{"id":62038,"date":"2025-07-14T19:02:29","date_gmt":"2025-07-14T11:02:29","guid":{"rendered":"https:\/\/swarma.org\/?p=62038"},"modified":"2025-07-14T19:02:29","modified_gmt":"2025-07-14T11:02:29","slug":"ai%e5%a4%9a%e7%bb%84%e5%ad%a6%e5%bc%95%e7%88%86%e5%8c%bb%e7%96%97%e9%9d%a9%e5%91%bd%ef%bc%8c%e8%bf%99%e6%ac%a1%e6%98%af%e5%90%a6%e7%9c%9f%e7%9a%84%e4%b8%8d%e4%b8%80%e6%a0%b7","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=62038","title":{"rendered":"AI+\u591a\u7ec4\u5b66\u5f15\u7206\u533b\u7597\u9769\u547d\uff0c\u8fd9\u6b21\u662f\u5426\u771f\u7684\u4e0d\u4e00\u6837"},"content":{"rendered":"
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\u56fe1 <\/span><\/span><\/em><\/span><\/span>\u591a\u7ec4\u5b66\u4e2d\u764c\u75c7\u76f8\u5173\u7814\u7a76\u4e2d\u7684\u5e94\u7528 \u6765\u81ea[<\/span><\/span><\/em><\/span>1<\/span><\/span><\/em><\/span><\/span>]<\/span><\/span><\/em><\/span><\/p>\n


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\u56de\u5230\u6700\u521d\u7684\u95ee\u9898\uff1a\u8fd9\u6b21AI+\u591a\u7ec4\u5b66\u7684\u6d6a\u6f6e\uff0c\u80fd\u5426\u5e26\u6765\u771f\u6b63\u7684\u4e0d\u540c\uff1f\u7b54\u6848\u7684\u5173\u952e\u5c31\u5728\u4e8e\u5b83\u76f4\u9762\u4e86\u57fa\u56e0\u7ec4\u5b66\u65f6\u4ee3\u7684\u6838\u5fc3\u6311\u6218\u2014\u2014\u751f\u547d\u590d\u6742\u6027\u7684\u591a\u7ef4\u5ea6\u672c\u8d28\u3002<\/span><\/span><\/strong>\u5b83\u4e0d\u518d\u5c40\u9650\u4e8e\u5355\u4e00\u7684\u201c\u84dd\u56fe\u201d\uff0c\u800c\u662f\u8bd5\u56fe\u6784\u5efa\u4e00\u4e2a\u52a8\u6001\u7684\u3001\u591a\u5c42\u6b21\u7684\u201c\u751f\u547d\u8fd0\u884c\u6a21\u62df\u5668\u201d\u3002\u63a5\u4e0b\u6765\uff0c\u8ba9\u6211\u4eec\u770b\u770b\u6700\u8fd1\u6709\u90a3\u4e9b\u76f8\u5173\u7684\u7814\u7a76\uff0c\u4ed6\u4eec\u505a\u4e86\u4ec0\u4e48\uff0c\u548c\u4e4b\u524d\u6709\u4f55\u4e0d\u540c\u3002<\/span><\/span><\/p>\n


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<\/span><\/h2>\n

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<\/section>\n<\/section>\n<\/section>\n
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\u4eceDNA\u2192RNA\u2192\u86cb\u767d\u8d28\uff0c\u591a\u7ec4\u5b66\u7684\u7814\u7a76\u8fdb\u5c55<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/span><\/p>\n

\u6240\u8c13\u591a\u7ec4\u5b66\uff0c\u4ece\u4e2d\u5fc3\u6cd5\u5219\u6765\u770b\uff0c\u662f\u4eceDNA\u2192RNA\u2192\u86cb\u767d\u8d28\u7684\u4fe1\u606f\u6d41\u52a8\u8fc7\u7a0b\uff0cDNA\u4e0a\u7684\u7a81\u53d8\uff0c\u662f\u57fa\u56e0\u68c0\u6d4b\u7684\u5173\u6ce8\u70b9\uff0c\u800c\u5bf9\u4e8e\u57fa\u56e0\u7a81\u53d8\u7684\u89e3\u8bfb\uff0c\u5df2\u7ecf\u4ece\u6570\u636e\u5e93\u7684\u67e5\u8be2\uff0c\u8d70\u5411\u4e86\u6a21\u578b\u9884\u6d4b\u3002\u4f8b\u5982Evo 2 \u6a21\u578b[2]\uff0c\u8fd9\u662f\u4e00\u4e2a\u8de8\u751f\u547d\u9886\u57df\u7684\u751f\u7269\u57fa\u7840\u6a21\u578b\uff0c\u8bad\u7ec3\u4e8e9.3\u4e07\u4ebfDNA\u78b1\u57fa<\/span>\uff08\u6db5\u76d6\u7ec6\u83cc\u3001\u53e4\u83cc\u3001\u771f\u6838\u751f\u7269\u3001\u566c\u83cc\u4f53\uff09<\/span>\uff0c\u51ed\u501f100 \u4e07 token \u4e0a\u4e0b\u6587\u7a97\u53e3\u80fd\u6709\u6548\u6355\u6349\u957f\u8ddd\u79bb\u57fa\u56e0\u7ec4\u6a21\u5f0f\uff0c\u80fd\u591f\u5728\u5355\u6838\u82f7\u9178\u5206\u8fa8\u7387\u4e0b\u9884\u6d4b\u53d8\u5f02\u81f4\u75c5\u6027\u3001\u8fd8\u53ef\u4ee5\u751f\u6210\u7ed9\u5b9a\u529f\u80fd\u7684\u57fa\u56e0\u7ec4\u5e8f\u5217\uff0c\u6a21\u578b\u5177\u5907\u8de8\u7269\u79cd\u9884\u6d4b\u548c\u8bbe\u8ba1\u80fd\u529b\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u975e\u7f16\u7801\u53d8\u5f02\u81f4\u75c5\u6027\u5224\u8bfb\uff0c\u4e3a\u9057\u4f20\u75c5\u8bca\u65ad\u548c\u5408\u6210\u751f\u7269\u5b66\u5e26\u6765\u5168\u65b0\u5de5\u5177\u3002<\/span><\/span><\/p>\n


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<\/section>\n

\u56fe2 Evo 2\u7b80\u5355\u793a\u610f\u56fe\uff0c<\/span><\/span><\/em><\/span>\u6765\u81ea<\/span><\/span><\/em><\/span>https:\/\/github.com\/arcinstitute\/evo2<\/span><\/span><\/em><\/span><\/p>\n


<\/span><\/em><\/span><\/p>\n

DNA\u5982\u540c\u5efa\u7b51\u84dd\u56fe\uff0c\u800cRNA\u5219\u5982\u540c\u5efa\u7b51\u5e08\uff0c\u5c06\u84dd\u56fe\u5b9e\u73b0\u4e3a\u5177\u4f53\u7684\u4e00\u680b\u680b\u9ad8\u697c\u5927\u53a6\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u88ab\u79f0\u4e3a\u7ffb\u8bd1\uff0c\u800c\u5728\u7ffb\u8bd1\u8fc7\u7a0b\u4e2d\uff0c\u5efa\u7b51\u5e08\u4f1a\u6839\u636e\u5468\u56f4\u7684\u73af\u5883\u4fee\u6539\u84dd\u56fe\uff0c\u4f8b\u5982\u8fdb\u884c\u53ef\u53d8\u526a\u5207<\/span>\uff08\u5355\u4e2a\u57fa\u56e0\u53ef\u88ab\u526a\u63a5\u6210\u591a\u79cdRNA\u53d8\u4f53\uff0c\u751f\u6210\u529f\u80fd\u8fe5\u5f02\u7684\u86cb\u767d\u8d28\uff09<\/span>\uff0c\u7532\u57fa\u5316\u6807\u7b7e<\/span>\uff08\u5728\u84dd\u56fe\u4e0aDNA\u6dfb\u52a0\u53ef\u64e6\u5199\u7684\u73af\u5883\u6ce8\u91ca\u8d34\uff0c\u6307\u793a\u54ea\u4e9b\u533a\u57df\u8be5\u4f18\u5148\u5efa\u9020\u6216\u6682\u65f6\u5c01\u5b58\uff09<\/span>\u5bf9\u6b64\u7684\u7814\u7a76\u79f0\u4e4b\u4e3a\u8868\u89c2\u57fa\u56e0\u7ec4\u3002\u5982\u540c\u5efa\u7b51\u5de5\u5730\u7684\u667a\u80fd\u603b\u63a7\u4e2d\u5fc3\uff0c\u63a5\u6536\u8425\u517b\u3001\u538b\u529b\u3001\u6bd2\u7d20\u7b49\u73af\u5883\u4fe1\u53f7\uff0c\u901a\u8fc7\u5316\u5b66\u6807\u8bb0<\/span>\uff08DNA\u7532\u57fa\u5316\u3001\u7ec4\u86cb\u767d\u4fee\u9970\u3001\u975e\u7f16\u7801RNA\uff09<\/span>\u6307\u6325\u57fa\u56e0\u7684\u201c\u5f00\u5de5\u201d\u4e0e\u201c\u505c\u5de5\u201d\uff0c\u4f7f\u540c\u4e00\u4efdDNA\u84dd\u56fe\u5728\u4e0d\u540c\u7ec6\u80de\u4e2d\u5efa\u51fa\u5343\u5dee\u4e07\u522b\u7684\u201c\u751f\u547d\u5efa\u7b51\u201d\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u7531\u4e8e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u4ec5\u6709\u4e0d\u5230 2% \u7684\u533a\u57df\u76f4\u63a5\u7f16\u7801\u86cb\u767d\u8d28\uff0c\u800c\u5927\u90e8\u5206\u9057\u4f20\u53d8\u5f02\u4f4d\u4e8e\u975e\u7f16\u7801\u533a\uff0c\u867d\u7136\u5b83\u4eec\u4e0d\u4f1a\u6539\u53d8\u86cb\u767d\u5e8f\u5217\uff0c\u4f46\u5176\u4e2d\u4e00\u90e8\u5206\u53ef\u4ee5\u901a\u8fc7\u8c03\u63a7\u8f6c\u5f55\u3001\u526a\u63a5\u3001mRNA \u7a33\u5b9a\u6027\u6216\u7ffb\u8bd1\u7b49\u73af\u8282\u5f71\u54cd\u57fa\u56e0\u529f\u80fd\u3002\u6d59\u6c5f\u5927\u5b66\u826f\u6e1a\u5b9e\u9a8c\u5ba4\/\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u718a\u65ed\u6df1\u8bfe\u9898\u7ec424\u5e74\u5728<\/span><\/span> Nature Machine Intelligence<\/span><\/span><\/em> \u53d1\u8868\u7684\u57fa\u4e8eTransformer\u67b6\u6784\u7684\u591a\u6a21\u6001\u6df1\u5ea6\u5b66\u4e60\u6a21\u578bTranslatomer[3]\uff0c\u8be5\u6a21\u578b\u6574\u5408 mRNA \u8868\u8fbe\u3001\u57fa\u56e0\u5e8f\u5217\u7b49\u4fe1\u606f\uff0c\u5728 33 \u79cd\u4eba\u7c7b\u7ec4\u7ec7\u548c\u7ec6\u80de\u7cfb\u7684 RNA-seq \u4e0e Ribo-seq \u6570\u636e\u4e0a\u8bad\u7ec3\uff1b\u5728\u8de8\u7ec6\u80de\u7c7b\u578b\u9884\u6d4b\u6838\u7cd6\u4f53\u5360\u636e\u56fe\u8c31\u65f6\u53ef\u53d6\u5f97 0.72\u20130.80 \u7684 Pearson\/Spearman \u76f8\u5173\u7cfb\u6570\u3002\u4f9d\u6258\u6a21\u578b\u7684\u89e3\u91ca\u80fd\u529b\uff0c\u7814\u7a76\u8005\u9274\u5b9a\u51fa 3041 \u4e2a\u4e0e\u590d\u6742\u75be\u75c5\u76f8\u5173\u3001\u4f4d\u4e8e\u975e\u7f16\u7801\u533a\u7684\u9057\u4f20\u53d8\u5f02\uff0c\u8fd9\u4e9b\u53d8\u5f02\u5bf9\u7ffb\u8bd1\u6548\u7387\u7684\u5f71\u54cd\u5448\u7ec4\u7ec7\u7279\u5f02\u6027\uff0c\u4e3a\u63ed\u793a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u81ea\u95ed\u75c7\u7b49\u590d\u6742\u75be\u75c5\u7684\u5206\u5b50\u673a\u5236\u63d0\u4f9b\u4e86\u65b0\u7684\u7ebf\u7d22\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

<\/section>\n

\u56fe3 <\/span><\/span><\/em><\/span>Translatomer<\/span><\/span><\/em><\/span>\u7684\u8f93\u5165\u8f93\u51fa\u96c6\u5176\u5728\u8fdb\u5316\u7814\u7a76\uff0c\u75be\u75c5\u4f4d\u70b9\u89e3\u8bfb\u4e0a\u7684\u5e94\u7528<\/span><\/span><\/em><\/span>\u3002\u6765\u81ea<\/span><\/span><\/em><\/span><\/span>https:\/\/github.com\/xiongxslab\/Translatomer<\/span><\/span><\/em><\/span><\/p>\n


<\/span><\/em><\/span><\/p>\n

\u9664\u4e86\u89e3\u91ca\u673a\u5236\uff0c\u8868\u89c2\u57fa\u56e0\u7ec4\u4e0eAI\u7684\u7ed3\u5408\u8fd8\u53ef\u8f85\u52a9\u8bca\u65adcrossNN[4]\uff0c\u4e00\u4e2a\u8de8\u5e73\u53f0\u7684\u57fa\u4e8eDNA \u7532\u57fa\u5316\u6570\u636e\uff0c\u5bf9178\u79cd\u80bf\u7624\u8fdb\u884c\u5206\u7c7b\u7684\u53ef\u89e3\u91ca\u6df1\u5ea6\u5b66\u4e60\u6846\u67b6\uff0c\u9002\u7528\u4e8e\u4e0d\u660e\u539f\u53d1\u90e8\u4f4d\u764c\u75c7\u7684\u8bca\u65ad\u5de5\u4f5c\uff0c\u5176\u8bca\u65ad\u7cbe\u5ea6\u8fbe\u5230\u4e8697.8%\uff0c\u5728\u8111\u80bf\u7624\u4e2d\u751a\u81f3\u8fbe\u5230\u4e8699.1%\u3002\u5728\u624b\u672f\u4e2d\u4f7f\u7528\u8be5\u6280\u672f\u5c06\u662f\u4e00\u4e2a\u6709\u8da3\u7684\u65b9\u5411\u3002\u901a\u8fc7\u7eb3\u7c73\u5b54\u6d4b\u5e8f\u53ef\u4ee5\u572890\u5206\u949f\u5185\u5f97\u51fa\u7ed3\u679c\uff0c\u8fd9\u4f7f\u5f97\u624b\u672f\u4e2d\u7684\u5e94\u7528\u6210\u4e3a\u53ef\u80fd\u3002\u5916\u79d1\u533b\u751f\u53ef\u4ee5\u5728\u624b\u672f\u8fc7\u7a0b\u4e2d\u6682\u505c\u624b\u672f\uff0c\u5e76\u6839\u636e\u8868\u89c2\u9057\u4f20\u6307\u7eb9\u7684\u7ed3\u679c\u6765\u51b3\u5b9a\u540e\u7eed\u7684\u624b\u672f\u6b65\u9aa4\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u800c\u6d59\u6c5f\u5927\u5b66\u90ed\u56fd\u9aa5\u56e2\u961f\u63d0\u51fa\u7684\u8ba1\u7b97\u6a21\u578b\u795e\u519c[5]\uff0c\u901a\u8fc7\u5bf9\u591a\u79cd\u764c\u7ec6\u80de\u53ca\u4e34\u8fd1\u7684\u5065\u5eb7\u7ec4\u7ec7\u53ca\u514d\u75ab\u7ec6\u80de\u8fdb\u884c\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6d4b\u5e8f\uff0c\u6784\u5efa\u6570\u636e\u96c6\uff0c\u4e4b\u540e\u901a\u8fc7\u6839\u636e\u53d8\u5206\u81ea\u7f16\u7801\u5668\u7684\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff0c\u8ba1\u7b97\u6bcf\u4e2a\u7ec6\u80de\u5bf9\u7279\u5b9a\u836f\u7269\u5904\u7406\u7684\u54cd\u5e94\u5f3a\u5ea6\uff0c\u8bc4\u4f30\u4e0d\u540c\u836f\u7269\u5bf9\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u7684\u5f71\u54cd\u3002\u8be5\u65b9\u6cd5\u80fd\u7b5b\u9009\u6f5c\u5728\u7684\u5e7f\u8c31\u6297\u764c\u836f\uff0c\u8fd8\u80fd\u9884\u6d4b\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\u548c\u526f\u4f5c\u7528\uff0c\u6307\u5bfc\u836f\u7269\u7b5b\u9009\uff0c\u4ece\u800c\u53d1\u73b0\u9488\u5bf9\u7279\u5b9a\u7ec6\u80de\u7c7b\u578b\u7684\u5019\u9009\u836f\u7269\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u9664\u4e86\u4eceDNA\u5230RNA\u7684\u8fc7\u7a0b\u590d\u6742\uff0c\u6bcf\u4e00\u4e2a\u7ec6\u80de\u4e5f\u5e76\u975e\u4e00\u5ea7\u5b64\u5c9b\uff0c\u800c\u662f\u53d7\u5230\u5468\u56f4\u7ec6\u80de\u7684\u5f71\u54cd\uff0c\u56e0\u800c\u80fd\u591f\u4fdd\u7559\u76f8\u5bf9\u4f4d\u7f6e\u4fe1\u606f\uff0c\u5e76\u68c0\u6d4b\u5206\u5b50\u751f\u7269\u5b66\u7279\u5f81<\/span>\uff08\u4f8b\u5982\u57fa\u56e0\u7a81\u53d8\uff0c\u8f6c\u5f55\u8868\u8fbe\u8c31\uff0c\u8868\u89c2\u8c03\u8282\uff09<\/span>\u7684\u7a7a\u95f4\u7ec4\u5b66\u6210\u4e3a\u4e86\u7834\u89e3\u751f\u547d\u590d\u6742\u6027\u7684\u53e6\u4e00\u5757\u5173\u952e\u62fc\u56fe\u30022024\u5e748\u670823\u65e5\uff0cNature method \u520a\u53d1\u8bc4\u8bba\u6587\u7ae0[6]\uff1a\u7ecf\u7531 AI \u89e3\u9501\u7a7a\u95f4\u7ec4\u5b66\u6570\u636e\u7684\u80fd\u529b\uff0c\u6307\u51fa\u4eba\u5de5\u667a\u80fd\u6709\u53ef\u80fd\u91ca\u653e\u7a7a\u95f4\u7ec4\u5b66\u7684\u5168\u90e8\u6f5c\u529b\uff0c\u4fc3\u8fdb\u590d\u6742\u6570\u636e\u96c6\u7684\u6574\u5408\u548c\u65b0\u751f\u7269\u533b\u5b66\u89c1\u89e3\u7684\u53d1\u73b0\u3002\u5bf9\u6b64\uff0c\u6d59\u6c5f\u5927\u5b66\u90ed\u56fd\u9aa5\u56e2\u961f2024\u53d1\u8868\u7684\u5173\u4e8e\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u7efc\u8ff0\u8bba\u6587[7]\u4e2d\uff0c\u8ba8\u8bba\u4e86\u4ece\u7ec4\u7ec7\u6837\u672c<\/span>\uff08bulk\uff09<\/span>\u5230\u5355\u7ec6\u80de\uff0c\u518d\u5230\u7ed3\u5408\u7a7a\u95f4\u7ec4\uff0c\u8868\u89c2\u7ec4\uff0c\u4ece\u6570\u4e2a\u7ec6\u80de\u5230\u767e\u4e07\u7ec6\u80de\u7684\u53d1\u5c55\u8fc7\u7a0b\uff0c\u5bf9\u76f8\u5173\u95ee\u9898\u611f\u5174\u8da3\u7684\u53ef\u9605\u8bfb\u539f\u6587\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

AI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\u7814\u8ba8\u4f1a\u7b2c\u4e8c\u671f\u4e2d\uff0c\u90ed\u56fd\u9aa5\u8001\u5e08\u5206\u4eab\u62a5\u544a\u300a\u7528AI\u89e3\u8bfb\u57fa\u56e0\u7ec4\u8c03\u63a7\u8bed\u6cd5\u300b<\/span><\/span>\u8ba8\u8bba\u4e86\u795e\u519c\u6a21\u578b\u7b49\u5de5\u4f5c\u548c2025\u5e747\u6708\u65b0\u5de5\u4f5c\u5973\u5a32CE\u6a21\u578b\uff08<\/span>Cell \u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\uff1a\u201c\u5973\u5a32\u6a21\u578b\u201d\u89e3\u7801\u57fa\u56e0\u8c03\u63a7\u201c\u8bed\u6cd5\u201d<\/span><\/a>\uff09\uff0c\u718a\u65ed\u6df1\u5206\u4eab\u62a5\u544a\u300a<\/span><\/span>\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684RNA\u8c03\u63a7\u53ca\u75be\u75c5\u89e3\u6790<\/span><\/span>\u300b\u5177\u4f53\u4ecb\u7ecd\u4e86<\/span><\/span>Translatomer\u6a21\u578b\u7b49\u5de5\u4f5c<\/span><\/span>\u3002\u62a5\u540d<\/span>\u8ba1\u7b97\u533b\u5b66\u7814\u8ba8\u4f1a<\/span><\/a>\u53ef\u67e5\u770b\u8bb2\u5ea7\u5f55\u64ad\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

<\/section>\n

\u56fe4 <\/span><\/span><\/em><\/span>\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u7684\u53d1\u5c55\u65b9\u5411 \u6765\u81ea[<\/span><\/span><\/em><\/span>7<\/span><\/span><\/em><\/span><\/span>]<\/span><\/span><\/em><\/span><\/p>\n


<\/span><\/em><\/span><\/p>\n

\u800c\u5728\u7ecf\u5386\u4e86\u4eceDNA\u5230RNA\u518d\u5230\u86cb\u767d\u7684\u4e00\u7cfb\u5217\u8fc7\u7a0b\uff0c\u6700\u7ec8\u7684\u7ed3\u679c\u662f\u53c2\u4e0e\u65b0\u9648\u4ee3\u8c22\u7684\u4e00\u7cfb\u5217\u5c0f\u5206\u5b50\uff0c\u4f8b\u5982\u8102\u80aa\uff0c\u78b3\u6c34\u7b49\uff0c\u5bf9\u6b64\u7684\u7814\u7a76\u88ab\u79f0\u4e3a\u4ee3\u8c22\u7ec4\u30022025 \u5e74 3 \u6708\uff0c\u7f8e\u56fd\u4f5b\u7f57\u91cc\u8fbe\u5927\u5b66\u53d1\u5e03\u4e86 MetaVision3D\u2014\u2014\u4e00\u79cd\u501f\u52a9\u4eba\u5de5\u667a\u80fd\u7684\u9ad8\u5206\u8fa8\u7387 3D \u4ee3\u8c22\u7ec4\u6210\u50cf\u5e73\u53f0\uff0c\u53ef\u4e3a\u6b63\u5e38\u5c0f\u9f20\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6a21\u578b\u5c0f\u9f20\u6784\u5efa\u53ef\u4ea4\u4e92\u7684\u5927\u8111\u4ee3\u8c22\u56fe\u8c31[8]\u3002\u7814\u7a76\u8005\u548c\u4e34\u5e8a\u4eba\u5458\u53ef\u4ee5\u81ea\u7531\u7f29\u653e\u5e76\u63a2\u67e5\u4efb\u610f\u8111\u533a\uff0c\u76f4\u89c2\u6bd4\u8f83\u4e0d\u540c\u5206\u5b50<\/span>\uff08\u5c24\u5176\u662f\u4e0e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u76f8\u5173\u7684\u4ee3\u8c22\u7269\uff09<\/span>\u5728\u7a7a\u95f4\u4e0a\u7684\u5206\u5e03\u5dee\u5f02\u3002MetaVision3D \u4e3a\u89e3\u6790\u996e\u98df\u3001\u8fd0\u52a8\u3001\u9057\u4f20\u7b49\u56e0\u7d20\u5bf9\u8111\u7ec6\u80de\u4ee3\u8c22\u53ca\u75be\u75c5\u8fdb\u7a0b\u7684\u5f71\u54cd\u63d0\u4f9b\u4e86\u5168\u65b0\u89c6\u89d2\u548c\u5de5\u5177\u3002<\/span><\/span><\/p>\n


<\/span><\/h2>\n

\n
\n
\n
\n
\n

<\/span><\/section>\n

<\/span><\/section>\n
\n
<\/section>\n<\/section>\n<\/section>\n
\n

AI+\u591a\u7ec4\u5b66\u63a8\u52a8\u8d70\u5411\u7cbe\u51c6\u533b\u7597<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/span><\/p>\n

\u7cbe\u51c6\u533b\u7597\u6b63\u5728\u901a\u8fc7\u6839\u636e\u4e2a\u4f53\u60a3\u8005\u7684\u72ec\u7279\u7279\u5f81\u91cf\u8eab\u5b9a\u5236\u6cbb\u7597\u65b9\u6848\u6765\u91cd\u5851\u533b\u7597\u4fdd\u5065\u683c\u5c40\u3002\u76f8\u6bd4\u4e4b\u524d\uff0c\u751f\u7269\u533b\u5b66\u7684\u7814\u7a76\u8005\u80fd\u591f\u4f7f\u7528\u66f4\u591a\u6837\u7684\u5de5\u5177\uff0c\u8ddf\u8e2a\u751f\u7269\u4f53\u4ece\u8bbe\u8ba1<\/span>\uff08DNA\uff09<\/span>\u5230\u5b9e\u73b0<\/span>\uff08\u4ee3\u8c22\u7269\uff09<\/span>\u7684\u8fd9\u4e00\u52a8\u6001\u8fc7\u7a0b\u4e2d\u7684\u6bcf\u4e00\u6b65\uff0c\u5e76\u5bf9\u53ef\u80fd\u7684\u6270\u52a8\u6240\u5e26\u6765\u7684\u5f71\u54cd\u8fdb\u884c\u9884\u6d4b\u3002\u8fd9\u5c31\u5982\u540c\u4e4b\u524d\u7684\u7814\u7a76\u8005\u8bd5\u56fe\u653b\u514b\u764c\u75c7\u65f6\u662f\u8499\u7740\u773c\u5c04\u7bad\uff0c\u800cAI\u7684\u5f15\u5165\u8ba9\u8fd9\u4e00\u8fc7\u7a0b\u5e26\u4e0a\u4e86\u7784\u51c6\u955c\uff0c\u540c\u65f6\u8fd8\u4f1a\u6839\u636e\u98ce\u901f\u9884\u6d4b\u6700\u4f73\u8f68\u8ff9\uff0c\u4ece\u800c\u505a\u5230\u8f95\u95e8\u5c04\u621f\u7ea7\u7684\u7cbe\u51c6\u6253\u51fb\u764c\u7ec6\u80de\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u4e0b\u56fe\u662f\u4e00\u4e2a\u5b8c\u6574\u7684AI\u9a71\u52a8\u7684\u591a\u7ec4\u5b66\u6574\u5408\u4e34\u5e8a\u51b3\u7b56\u7cfb\u7edf\uff0c\u5b9e\u73b0\u4e86\u4ece\u60a3\u8005\u6837\u672c\u5230\u7528\u836f\u5efa\u8bae\u7684\u7aef\u5230\u7aef\u95ed\u73af\u3002\u901a\u8fc7\u591a\u7ec4\u5b66\u6570\u636e\u91c7\u96c6\uff0c\u7535\u5b50\u75c5\u5386\uff0c\u7531AI\u6a21\u578b\u8fdb\u884c\u6570\u636e\u6574\u5408\uff0c\u9884\u6d4b\u836f\u7269\u54cd\u5e94\uff0c\u652f\u6301\u4e34\u5e8a\u51b3\u7b56\uff0c\u6700\u7ec8\u901a\u8fc7\u91c7\u96c6\u60a3\u8005\u7684\u5b9e\u9645\u60c5\u51b5\uff0c\u6301\u7eed\u6539\u8fdb\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

<\/section>\n

\u56fe<\/span><\/span><\/em><\/span>5 <\/span><\/span><\/em><\/span>\u9884\u6d4b\u836f\u7269\u53cd\u5e94\u7684 AI \u9a71\u52a8\u591a\u7ec4\u5b66\u6d41\u7a0b\u3002\u6e90\u81ea\u60a3\u8005\u7684\u7ec4\u5b66\u6570\u636e\uff0c\u5305\u62ec\u57fa\u56e0\u7ec4\u5b66\uff08\u4f8b\u5982\uff0cWES\/WGS\uff09\u3001\u8868\u89c2\u57fa\u56e0\u7ec4\u5b66\uff08\u4f8b\u5982\uff0cBS-seq\u3001ATAC-seq\uff09\u3001\u8f6c\u5f55\u7ec4\u5b66\uff08RNA-seq\uff09\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\uff08\u8d28\u8c31\u5206\u6790\uff09\u548c\u4ee3\u8c22\u7ec4\u5b66\uff08\u4f8b\u5982\uff0cLC-MS\u3001NMR\uff09\uff0c\u88ab\u878d\u5408\u4e0e\u534f\u8c03\u4ee5\u4f5c\u4e3a\u6a21\u578b\u8f93\u5165\u3002\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff08\u4f8b\u5982\uff0cVAEs\u3001GANs\u3001GNNs\uff09\u9884\u6d4b\u836f\u7269\u7597\u6548\u3001\u4e0d\u826f\u836f\u7269\u53cd\u5e94\uff08ADR\uff09\u98ce\u9669\u548c\u5242\u91cf\u5efa\u8bae\u3002\u53ef\u89e3\u91ca\u6027\u6a21\u5757\u589e\u5f3a\u6a21\u578b\u900f\u660e\u5ea6\uff0c\u800c\u57fa\u4e8e\u771f\u5b9e\u4e16\u754c\u7ed3\u679c\u7684\u9a8c\u8bc1\u5219\u5b9e\u73b0\u6301\u7eed\u4f18\u5316\u3002\u6700\u7ec8\u8f93\u51fa\u901a\u8fc7\u96c6\u6210\u5230\u7535\u5b50\u5065\u5eb7\u8bb0\u5f55\uff08EHR\uff09\u7684\u4e34\u5e8a\u51b3\u7b56\u652f\u6301\u7cfb\u7edf\uff08CDSS\uff09\u4ea4\u4ed8\u7ed9\u4e34\u5e8a\u533b\u751f\u3002\u6765\u81ea [<\/span><\/span><\/em><\/span>9<\/span><\/span><\/em><\/span><\/span>]<\/span><\/span><\/em><\/span><\/p>\n


<\/span><\/em><\/span><\/p>\n

\u6b64\u5916\uff0c\u5bf9\u4e8e\u590d\u6742\u7684\u590d\u6742\u591a\u57fa\u56e0\u6027\u72b6<\/span>\uff08\u5982\u7cd6\u5c3f\u75c5\uff0c\u963f\u5179\u6d77\u9ed8\u7b49\uff09<\/span>\u673a\u5668\u5b66\u4e60\u6a21\u578b\u901a\u8fc7\u6539\u8fdb\u53d8\u91cf\u9009\u62e9\u548c\u52a0\u6743\u6765\u589e\u5f3a\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u5206\uff0c\u63d0\u9ad8\u9884\u6d4b\u6548\u7528\u3002\u8d85\u8d8a\u57fa\u56e0\u7ec4\u5b66\uff0c\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7684\u6574\u5408\u63d0\u4f9b\u4e86\u5bf9\u75be\u75c5\u8868\u578b\u7684\u66f4\u7cbe\u7ec6\u7684\u7406\u89e3[10]\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u5c3d\u7ba1\u5177\u6709\u5de8\u5927\u6f5c\u529b\uff0c\u4f46\u8fd9\u79cd\u65b9\u6cd5\u9762\u4e34\u7740\u6570\u636e\u6709\u9650\u3001\u9690\u79c1\u95ee\u9898\u548c\u751f\u7269\u7cfb\u7edf\u590d\u6742\u6027\u7684\u6311\u6218\u3002\u6574\u5408\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u548c\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\u5bf9\u4e8e\u5168\u9762\u4e86\u89e3\u60a3\u8005\u5065\u5eb7\u72b6\u51b5\u81f3\u5173\u91cd\u8981\u3002omicsGAN[11] \u7b49\u6a21\u578b\u901a\u8fc7\u7ed3\u5408\u591a\u79cd\u6570\u636e\u7c7b\u578b\u6765\u589e\u5f3a\u75be\u75c5\u8868\u578b\u9884\u6d4b\u548c\u6cbb\u7597\u8ba1\u5212\u3002\u5229\u7528\u81ea\u7f16\u7801\u5668\u3001\u56fe\u5377\u79ef\u7f51\u7edc\uff0c\u5982MOGONET[12]\u3001\u96c6\u6210\u65b9\u6cd5\u548c\u5bf9\u6bd4\u5b66\u4e60\u7b49\u6280\u672f\u6765\u53ef\u5e94\u5bf9\u591a\u7ec4\u5b66\u5f02\u6784\u6570\u636e\u96c6\u6210\u5e26\u6765\u7684\u6311\u6218\u3002\u8fd9\u4e9b\u65b9\u6cd5\u901a\u8fc7\u8bc6\u522b\u5171\u540c\u6f5c\u5728\u56e0\u7d20\u548c\u5b66\u4e60\u8de8\u7ec4\u5b66\u8868\u793a\uff0c\u80fd\u591f\u5b66\u4e60\u4e0d\u540c\u7ec4\u5b66\u5c42\u4e4b\u95f4\u7684\u590d\u6742\u975e\u7ebf\u6027\u76f8\u4e92\u4f5c\u7528\uff0c\u901a\u5e38\u5728\u836f\u7269\u53cd\u5e94\u548c\u75be\u75c5\u9884\u540e\u65b9\u9762\u5b9e\u73b0\u5353\u8d8a\u7684\u9884\u6d4b\u6027\u80fd\uff0c\u4fc3\u8fdb\u4e86\u7a33\u5065\u751f\u7269\u6807\u5fd7\u7269\u7684\u68c0\u6d4b\u3002<\/span><\/span><\/p>\n


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\u6b64\u5916\uff0c\u4eba\u5de5\u667a\u80fd\u4e0d\u4ec5\u6709\u52a9\u4e8e\u6570\u636e\u96c6\u6210\uff0c\u8fd8\u901a\u8fc7\u53ef\u89e3\u91ca\u4eba\u5de5\u667a\u80fd<\/span>\uff08XAI\uff09<\/span>\u6280\u672f\u63d0\u9ad8\u53ef\u89e3\u91ca\u6027\uff0c\u4ece\u800c\u5728\u4f9d\u8d56\u8fd9\u4e9b\u590d\u6742\u3001\u6570\u636e\u9a71\u52a8\u65b9\u6cd5\u7684\u4e34\u5e8a\u533b\u751f\u548c\u7814\u7a76\u4eba\u5458\u4e2d\u5efa\u7acb\u4e86\u4fe1\u4efb\u3002\u50cf MOVIS \u8fd9\u6837\u7684\u5e73\u53f0\u63d0\u4f9b\u52a8\u6001\u3001\u591a\u6a21\u6001\u65f6\u95f4\u5e8f\u5217\u805a\u7c7b\u548c\u5d4c\u5165\u4efb\u52a1\u7684\u53ef\u89c6\u5316\u5de5\u5177\u3002\u4f8b\u5982MOVIS [13]\u8bbe\u8ba1\u7528\u4e8e\u5904\u7406\u5404\u79cd\u7ec4\u5b66\u7c7b\u578b\u2014\u2014\u57fa\u56e0\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u4ee3\u8c22\u7ec4\u5b66\u2014\u2014\u4ee5\u53ca\u7269\u7406\u5316\u5b66\u6570\u636e\u3002\u5176\u57fa\u4e8e\u7f51\u7edc\u7684\u754c\u9762\u5141\u8bb8\u4e34\u5e8a\u533b\u751f\u548c\u7814\u7a76\u4eba\u5458\u4ee5\u5e76\u6392\u7684\u65b9\u5f0f\u63a2\u7d22\u548c\u4ea4\u4e92\u591a\u7ec4\u5b66\u6570\u636e\uff0c\u4fc3\u8fdb\u7eb5\u5411\u7814\u7a76\u4e2d\u7684\u5047\u8bbe\u68c0\u9a8c\u548c\u6a21\u5f0f\u8bc6\u522b\u3002<\/span><\/span><\/p>\n


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\u53c2\u8003\u6587\u732e<\/span><\/span><\/p>\n

[1] Yates, Josephine, and Eliezer M. Van Allen. “New horizons at the interface of artificial intelligence and translational cancer research.” <\/span><\/span>Cancer Cell<\/span><\/span><\/em> 43.4 (2025): 708-727.<\/span><\/span><\/span><\/p>\n

[2] Brixi G, Durrant MG, Ku J, et al. Genome modeling and design across all domains of life with Evo 2. bioRxiv. Preprint posted online February 21, 2025. doi: 10.1101\/2025.02.18.638918.<\/span><\/span><\/p>\n

[3] He, Jialin, et al. “Deep learning prediction of ribosome profiling with Translatomer reveals translational regulation and interprets disease variants.” <\/span><\/span>Nature Machine Intelligence<\/span><\/span><\/em> 6.11 (2024): 1314-1329.<\/span><\/span><\/span><\/p>\n

[4] Yuan, Dongsheng, et al. “crossNN is an explainable framework for cross-platform DNA methylation-based classification of tumors.” <\/span><\/span>Nature Cancer<\/span><\/span><\/em> (2025): 1-12.<\/span><\/span><\/span><\/p>\n

[5] Zhang, Peijing, et al. “A deep learning framework for in silico screening of anticancer drugs at the single-cell level.” <\/span><\/span>National Science Review<\/span><\/span><\/em> 12.2 (2025): nwae451.<\/span><\/span><\/span><\/p>\n

[6] Coleman, Kyle, Amelia Schroeder, and Mingyao Li. “Unlocking the power of spatial omics with AI.” <\/span><\/span>nature methods<\/span><\/span><\/em> 21.8 (2024): 1378-1381.<\/span><\/span><\/span><\/p>\n

[7] Wang, Jingjing, et al. “Advances and applications in single-cell and spatial genomics.” <\/span><\/span>Science China Life Sciences<\/span><\/span><\/em> (2024): 1-57.<\/span><\/span><\/span><\/p>\n

[8] Ma, Xin, et al. “AI-driven framework to map the brain metabolome in three dimensions.” <\/span><\/span>Nature metabolism<\/span><\/span><\/em> (2025): 1-12.<\/span><\/span><\/span><\/p>\n

[9] Zack, Mike, et al. “AI and Multi-Omics in Pharmacogenomics: A New Era of Precision Medicine.” <\/span><\/span>Mayo Clinic Proceedings: Digital Health<\/span><\/span><\/em> (2025): 100246.<\/span><\/span><\/span><\/p>\n

[10] Ahmed Z, Thirunavukarasu R and Khan A (2025) Editorial: Computational genomic and precision medicine. Front. Genet. 16:1631668. doi: 10.3389\/fgene.2025.1631668<\/span><\/span><\/p>\n

[11] Ahmed, Khandakar Tanvir, et al. “Multi-omics data integration by generative adversarial network.” <\/span><\/span>Bioinformatics<\/span><\/span><\/em> 38.1 (2022): 179-186.<\/span><\/span><\/span><\/p>\n

[12] Wang, Tongxin, et al. “MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification.” <\/span><\/span>Nature communications<\/span><\/span><\/em> 12.1 (2021): 3445.<\/span><\/span><\/span><\/p>\n

[13] An\u017eel, Aleksandar, Dominik Heider, and Georges Hattab. “MOVIS: a multi-omics software solution for multi-modal time-series clustering, embedding, and visualizing tasks.” <\/span><\/span>Computational and Structural Biotechnology Journal<\/span><\/span><\/em><\/span> 20 (2022): 1044-1055.<\/span><\/span><\/p>\n

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<\/span><\/strong><\/p>\n

AI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\u7814\u8ba8\u4f1a<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/span><\/p>\n

DAMO\u5f00\u53d1\u8005\u77e9\u9635\uff08\u7531\u963f\u91cc\u5df4\u5df4\u8fbe\u6469\u9662\u548c\u4e2d\u56fd\u4e92\u8054\u7f51\u534f\u4f1a\u8054\u5408\u53d1\u8d77\uff09\u4e0e\u96c6\u667a\u4ff1\u4e50\u90e8\u5171\u540c\u4e3b\u529e<\/span>\u201cAI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\uff1a\u4ece\u79d1\u5b66\u53d1\u73b0\u5230\u6570\u5b57\u5b6a\u751f\u201d\u7cfb\u5217\u7814\u8ba8\u4f1a<\/span><\/a>\uff0c\u9080\u8bf7\u591a\u4f4d\u56fd\u5185\u5916\u524d\u6cbf\u5b66\u8005\u4e0e\u4e1a\u754c\u4e13\u5bb6\u5206\u4eab\u4ea4\u6d41\u3002\u672c\u6d3b\u52a8\u514d\u8d39\u62a5\u540d\uff0c\u5b9e\u884c\u5ba1\u6838\u5165\u7fa4\u5236\uff0c\u8bf7\u586b\u5199\u4fe1\u606f\u540e\u5165\u7fa4\u53c2\u4e0e\u4ea4\u6d41\u5e76\u83b7\u5f97\u6bcf\u671f\u6d3b\u52a8\u4fe1\u606f\u3002<\/span><\/span><\/span><\/section>\n
7\u670815\u65e5\uff08\u5468\u4e8c\uff09\u5c06\u4e3e\u529e\u7814\u8ba8\u4f1a\u7b2c\u4e09\u671f\uff0c\u300aAI for \u86cb\u767d\u8d28\u79d1\u5b66\uff1a\u4ece\u7ed3\u6784\u9884\u6d4b\u5230\u4e34\u5e8a\u6807\u5fd7\u7269\u300b\uff0c\u6b22\u8fce\u9884\u7ea6\u76f4\u64ad\u548c\u62a5\u540d\u53c2\u4e0e\u3002<\/span><\/span><\/span>\u9080\u8bf7\u5434\u5bb6\u777f\u8001\u5e08\u5206\u4eab\u300a  AI\u9a71\u52a8\u7684\u86cb\u767d\u8d28\u79d1\u5b66  \u300b\uff0c\u5e38\u4e58\u8001\u5e08\u5206\u4eab\u300a  \u86cb\u767d\u8d28\u7ec4\u5927\u6570\u636e\u667a\u80fd\u89e3\u6790  \u300b\uff0c\u5e76\u7ec4\u7ec7\u5706\u684c\u63a2\u8ba8\u201c  \u4eceAlphaFold\u5230\u865a\u62df\u7ec6\u80de\u2014\u2014AI\u591a\u7ec4\u5b66\u7684\u878d\u5408\u4e4b\u8def  \u201d\u3002<\/span><\/span>\u6b22\u8fce\u611f\u5174\u8da3\u7684\u670b\u53cb\u9884\u7ea6\u76f4\u64ad\uff0c\u62a5\u540d\u52a0\u5165\u7814\u8ba8\u4f1a\u4ea4\u6d41\uff01<\/span><\/span><\/section>\n
<\/section>\n
<\/span><\/a><\/section>\n

\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/span>AI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u524d\u6cbf\u7814\u8ba8\u4f1a\u5f00\u542f\u62a5\u540d\uff1a\u4ece\u79d1\u5b66\u53d1\u73b0\u5230\u6570\u5b57\u5b6a\u751f<\/span><\/a><\/span><\/span><\/p>\n

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1. PNAS\u901f\u9012\uff1a\u5f00\u653e\u5f0f\u533b\u7597\u8bca\u65ad\u4e2d\u6df7\u5408\u96c6\u4f53\u667a\u80fd\u7684\u81ea\u52a8\u5316<\/span><\/a><\/span><\/strong>
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2. \u53ef\u91cd\u6784\u5fae\u578b\u96c6\u7fa4\u673a\u5668\u4eba\uff0c\u70b9\u4eae\u672a\u6765\u533b\u7597\u4e0e\u73af\u5883\u4fee\u590d<\/span><\/a><\/span><\/strong>
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3. 319\u7bc7\u6587\u732e\u300141\u9875\u7efc\u8ff0\u6587\u7ae0\u8bb2\u8ff0\u56fe\u795e\u7ecf\u7f51\u7edc\u7528\u4e8e\u533b\u7597\u8bca\u65ad\u7684\u524d\u4e16\u4eca\u751f\u4e0e\u672a\u6765<\/span><\/a><\/span><\/strong><\/section>\n
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4. <\/span><\/strong><\/span>\u6d8c\u73b0\u52a8\u529b\u5b66\u5982\u4f55\u7528\u6765\u5206\u6790\u590d\u6742\u7cfb\u7edf\uff1f | \u65b0\u8bfe\u4e0a\u7ebf<\/a><\/span><\/strong><\/strong><\/span><\/section>\n
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6. <\/span><\/strong>\u63a2\u7d22\u8005\u8ba1\u5212 | \u96c6\u667a\u4ff1\u4e50\u90e82025\u5185\u5bb9\u56e2\u961f\u62db\u52df\uff08\u5168\u804c&\u517c\u804c\uff09<\/a><\/span><\/strong><\/span><\/p>\n

7.<\/span><\/span><\/strong><\/strong><\/span> <\/span><\/span><\/strong><\/strong><\/span>\u7cfb\u7edf\u79d1\u5b66\u524d\u6cbf\u5341\u8bb2\uff1a\u7406\u89e3\u81ea\u7136\u3001\u751f\u547d\u4e0e\u793e\u4f1a\u7684\u590d\u6742\u6027<\/span><\/a><\/span><\/strong><\/strong><\/span><\/p>\n


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