff0c\u53d1\u73b0\u53d7\u7ffb\u8bd1\u8c03\u63a7\u7684\u53d8\u5f02\u5728\u8fdb\u5316\u4e0a\u53d7\u5230\u660e\u663e\u7684\u7ea6\u675f\u3002\u91cd\u8981\u7684\u662f\uff0c\u6211\u4eec\u9274\u5b9a\u51fa 3041 \u4e2a\u975e\u7f16\u7801\u548c\u540c\u4e49\u4f4d\u70b9\u7684\u75be\u75c5\u76f8\u5173\u53d8\u5f02\uff0c\u8fd9\u4e9b\u53d8\u5f02\u5177\u6709\u72ec\u7acb\u4e8e eQTL \u7684\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7ffb\u8bd1\u8c03\u63a7\u4f5c\u7528\uff0c\u6697\u793a\u4e86\u5176\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u5148\u5929\u6027\u5fc3\u810f\u75c5\u4e2d\u7684\u6f5c\u5728\u673a\u5236\uff08Nature Machine Intelligence, 2024\uff09\u3002<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u7b2c\u4e8c\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u5f00\u53d1\u4e86\u53ef\u89e3\u91ca\u7684\u6df1\u5ea6\u5b66\u4e60\u6846\u67b6 TransRBP\uff0c\u4ee5\u78b1\u57fa\u5206\u8fa8\u7387\u6a21\u578b\u5316 RNA-\u7ed3\u5408\u86cb\u767d\uff08RBP\uff09\u4e0e RNA \u5e8f\u5217\u7684\u7ed3\u5408\uff0c\u5e76\u63a2\u7a76 m6A \u4fee\u9970\u4e0e RBP \u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002TransRBP \u5728 32 \u4e2a m6A \u76f8\u5173 RBP \u4e0a\u7684\u4e2d\u4f4d\u9884\u6d4b\u51c6\u786e\u7387\u8fbe\u5230 0.59\uff0c\u76f8\u8f83\u5f53\u524d\u6700\u4f73\u6a21\u578b\u63d0\u5347 28%\u3002\u68af\u5ea6\u89e3\u91ca\u5206\u6790\u663e\u793a\uff0cm6A \u76f8\u5173 RBP \u7684\u7ed3\u5408\u4f4d\u70b9\u4e2d\u5bcc\u96c6\u526a\u63a5\u5171\u8bc6\u57fa\u5e8f\uff0c\u51f8\u663e\u4e86 m6A \u4e0e\u526a\u63a5\u4e92\u4f5c\u7684\u4f5c\u7528\u3002\u6211\u4eec\u8fd8\u6784\u5efa\u4e86\u7a81\u53d8\u6a21\u62df\u6d4b\u5b9a\uff0c\u7528\u4e8e\u91cf\u5316 m6A \u5bf9 RBP \u7ed3\u5408\u7684\u5f71\u54cd\uff0c\u5e76\u5229\u7528\u6ce8\u610f\u529b\u673a\u5236\u9610\u91ca RBP-m6A \u76f8\u4e92\u4f5c\u7528\u3002\u8be5\u65b9\u6cd5\u63ed\u793a\u4e86 1806 \u5bf9\u5728\u591a\u79cd\u75be\u75c5\uff08\u5982\u5e15\u91d1\u68ee\u75c5\u3001\u81ea\u95ed\u75c7\u548c\u5fc3\u808c\u75c5\uff09\u4e2d\u663e\u8457\u6539\u53d8 RBP \u7ed3\u5408\u7684\u53d8\u5f02-RBP \u7ec4\u5408\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6211\u4eec\u53d1\u73b0\u4e86\u5f71\u54cd UPF1\uff08\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff09\u4ee5\u53ca DDX3X\uff08\u5fc3\u808c\u75c5\u548c\u808c\u8425\u517b\u4e0d\u826f\uff09\u7684 m6A \u90bb\u8fd1\u987a\u5f0f\u53d8\u5f02\u3002\u603b\u4f53\u800c\u8a00\uff0cTransRBP \u4e3a\u89e3\u6790 RBP-m6A \u52a8\u6001\u63d0\u4f9b\u4e86\u6709\u529b\u5de5\u5177\uff0c\u5e76\u63ed\u793a\u4e86\u590d\u6742\u75be\u75c5\u80cc\u540e\u8f6c\u5f55\u540e\u8c03\u63a7\u7684\u673a\u5236\u6027\u89c1\u89e3\u3002<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em;text-align: left\"><span style=\"font-size: 15px\"><br \/><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em;text-align: left\"><span style=\"font-size: 15px\"><span>\u53c2\u8003\u6587\u732e\uff1a<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em;text-align: left\"><span style=\"font-size: 15px\"><span style=\"font-size: 14px\"><span>1. Epigenomic dissection of Alzheimer\u2019s disease pinpoints causal variants and reveals epigenome erosion https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(23)00974-1<\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em;text-align: left\"><span style=\"font-size: 14px\"><span>2. Genetic drivers of m6A methylation in human brain, lung, heart and muscle https:\/\/www.nature.com\/articles\/s41588-021-00890-3<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em;text-align: left\"><span style=\"font-size: 14px\"><span>3. Multitissue H3K27ac profiling of GTEx samples links epigenomic variation to disease https:\/\/www.nature.com\/articles\/s41588-023-01509-5<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em;text-align: left\"><span style=\"font-size: 14px\"><span><span>4. Deep learning prediction of ribosome profiling with Translatomer reveals translational regulation and interprets disease variants&nbsp;<\/span><\/span><span><span><span><span style=\"text-decoration: none\">https:\/\/www.nature.com\/articles\/s42256-024-00915-6<\/span><\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em;text-align: left\"><span style=\"font-size: 15px\"><span style=\"font-size: 14px\"><span><span>5. In-silico<\/span><\/span><\/span><span style=\"font-size: 14px\"><span>&nbsp;modeling and interpretation of RBP binding disentangle m(6)A-RBP interaction https:\/\/www.biorxiv.org\/content\/10.1101\/2024.11.23.624962v1<\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><br \/><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><br \/><\/span><\/p>\n<h3 style=\", Arial, sans-serif;letter-spacing: 0.544px\">\n<section style=\"letter-spacing: 0.544px;text-align: right;font-size: 13px\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;letter-spacing: 0.544px;text-align: center\">\n<section style=\"vertical-align: middle\">\n<section style=\"margin-bottom: -2px;, Arial, sans-serif\">\n<section style=\"float: left;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"float: right;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"clear: both;line-height: 0\">\n<section style=\"line-height: 0;width: 0px\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;font-size: 16px;line-height: 1.4\">\n<p><strong><strong style=\"text-align: left;letter-spacing: 0.544px\"><span style=\", Arial, sans-serif\"><strong style=\"letter-spacing: 0.578px\"><span>\u5609\u5bbe\u4fe1\u606f<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;, Arial, sans-serif\">\n<section style=\"float: left;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"float: right;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;, Arial, sans-serif;letter-spacing: 0.578px;line-height: 1.75em\"><span><br \/><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><strong style=\"font-size: 15px\"><span><span>\u62a5\u544a\u5609\u5bbe<\/span><\/span><\/strong><\/p>\n<section style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><img class=\"rich_pages wxw-img\" data-ratio=\"0.5625\" data-type=\"jpeg\" data-w=\"1920\" style=\"width:100%\" data-width=\"1920\" data-height=\"1080\" data-backw=\"562\" data-backh=\"316\" data-imgfileid=\"100232876\" src=\"\/wp-content\/uploads\/2025\/07\/wxsync-2025-07-bb6fa420c6b4bbc2be49e9acd6143125.jpeg\" \/><\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><strong><span><span>\u90ed\u56fd\u9aa5<\/span><\/span><\/strong><span><span>\uff0c\u6d59\u6c5f\u5927\u5b66\u6c42\u662f\u7279\u8058\u6559\u6388\uff0c\u6d59\u6c5f\u5927\u5b66\u8840\u6db2\u5b66\u7814\u7a76\u6240\u526f\u6240\u957f\u3002\u5165\u9009\u4e2d\u7ec4\u90e8\u4e07\u4eba\u8ba1\u5212\u79d1\u6280\u521b\u65b0\u9886\u519b\u4eba\u624d\uff0c\u6559\u80b2\u90e8\u957f\u6c5f\u5b66\u8005\u7279\u8058\u6559\u6388\u3002\u66fe\u83b7\u201c\u8c08\u5bb6\u6862\u751f\u547d\u79d1\u5b66\u521b\u65b0\u5956\u201d\uff0c\u201c\u4e2d\u6e90\u534f\u548c\u751f\u547d\u533b\u5b66\u521b\u65b0\u7a81\u7834\u5956\u201d\uff0c\u201c\u6d59\u6c5f\u7701\u81ea\u7136\u79d1\u5b66\u4e00\u7b49\u5956\u201d\u7b49\u8363\u8a89\u3002\u4efb\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u534f\u4f1a\u57fa\u56e0\u68c0\u6d4b\u5206\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\uff0c\u4e2d\u56fd\u751f\u7406\u5b66\u4f1a\u8840\u6db2\u751f\u7406\u5b66\u4e13\u4e1a\u59d4\u5458\u4f1a\u59d4\u5458\uff0c\u517c\u4efbAdvanced Science, Cell Regeneration\u7b49\u671f\u520a\u7f16\u59d4\u3002\u4ee5\u901a\u8baf\u4f5c\u8005\u8eab\u4efd\u5728Cell, Nature, Science\u7b49\u8457\u540d\u671f\u520a\u53d1\u8868\u591a\u7bc7\u5b66\u672f\u8bba\u6587\u3002\u7814\u7a76\u6210\u679c\u83b7\u8bc4\u201c2020\u56fd\u9645\u5341\u5927\u79d1\u6280\u65b0\u95fb\u201d\uff0c\u201c2020\u4e2d\u56fd\u751f\u7269\u4fe1\u606f\u5b66\u5341\u5927\u8fdb\u5c55\u201d\uff0c\u201c\u4e2d\u56fd2020\u5e74\u5ea6\u91cd\u8981\u533b\u5b66\u8fdb\u5c55\u201d\uff0c\u201c2022\u4e2d\u56fd\u751f\u7269\u4fe1\u606f\u5b66\u5341\u5927\u8fdb\u5c55\u201d\u3002<\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><br \/><\/span><\/span><\/p>\n<section style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><img class=\"rich_pages wxw-img\" data-ratio=\"0.5625\" data-type=\"jpeg\" data-w=\"1920\" style=\"width:100%\" data-width=\"1920\" data-height=\"1080\" data-backw=\"562\" data-backh=\"316\" data-imgfileid=\"100232874\" src=\"\/wp-content\/uploads\/2025\/07\/wxsync-2025-07-b381de5c0d44f7734078071d14d5958a.jpeg\" \/><\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><strong><span><span>\u718a\u65ed\u6df1<\/span><\/span><\/strong><span><span>\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\/\u826f\u6e1a\u5b9e\u9a8c\u5ba4\u201c\u767e\u4eba\u8ba1\u5212\u201d\u7814\u7a76\u5458\u3002\u718a\u65ed\u6df1\u672c\u79d1\u6bd5\u4e1a\u4e8e\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u751f\u7269\u4fe1\u606f\u5b66\u4e13\u4e1a\uff0c\u535a\u58eb\u6bd5\u4e1a\u4e8e\u5317\u4eac\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\uff0c\u535a\u58eb\u7814\u7a76\u65b9\u5411\u4e3aRNA\u4fee\u9970\u548c\u751f\u7269\u4fe1\u606f\u5b66\uff1b\u968f\u540e\u5728MIT\u8ba1\u7b97\u673a\u4e0e\u4eba\u5de5\u667a\u80fd\u7cfb\u8fdb\u884c\u535a\u58eb\u540e\u7814\u7a76\uff0c\u65b9\u5411\u4e3a\u8ba1\u7b97\u751f\u7269\u5b66\u548c\u4eba\u7c7b\u591a\u57fa\u56e0\u590d\u6742\u75be\u75c5\u3002\u81f4\u529b\u4e8e\u5229\u7528\u7edf\u8ba1\u9057\u4f20\u548c\u4eba\u5de5\u667a\u80fd\u7684\u624b\u6bb5\u63a2\u7a76\u8868\u89c2\u8f6c\u5f55\u7ec4\u548c\u8868\u89c2\u57fa\u56e0\u7ec4\u5728\u4eba\u7c7b\u5927\u8111\u9057\u4f20\u75be\u75c5\u4e2d\u53d1\u6325\u4f5c\u7528\u7684\u751f\u7269\u5b66\u673a\u5236\u3002\u4ee5\u901a\u8baf\u4f5c\u8005\u6216\u7b2c\u4e00\u4f5c\u8005\uff08\u542b\u5171\u540c\uff09\u53d1\u8868Cell, Nature Genetics, Nature Machine Intelligence\u7b49\u8bba\u6587\u591a\u7bc7\u3002<\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><br \/><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><strong style=\"font-size: 15px\"><span><span>\u5706\u684c\u5609\u5bbe<\/span><\/span><\/strong><\/p>\n<section style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><img class=\"rich_pages wxw-img\" data-ratio=\"0.5625\" data-type=\"jpeg\" data-w=\"1920\" style=\"width:100%\" data-width=\"1920\" data-height=\"1080\" data-backw=\"562\" data-backh=\"316\" data-imgfileid=\"100232875\" src=\"\/wp-content\/uploads\/2025\/07\/wxsync-2025-07-f4d8f30b24b9f5ebc127a850f6e480a0.jpeg\" \/><\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><strong><span><span>\u5434\u5bb6\u777f<\/span><\/span><\/strong><span><span>\uff0c\u73b0\u4efb\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u4e3b\u52a8\u5065\u5eb7\u6218\u7565\u4e0e\u53d1\u5c55\u7814\u7a76\u9662\u6267\u884c\u9662\u957f\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u9ad8\u7b49\u7814\u7a76\u9662\u56fd\u5bb6\u86cb\u767d\u8d28\u79d1\u5b66\u7814\u7a76\uff08\u4e0a\u6d77\uff09\u8bbe\u65bd\u4e3b\u4efb\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u7cfb\u7edf\u751f\u7269\u5b66\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\uff0c\u4e0a\u6d77\u5e02\u79d1\u666e\u4f5c\u5bb6\u534f\u4f1a\u7406\u4e8b\u957f\u3002\u4ed6\u7684\u5b9e\u9a8c\u5ba4\u4e3b\u8981\u91c7\u7528\u7cfb\u7edf\u751f\u7269\u5b66\u65b9\u6cd5\u7814\u7a76\u7cd6\u5c3f\u75c5\u548c\u80bf\u7624\u7b49\u91cd\u5927\u6162\u6027\u75c5\u53d1\u751f\u4e0e\u53d1\u5c55\u7684\u5206\u5b50\u673a\u5236\u3002<\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><br \/><\/span><\/span><\/p>\n<section style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><img class=\"rich_pages wxw-img\" data-ratio=\"0.5625\" data-type=\"jpeg\" data-w=\"1920\" style=\"width:100%\" data-width=\"1920\" data-height=\"1080\" data-backw=\"562\" data-backh=\"316\" data-imgfileid=\"100232881\" src=\"\/wp-content\/uploads\/2025\/07\/wxsync-2025-07-3c8a4a7f3204d9da4747e5b0a78b2cf2.jpeg\" \/><\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><strong><span><span>\u5f20\u6e05\u9e4f<\/span><\/span><\/strong><span><span>\uff0c\u9999\u6e2f\u5927\u5b66\u6570\u636e\u79d1\u5b66\u7814\u7a76\u9662\u548c\u836f\u7406\u53ca\u836f\u5242\u5b66\u7cfb\u526f\u6559\u6388\uff0c\u4ed6\u7684\u7814\u7a76\u65b9\u5411\u662f\u590d\u6742\u7cfb\u7edf\u548c\u533b\u5b66\u4fe1\u606f\u5b66\u3002\u4ed6\u4e8e2009\u5e74\u83b7\u5f97\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u81ea\u52a8\u5316\u5b66\u58eb\u5b66\u4f4d\uff0c2012\u5e74\u83b7\u5f97\u4e9a\u5229\u6851\u90a3\u5927\u5b66\u7cfb\u7edf\u4e0e\u5de5\u4e1a\u5de5\u7a0b\u535a\u58eb\u5b66\u4f4d\uff0c\u5e76\u5728\u4f26\u65af\u52d2\u7406\u5de5\u5b66\u9662\u8ba1\u7b97\u673a\u79d1\u5b66\u7cfb\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\u3002\u4ed6\u7684\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728Nature Human Behaviour, Nature Communications, MIS Quarterly\u7b49\u9876\u7ea7\u671f\u520a\u4e0a\uff0c\u5e76\u53d7\u5230\u534e\u76db\u987f\u90ae\u62a5\u3001\u7ebd\u7ea6\u65f6\u62a5\u3001\u6cf0\u6664\u58eb\u62a5\u3001BBC\u3001\u536b\u62a5\u7b49\u56fd\u5185\u5916\u591a\u5bb6\u5a92\u4f53\u7684\u62a5\u9053\u3002\u4ed6\u76ee\u524d\u7684\u7814\u7a76\u91cd\u70b9\u662f\u5f00\u53d1\u57fa\u4e8e\u77e5\u8bc6\u7684\u9884\u6d4b\u51b3\u7b56\u5206\u6790\u65b9\u6cd5\uff0c\u5229\u7528\u9ad8\u7ef4\u751f\u7269\u3001\u4e34\u5e8a\u548c\u884c\u4e3a\u6570\u636e\u8fdb\u884c\u836f\u7269\u53d1\u73b0\u3001\u7cbe\u51c6\u533b\u7597\u548c\u516c\u5171\u536b\u751f\u7814\u7a76\u3002<\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><br \/><\/span><\/span><\/p>\n<section style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><img class=\"rich_pages wxw-img\" data-ratio=\"0.5625\" data-type=\"jpeg\" data-w=\"1920\" style=\"width:100%\" data-width=\"1920\" data-height=\"1080\" data-backw=\"562\" data-backh=\"316\" data-imgfileid=\"100232880\" src=\"\/wp-content\/uploads\/2025\/07\/wxsync-2025-07-9e40df6b3bd5ed8b703d17c6e6617ba7.jpeg\" \/><\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><strong><span><span>\u5f20\u79b9\u6d35<\/span><\/span><\/strong><span><span>\uff0c\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u57fa\u56e0\u4e2d\u5fc3\u5728\u8bfb\u535a\u58eb\uff0c\u7814\u7a76\u9886\u57df\u5305\u62ec\u75c5\u7406\u57fa\u56e0\u7ec4\u5b66\uff0c\u86cb\u767d\u7ec4\u5b66\uff0c\u7f55\u89c1\u75c5\uff0c\u516c\u5171\u536b\u751f\u3002\u672c\u79d1\u53ca\u7855\u58eb\u9636\u6bb5\u7559\u5b66\u7f8e\u56fd\uff0c\u4e3b\u4fee\u5fae\u751f\u7269\u5b66\u4e0e\u6d41\u884c\u75c5\u5b66\uff0c\u76ee\u524d\u4e8e\u4eac\u90fd\u5927\u5b66\u653b\u8bfb\u75c5\u7406\u57fa\u56e0\u7ec4\u5b66\u535a\u58eb\u5b66\u4f4d\u3002\u5177\u5907\u4e00\u5b9a\u7684\u6e7f\u5b9e\u9a8c\u64cd\u4f5c\u3001\u751f\u7269\u7edf\u8ba1\u5206\u6790\u4ee5\u53ca\u9ad8\u901a\u91cf\u7ec4\u5b66\u7814\u7a76\u7ecf\u9a8c\u3002\u7814\u7a76\u6210\u679c\u66fe\u5728\u65e5\u672c\u4eba\u7c7b\u9057\u4f20\u5b66\u4f1a\uff08JSHG\uff09\u3001\u7f8e\u56fd\u4eba\u7c7b\u9057\u4f20\u5b66\u4f1a\uff08ASHG\uff09\u53ca\u6cf0\u56fd\u4eba\u7c7b\u9057\u4f20\u5b66\u4f1a\uff08TSHG\uff09\u7b49\u56fd\u9645\u5b66\u672f\u4f1a\u8bae\u4e0a\u53d1\u8868\u3002\u5173\u4e8e\u201cIgG4\u76f8\u5173\u75be\u75c5\u201d\u7684\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\u6210\u679c\u5373\u5c06\u5728\u300aThe Lancet Rheumatology\u300b\u671f\u520a\u53d1\u8868\u3002<\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><br \/><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><br \/><\/span><\/span><\/p>\n<h3 style=\", Arial, sans-serif;letter-spacing: 0.544px\">\n<section style=\"letter-spacing: 0.544px;text-align: right;font-size: 13px\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;letter-spacing: 0.544px;text-align: center\">\n<section style=\"vertical-align: middle\">\n<section style=\"margin-bottom: -2px;, Arial, sans-serif\">\n<section style=\"float: left;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"float: right;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"clear: both;line-height: 0\">\n<section style=\"line-height: 0;width: 0px\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;font-size: 16px;line-height: 1.4\">\n<p><strong><strong style=\"text-align: left;letter-spacing: 0.544px\"><span style=\", Arial, sans-serif\"><strong style=\"letter-spacing: 0.578px\"><span>\u62a5\u540d\u53c2\u4e0e<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;, Arial, sans-serif\">\n<section style=\"float: left;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"float: right;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;, Arial, sans-serif;letter-spacing: 0.578px;line-height: 1.75em\"><span><br \/><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><strong style=\"font-size: 15px\"><span><span>\u76f4\u64ad\u4fe1\u606f<\/span><\/span><\/strong><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>2025\u5e747\u670810\u65e5\uff08\u5468\u56db\uff09 19:00-21:00<\/span><\/span><\/p>\n<section class=\"channels_iframe_wrp\"><\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><strong style=\"font-size: 15px\"><span><span>\u62a5\u540d\u52a0\u5165\u793e\u7fa4<\/span><\/span><\/strong><\/p>\n<section style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em;text-align: center\"><img class=\"rich_pages wxw-img\" data-ratio=\"1\" data-type=\"other\" data-w=\"400\" style=\"width: 145px;height: 145px\" data-width=\"400\" data-height=\"400\" data-imgfileid=\"100232879\" src=\"\" \/><\/section>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em;text-align: center\"><span style=\"font-size: 15px\"><span style=\"font-size: 13px\" data-mpa-action-id=\"mcvf8g8aw3j\" data-pm-slice=\"0 0 []\"><span>\u626b\u7801\u62a5\u540d<\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><br \/><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u586b\u5199\u4fe1\u606f\u540e\uff0c\u6dfb\u52a0\u8fd0\u8425\u8d1f\u8d23\u4eba\u5fae\u4fe1\uff0c\u5907\u6ce8\u201c<\/span><a class=\"normal_text_link\" target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247715330&amp;idx=1&amp;sn=83ee73e15fe4f0670cdcdc1211d0c1b0&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" data-linktype=\"2\" rel=\"noopener noreferrer\"><span style=\"text-decoration: underline\">\u62a5\u540d\u8ba1\u7b97\u533b\u5b66\u7814\u8ba8\u4f1a<\/span><\/a><span>\u201d\u3002\u901a\u8fc7\u5ba1\u6838\u540e\uff0c\u540e\u7eed\u5c06\u9080\u8bf7\u52a0\u5165\u5bf9\u5e94\u4e3b\u9898\u7684\u793e\u533a\uff08\u5fae\u4fe1\u7fa4\uff09\u3002<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><span>\u6211\u4eec\u91c7\u53d6<\/span><\/span><strong><span><span>\u5f00\u653e\u4ea4\u6d41\u7814\u8ba8\u7684\u65b9\u5f0f\uff0c<\/span><\/span><\/strong><span><span>\u5982\u679c\u4f60\u5728\u76f8\u5173\u8bae\u9898\u65b9\u5411\u4e0a\u6709<\/span><\/span><strong><span><span>\u7814\u7a76\u6210\u679c<\/span><\/span><\/strong><span><span>\u548c<\/span><\/span><strong><span><span>\u884c\u4e1a\u6848\u4f8b<\/span><\/span><\/strong><span><span>\uff0c\u610f\u613f\u4ee5<\/span><\/span><strong><span><span>\u7ed3\u6784\u5316\u5f62\u5f0f<\/span><\/span><\/strong><span><span>\u5206\u4eab\u4ea4\u6d41\uff0c\u8bf7\u5728\u62a5\u540d\u540e\u8054\u7cfb<\/span><\/span><strong><span><span>\u8fd0\u8425\u8d1f\u8d23\u4eba<\/span><\/span><\/strong><span><span>\u3002<\/span><\/span><\/span><\/p>\n<h2 style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><br \/><\/span><\/h2>\n<h2 style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><br \/><\/span><\/h2>\n<h3 style=\", Arial, sans-serif;letter-spacing: 0.544px\">\n<section style=\"letter-spacing: 0.544px;text-align: right;font-size: 13px\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;letter-spacing: 0.544px;text-align: center\">\n<section style=\"vertical-align: middle\">\n<section style=\"margin-bottom: -2px;, Arial, sans-serif\">\n<section style=\"float: left;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"float: right;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"clear: both;line-height: 0\">\n<section style=\"line-height: 0;width: 0px\"><\/section>\n<\/section>\n<\/section>\n<section style=\"padding-right: 10px;padding-left: 10px;font-size: 16px;line-height: 1.4\">\n<p><strong><strong style=\"text-align: left;letter-spacing: 0.544px\"><span style=\", Arial, sans-serif\"><strong style=\"letter-spacing: 0.578px\"><span>\u7814\u8ba8\u4f1a\u7b80\u4ecb<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n<section style=\"margin-top: -2px;, Arial, sans-serif\">\n<section style=\"float: left;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<section style=\"float: right;width: 8px;height: 3px;line-height: 0\"><span><br \/><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;, Arial, sans-serif;letter-spacing: 0.578px;line-height: 1.75em\"><span><br \/><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><span>\u4e3a\u4e86\u66f4\u597d\u5730\u4fc3\u8fdb\u751f\u547d\u79d1\u5b66\u4e0e\u4eba\u5de5\u667a\u80fd\u9886\u57df\u7684\u6df1\u5ea6\u4ea4\u53c9\u878d\u5408\uff0c\u63a8\u52a8\u524d\u6cbf\u7814\u7a76\u4e0e\u533b\u7597\u5b9e\u8df5\u7684\u5feb\u901f\u843d\u5730\uff0c<\/span><\/span><strong><span><span>DAMO\u5f00\u53d1\u8005\u77e9\u9635\u4e0e\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u53d1\u8d77\u4e86<\/span><\/span><\/strong><strong><span><a class=\"normal_text_link\" target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzIzMjQyNzQ5MA==&amp;mid=2247715330&amp;idx=1&amp;sn=83ee73e15fe4f0670cdcdc1211d0c1b0&amp;scene=21#wechat_redirect\" data-itemshowtype=\"0\" data-linktype=\"2\" rel=\"noopener noreferrer\"><span style=\"text-decoration: underline\">\u201cAI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\uff1a\u4ece\u79d1\u5b66\u53d1\u73b0\u5230\u6570\u5b57\u5b6a\u751f\u201d\u7814\u8ba8\u4f1a<\/span><\/a><\/span><\/strong><span><span>\uff0c\u65e8\u5728\u6784\u5efa\u8de8\u5b66\u79d1\u4ea4\u6d41\u5e73\u53f0\uff0c\u63a8\u52a8\u77e5\u8bc6\u5171\u4eab\u4e0e\u6280\u672f\u521b\u65b0\u3002<\/span><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span><br \/><\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u672c\u7cfb\u5217\u6d3b\u52a8\u5c06\u901a\u8fc7\u7ed3\u6784\u5316\u7684\u6df1\u5ea6\u4e3b\u9898\u5bf9\u8bdd\uff0c\u9080\u8bf7\u56fd\u5185\u5916\u751f\u547d\u79d1\u5b66\u4e0eAI\u4ea4\u53c9\u9886\u57df\u7684\u524d\u6cbf\u7814\u7a76\u8005\u548c\u4ea7\u4e1a\u5b9e\u8df5\u8005\uff0c\u5171\u540c\u63a2\u8ba8\u5982\u4f55\u7528AI\u8d4b\u80fd\u751f\u547d\u79d1\u5b66\u4e0e\u7cbe\u51c6\u533b\u7597\uff0c\u63a8\u52a8\u7814\u7a76\u8303\u5f0f\u4e0e\u533b\u7597\u6a21\u5f0f\u7684\u9769\u65b0\u3002<\/span><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><br \/><\/span><\/p>\n<section style=\"margin: 10px auto\">\n<section style=\"border-width: 1px;border-style: solid;padding: 10px 15px\">\n<section data-autoskip=\"1\" style=\"line-height: 1.75em;letter-spacing: 1.5px;font-size: 14px\">\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><strong><span><span>\u6838\u5fc3\u95ee\u9898<\/span><\/span><\/strong><\/span><\/p>\n<ol style=\"margin-left: 8px;margin-right: 8px\" class=\"list-paddingleft-1\">\n<li style=\"text-align: left\">\n<p style=\"margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>AI\u9a71\u52a8\u7684\u591a\u667a\u80fd\u4f53\u751f\u7269\u533b\u5b66\u4e0e\u533b\u7597\u667a\u80fd\u4f53\u7a76\u7adf\u662f\u4ec0\u4e48\uff1f\u5b83\u4eec\u5982\u4f55\u4ece\u5b9e\u9a8c\u5ba4\u8d70\u5411\u771f\u5b9e\u4e16\u754c\uff1f<\/span><\/span><\/p>\n<\/li>\n<li style=\"text-align: left\">\n<p style=\"margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u591a\u7ec4\u5b66\u878d\u5408\u7684\u6838\u5fc3\u6280\u672f\u969c\u788d\u6709\u54ea\u4e9b\uff1fAI\u5982\u4f55\u8de8\u8d8a\u8fd9\u4e9b\u969c\u788d\u52a9\u529b\u7cbe\u51c6\u533b\u5b66\u843d\u5730\uff1f<\/span><\/span><\/p>\n<\/li>\n<li style=\"text-align: left\">\n<p style=\"margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u533b\u5b66\u5f71\u50cf\u5982\u4f55\u4eceAI\u8f85\u52a9\u8bca\u65ad\u8d70\u5411\u667a\u80fd\u4f53\u81ea\u52a8\u5316\u95ed\u73af\uff1f\u843d\u5730\u8fc7\u7a0b\u4e2d\u7684\u5173\u952e\u6311\u6218\u662f\u4ec0\u4e48\uff1f<\/span><\/span><\/p>\n<\/li>\n<li style=\"text-align: left\">\n<p style=\"margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>AI\u6280\u672f\u5982\u4f55\u6709\u6548\u5730\u878d\u5165\u4e25\u8083\u533b\u7597\u4f53\u7cfb\uff1f\u653f\u7b56\u3001\u76d1\u7ba1\u4e0e\u4ea7\u4e1a\u534f\u540c\u8def\u5f84\u5982\u4f55\u4f18\u5316\uff1f<\/span><\/span><\/p>\n<\/li>\n<li style=\"text-align: left\">\n<p style=\"margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><span>\u6cdb\u5065\u5eb7\u9886\u57df\u4e2d\uff0cAI\u5982\u4f55\u91cd\u5851\u5065\u5eb7\u7ba1\u7406\u3001\u4fdd\u9669\u5b9a\u4ef7\u4e0e\u7528\u6237\u53c2\u4e0e\u6a21\u5f0f\uff0c\u6253\u9020\u5168\u751f\u547d\u5468\u671f\u7684\u667a\u6167\u533b\u7597\u751f\u6001\uff1f<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span style=\"font-size: 15px\"><strong><span><br \/><\/span><\/strong><\/span><\/p>\n<p style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 15px\"><strong><span><span>\u4f60\u5c06\u6536\u83b7<\/span><\/span><\/strong><\/span><\/p>\n<ol style=\"margin-left: 8px;margin-right: 8px\" class=\"list-paddingleft-1\">\n<li style=\"text-align: left\">\n<p style=\"margin-bottom: 8px;line-height: 1.75em\"><span style=\"font-size: 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\/><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><span><br \/><\/span><\/p>\n<section style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><img class=\"rich_pages wxw-img\" data-ratio=\"1.837037037037037\" data-type=\"other\" data-w=\"1080\" style=\"width:100%\" data-width=\"1080\" data-height=\"1984\" data-backw=\"562\" data-backh=\"1032\" data-imgfileid=\"100232882\" src=\"\" \/><\/section>\n<section style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span data-mpa-action-id=\"mcvewpwjup5\"><\/span><\/section>\n<section style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span><br \/><\/span><\/section>\n<section style=\"margin-left: 8px;margin-right: 8px;margin-bottom: 0px;line-height: 1.75em\"><span><br \/><\/span><\/section>\n<section style=\"margin-left: 0px;margin-right: 0px;margin-bottom: 0px;line-height: 1.75em\"><strong style=\"margin-top: 0px;margin-bottom: 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