{"id":63753,"date":"2025-08-23T16:59:15","date_gmt":"2025-08-23T08:59:15","guid":{"rendered":"https:\/\/swarma.org\/?p=63753"},"modified":"2025-08-23T16:59:15","modified_gmt":"2025-08-23T08:59:15","slug":"%e6%95%b0%e6%8d%ae%e9%a9%b1%e5%8a%a8ai%e8%99%9a%e6%8b%9f%e7%bb%86%e8%83%9e%e6%8e%a2%e7%b4%a2%ef%bc%9a%e4%bb%8earc%e6%8c%91%e6%88%98%e8%b5%9b%e7%9c%8b%e6%95%b0%e6%8d%ae%e5%9f%ba%e5%ba%a7","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=63753","title":{"rendered":"\u6570\u636e\u9a71\u52a8AI\u865a\u62df\u7ec6\u80de\u63a2\u7d22\uff1a\u4eceArc\u6311\u6218\u8d5b\u770b\u201c\u6570\u636e\u57fa\u5ea7\u201d\u7684\u529b\u91cf"},"content":{"rendered":"
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2025\u5e746\u6708\uff0cArc Institute\u53d1\u8d77\u4e86\u9996\u5c4a\u201c\u865a\u62df\u7ec6\u80de\u6311\u6218\u8d5b\u201d<\/span>\uff08Virtual Cell Challenge\uff09<\/span>\uff0c\u5f15\u8d77\u4e86AI\u548c\u751f\u7269\u533b\u5b66\u754c\u7684\u5e7f\u6cdb\u5173\u6ce8[1]\u3002\u4e00\u77f3\u6fc0\u8d77\u5343\u5c42\u6d6a\uff0c\u56e0\u4e3aArc \u4ee5\u7ade\u8d5b\u7684\u5f62\u5f0f\u91cd\u65b0<\/span><\/span>\u5b9a\u4e49\u4e86\u6570\u636e\u548c\u8bc4\u6d4b\u8303\u5f0f<\/span><\/span><\/strong>\uff1a\u6211\u4eec\u5e94\u8be5\u7528\u4ec0\u4e48\u6570\u636e\u6765\u8bad\u7ec3\u6a21\u578b\u3001\u5982\u4f55\u6d4b\u91cf\u6a21\u578b\u8868\u73b0\u3001\u4ee5\u53ca\u4ee5\u600e\u6837\u7684\u6807\u51c6\u5224\u5b9a\u4f18\u52a3\uff0c\u4ece\u800c\u63a8\u52a8\u4eba\u5de5\u667a\u80fd\u865a\u62df\u7ec6\u80de<\/span>\uff08Artificial Intelligence Virtual Cell, <\/span><\/span>AIVC<\/span><\/span><\/strong>\uff09<\/span>\u8fc8\u5411\u65b0\u9636\u6bb5\u3002<\/span><\/span><\/span><\/p>\n

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1. \u6570\u636e\u57fa\u5ea7\uff1a\u4ece\u89c2\u6d4b\u5230\u5e72\u9884<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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AIVC\u7684\u57fa\u672c\u8fc7\u7a0b\uff0c\u662f\u6784\u5efa\u80fd\u591f\u53cd\u6620\u7ec6\u80de\u5185\u90e8\u8c03\u63a7\u673a\u5236\u3001\u5177\u5907\u6cdb\u5316\u80fd\u529b\u7684\u6a21\u578b\u3002\u8981\u8ba9AI\u771f\u6b63\u5177\u5907\u9884\u6d4b\u7ec6\u80de\u6270\u52a8\u54cd\u5e94\u7684\u80fd\u529b\uff0c\u4ec5\u6709\u89c2\u5bdf\u6027\u6570\u636e\u8fdc\u8fdc\u4e0d\u591f\u3002\u8fc7\u53bb\u7edd\u5927\u591a\u6570\u516c\u5f00\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\u90fd\u662f\u89c2\u6d4b\u6027\u7684\uff0c\u53ea\u63cf\u7ed8\u4e86\u7ec6\u80de\u5929\u7136\u72b6\u6001\u4e0b\u57fa\u56e0\u8868\u8fbe\u7684\u9759\u6001\u56fe\u8c31\uff0c\u65e0\u6cd5\u652f\u6301\u7ec6\u80de\u5185\u90e8\u56e0\u679c\u673a\u5236\u7684\u6709\u6548\u63a8\u65ad\u3002<\/span><\/span><\/p>\n

Arc Institute\u610f\u8bc6\u5230\uff0c\u8981\u5b9e\u73b0\u865a\u62df\u7ec6\u80de\u6a21\u578b\u771f\u6b63\u7684\u56e0\u679c\u9884\u6d4b\u80fd\u529b\uff0c\u5fc5\u987b\u6784\u5efa\u5e76\u5f15\u5165\u5927\u89c4\u6a21\u7684\u5e72\u9884\u578b\u6570\u636e\u4f5c\u4e3a\u8bad\u7ec3\u57fa\u77f3\u3002\u4e3a\u6b64\uff0c\u4ed6\u4eec\u57282025\u5e742\u6708\u53d1\u5e03\u4e86\u4e00\u4e2a\u7a7a\u524d\u5e9e\u5927\u7684\u5f00\u653e\u6570\u636e\u8d44\u6e90\u7ec4\u5408\u2014\u2014<\/span><\/span>Arc\u865a\u62df\u7ec6\u80de\u56fe\u8c31Atlas<\/span><\/span><\/strong>\uff0c\u5305\u542b\u89c2\u6d4b\u6570\u636e\u4e0e\u4e3b\u52a8\u5e72\u9884\u6570\u636e\uff0c\u5355\u7ec6\u80de\u6570\u636e\u603b\u89c4\u6a21\u5df2\u8d85\u8fc73\u4ebf\u4e2a\u7ec6\u80de[4]\u3002<\/span><\/span><\/span><\/p>\n

Atlas\u6c47\u805a\u4e86\u5168\u7403\u8303\u56f4\u5185\u5f02\u8d28\u4e14\u5206\u6563\u7684\u5355\u7ec6\u80de\u6570\u636e\uff0c\u7ecf\u8fc7\u7edf\u4e00\u6807\u51c6\u5316\u5904\u7406\uff0c\u6210\u4e3aAI\u53ef\u76f4\u63a5\u8bfb\u53d6\u7684\u6807\u51c6\u8d44\u6e90\u3002Atlas\u7684\u9996\u6279\u57fa\u7840\u6570\u636e\u96c6\u5305\u62ec\uff1a<\/span><\/span><\/p>\n

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    Tahoe-100M\u836f\u7269\u6270\u52a8\u6570\u636e\u96c6<\/span><\/span><\/strong>\uff1a  \u7531\u751f\u7269\u6280\u672f\u516c\u53f8Tahoe<\/span>\uff08\u524d\u79f0Vevo Therapeutics\uff09<\/span>\u4e0eArc\u5408\u4f5c\u751f\u6210\uff0c\u5305\u542b\u7ea61\u4ebf\u4e2a\u5355\u7ec6\u80de\uff0c\u6db5\u76d650\u79cd\u764c\u75c7\u7ec6\u80de\u7cfb\u5bf9\u8d85\u8fc71100\u79cd\u5c0f\u5206\u5b50\u836f\u7269\u5904\u7406\u540e\u7684\u8f6c\u5f55\u54cd\u5e94\uff0c\u6761\u4ef6\u603b\u6570\u9ad8\u8fbe6\u4e07\u4f59\u4e2a[5]\u3002<\/span><\/span><\/span><\/p>\n<\/li>\n

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    scBaseCount\u89c2\u6d4b\u6570\u636e\u96c6<\/span><\/span><\/strong>\uff1a  \u8fd9\u662f\u7531Arc\u81ea\u4e3b\u5f00\u53d1\u7684\u667a\u80fdAI Agent\u4eceNCBI\u7684SRA\u516c\u5171\u6570\u636e\u5e93\u81ea\u52a8\u722c\u53d6\u3001\u6807\u51c6\u5316\u5904\u7406\u5e76\u7edf\u4e00\u8d28\u63a7\u6ce8\u91ca\u800c\u6210\u7684\u6570\u636e\u96c6\uff0c\u56ca\u62ec21\u4e2a\u7269\u79cd\u300172\u4e2a\u7ec4\u7ec7\uff0c\u603b\u89c4\u6a21\u8d85\u8fc72\u4ebf\u5355\u7ec6\u80de\u8f6c\u5f55\u8c31\uff0c\u4e14\u6301\u7eed\u66f4\u65b0[6]\u3002<\/span><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \u901a\u8fc7AI\u9a71\u52a8\u7684\u7edf\u4e00\u8d28\u63a7\u3001\u9884\u5904\u7406\u4e0e\u6ce8\u91ca\u6d41\u7a0b\uff0cArc\u6700\u5927\u9650\u5ea6\u5730\u6d88\u9664\u4e86\u4e0d\u540c\u5b9e\u9a8c\u6279\u6b21\u3001\u6d4b\u5e8f\u5e73\u53f0\u4e4b\u95f4\u7684\u6280\u672f\u566a\u97f3\uff0c\u4f7f\u8fd9\u4e9b\u5f02\u6e90\u6570\u636e\u5f97\u4ee5\u9996\u6b21\u771f\u6b63\u610f\u4e49\u4e0a\u7684\u878d\u5408\u3002\u8fd9\u6807\u5fd7\u7740\u5355\u7ec6\u80de\u6570\u636e\u6574\u5408\u8fdb\u5165\u4e86\u65b0\u7684\u9636\u6bb5\uff1a\u7814\u7a76\u8005\u65e0\u9700\u518d\u8d39\u529b\u5730\u4ece\u5934\u6e05\u6d17\u3001\u8f6c\u6362\u7e41\u6742\u7684\u6570\u636e\uff0c\u4fbf\u53ef\u76f4\u63a5\u4f7f\u7528\u9ad8\u8d28\u91cf\u7684\u516c\u5171\u8d44\u6e90\u8fdb\u884c\u5206\u6790\u3002\u5c31\u50cf\u8ba1\u7b97\u673a\u89c6\u89c9\u9886\u57df\u7684ImageNet\u4e00\u6837\uff0c\u6210\u4e3a\u5f00\u653e\u6570\u636e\u201c\u5e95\u5ea7\u201d\u3002<\/span><\/span><\/p>\n

    \u540c\u65f6\uff0cArc\u5c06Atlas\u6570\u636e\u4ee5AnnData\u7684H5AD\u6807\u51c6\u683c\u5f0f\u548cCC0\u516c\u5171\u534f\u8bae\u5f00\u653e\u5171\u4eab\u3002\u8fd9\u610f\u5473\u7740\u4efb\u4f55\u4eba\u90fd\u53ef\u4ee5\u81ea\u7531\u83b7\u53d6\u8fd93\u4ebf\u7ec6\u80de\u7ea7\u7684\u6570\u636e\uff0c\u7528\u4e8e\u6a21\u578b\u9884\u8bad\u7ec3\u548c\u91cd\u590d\u5206\u6790\uff0c\u5927\u5927\u964d\u4f4e\u4e86\u8fdb\u5165AIVC\u7814\u7a76\u7684\u95e8\u69db\u3002<\/span><\/span><\/p>\n

    \u7136\u800c\uff0c\u4ec5\u6709\u5927\u91cf\u7684\u89c2\u6d4b\u6570\u636e\u8fd8\u4e0d\u8db3\u4ee5\u652f\u6491\u771f\u6b63\u7684\u56e0\u679c\u6a21\u578b\u8bad\u7ec3\u3002Arc\u6311\u6218\u8d5b\u7684\u5173\u952e\u5728\u4e8e\u4e13\u95e8\u8bbe\u8ba1\u4e86\u5e72\u9884\u578b\u57fa\u51c6\u6570\u636e\u96c6\u3002\u4ed6\u4eec\u9009\u62e9\u5728\u4eba\u7c7bH1\u80da\u80ce\u5e72\u7ec6\u80de<\/span>\uff08H1 human embryonic stem cells, H1 hESC\uff09<\/span>\u4e0a\u8fdb\u884cCRISPR\u5e72\u6270<\/span>\uff08CRISPR interference, CRISPRi\uff09<\/span>\u5b9e\u9a8c\uff0c\u4ea7\u751f\u4e86\u7ea630\u4e07\u4e2a\u5355\u7ec6\u80de\u7684\u9ad8\u8d28\u91cf\u8bad\u7ec3\u3001\u9a8c\u8bc1\u548c\u6d4b\u8bd5\u6570\u636e\u96c6[7]\u3002<\/span><\/span><\/p>\n

    \u9009\u62e9H1\u7ec6\u80de\u7684\u539f\u56e0\u6709\u4e8c\uff1a\u5176\u4e00\uff0c\u80da\u80ce\u5e72\u7ec6\u80de\u5177\u6709\u591a\u80fd\u5206\u5316\u6f5c\u80fd\uff0c\u57fa\u56e0\u6270\u52a8\u540e\u5bb9\u6613\u8868\u73b0\u51fa\u4e30\u5bcc\u591a\u6837\u7684\u8f6c\u5f55\u53d8\u5316\uff1b\u5176\u4e8c\uff0cH1\u7ec6\u80de\u4f5c\u4e3a\u65b0\u80cc\u666f\uff0c\u6709\u52a9\u4e8e\u8003\u5bdf\u6a21\u578b\u5bf9\u672a\u89c1\u7ec6\u80de\u7c7b\u578b\u7684\u6cdb\u5316\u80fd\u529b\u3002<\/span><\/span><\/p>\n

    <\/section>\n

    \u56fe2\uff1aArc\u6311\u6218\u8d5b\u7684\u76ee\u6807\u57fa\u56e0\u7b5b\u9009\u3002<\/span><\/span><\/span><\/p>\n

    Arc\u7814\u7a76\u56e2\u961f\u9996\u5148\u5bf9\u5927\u7ea62500\u4e2a\u5019\u9009\u57fa\u56e0\u8fdb\u884c\u4e86\u9884\u7b5b\u9009\u5b9e\u9a8c\uff0c\u6839\u636e\u6572\u4f4e<\/span>\uff08Knockdown\uff09<\/span>\u540e\u5f15\u8d77\u7684\u8f6c\u5f55\u53d8\u5316\u5f3a\u5ea6\u5c06\u5176\u5206\u4e3a\u4e09\u7c7b\uff1a<\/span><\/span><\/span><\/p>\n

      \n
    • \n

      \u5f3a\u6548\u5e94<\/span><\/span><\/strong>\uff1a\u6bcf\u4e2a\u6270\u52a8\u5f15\u8d77 >100 \u4e2a\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0<\/span><\/span><\/span><\/p>\n<\/li>\n

    • \n

      \u4e2d\u7b49\u6548\u5e94<\/span><\/span><\/strong>\uff1a\u6bcf\u4e2a\u6270\u52a8\u5f15\u8d77 10\u2013100 \u4e2a\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0<\/span><\/span><\/span><\/p>\n<\/li>\n

    • \n

      \u53ef\u5ffd\u7565\u6548\u5e94<\/span><\/span><\/strong>\uff1a\u51e0\u4e4e\u4e0d\u5f15\u8d77\u660e\u663e\u7684\u8f6c\u5f55\u53d8\u5316<\/span><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      \u968f\u540e\uff0cArc\u56e2\u961f\u5728\u6b64\u57fa\u7840\u4e0a\u7cbe\u9009\u51fa300\u4e2a\u57fa\u56e0\u4f5c\u4e3a\u6700\u7ec8\u6270\u52a8\u6570\u636e\u96c6\uff0c\u6db5\u76d6\u4e86\u4ece\u65e0\u660e\u663e\u53d8\u5316\u5230\u5f3a\u70c8\u53d8\u5316\u7684\u4e0d\u540c\u6548\u5e94\u7a0b\u5ea6\uff0c\u5e76\u5728\u6bcf\u4e2a\u6548\u5e94\u5f3a\u5ea6\u7c7b\u522b\u5185\u8fdb\u4e00\u6b65\u6839\u636e\u8f6c\u5f55\u7ec4\u8868\u578b\u8fdb\u884c\u805a\u7c7b\uff0c\u4ee5\u786e\u4fdd\u6240\u9009\u6270\u52a8\u80fd\u591f\u5168\u9762\u8986\u76d6\u5c3d\u53ef\u80fd\u591a\u6837\u7684\u7ec6\u80de\u54cd\u5e94\u6a21\u5f0f<\/span>\uff08\u5373<\/span><\/span>\u8868\u578b\u591a\u6837\u6027<\/span><\/span><\/strong>\uff09<\/span>\u3002 \u540c\u65f6\uff0c\u5927\u90e8\u5206\u6240\u9009\u57fa\u56e0\u5728\u5176\u4ed6\u7ec6\u80de\u7c7b\u578b\u7684\u516c\u5f00\u6270\u52a8\u6570\u636e\u96c6\u4e2d\u6709\u660e\u786e\u8bb0\u5f55\u3002\u8fd9\u610f\u5473\u7740\uff0c\u8fd9\u4e9b\u57fa\u56e0\u5e76\u975e\u968f\u673a\u9009\u62e9\uff0c\u800c\u662f\u7279\u610f\u8986\u76d6\u4e86\u4e0d\u540c\u5f3a\u5ea6\u7684\u6270\u52a8\u6548\u5e94\uff0c\u5e76\u5728\u5916\u90e8\u5df2\u6709\u6570\u636e\u652f\u6491\uff0c\u4fbf\u4e8e\u53c2\u8d5b\u8005\u5229\u7528\u5df2\u6709\u77e5\u8bc6\u6765\u8bad\u7ec3\u548c\u9a8c\u8bc1\u6a21\u578b\u5bf9\u8de8\u7ec6\u80de\u80cc\u666f\u7684\u6cdb\u5316\u80fd\u529b[7]\u3002<\/span><\/span><\/span><\/p>\n

      \u5728\u6280\u672f\u89c4\u683c\u65b9\u9762\uff0cArc\u7684\u6570\u636e\u751f\u4ea7\u5177\u6709\u663e\u8457\u4f18\u52bf\u3002\u4ed6\u4eec\u4f7f\u752810x Genomics\u6700\u65b0\u7684<\/span><\/span>Chromium GEM-X Flex\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5e73\u53f0<\/span><\/span><\/strong>\u8fdb\u884c\u6d4b\u5e8f\uff0c<\/span><\/span>\u6bcf\u4e2a\u57fa\u56e0\u6270\u52a8\u5e73\u5747\u6d4b\u5e8f\u7ea61000\u4e2a\u5355\u7ec6\u80de\uff0c\u6bcf\u4e2a\u6270\u52a8\u6761\u4ef6\u4e0b\u7ec6\u80de\u83b7\u5f97\u7684\u72ec\u7acb\u8f6c\u5f55\u672c\u6570<\/span>\uff08UMIs\uff09<\/span>\u4e2d\u4f4d\u6570\u7ea6\u4e3a5\u4e07\u4e2a<\/span><\/span><\/span>\u3002\u8fd9\u79cd\u6d4b\u5e8f\u6df1\u5ea6\u8fdc\u9ad8\u4e8e\u6b64\u524d\u516c\u5f00\u7684\u5355\u7ec6\u80de\u6570\u636e\u96c6\uff0c\u4f8b\u5982\u5178<\/span><\/span>\u578b\u7684Perturb-seq\u5b9e\u9a8c\u4e2d\u6bcf\u4e2a\u6270\u52a8\u901a\u5e38\u4ec5\u6d4b\u91cf\u51e0\u5341\u5230\u51e0\u767e\u7ec6\u80de\u3001\u6bcf\u7ec6\u80de\u4ec5\u80fd\u68c0\u6d4b\u6570\u5343\u4e2a\u8f6c\u5f55\u672c\u3002<\/span><\/span><\/span><\/p>\n

      \u524d\u6240\u672a\u6709\u7684\u6570\u636e\u54c1\u8d28\uff0c\u8981\u6c42\u865a\u62df\u7ec6\u80de\u6a21\u578b\u4e0d\u4ec5\u80fd\u51c6\u786e\u6355\u6349\u6270\u52a8\u540e\u7684\u57fa\u56e0\u8868\u8fbe\u6574\u4f53\u8d8b\u52bf\uff0c\u66f4\u80fd\u63ed\u793a\u7ec6\u80de\u7fa4\u4f53\u5185\u90e8\u7684\u771f\u5b9e\u5f02\u8d28\u6027\u53ca\u957f\u5c3e\u7279\u5f81[8]\u3002<\/span><\/span><\/span><\/p>\n


      <\/span><\/h2>\n

      \n
      \n
      \n
      \n
      \n

      <\/span><\/section>\n

      <\/span><\/section>\n
      \n
      <\/section>\n<\/section>\n<\/section>\n
      \n

      2. Arc\u6311\u6218\u8d5b\u57fa\u51c6\u8bc4\u6d4b\uff1a\u4ece\u5747\u503c\u5230\u5206\u5e03<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

      \n

      <\/span><\/section>\n

      <\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


      <\/span><\/p>\n

      \u4f20\u7edf\u4e0a\uff0c\u6a21\u578b\u7684\u9884\u6d4b\u80fd\u529b\u4e00\u822c\u901a\u8fc7\u5176\u9884\u6d4b\u503c\u4e0e\u771f\u5b9e\u503c\u4e4b\u95f4\u7684\u5747\u503c\u8bef\u5dee<\/span>\uff08\u5982\u5747\u65b9\u8bef\u5dee\uff09<\/span>\u6765\u8bc4\u4ef7\u3002\u7136\u800c\uff0cArc\u865a\u62df\u7ec6\u80de\u6311\u6218\u8d5b\u521b\u5efa\u4e86\u4e00\u5957\u66f4\u5173\u6ce8\u8868\u8fbe\u5206\u5e03\u9884\u6d4b\u7684\u8bc4\u6d4b\u4f53\u7cfb\uff0c\u63a8\u52a8\u6a21\u578b\u6446\u8131\u5bf9\u5747\u503c\u62df\u5408\u7684\u4f9d\u8d56\uff0c\u8f6c\u5411\u66f4\u7cbe\u7ec6\u7684\u9884\u6d4b\u8bc4\u4f30\u3002<\/span><\/span><\/p>\n

      \u8fd9\u5957\u4f53\u7cfb\u5305\u62ec\u4e09\u4e2a\u5177\u4f53\u6307\u6807[9]\uff1a<\/span><\/span><\/p>\n

        \n
      • \n

        \u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u96c6\u5339\u914d\u5ea6\uff08Differential Expression Score, DES\uff09<\/span><\/span><\/strong>\uff1a \u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u96c6\u5339\u914d\u5ea6 DES \u8861\u91cf\u6a21\u578b\u9884\u6d4b\u6270\u52a8\u5f15\u8d77\u7684\u663e\u8457\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0<\/span>\uff08Differentially Expressed Genes, DEGs\uff09<\/span>\u96c6\u5408\u7684\u51c6\u786e\u6027\u3002\u5177\u4f53\u800c\u8a00\uff0c\u5148\u5bf9\u6bcf\u4e2a\u6270\u52a8\u5206\u522b\u5728\u771f\u5b9e\u6570\u636e\u548c\u6a21\u578b\u9884\u6d4b\u6570\u636e\u4e2d\u8fdb\u884c\u5dee\u5f02\u8868\u8fbe\u5206\u6790<\/span>\uff08\u5982 Wilcoxon \u79e9\u548c\u68c0\u9a8c\u53ca FDR \u6821\u6b63\uff09<\/span>\uff0c\u518d\u8ba1\u7b97\u4e24\u7ec4\u5339\u914d\u5ea6\u540d\u5355\u7684\u91cd\u5408\u6bd4\u4f8b\u3002\u5982\u679c\u6a21\u578b\u6f0f\u6389\u4e86\u5173\u952e\u54cd\u5e94\u57fa\u56e0\uff0c\u6216\u9519\u8bef\u9884\u6d4b\u8fc7\u591a\u65e0\u5173\u57fa\u56e0\uff0c\u5339\u914d\u5ea6\u5f97\u5206\u5c31\u4f1a\u964d\u4f4e\u3002\u8be5\u6307\u6807\u660e\u786e\u5173\u6ce8\u6a21\u578b\u6355\u83b7\u5173\u952e\u57fa\u56e0\u53d8\u5316\u7684\u80fd\u529b[9]\u3002<\/span><\/span><\/span><\/p>\n<\/li>\n

      • \n

        \u6270\u52a8\u5206\u5e03\u533a\u5206\u5ea6\uff08Perturbation Discrimination Score, PDS\uff09<\/span><\/span><\/strong>\uff1a \u6270\u52a8\u5206\u5e03\u533a\u5206\u5ea6 PDS \u7528\u4e8e\u8bc4\u4f30\u6a21\u578b\u751f\u6210\u7684\u7ec6\u80de\u8868\u8fbe\u5206\u5e03\u80fd\u5426\u6709\u6548\u533a\u5206\u4e0d\u540c\u6270\u52a8\u3002\u5177\u4f53\u505a\u6cd5\u662f\uff1a\u9996\u5148\u8ba1\u7b97\u6bcf\u4e2a\u6270\u52a8\u6761\u4ef6\u4e0b\u6240\u6709\u7ec6\u80de\u7684\u8868\u8fbe\u5747\u503c<\/span>\uff08pseudobulk\u5411\u91cf\uff09<\/span>\uff0c\u7136\u540e\u6bd4\u8f83\u6a21\u578b\u9884\u6d4b\u7684\u6270\u52a8\u5747\u503c\u4e0e\u6240\u6709\u771f\u5b9e\u6270\u52a8\u5747\u503c\u4e4b\u95f4\u7684\u8ddd\u79bb\uff0c\u68c0\u67e5\u771f\u5b9e\u6270\u52a8\u5728\u9884\u6d4b\u8ddd\u79bb\u6392\u5e8f\u4e2d\u7684\u6392\u540d\u4f4d\u7f6e\u3002\u5982\u679c\u9884\u6d4b\u4e0e\u771f\u5b9e\u6270\u52a8\u6700\u4e3a\u63a5\u8fd1\uff0c\u5219\u8be5\u6270\u52a8\u7684\u533a\u5206\u5ea6\u5f97\u5206\u4e3a1\uff1b\u5426\u5219\u6839\u636e\u6392\u540d\u8fdc\u8fd1\u8d4b\u4e880\u52301\u4e4b\u95f4\u7684\u5f97\u5206\u3002\u7b80\u8a00\u4e4b\uff0c\u5373\u4f7f\u4e24\u4e2a\u6270\u52a8\u7684\u5747\u503c\u53d8\u5316\u76f8\u4f3c\uff0c\u533a\u5206\u5ea6\u5173\u6ce8\u6a21\u578b\u80fd\u5426\u901a\u8fc7\u8868\u8fbe\u5206\u5e03\u7684\u7ec6\u8282\u5dee\u5f02\u533a\u5206\u4e0d\u540c\u6270\u52a8\u7684\u8eab\u4efd\u3002<\/span><\/span><\/span><\/p>\n<\/li>\n

      • \n

        \u5168\u5c40\u8868\u8fbe\u8bef\u5dee\uff08Mean Absolute Error, MAE\uff09<\/span><\/span><\/strong>\uff1a \u5168\u5c40\u8868\u8fbe\u8bef\u5dee MAE \u5219\u662f\u57fa\u7840\u7684\u5168\u5c40\u9884\u6d4b\u7cbe\u5ea6\u6307\u6807\uff0c\u8ba1\u7b97\u65b9\u6cd5\u4e3a\uff1a\u5bf9\u6bcf\u4e2a\u6270\u52a8\uff0c\u8ba1\u7b97\u6a21\u578b\u9884\u6d4b\u7ec6\u80de\u7fa4\u4f53\u8868\u8fbe\u7684\u6574\u4f53\u5747\u503c\u4e0e\u771f\u5b9e\u5747\u503c\u4e4b\u95f4\u7684\u7edd\u5bf9\u5dee\uff0c\u518d\u5bf9\u6240\u6709\u6270\u52a8\u53d6\u5e73\u5747\u3002\u8bef\u5dee\u6307\u6807\u5e76\u4e0d\u5f3a\u8c03\u5177\u4f53\u57fa\u56e0\u7684\u751f\u7269\u5b66\u6548\u5e94\uff0c\u800c\u662f\u4f5c\u4e3a\u6a21\u578b\u5168\u5c40\u51c6\u786e\u6027\u7684\u57fa\u672c\u4fdd\u969c\uff0c\u786e\u4fdd\u6a21\u578b\u5728\u975e\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u4e0a\u4e5f\u4fdd\u6301\u4e00\u5b9a\u7684\u9884\u6d4b\u53ef\u9760\u6027\u3002<\/span><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \u6bd4\u8d5b\u6700\u7ec8\u6210\u7ee9\u4ee5\u76f8\u5bf9\u57fa\u7ebf\u6a21\u578b\u7684\u5e73\u5747\u63d0\u5347\u6765\u8ba1\u7b97\uff1a\u5206\u522b\u770b\u6a21\u578b\u5728\u5339\u914d\u5ea6\u3001\u533a\u5206\u5ea6\u3001\u8bef\u5dee\u4e0a\u76f8\u6bd4\u57fa\u7ebf\u7684\u6539\u8fdb\u767e\u5206\u6bd4\uff0c\u518d\u53d6\u5e73\u5747\u3002<\/span><\/span><\/span><\/p>\n

        <\/section>\n

        \u56fe3\uff1aArc\u6311\u6218\u8d5b\u7684\u8bc4\u6d4b\u6846\u67b6\u3002\u5305\u62ec\uff1a(1) \u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u96c6\u5339\u914d\u5ea6\uff08DES\uff09\uff1a\u8bc4\u4f30\u6a21\u578b\u9884\u6d4b\u5173\u952e\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u7684\u51c6\u786e\u6027\uff1b(2) \u6270\u52a8\u5206\u5e03\u533a\u5206\u5ea6\uff08PDS\uff09\uff1a\u8861\u91cf\u6a21\u578b\u533a\u5206\u4e0d\u540c\u6270\u52a8\u6761\u4ef6\u7684\u80fd\u529b\uff1b(3) \u5168\u5c40\u8868\u8fbe\u8bef\u5dee\uff08MAE\uff09\uff1a\u63d0\u4f9b\u57fa\u7840\u7684\u9884\u6d4b\u7cbe\u5ea6\u4fdd\u969c\u3002\u5339\u914d\u5ea6\u9ad8\uff0c\u610f\u5473\u7740\u66f4\u7b26\u5408\u5148\u9a8c\u77e5\u8bc6\uff0c\u5177\u6709\u66f4\u9ad8\u7684\u751f\u7269\u5b66\u53ef\u89e3\u91ca\u6027\uff1b\u8868\u8fbe\u8bef\u5dee\u4f4e\uff0c\u610f\u5473\u7740\u5177\u5907\u523b\u753b\u590d\u6742\u6a21\u5f0f\u7684\u80fd\u529b\uff0c\u5177\u6709\u66f4\u597d\u7684\u8868\u8fbe\u6027\uff08\u9884\u6d4b\u7cbe\u5ea6\u66f4\u9ad8\uff09\u3002\u8be5\u8bc4\u6d4b\u6846\u67b6\u65e8\u5728\u83b7\u5f97\u5e73\u8861\u3002<\/span><\/span><\/span><\/p>\n

        Arc\u5b9a\u4e49\u7684\u57fa\u7ebf\u4e3a\u201c\u7ec6\u80de\u5747\u503c\u6a21\u578b\u201d\uff0c\u5373\u5bf9\u4efb\u610f\u6270\u52a8\u6761\u4ef6\uff0c\u5747\u9884\u6d4b\u4e3a\u8bad\u7ec3\u96c6\u4e2d\u6240\u6709\u6270\u52a8\u7ec6\u80de\u8868\u8fbe\u7684\u6574\u4f53\u5747\u503c\u3002\u8fd9\u610f\u5473\u7740\uff0c\u4ec5\u505a\u5747\u503c\u9884\u6d4b\u7684\u7b80\u5355\u6a21\u578b\u65e0\u6cd5\u83b7\u5f97\u8f83\u9ad8\u7684\u5339\u914d\u5ea6\u548c\u533a\u5206\u5ea6\u5f97\u5206\uff0c\u53ea\u6709\u51c6\u786e\u6355\u83b7\u4e0d\u540c\u6270\u52a8\u7684\u8868\u8fbe\u5206\u5e03\u5dee\u5f02\uff0c\u624d\u80fd\u663e\u8457\u8d85\u8d8a\u8fd9\u4e00\u57fa\u7ebf\u3002\u6362\u8a00\u4e4b\uff0c\u8bc4\u6d4b\u6807\u51c6\u672c\u8eab\u5012\u903c\u6a21\u578b\u201c\u5b66\u4e60\u5206\u5e03\u800c\u975e\u5b66\u4e60\u5747\u503c\u201d\u3002<\/span><\/span><\/span><\/p>\n

        \u8fd9\u79cd\u8bc4\u6d4b\u65b9\u5f0f\u7684\u8c03\u6574\u4f7f\u5f97\u4e00\u4e9b\u8fc7\u53bb\u8868\u73b0\u5c1a\u53ef\u7684\u7b80\u5355\u6a21\u578b<\/span>\uff08\u5982\u7ebf\u6027\u56de\u5f52\u7c7b\u6a21\u578b\uff09<\/span>\u5728\u65b0\u8bc4\u6d4b\u4f53\u7cfb\u4e0b\u4e0d\u518d\u5177\u6709\u4f18\u52bf\uff0c\u751a\u81f3\u6210\u4e3a\u6700\u4f4e\u6807\u51c6\u7684\u57fa\u7ebf\u3002\u793e\u533a\u9010\u6e10\u8fbe\u6210\u65b0\u7684\u5171\u8bc6\uff1a\u8981\u5728\u5339\u914d\u5ea6\u548c\u533a\u5206\u5ea6\u4e0a\u53d6\u5f97\u597d\u6210\u7ee9\uff0c\u6a21\u578b\u5fc5\u987b\u5177\u5907\u751f\u6210\u5f0f\u3001\u5206\u5e03\u5c42\u9762\u7684\u9884\u6d4b\u80fd\u529b\u3002<\/span><\/span><\/p>\n

        \u9664\u4e86\u6307\u6807\u672c\u8eab\uff0cArc\u8fd8\u5c06\u7ade\u8d5b\u8bbe\u8ba1\u4e3a<\/span><\/span>\u5e74\u5ea6\u5f00\u653e\u6311\u6218<\/span><\/span><\/strong>\uff0c\u8bbe\u6709\u5b9e\u65f6\u6392\u884c\u699c\uff0c\u6bcf\u5e74\u5f15\u5165\u65b0\u7684\u6570\u636e\u96c6\u548c\u4efb\u52a1\uff0c\u540c\u65f6\u4fdd\u6301\u8bc4\u6d4b\u6807\u51c6\u7684\u8fde\u8d2f\u6027\u3002\u8fd9\u79cd\u5f62\u5f0f\u7c7b\u4f3c\u4e8e\u86cb\u767d\u7ed3\u6784\u9884\u6d4b\u9886\u57df\u8457\u540d\u7684CASP\u7ade\u8d5b\uff0cCASP\u8d85\u8fc7\u4e8c\u5341\u5e74\u7684\u6301\u7eed\u8fed\u4ee3\u652f\u6491\u4e86AlphaFold\u7cfb\u5217\u5de5\u4f5c\u7684\u7a81\u7834\u3002CASP\u81ea1994\u5e74\u5f00\u59cb\uff0c\u6bcf\u4e24\u5e74\u4e00\u5c4a[10]\u3002\u57282020\u5e74\u7684CASP14\u4e2d\uff0cAlphaFold 2 \u83b7\u5f97\u4e86\u7ea6 <\/span><\/span>92.4 \u5206\uff08\u6ee1\u5206 100 \u5206\uff09<\/span><\/span><\/strong> \u7684\u5168\u7403\u8ddd\u79bb\u6d4b\u8bd5\u5206\u6570<\/span>\uff08GDT-TS\uff09<\/span>\uff0c\u8fd9\u4e00\u6c34\u5e73\u63a5\u8fd1\u5b9e\u9a8c\u7cbe\u5ea6[11]\u3002<\/span><\/span><\/span><\/p>\n

        \u867d\u7136\u8ddd\u79bb\u865a\u62df\u7ec6\u80deAlphaFold\u65f6\u523b\u5c1a\u4e14\u9065\u8fdc\uff0c\u4f46Arc\u6784\u5efa\u7684\u7edf\u4e00\u6570\u636e\u57fa\u51c6\u548c\u8bc4\u6d4b\u4f53\u7cfb\uff0c\u4e3a\u6574\u4e2a\u793e\u533a\u5411\u8be5\u76ee\u6807\u7a33\u6b65\u524d\u8fdb\u63d0\u4f9b\u4e86\u5177\u4f53\u53ef\u884c\u7684\u8def\u7ebf\u56fe\u3002<\/span><\/span><\/p>\n


        <\/span><\/h2>\n

        \n
        \n
        \n
        \n
        \n

        <\/span><\/section>\n

        <\/span><\/section>\n
        \n
        <\/section>\n<\/section>\n<\/section>\n
        \n

        3. AIVC\u7684\u6570\u636e\u7248\u56fe\uff1a\u89c2\u6d4b\u6570\u636e\u4e0e\u6270\u52a8\u6570\u636e<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

        \n

        <\/span><\/section>\n

        <\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


        <\/span><\/p>\n

        \u8fd1\u5e74\u6765\uff0cAI\u7ec6\u80de\u5efa\u6a21\u9886\u57df\u6d8c\u73b0\u4e86\u591a\u79cd\u91cd\u8981\u6570\u636e\u8d44\u6e90\u548c\u524d\u9a71\u7814\u7a76\uff0c\u4e3aAIVC\u63d0\u4f9b\u4e86\u80a5\u6c83\u571f\u58e4\u3002\u6982\u62ec\u6765\u8bf4\uff0c<\/span><\/span>AIVC\u6240\u9700\u7684\u6570\u636e\u53ef\u5206\u4e3a\u4e24\u5927\u7c7b\uff1a\u4e00\u7c7b\u662f\u89c2\u6d4b\u6027\u7ec6\u80de\u56fe\u8c31\u6570\u636e\uff0c\u63cf\u7ed8\u5404\u79cd\u7ec6\u80de\u7c7b\u578b\u5728\u7a33\u6001\u4e0b\u7684\u5206\u5b50\u7279\u5f81\u5206\u5e03\uff1b\u53e6\u4e00\u7c7b\u662f\u5e72\u9884\u6027\u6270\u52a8\u6570\u636e\uff0c\u8bb0\u5f55\u7ec6\u80de\u5728\u7279\u5b9a\u64cd\u4f5c\uff08\u57fa\u56e0\u7f16\u8f91\u3001\u836f\u7269\u5904\u7406\u7b49\uff09\u4e0b\u53d1\u751f\u7684\u53d8\u5316<\/span><\/span><\/strong>\u3002\u4e24\u8005\u76f8\u8f85\u76f8\u6210\u2014\u2014\u524d\u8005\u63d0\u4f9b\u751f\u7269\u7cfb\u7edf\u7684\u80cc\u666f\u53c2\u7167\uff0c\u540e\u8005\u63ed\u793a\u56e0\u679c\u6270\u52a8\u7684\u529f\u80fd\u7ed3\u679c\u3002<\/span><\/span><\/span><\/p>\n

        \u9996\u5148\uff0c\u5728<\/span><\/span>\u89c2\u6d4b\u6027\u5355\u7ec6\u80de\u56fe\u8c31<\/span><\/span><\/strong>\u65b9\u9762\uff0c\u6700\u5177\u4ee3\u8868\u6027\u7684\u662f\u7531CZI<\/span>\uff08Chan Zuckerberg Initiative\uff09<\/span>\u8d44\u52a9\u7684<\/span><\/span>Tabula Sapiens<\/span><\/span><\/strong>\u8ba1\u5212\u3002Tabula Sapiens\u6784\u5efa\u4e86\u4e00\u4e2a\u8de8\u7ec4\u7ec7\u3001\u8de8\u7ec6\u80de\u7c7b\u578b\u7684\u4eba\u7c7b\u7ec6\u80de\u53c2\u8003\u56fe\u8c31\uff1a\u6536\u96c6\u4e86\u6765\u81ea24\u4f4d\u6b63\u5e38\u4eba\u4f53\u4f9b\u8005\u300128\u4e2a\u7ec4\u7ec7\u5668\u5b98\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\uff0c\u603b\u8ba1\u8d85\u8fc7<\/span><\/span>110\u4e07\u7ec6\u80de<\/span><\/span><\/strong>\u3002\u8fd9\u662f\u4eba\u7c7b\u591a\u5668\u5b98\u5355\u7ec6\u80de\u56fe\u8c31\u7684\u521d\u7a3f\uff0c\u88ab\u8a89\u4e3a\u201c\u57fa\u51c6\u7ea7\u201d\u7684\u53c2\u8003\u6570\u636e\u96c6[12]\u3002<\/span><\/span><\/span><\/p>\n

        \u901a\u8fc7Tabula Sapiens\u548c\u76f8\u5173\u7684\u4eba\u7c7b\u7ec6\u80de\u56fe\u8c31\u8ba1\u5212<\/span>\uff08Human Cell Atlas\u7b49\uff09<\/span>\uff0c\u7814\u7a76\u8005\u9996\u6b21\u7cfb\u7edf\u5730\u63cf\u7ed8\u4e86\u6570\u767e\u79cd\u7ec6\u80de\u7c7b\u578b\u5728\u6b63\u5e38\u751f\u7406\u6761\u4ef6\u4e0b\u7684\u57fa\u56e0\u8868\u8fbe\u201c\u5e95\u7a3f\u201d\u3002\u8fd9\u4e9b\u6570\u636e\u4e3aAIVC\u63d0\u4f9b\u4e86<\/span><\/span>\u666e\u9002\u7684\u8d77\u70b9<\/span><\/span><\/strong>\uff1a\u6a21\u578b\u53ef\u4ee5\u4ece\u4e2d\u5b66\u4e60\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u7684\u57fa\u56e0\u8868\u8fbe\u5206\u5e03\uff0c\u5efa\u7acb\u5bf9\u201c\u5065\u5eb7\u7ec6\u80de\u72b6\u6001\u201d\u7684\u57fa\u672c\u8ba4\u77e5\u3002<\/span><\/span><\/span><\/p>\n

        \u4e3e\u4f8b\u6765\u8bf4\uff0cCZI\u56e2\u961f\u5f00\u53d1\u7684<\/span><\/span>TranscriptFormer<\/span><\/span><\/strong>\u6a21\u578b\u6b63\u662f\u57fa\u4e8e\u8de8\u7269\u79cd\u3001\u8de8\u7ec4\u7ec7\u7684\u4e0a\u4ebf\u7ec6\u80de\u89c2\u6d4b\u6570\u636e\u8bad\u7ec3\u800c\u6210\uff0c\u5b83\u5c1d\u8bd5\u4ee5\u751f\u6210\u5f0fTransformer\u6765\u6355\u83b7<\/span><\/span>\u666e\u9002\u7684\u7ec6\u80de\u8868\u8fbe\u5206\u5e03<\/span><\/span><\/strong>[13]\u3002<\/span><\/span><\/span><\/p>\n

        \u53ef\u4ee5\u8bf4\uff0c\u6ca1\u6709\u50cfTabula Sapiens\u8fd9\u6837\u5e7f\u8986\u76d6\u7684\u57fa\u7ebf\u6570\u636e\uff0c\u5c31\u96be\u4ee5\u8c08\u53ca\u6784\u5efa\u201c\u901a\u7528\u7ec6\u80de\u8868\u793a\u201d<\/span>\uff08Universal Representation\uff09<\/span>\u7684AI\u6a21\u578b\u3002\u8fd9\u4e5f\u662f2024\u5e7412\u6708\u65af\u5766\u798f\u3001Genentech\u3001CZI\u7b49\u673a\u6784\u7684\u9876\u5c16\u79d1\u5b66\u5bb6\u5728\u300aCell\u300b\u53d1\u8868\u201cAI\u865a\u62df\u7ec6\u80de\u7814\u7a76\u5021\u8bae\u201d<\/span>\uff08How to build the virtual cell with artificial intelligence: Priorities and opportunities\uff09<\/span>\u65f6\u6240\u63d0\u51fa\u7684\u89c2\u70b9[14]\u3002<\/span><\/span><\/p>\n

        <\/section>\n

        \u56fe4\uff1a<\/span><\/span><\/span>2024\u5e74\u300aCell\u300b\u89c2\u70b9\u6587\u7ae0\u9996\u6b21\u4e3aAIVC\u4e0b\u5b9a\u4e49\uff1a\u4e00\u4e2a\u591a\u5c3a\u5ea6\u3001\u591a\u6a21\u6001\u3001\u57fa\u4e8e\u5927\u578b\u795e\u7ecf\u7f51\u7edc\u7684\u6a21\u578b\uff0c\u80fd\u591f\u8868\u5f81\u548c\u6a21\u62df\u5206\u5b50\u3001\u7ec6\u80de\u548c\u7ec4\u7ec7\u5728\u4e0d\u540c\u72b6\u6001\u4e0b\u7684\u884c\u4e3a\u3002AIVC\u63d0\u4f9b\u8de8\u7269\u79cd\u3001\u8de8\u6761\u4ef6\u53ca\u8de8\u5c3a\u5ea6\uff08\u5206\u5b50\u3001\u7ec6\u80de\u3001\u591a\u7ec6\u80de\uff09\u7684\u901a\u7528\u7ec6\u80de\u72b6\u6001\u8868\u5f81\uff0c\u53ef\u6574\u5408\u591a\u79cd\u6570\u636e\u6a21\u6001\u3002\u5176\u901a\u7528\u6027\u4f7f\u5f97\u8be5\u8868\u5f81\u80fd\u63a8\u5e7f\u81f3\u672a\u89c2\u6d4b\u7684\u7ec6\u80de\u72b6\u6001\uff0c\u6307\u5bfc\u672a\u6765\u6570\u636e\u751f\u6210\uff0c\u4e14\u5bf9\u5177\u4f53\u6570\u636e\u7c7b\u578b\u4e0d\u654f\u611f\u3002\u6b64\u5916\uff0cAIVC\u8fd8\u80fd\u6a21\u62df\u7ec6\u80de\u5728\u81ea\u7136\uff08\u5982\u5206\u5316\u3001\u9057\u4f20\u53d8\u5f02\uff09\u6216\u4eba\u4e3a\u6270\u52a8\u4e0b\u7684\u52a8\u6001\u8f6c\u53d8\uff0c\u5b9e\u73b0\u4f4e\u6210\u672c\u751a\u81f3\u5b9e\u9a8c\u5ba4\u65e0\u6cd5\u5b9e\u73b0\u7684\u865a\u62df\u5b9e\u9a8c\u3002AIVC\u7684\u5e94\u7528\u9700\u8981\u5f00\u653e\u83b7\u53d6\u3001\u8ba1\u7b97\u8d44\u6e90\u5171\u4eab\u53ca\u9ad8\u6548\u7684\u4eba\u673a\u4ea4\u4e92\uff0c\u4ee5\u63a8\u52a8\u79d1\u5b66\u5171\u540c\u4f53\u7684\u53d1\u5c55<\/span><\/span>[14]\u3002<\/span><\/span><\/span><\/span><\/p>\n

        \u7136\u800c\uff0c\u89c2\u6d4b\u6570\u636e\u53ea\u80fd\u544a\u8bc9\u6211\u4eec\u201c\u7ec6\u80de\u81ea\u7136\u72b6\u6001\u4e0b\u7684\u6837\u5b50\u201d\uff0c\u5374\u65e0\u6cd5\u8bf4\u660e\u7ec6\u80de\u7ecf\u53d7\u5e72\u9884\u540e\u7684\u5177\u4f53\u53d8\u5316\u3002\u4e3a\u4e86\u5f25\u8865\u8fd9\u4e00\u4e0d\u8db3\uff0c\u751f\u547d\u79d1\u5b66\u9886\u57df\u8fd1\u5e74\u6765\u5f00\u5c55\u4e86\u5927\u91cf\u5e72\u9884\u578b\u5927\u6570\u636e\u5b9e\u9a8c\u3002<\/span><\/span><\/p>\n

        Broad Institute\u7684\u79d1\u5b66\u5bb6\u65e9\u5e74\u542f\u52a8\u4e86\u8457\u540d\u7684<\/span><\/span>Connectivity Map (CMap) <\/span><\/span><\/strong>\u9879\u76ee\uff0c\u8fd9\u662f\u6700\u65e9\u5927\u89c4\u6a21\u7ec6\u80de\u6270\u52a8\u6570\u636e\u8d44\u6e90\u4e4b\u4e00\u3002CMap\u91c7\u7528\u9ad8\u901a\u91cfL1000\u57fa\u56e0\u8868\u8fbe\u5e73\u53f0\uff0c\u7cfb\u7edf\u6d4b\u91cf\u4e86\u6570\u4ee5\u5343\u8ba1\u7684\u57fa\u56e0\u6572\u4f4e\u6216\u5c0f\u5206\u5b50\u836f\u7269\u5904\u7406\u5bf9\u7ec6\u80de\u57fa\u56e0\u8868\u8fbe\u8c31\u7684\u5f71\u54cd\uff0c\u7ed8\u5236\u51fa\u4e0d\u540c\u6270\u52a8\u6761\u4ef6\u4e4b\u95f4\u7684\u5173\u8054\u201c\u8fde\u63a5\u5730\u56fe\u201d\u3002\u622a\u81f32017\u5e74\uff0cCMap\u5df2\u7d2f\u79ef\u8d85\u8fc7150\u4e07\u4efd\u57fa\u56e0\u8868\u8fbe\u8c31\u6570\u636e\uff0c\u6db5\u76d6\u7ea65000\u79cd\u5316\u5408\u7269\u548c3000\u79cd\u57fa\u56e0\u6270\u52a8\uff0c\u8986\u76d6\u591a\u4e2a\u5e38\u7528\u7684\u4eba\u7c7b\u7ec6\u80de\u7cfb\u3002\u867d\u7136CMap\u7684\u6570\u636e\u662fbulk\u7ec6\u80de\u6c34\u5e73\u800c\u975e\u5355\u7ec6\u80de\u7ea7\u522b\uff0c\u4f46\u5b83\u9996\u6b21\u5b9e\u73b0\u4e86<\/span><\/span>\u57fa\u56e0-\u836f\u7269-\u75be\u75c5\u8868\u578b\u95f4\u7684\u89c4\u6a21\u5316\u6620\u5c04<\/span><\/span><\/strong>\uff0c\u6210\u4e3a\u7814\u7a76\u7ec6\u80de\u6270\u52a8\u54cd\u5e94\u7684\u91cd\u8981\u53c2\u8003\u6570\u636e\u5e93[15]\u3002<\/span><\/span><\/span><\/p>\n

        CMap\u8bc1\u660e\u4e86\u4e00\u4e2a\u7406\u5ff5\uff1a<\/span><\/span>\u5927\u89c4\u6a21\u6270\u52a8\u6570\u636e<\/span><\/span><\/strong>\u53ef\u4ee5\u6316\u6398\u51fa\u8bb8\u591a\u8fc7\u53bb\u96f6\u6563\u5b9e\u9a8c\u96be\u4ee5\u5bdf\u89c9\u7684\u751f\u7269\u6a21\u5f0f\uff0c\u4ece\u800c\u4e3aAI\u6a21\u578b\u63d0\u4f9b\u5b9d\u8d35\u7684\u5b66\u4e60\u7d20\u6750\u3002<\/span><\/span><\/span><\/p>\n

        \u968f\u7740\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u7684\u5174\u8d77\uff0c\u7814\u7a76\u8005\u53d1\u5c55\u51fa<\/span><\/span>Perturb-seq<\/span><\/span><\/strong>\u6280\u672f\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5c06CRISPR\u57fa\u56e0\u7f16\u8f91\u4e0e\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u7ed3\u5408\uff0c\u5141\u8bb8\u540c\u65f6\u5bf9\u6570\u5343\u4e2a\u57fa\u56e0\u5206\u522b\u8fdb\u884c\u6270\u52a8\uff0c\u5e76\u7cbe\u786e\u6355\u83b7\u6bcf\u4e2a\u5355\u7ec6\u80de\u7684\u6270\u52a8\u54cd\u5e94\u4fe1\u606f\u3002Perturb-seq\u89e3\u51b3\u4e86\u4f20\u7edf\u9010\u4e2a\u57fa\u56e0\u6270\u52a8\u5b9e\u9a8c\u89c4\u6a21\u6709\u9650\u7684\u95ee\u9898\uff0c\u6210\u4e3a\u65b0\u4e00\u4ee3\u5927\u89c4\u6a21\u529f\u80fd\u57fa\u56e0\u7ec4\u7b5b\u9009\u7684\u91cd\u8981\u5de5\u5177[16]\u3002<\/span><\/span><\/span><\/p>\n

        2022\u5e74\uff0cReplogle\u7b49\u4eba\u5229\u7528Perturb-seq\u6280\u672f\u5728K562<\/span>\uff08\u767d\u8840\u75c5\u7ec6\u80de\uff09<\/span>\u548cRPE1<\/span>\uff08\u4e0a\u76ae\u7ec6\u80de\uff09<\/span>\u4e24\u79cd\u7ec6\u80de\u7cfb\u4e2d\uff0c\u5bf9\u7ea62500\u4e2a\u57fa\u56e0\u8fdb\u884c\u4e86CRISPR\u5e72\u6270<\/span>\uff08CRISPRi\uff09<\/span>\uff0c\u6700\u7ec8\u83b7\u5f97\u7ea6250\u4e07\u4e2a\u5355\u7ec6\u80de\u7684\u6270\u52a8\u8f6c\u5f55\u7ec4\u6570\u636e\u3002\u5e73\u5747\u6bcf\u4e2a\u57fa\u56e0\u6270\u52a8\u5bf9\u5e94\u6570\u767e\u4e2a\u7ec6\u80de\uff0c\u6d4b\u5e8f\u6df1\u5ea6<\/span>\uff08UMIs\uff09<\/span>\u4e2d\u4f4d\u6570\u5728\u6570\u5343\u5de6\u53f3\u3002\u867d\u7136\u5355\u4e2a\u6270\u52a8\u6761\u4ef6\u4e0b\u7ec6\u80de\u6570\u91cf\u6709\u9650\uff0c\u4f46\u6574\u4f53\u6a2a\u8de8\u4e86\u5927\u91cf\u57fa\u56e0\uff0c\u63d0\u4f9b\u4e86\u6270\u52a8\u54cd\u5e94\u5e7f\u6cdb\u7684\u4fe1\u606f[17]\u3002\u6b64\u5916\uff0c\u8fd1\u5e74\u8fd8\u6709\u591a\u9879Perturb-seq\u53d8\u4f53\u7814\u7a76\uff0c\u5305\u62ecNadig\u7b49\u4eba2025\u5e74\u5728Jurkat T\u7ec6\u80de\u548cHepG2\u809d\u7ec6\u80de\u4e2d\u7684\u5fc5\u9700\u57fa\u56e0\u7b5b\u9009\u7b49\u5b9e\u9a8c\uff0c\u8fdb\u4e00\u6b65\u6269\u5c55\u4e86\u6270\u52a8\u6570\u636e\u8986\u76d6\u7684\u7ec6\u80de\u7c7b\u578b\u548c\u7814\u7a76\u95ee\u9898[18]\u30022025\u5e746\u6708\uff0c\u4e00\u5bb6\u65b0\u521b\u516c\u53f8Xaira Therapeutics\u53d1\u5e03\u4e86\u8fc4\u4eca\u89c4\u6a21\u6700\u5927\u7684Perturb-seq\u6570\u636e\u96c6X-Atlas\/Orion\uff0c\u5305\u542b\u7ea6800\u4e07\u5355\u7ec6\u80de\uff0c\u8986\u76d6\u51e0\u4e4e\u6240\u6709\u4eba\u7c7b\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u7684CRISPR\u5e72\u6270\uff0c\u5e76\u5bf9\u6bcf\u4e2a\u7ec6\u80de\u8fdb\u884c\u4e86\u6df1\u5ea6\u6d4b\u5e8f<\/span>\uff08>1.6\u4e07UMIs\uff09<\/span>[19]\u3002<\/span><\/span><\/p>\n

        \u4e0d\u4ec5\u662f\u57fa\u56e0\u6270\u52a8\uff0c\u5c0f\u5206\u5b50\u836f\u7269\u6270\u52a8\u4e5f\u9010\u6e10\u8fdb\u5165\u5355\u7ec6\u80de\u7b5b\u9009\u65f6\u4ee3\u3002\u4f8b\u5982\uff0cSrivatsan\u7b49\u4eba\u5f00\u53d1\u7684<\/span><\/span>Sci-Plex<\/span><\/span><\/strong>\u6280\u672f\u901a\u8fc7\u5316\u5b66\u6807\u7b7e\u5b9e\u73b0\u591a\u79cd\u836f\u7269\u6761\u4ef6\u4e0b\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u5e76\u884c\u6d4b\u91cf[20]\u3002Parse Biosciences\u516c\u53f8\u53d1\u5e03\u4e86\u5343\u4e07\u7ea7PBMC<\/span>\uff08\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de\uff09<\/span>\u6570\u636e\u96c6\uff0c\u6d4b\u91cf\u4e8690\u79cd\u7ec6\u80de\u56e0\u5b50\u5bf9\u514d\u75ab\u7ec6\u80de\u7684\u5f71\u54cd[21]\u3002<\/span><\/span><\/span><\/p>\n

        \u5c06\u4e0a\u8ff0\u89c2\u6d4b\u548c\u5e72\u9884\u6570\u636e\u8d44\u6e90\u6a2a\u5411\u6bd4\u8f83\uff0c\u53ef\u4ee5\u770b\u51fa\u5404\u6709\u4fa7\u91cd\uff1a<\/span><\/span><\/p>\n

          \n
        • \n

          Tabula Sapiens\u7b49\u7ec6\u80de\u56fe\u8c31<\/span><\/span><\/strong>\u63d0\u4f9b\u4e86\u5bf9\u6b63\u5e38\u751f\u7269\u7cfb\u7edf\u5e7f\u8986\u76d6\u7684<\/span><\/span>\u9759\u6001\u63cf\u7ed8<\/span><\/span><\/strong>\u3002\u5b83\u4eec\u7ec6\u80de\u7c7b\u578b\u4e30\u5bcc<\/span>\uff08\u4e0a\u767e\u79cd\u7ec6\u80de\uff09<\/span>\uff0c\u4f46\u672a\u5305\u542b\u4eba\u4e3a\u6270\u52a8\uff0c\u56e0\u6b64\u9002\u5408\u4f5c\u4e3a\u6a21\u578b\u7684\u80cc\u666f\u77e5\u8bc6\u548c\u8868\u578b\u5206\u7c7b\u57fa\u51c6\uff0c\u5374\u65e0\u6cd5\u76f4\u63a5\u7528\u4e8e\u5b66\u4e60\u56e0\u679c\u5173\u7cfb[12]\u3002<\/span><\/span><\/span><\/p>\n<\/li>\n

        • \n

          Perturb-seq\u53ca\u7c7b\u4f3c\u6270\u52a8\u6570\u636e<\/span><\/span><\/strong>\u5219\u63d0\u4f9b\u4e86\u9488\u5bf9\u7279\u5b9a\u7ec6\u80de\u7cfb\u6216\u6761\u4ef6\u4e0b\u7684<\/span><\/span>\u529f\u80fd\u54cd\u5e94<\/span><\/span><\/strong>\u3002\u5b83\u4eec\u76f4\u63a5\u63ed\u793a\u56e0\u679c\u6548\u5e94\uff0c\u4f46\u901a\u5e38\u5c40\u9650\u4e8e\u67d0\u51e0\u4e2a\u5b9e\u9a8c\u7cfb\u7edf<\/span>\uff08\u4f8b\u5982\u4ec5\u9650\u4e8e\u80bf\u7624\u7ec6\u80de\u7cfb\u6216\u514d\u75ab\u7ec6\u80de\u7cfb\uff09<\/span>\u4e14\u6bcf\u4e2a\u6761\u4ef6\u7684\u6570\u636e\u91cf\u76f8\u5bf9\u6709\u9650\uff0c\u9700\u8981\u4e0e\u5176\u4ed6\u6570\u636e\u7ed3\u5408\u4ee5\u63d0\u9ad8\u6cdb\u5316\u6027[16]\u3002<\/span><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          Arc\u5de6\u53f3\u5f00\u5f13\uff0c\u7740\u91cd\u6295\u5165\u201c\u4e00\u6279\u7ec6\u80de\u7cfb \u00d7 \u4e0a\u5343\u6270\u52a8\u201d\u7684\u5e7f\u8c31\u836f\u7269\u6570\u636e\uff0c\u8f85\u4ee5\u201c\u4e00\u79cd\u7ec6\u80de \u00d7 \u591a\u79cd\u6270\u52a8\u201d\u7684\u7cbe\u7ec6\u57fa\u56e0\u6570\u636e\u3002\u6700\u65b0\u7684STATE\u6a21\u578b\u7684\u7ed3\u679c\u5df2\u7ecf\u8bc1\u660e\uff0c\u8fd9\u79cd\u9ad8\u8d28\u91cf\u6570\u636e\u7684\u6295\u5165\u4ea7\u51fa\u6bd4\u662f\u60ca\u4eba\u7684\uff1a\u5927\u91cf\u4e14\u9ad8\u7cbe\u5ea6\u7684\u6570\u636e\u4f1a\u5e26\u6765\u6a21\u578b\u6027\u80fd\u7684\u975e\u7ebf\u6027\u63d0\u5347[22]\u3002<\/span><\/span><\/p>\n


          <\/span><\/h2>\n

          \n
          \n
          \n
          \n
          \n

          <\/span><\/section>\n

          <\/span><\/section>\n
          \n
          <\/section>\n<\/section>\n<\/section>\n
          \n

          4. \u5168\u7403\u865a\u62df\u7ec6\u80de\u6570\u636e\u751f\u6001\u7684\u65e9\u671f\u73a9\u5bb6<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

          \n

          <\/span><\/section>\n

          <\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


          <\/span><\/p>\n

          \u5728\u6253\u9020\u865a\u62df\u7ec6\u80de\u7684\u6570\u636e\u751f\u6001\u7cfb\u7edf\u65b9\u9762\uff0cArc Institute\u5e76\u975e\u5b64\u519b\u594b\u6218\u3002\u56fd\u9645\u4e0a\u4e00\u4e9b\u9876\u5c16\u673a\u6784\u4e0e\u7ec4\u7ec7\u540c\u6837\u5728\u5e03\u5c40\u8fd9\u4e00\u65b0\u5174\u9886\u57df\uff0c\u53ea\u662f\u5207\u5165\u89d2\u5ea6\u5404\u6709\u4fa7\u91cd\u3002<\/span><\/span><\/p>\n

          Arc Institute <\/span><\/span><\/strong>\u662f\u6210\u7acb\u4e8e 2021 \u5e74\u7684\u975e\u8425\u5229\u7814\u7a76\u673a\u6784\uff0c\u7531 Stripe \u8054\u5408\u521b\u59cb\u4eba Patrick Collison \u53ca\u4e24\u4f4d\u79d1\u5b66\u5bb6 Patrick Hsu<\/span>\uff08\u4f2f\u514b\u5229\u52a9\u7406\u6559\u6388\u3001Arc \u6838\u5fc3\u7814\u7a76\u5458\uff09<\/span>\u4e0e Silvana Konermann<\/span>\uff08\u65af\u5766\u798f\u52a9\u7406\u6559\u6388\u3001Arc \u6267\u884c\u4e3b\u4efb\uff09<\/span>\u5171\u540c\u521b\u5efa\uff0c\u521d\u59cb\u6350\u8d60\u8d44\u91d1\u9ad8\u8fbe6.5\u4ebf\u7f8e\u5143\u3002\u5b83\u901a\u8fc7\u9ad8\u5ea6\u7075\u6d3b\u7684\u72ec\u7acb\u5b9e\u9a8c\u5ba4<\/span>\uff08Core Investigator\uff09<\/span>\u6a21\u5f0f\u8fd0\u4f5c\uff0c\u5e76\u4e14\u4eb2\u81ea\u53c2\u4e0e\u5927\u89c4\u6a21\u6570\u636e\u751f\u4ea7<\/span>\uff08\u53c2\u4e0eTahoe-100M\uff0c\u5e76\u6574\u5408\u516c\u5171\u6570\u636e\u6784\u5efascBaseCount\uff09<\/span>\u3002\u76ee\u524d\uff0c\u65af\u5766\u798f\u5927\u5b66\u3001\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u3001\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u5df2\u7ecf\u4e0eArc\u5efa\u7acb\u5236\u5ea6\u5316\u7684\u5408\u4f5c\uff0c\u7814\u7a76\u4eba\u5458\u5728\u9ad8\u6821\u4efb\u804c\u7684\u540c\u65f6\uff0c\u53ef\u4ee5\u83b7\u5f97\u957f\u671f\u7ecf\u8d39\u4e0e\u6280\u672f\u5e73\u53f0\u652f\u6301[23]\u3002<\/span><\/span><\/span><\/p>\n

          Arc\u5728\u751f\u7269\u6570\u636e\u79ef\u7d2f\u4e0e\u6a21\u578b\u8bad\u7ec3\u4e0a\u5747\u9887\u6709\u79ef\u7d2f\u3002\u5728\u53d1\u5e03Arc\u865a\u62df\u7ec6\u80de\u56fe\u8c31Atlas\u76842025\u5e742\u6708\uff0cHsu\u9886\u8854\u7684\u56e2\u961f\u53d1\u5e03\u4e86\u57fa\u56e0\u7ec4\u57fa\u7840\u6a21\u578bEvo2<\/span>\uff0840B\u53c2\u6570\u30011Mb\u4e0a\u4e0b\u6587\uff09<\/span>[24]\u3002\u8be5\u6a21\u578b\u57fa\u4e8e\u751f\u7269\u9886\u57df\u768412.8\u4e07\u4e2a\u57fa\u56e0\u7ec4\u76849.3\u4e07\u4ebf\u4e2a\u78b1\u57fa\u5bf9\u8fdb\u884c\u8bad\u7ec3\uff0c\u80fd\u591f\u9884\u6d4b\u53d8\u5f02\u6548\u5e94\u3002\u53ef\u4ee5\u9884\u89c1\uff0cArc\u5728\u53d1\u8d77\u865a\u62df\u7ec6\u80de\u6311\u6218\u8d5b\u540e\uff0c\u4f1a\u4e0d\u65ad\u5f15\u5165\u66f4\u591a\u7c7b\u578b\u3001\u66f4\u5927\u89c4\u6a21\u7684\u6570\u636e\u5e76\u62d3\u5c55\u53ef\u64cd\u4f5c\u7a7a\u95f4\uff0c\u8fdb\u4e00\u6b65\u5f3a\u5316\u5176\u6570\u636e\u751f\u4ea7\u8005\u548c\u8bae\u9898\u8bbe\u7f6e\u8005\u7684\u53cc\u91cd\u89d2\u8272\u3002<\/span><\/span><\/p>\n

          \u5728AIVC\u73a9\u5bb6\u4e2d\uff0c<\/span><\/span>Broad Institute<\/span><\/span><\/strong>\u662f\u8001\u724c\u7684\u57fa\u56e0\u7ec4\u5b66\u548c\u8ba1\u7b97\u751f\u7269\u5b66\u7814\u7a76\u673a\u6784\uff0c\u66fe\u7ecf\u652f\u6301\u4e86\u5f20\u950b\u7b49\u5728CRISPER\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u65b9\u9762\u7684\u9769\u547d\u6027\u5de5\u4f5c\u3002Broad\u6210\u7acb\u4e8e2004\u5e74\uff0c\u7531MIT\u4e0e\u54c8\u4f5b\u5927\u5b66\u5171\u540c\u53d1\u8d77\uff0c\u5e76\u83b7\u5f97\u4e86Broad\u592b\u5987\u5de8\u989d\u6350\u8d60\u3002Broad\u5728\u521b\u59cb\u4e4b\u521d\u5c31\u6781\u5176\u91cd\u89c6\u6570\u636e\u57fa\u7840\uff0c\u53ef\u4ee5\u8bf4\u662f\u5f00\u521b\u4e86\u529f\u80fd\u57fa\u56e0\u7ec4\u201c\u5927\u6570\u636e\u201d\u7684\u5148\u6cb3\u3002\u65e9\u57282006\u5e74\uff0cBroad\u5c31\u4f5c\u4e3aCMap\u7275\u5934\u65b9\uff0c\u63d0\u51fa\u4e86\u5927\u89c4\u6a21\u684c\u6270\u52a8\u6570\u636e\u7ed8\u5236\u7ec6\u80de\u8fde\u63a5\u7f51\u7edc\u7684\u613f\u666f\u3002\u9664\u4e86CMap\uff0c\u5b83\u8fd8\u53d1\u8d77\u6210\u7acb\u4e86\u5168\u7403\u89c4\u6a21\u6700\u5927\u7684\u516c\u5f00\u4eba\u7c7b\u57fa\u56e0\u7ec4\u53d8\u5f02\u6570\u636e\u5e93<\/span>\uff08gnomAD\uff09<\/span>\uff0c\u4ee5\u53ca\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31<\/span>\uff08TCGA\uff09<\/span>\u7b49[25]\u3002<\/span><\/span><\/span><\/p>\n

          2025\u5e748\u6708\uff0cBroad Institute \u7684Anne E. Carpente<\/span>\uff08Cell Painting\u6280\u672f\u63d0\u51fa\u8005\u4e4b\u4e00\uff09<\/span>\u4e0eShantanu Sing \u9886\u8854\u7684\u56e2\u961f\u5728\u300aNature Methods\u300b\u53d1\u8868\u6587\u7ae0\uff0c\u63a8\u51fa\u4e86\u8986\u76d6\u8d85\u8fc715000\u4e2a\u57fa\u56e0\u6270\u52a8\u540e\u7684\u5168\u57fa\u56e0\u7ec4\u5c3a\u5ea6\u7ec6\u80de\u5f62\u6001\u5b66\u56fe\u8c31\u3002\u4ed6\u4eec\u901a\u8fc7\u6574\u5408\u57fa\u56e0\u6270\u52a8\u4e0eCell Painting\u6280\u672f\u7cfb\u7edf\u7ed8\u5236\u4e86\u57fa\u56e0-\u8868\u578b\u5173\u7cfb\u56fe\u8c31\u3002\u8fd9\u8fdb\u4e00\u6b65\u628a\u865a\u62df\u7ec6\u80de\u6570\u636e\u4ece\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e\uff0c\u62d3\u5c55\u5230\u591a\u6a21\u6001\u6570\u636e\u7ef4\u5ea6<\/span>\uff08\u5982\u9ad8\u5185\u6db5\u6210\u50cf\uff09<\/span>[26]\u3002<\/span><\/span><\/p>\n

          Chan Zuckerberg Initiative\uff08CZI\uff09<\/span><\/span><\/strong>\u6210\u7acb\u4e8e2015\u5e74\uff0c\u662f\u7531Facebook\u521b\u59cb\u4ebaMark Zuckerberg \u4e0e Priscilla Chan\u521b\u7acb\u7684\u79c1\u4eba\u6148\u5584\u673a\u6784\u3002\u5728\u79d1\u5b66\u9886\u57df\u4ee5\u201c\u5927\u89c4\u6a21\u8d44\u52a9\u4e0e\u6280\u672f\u57fa\u7840\u8bbe\u65bd\u5efa\u8bbe\u201d\u8457\u79f0\uff0c\u7740\u529b\u4e8e\u6253\u9020\u5168\u7403\u5171\u4eab\u7684\u5f00\u653e\u79d1\u5b66\u5e73\u53f0\uff0c\u5305\u62ec\u4eba\u7c7b\u7ec6\u80de\u56fe\u8c31<\/span>\uff08Human Cell Atlas\uff09<\/span>\u3001\u5355\u7ec6\u80de\u6570\u636e\u5171\u4eab\u5e73\u53f0CELLxGENE\u3002\u5e76\u4e14\uff0cCZI\u8fd8\u957f\u671f\u8d44\u52a9\u4e00\u7cfb\u5217\u5f00\u6e90\u8f6f\u4ef6\u9879\u76ee\uff0c\u5305\u62ec\u8457\u540d\u7684\u6570\u636e\u79d1\u5b66\u5de5\u5177numpy\u3001pandas\u3001scikit-learn\u7b49\uff0c\u5b83\u652f\u6301\u5f00\u53d1\u7684napari\u5f00\u6e90\u8f6f\u4ef6\u662f\u76ee\u524d\u6700\u53d7\u6b22\u8fce\u7684\u751f\u7269\u533b\u5b66\u56fe\u50cf\u5206\u6790\u548c\u673a\u5668\u5b66\u4e60\u5de5\u5177\u4e4b\u4e00[27]\u3002<\/span><\/span><\/span><\/p>\n

          \u81ea2023\u5e74\u5f00\u59cb\uff0cCZI\u6210\u7acb\u4e86\u4e13\u95e8\u7684\u201cVirtual Cell\u201d\u8ba1\u5212\u3002CZI\u4e5f\u53c2\u4e0e\u4e862024\u5e74\u7684Cell\u7684AIVC\u8def\u7ebf\u56fe\u9886\u57df\u5ba3\u8a00\u6587\u7ae0\u3002\u7d27\u63a5\u77402025\u5e74\u521d\uff0cCZI\u53d1\u5e03\u4e86\u9996\u6279AI\u865a\u62df\u7ec6\u80de\u6a21\u578b\u53ca\u914d\u5957\u5e73\u53f0\uff0c\u5305\u62ec\u524d\u8ff0\u7684TranscriptFormer<\/span>\uff08\u8de8\u7269\u79cd\u7684\u5927\u578b\u8f6c\u5f55\u7ec4\u751f\u6210\u6a21\u578b\uff09<\/span>\u548cSubCell<\/span>\uff08\u57fa\u4e8e\u4eba\u7c7b\u86cb\u767d\u8d28\u7ec4\u5b66\u56fe\u50cf\u7684\u7ec6\u80de\u5f62\u6001\u8868\u5f81\u6a21\u578b\uff09<\/span>\u7b49\u3002\u5e76\u4e14\u5b83\u5efa\u7acb\u4e861024\u5f20NVIDIA H100 GPU\u6784\u6210\u4e86\u8ba1\u7b97\u673a\u7fa4\uff0c\u4e13\u95e8\u4e3a\u7f8e\u56fd\u7684\u76f8\u5173\u56e2\u961f\u63d0\u4f9b\u7b97\u529b\u652f\u6301\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cCZI\u901a\u8fc7CELL\u00d7GENE\u5e73\u53f0\u548cTranscriptFormer\u6a21\u578b\u5f15\u9886\u4e86\u5f00\u653e\u89c2\u6d4b\u6570\u636e\u7684\u6f6e\u6d41\u3002CZI\u751a\u81f3\u542f\u52a8\u4e86\u201c\u5341\u4ebf\u7ec6\u80de\u8ba1\u5212\u201d\uff0c\u8bd5\u56fe\u751f\u6210\u524d\u6240\u672a\u6709\u7684\u5341\u4ebf\u7ea7\u5355\u7ec6\u80de\u6570\u636e\u6765\u52a0\u901f\u6a21\u578b\u8bad\u7ec3[28]\u3002<\/span><\/span><\/p>\n

          \u5728\u4ea7\u4e1a\u754c\uff0c\u591a\u5bb6<\/span><\/span>\u751f\u7269\u79d1\u6280\u521b\u65b0\u516c\u53f8<\/span><\/span><\/strong>\u6b63\u6295\u8eab\u6570\u636e\u9a71\u52a8\u7684\u7ec6\u80de\u6a21\u62df\u5b9e\u8df5\u3002\u5176\u4e2d\u7684\u5148\u950b\u516c\u53f8<\/span><\/span>Insitro<\/span><\/span><\/strong>\u7531Daphne Koller<\/span>\uff08\u65af\u5766\u798f\u5927\u5b66\u8ba1\u7b97\u673a\u7cfb\u6559\u6388\uff0c\u66fe\u8054\u5408\u521b\u529eCoursera\uff09<\/span>\u57282018\u5e74\u521b\u7acb\uff0c\u81f4\u529b\u4e8e\u5c06\u673a\u5668\u5b66\u4e60\u5e94\u7528\u4e8e\u836f\u7269\u53d1\u73b0\u3002Insitro\u5728\u81ea\u6709\u5b9e\u9a8c\u5ba4\u4e2d\u751f\u4ea7\u4e86\u6d77\u91cf\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de<\/span> (iPSC) <\/span>\u6a21\u578b\u6570\u636e\uff0c\u901a\u8fc7CRISPR\u57fa\u56e0\u7f16\u8f91\u548c\u9ad8\u5185\u6db5\u6210\u50cf\u7b5b\u9009\u75be\u75c5\u8868\u578b[29]\u3002<\/span><\/span><\/span><\/p>\n

          Recursion<\/span><\/span><\/strong>\u4e5f\u662f\u5907\u53d7\u77a9\u76ee\u7684\u4f01\u4e1a\uff0c\u901a\u8fc7\u81ea\u52a8\u5316\u663e\u5fae\u6210\u50cf\u83b7\u53d6\u6570\u5341\u4ebf\u8ba1\u7684\u7ec6\u80de\u56fe\u50cf\uff0c\u5e76\u5e94\u7528\u6df1\u5ea6\u5b66\u4e60\u5bfb\u627e\u836f\u7269\u548c\u57fa\u56e0\u5bf9\u7ec6\u80de\u5f62\u6001\u7684\u5f71\u54cd\u6a21\u5f0f\u3002Recursion\u65e9\u671f\u66fe\u5f00\u653e\u90e8\u5206\u7ec6\u80de\u5f71\u50cf\u6570\u636e\u96c6\u4e3e\u529eKaggle\u7ade\u8d5b\uff0c\u5e76\u53c2\u4e0eBroad Institute\u7684Cell Painting\u8054\u76df\uff0c\u53d1\u5e03\u4e86\u5927\u89c4\u6a21\u7ec6\u80de\u5f62\u6001\u5b66\u6570\u636e\u5e93[30]\u3002\u6b64\u5916\uff0cRecursion\u8fd8\u4e0eNVIDIA\u5408\u4f5c\uff0c\u501f\u52a9\u8d85\u7ea7\u8ba1\u7b97\u5e73\u53f0\u8fdb\u4e00\u6b65\u6269\u5c55\u865a\u62df\u7ec6\u80de\u5efa\u6a21\u80fd\u529b[31]\u3002<\/span><\/span><\/span><\/p>\n

          Cellarity<\/span><\/span><\/strong>\uff08Flagship Pioneering\u65d7\u4e0b\uff09\u8d70\u7684\u662f\u53e6\u4e00\u8def\u5f84\uff1a\u5b83\u4ee5\u7ec6\u80de\u72b6\u6001\u4e3a\u9776\u70b9\uff0c\u7528\u5355\u7ec6\u80de\u7ec4\u5b66\u5b9a\u4e49\u75be\u75c5\u76f8\u5173\u7ec6\u80de\u72b6\u6001\uff0c\u518d\u8bbe\u8ba1\u5e72\u9884\u5c06\u7ec6\u80de\u4ece\u75c5\u6001\u62c9\u56de\u5065\u5eb7\u6001\u3002\u4ed6\u4eec\u6ca1\u6709\u516c\u5f00\u5927\u91cf\u6570\u636e\uff0c\u4f46\u5ba3\u79f0\u4f7f\u7528\u4e86\u6570\u767e\u4e07\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6765\u8bad\u7ec3\u6a21\u578b\u8bc6\u522b\u5173\u952e\u7f51\u7edc\u8282\u70b9\u3002\u8fd9\u79cd\u601d\u8def\u4e0e\u201c\u865a\u62df\u7ec6\u80de\u201d\u9ad8\u5ea6\u5951\u5408\uff0c\u5373\u5173\u6ce8\u6574\u4f53\u7ec6\u80de\u8868\u578b\u800c\u975e\u5355\u4e00\u5206\u5b50\u9776\u6807[32]\u3002<\/span><\/span><\/span><\/p>\n

          Tahoe Therapeutics <\/span><\/span><\/strong>\u662f\u5f53\u524dAIVC\u91cd\u8981\u6570\u636e\u8d21\u732e\u8005\uff0c\u4f4d\u4e8e\u65e7\u91d1\u5c71\uff0c\u4f9d\u6258\u4e0e\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u5408\u4f5c\u7814\u53d1\u7684\u9ad8\u901a\u91cf\u5355\u7ec6\u80de\u5e73\u53f0\u201cMosaic\u201d\u751f\u6210\u89c4\u6a21\u5316\u836f\u7269-\u7ec6\u80de\u6270\u52a8\u6570\u636e\uff0c\u5e76\u79ef\u6781\u901a\u8fc7\u5f00\u6e90\u6a21\u5f0f\u5c06\u5176\u6210\u679c\u7eb3\u5165\u5168\u7403\u865a\u62df\u7ec6\u80de\u751f\u6001\u30022025\u5e748\u6708\uff0cTahoe\u5ba3\u5e03\u83b7\u5f973000\u4e07\u7f8e\u5143\u878d\u8d44\uff0c\u5c06\u6570\u636e\u6269\u5c55\u81f310\u4ebf\u5355\u7ec6\u80de\uff0c\u7ed8\u5236\u767e\u4e07\u7ea7\u836f\u7269-\u60a3\u8005\u7ec6\u80de\u53cd\u5e94\u56fe\u8c31\uff0c\u652f\u6491\u201c\u6570\u636e\u9a71\u52a8\u836f\u7269\u53d1\u73b0\u201d\u7684\u6218\u7565[33]\u3002<\/span><\/span><\/span><\/p>\n

          \u8fd9\u6761\u8def\u4e0a\uff0c\u5de8\u5934\u4e5f\u5e76\u4e0d\u6c89\u5bc2\u3002DeepMind\u5728AlphaFold\u6210\u529f\u540e\uff0c\u5176\u59ca\u59b9\u516c\u53f8Isomorphic Labs\u636e\u79f0\u6b63\u5c1d\u8bd5\u66f4\u5e7f\u6cdb\u7684\u751f\u7269\u7cfb\u7edf\u6a21\u62df\uff0c\u5305\u62ec\u7ec6\u80de\u7ea7\u522b\u7684\u5efa\u6a21\u63a2\u7d22[34]\u3002\u9664\u4e86CZI\uff0c\u8c37\u6b4c\u3001\u5fae\u8f6f\u3001Genentech\u7684\u79d1\u5b66\u5bb6\u540c\u6837\u53c2\u4e0e\u4e862024\u5e74\u300aCell\u300bAIVC\u5021\u8bae[14]\u3002<\/span><\/span><\/p>\n

          \u53c2\u4e0e\u8005\u4f17\u591a\u7684\u5168\u7403\u865a\u62df\u7ec6\u80de\u6570\u636e\u3001\u7b97\u529b\u3001\u79d1\u7814\u751f\u6001\uff0c\u4f1a\u5982\u4f55\u5f71\u54cdAIVC\u4e43\u81f3\u751f\u547d\u79d1\u5b66\uff1fCZI\u79d1\u5b66\u987e\u95eeStephen Quake\u5728\u300aNature\u300b\u62a5\u9053\u4e2d\u4e00\u8bed\u9053\u7834\uff1a\u6211\u4eec\u7684\u76ee\u6807\u662f\u8ba9\u7ec6\u80de\u751f\u7269\u5b66\u4ece\u76ee\u524d\u7684\u201c90%\u5b9e\u9a8c+10%\u8ba1\u7b97\u201d\uff0c\u9006\u8f6c\u4e3a\u201c10%\u5b9e\u9a8c+90%\u8ba1\u7b97\u201d[35]\u3002\u8fd9\u53cd\u6620\u51fa\u5bf9\u6570\u636e\u548cAI\u9a71\u52a8\u79d1\u7814\u8303\u5f0f\u8f6c\u53d8\u7684\u5f3a\u70c8\u4fe1\u5fc3\uff1a\u672a\u6765\u79d1\u5b66\u5bb6\u505a\u5b9e\u9a8c\uff0c\u5927\u90e8\u5206\u53ea\u662f\u4e3a\u4e86\u9a8c\u8bc1AI\u6a21\u578b\u7684\u9884\u6d4b\u3002<\/span><\/span><\/p>\n


          <\/span><\/p>\n

          \n
          \n
          \n
          \n
          \n

          <\/span><\/section>\n

          <\/span><\/section>\n
          \n
          <\/section>\n<\/section>\n<\/section>\n
          \n

          5. \u4ece\u6570\u636e\u5230\u95ed\u73af\uff1aSTATE\u6a21\u578b\u53ea\u662f\u5f00\u59cb<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

          \n

          <\/span><\/section>\n

          <\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


          <\/span><\/p>\n

          \u5927\u91cf\u9ad8\u8d28\u91cf\u6570\u636e\u7684\u6d8c\u73b0\uff0c\u4e0d\u4ec5\u6539\u53d8\u4e86\u8bc4\u6d4b\u6807\u51c6\uff0c\u4e5f\u6b63\u5728\u91cd\u5851\u6a21\u578b\u8bbe\u8ba1\u7684\u601d\u8def\u3002Arc\u5728\u7ade\u8d5b\u53d1\u5e03\u4e0d\u4e45\u540e\u63d0\u51fa\u7684STATE\u6a21\u578b\uff0c\u5c31\u662f\u201c\u6570\u636e-\u6a21\u578b\u5171\u8bbe\u8ba1\u201d\u7684\u5178\u578b[22]\u3002<\/span><\/span><\/p>\n

          <\/section>\n

          \u56fe3\uff1aSTATE\u6a21\u578b\u67b6\u6784\u3002\u9996\u5148\u901a\u8fc7\u72b6\u6001\u5d4c\u5165\u6a21\u5757SE\uff0c\u5c06\u9ad8\u5ea6\u5f02\u8d28\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u6570\u636e\u7edf\u4e00\u4e3a\u5e73\u6ed1\u3001\u7ed3\u6784\u5316\u7684\u8868\u8fbe\u7a7a\u95f4\uff08\u6570\u636e\u2192\u5d4c\u5165\u8868\u5f81\uff09\u3002\u518d\u901a\u8fc7\u72b6\u6001\u8f6c\u6362\u6a21\u5757ST\uff0c\u4ece\u8fd9\u4e00\u5d4c\u5165\u7a7a\u95f4\u9884\u6d4b\u65b0\u7684\u7ec6\u80de\u54cd\u5e94\u4e0e\u6270\u52a8\u6548\u5e94\uff08\u5d4c\u5165\u8868\u5f81\u2192\u9884\u6d4b\u6570\u636e\uff09\uff0c\u5f62\u6210\u521d\u6b65\u9884\u6d4b\u7ed3\u679c[36]\u3002<\/span><\/span><\/p>\n

          \u4ece\u67b6\u6784\u4e0a\u770b\uff0c<\/span><\/span>STATE\u6a21\u578b<\/span><\/span><\/strong>\u7531\u4e24\u4e2a\u6a21\u5757\u4e32\u8054\u800c\u6210\uff1a<\/span><\/span>\u72b6\u6001\u5d4c\u5165\u6a21\u5757\uff08State Embedding, SE\uff09\u548c\u72b6\u6001\u8f6c\u6362\u6a21\u5757\uff08State Transition, ST\uff09<\/span><\/span><\/strong>\u3002SE\u6a21\u5757\u5c06\u539f\u59cb\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u8868\u8fbe\u6620\u5c04\u5230\u4e00\u4e2a\u5e73\u6ed1\u7684\u9ad8\u7ef4\u5411\u91cf\u7a7a\u95f4\uff0c\u7c7b\u4f3c\u4e8e\u5bf9\u7ec6\u80de\u505a\u964d\u566a\u548c\u7279\u5f81\u63d0\u53d6\uff0c\u628a\u5608\u6742\u7684\u57fa\u56e0\u8868\u8fbe\u8c31\u538b\u7f29\u6210\u6613\u4e8e\u5efa\u6a21\u7684\u201c\u7ec6\u80de\u72b6\u6001\u201d\u5411\u91cf\u3002\u800cST\u6a21\u5757\u57fa\u4e8e<\/span><\/span>\u53cc\u5411Transformer<\/span><\/span><\/strong>\u67b6\u6784\uff0c\u63a5\u53d7\u4e00\u7ec4\u7ec6\u80de\u7684SE\u5411\u91cf\u8868\u793a\u4f5c\u4e3a\u8f93\u5165\uff0c\u5229\u7528\u81ea\u6ce8\u610f\u529b\u673a\u5236\u6765<\/span><\/span>\u9884\u6d4b\u7ed9\u5b9a\u6270\u52a8\u4e0b\u7ec6\u80de\u72b6\u6001\u5982\u4f55\u5728\u5d4c\u5165\u7a7a\u95f4\u53d1\u751f\u8f6c\u79fb<\/span><\/span><\/strong>\u3002<\/span><\/span><\/span><\/p>\n

          STATE\u6a21\u578b\u7684<\/span><\/span>\u8f93\u5165\u5e76\u975e\u5355\u4e2a\u7ec6\u80de\uff0c\u800c\u662f\u4e00\u7ec4\u7ec6\u80de<\/span><\/span><\/strong>\u3002\u8fd9\u4f7f\u5f97\u6a21\u578b\u80fd\u591f\u5145\u5206\u5229\u7528\u540c\u4e00\u6270\u52a8\u6761\u4ef6\u4e0b\u7ec6\u80de\u7fa4\u4f53\u5185\u90e8\u7684\u53d8\u5f02\u4fe1\u606f<\/span>\uff08\u5982\u7ec6\u80de\u5468\u671f\u5dee\u5f02\u3001\u7ec6\u80de\u72b6\u6001\u5f02\u8d28\u6027\u7b49\uff09<\/span>\uff0c\u66f4\u5168\u9762\u5730\u63a8\u65ad\u6270\u52a8\u6548\u5e94\u3002\u540c\u65f6\uff0c\u6a21\u578b<\/span><\/span>\u4e0d\u5bf9\u8f93\u51fa\u5206\u5e03\u9884\u8bbe\u7279\u5b9a\u7684\u53c2\u6570\u5316\u5047\u8bbe<\/span><\/span><\/strong>\uff0c\u800c\u662f\u501f\u52a9\u6ce8\u610f\u529b\u673a\u5236\u4e0e\u5206\u5e03\u5bf9\u9f50\u635f\u5931<\/span>\uff08\u5982\u6700\u5927\u5747\u503c\u5dee\u5f02MMD\uff09<\/span>\u81ea\u9002\u5e94\u5730\u6355\u6349\u590d\u6742\u7684\u8868\u8fbe\u5206\u5e03\u5dee\u5f02\u3002<\/span><\/span><\/span><\/p>\n

          \u5982\u6b64\u201c\u5962\u4f88\u201d\u7684\u6a21\u578b\uff0c\u53ea\u6709\u5728\u6570\u636e\u201c\u6301\u7eed\u5806\u80a5\u201d\u52302025\u5e74\u540e\u624d\u5f97\u4ee5\u5b9e\u73b0\u3002\u5982\u524d\u6240\u8ff0\uff0cArc\u81ea\u4e3b\u751f\u6210\u7684<\/span><\/span>H1\u5e72\u9884\u6570\u636e\u96c6<\/span><\/span><\/strong>\uff0c\u6bcf\u4e2a\u6270\u52a8\u5b9e\u9a8c\u5305\u542b\u7ea61000\u4e2a\u5355\u7ec6\u80de\uff0c\u5355\u7ec6\u80de\u6d4b\u5e8f\u6df1\u5ea6\u5e73\u5747\u8fbe\u52305\u4e07UMIs\uff0c\u4e3a\u8bad\u7ec3\u751f\u6210\u5f0fTransformer\u63d0\u4f9b\u4e86\u5145\u8db3\u6837\u672c\u3002\u5176\u6b21\uff0cArc\u5c06<\/span><\/span>Tahoe-100M\u836f\u7269\u6570\u636e\u548c\u516c\u5171CRISPR\u6570\u636e<\/span><\/span><\/strong>\u4e00\u8d77\u4f5c\u4e3a\u8bad\u7ec3\u8bed\u6599\u4f9b\u7ed9STATE\uff0c\u4f7f\u5176\u5728\u8de8\u7ec6\u80de\u7c7b\u578b\u3001\u8de8\u6270\u52a8\u7c7b\u578b\u4e0a\u5b66\u4e60\u5230\u4e00\u822c\u89c4\u5f8b\u3002Arc\u58f0\u79f0\uff0cSTATE\u603b\u8ba1\u8bad\u7ec3\u4e86\u8d85\u8fc71\u4ebf\u4e2a\u7ec6\u80de\u7684\u5355\u7ec6\u80de\u6570\u636e\uff0c\u6db5\u76d670\u79cd\u4e0d\u540c\u7ec6\u80de\u7cfb\uff0c\u662f\u8fc4\u4eca\u6b64\u7c7b\u6a21\u578b\u6700\u5e9e\u5927\u7684\u8bad\u7ec3\u89c4\u6a21[36]\u3002<\/span><\/span><\/span><\/p>\n

          STATE<\/span><\/span>\u9996\u6b21\u7cfb\u7edf\u6027\u5730\u8d85\u8d8a\u4e86\u7b80\u5355\u7ebf\u6027\u57fa\u7ebf\u6a21\u578b<\/span><\/span><\/strong>\u7684\u5404\u9879\u6307\u6807\u3002\u5728Tahoe-100M\u57fa\u51c6\u6d4b\u8bd5\u4e2d\uff0cSTATE\u533a\u5206\u4e0d\u540c\u6270\u52a8\u6548\u5e94\u7684\u80fd\u529b<\/span>\uff08PDS\uff09<\/span>\u76f8\u5bf9\u4ee5\u5f80\u6700\u4f73\u65b9\u6cd5\u63d0\u9ad8\u4e8650%\uff0c\u8bc6\u522b\u771f\u5b9e\u5dee\u5f02\u57fa\u56e0\u7684\u51c6\u786e\u7387<\/span>\uff08DES\uff09<\/span>\u63d0\u9ad8\u4e86100%\u3002\u957f\u671f\u4ee5\u6765\uff0c\u5728\u8bb8\u591a\u5355\u7ec6\u80de\u9884\u6d4b\u4efb\u52a1\u4e0a\uff0c\u4eba\u4eec\u53d1\u73b0\u590d\u6742\u6a21\u578b\u5e76\u4e0d\u4e00\u5b9a\u6bd4\u4e00\u4e2a\u7b80\u5355\u7684\u7ebf\u6027\u56de\u5f52\u8868\u73b0\u66f4\u597d\uff0c\u5c24\u5176\u5728\u6570\u636e\u6709\u9650\u65f6\u7ecf\u5e38\u51fa\u73b0\u8fc7\u62df\u5408\u3002\u800c<\/span><\/span>STATE\u8bc1\u660e\u4e86\u5f53\u6570\u636e\u91cf\u548c\u8d28\u91cf\u4e0a\u5347\u5230\u4e00\u5b9a\u5c42\u6b21\u540e\uff0cTransformer\u7b49\u590d\u6742\u6a21\u578b\u5b8c\u5168\u53ef\u4ee5\u5728\u751f\u7269\u7cfb\u7edf\u4e0a\u5c55\u73b0\u51fa\u7c7b\u4f3c\u5728\u8bed\u8a00\u3001\u56fe\u50cf\u9886\u57df\u7684\u98de\u8dc3\u5f0f\u63d0\u5347\u3002<\/span><\/span><\/strong><\/span><\/p>\n

          \u8fd9\u79cd\u4ee5\u6570\u636e\u4e3a\u4e2d\u5fc3\u7684\u6a21\u578b\u67b6\u6784\u610f\u5473\u7740\uff0c\u5f53\u6570\u636e\u89c4\u6a21\u79ef\u7d2f\u5230\u4e00\u5b9a\u7a0b\u5ea6\u540e\uff0c\u5c06\u50ac\u751f\u6a21\u578b\u4e0e\u5b9e\u9a8c\u4e4b\u95f4\u66f4\u7d27\u5bc6\u7684\u95ed\u73af\u30022025\u5e743\u6708\uff0c\u897f\u6e56\u5927\u5b66\u90ed\u5929\u5357\u56e2\u961f\u5728\u300aCell Research\u300b\u7684\u8bc4\u8bba\u6587\u7ae0\u4e2d\u9996\u6b21\u660e\u786e\u63d0\u51fa\uff0c<\/span><\/span>AIVC\u7684\u53d1\u5c55\u4f9d\u8d56\u4e8e\u201c\u4e09\u5927\u6570\u636e\u652f\u67f1\u201d\uff08\u5148\u9a8c\u77e5\u8bc6\u3001\u9759\u6001\u67b6\u6784\u548c\u52a8\u6001\u72b6\u6001\uff09\u4e0e\u201c\u95ed\u73af\u5b66\u4e60\u201d<\/span><\/span><\/strong>\uff08closed-loop learning\uff09<\/span>[37]\u3002\u4f5c\u8005\u5f3a\u8c03\uff1a\u201c\u6784\u5efa\u771f\u6b63\u7684\u865a\u62df\u7ec6\u80de\u4e0d\u4ec5\u9700\u8981\u5927\u89c4\u6a21\u6570\u636e\uff0c\u66f4\u9700\u8981\u901a\u8fc7\u4e3b\u52a8\u5b66\u4e60<\/span>\uff08active learning\uff09<\/span>\u7ed3\u5408\u9ad8\u901a\u91cf\u6270\u52a8\u5b9e\u9a8c\uff0c\u4e0d\u65ad\u8fed\u4ee3\u6a21\u578b\u9884\u6d4b\u4e0e\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u9010\u6b65\u903c\u8fd1\u771f\u5b9e\u7ec6\u80de\u52a8\u529b\u5b66\u201d\u3002\u53ea\u6709\u5728\u6570\u636e\u57fa\u7840\u4e0a\u5f62\u6210\u95ed\u73af\u5b66\u4e60\uff0c\u6a21\u578b\u624d\u80fd\u4ece\u76f8\u5173\u6027\u5b66\u4e60\u771f\u6b63\u8fc7\u6e21\u5230\u56e0\u679c\u9884\u6d4b\u548c\u673a\u5236\u53d1\u73b0\u3002<\/span><\/span><\/span><\/p>\n

          <\/section>\n

          \u56fe4\uff1a\u901a\u8fc7\u95ed\u73af\u5b66\u4e60\u5b9e\u73b0AIVC\u6301\u7eed\u8fdb\u5316\u3002\u5148\u9a8c\u77e5\u8bc6\u3001\u9759\u6001\u7ed3\u6784\uff08\u5206\u5b50\u4e0e\u7a7a\u95f4\u8868\u5f81\uff09\u4e0e\u52a8\u6001\u72b6\u6001\uff08\u81ea\u7136\u8fc7\u7a0b\u4e0e\u6270\u52a8\uff09\uff0c\u7531 AI \u7b97\u6cd5\u6574\u5408\u4ee5\u6a21\u62df\u7ec6\u80de\u884c\u4e3a\uff08\u5178\u578b\u7cfb\u7edf\u5305\u62ec\u5927\u80a0\u6746\u83cc\u3001\u9175\u6bcd\u4e0e\u7ec6\u80de\u7cfb\uff09\u3002\u56fe\u4e2d\u8fd8\u5c55\u793a\u4e86 AIVC \u7684\u8fdb\u5316\u8def\u5f84\uff1a\u95ed\u73af\u4e3b\u52a8\u5b66\u4e60\u7cfb\u7edf\u4e2d\uff0cAI \u9884\u6d4b\u6307\u5bfc\u81ea\u52a8\u5b9e\u9a8c\uff08\u5c24\u5176\u805a\u7126\u6270\u52a8\u7ec4\u5b66\u6570\u636e\uff09\uff0c\u5b9e\u73b0\u6a21\u578b\u4e0e\u5b9e\u9a8c\u4e4b\u95f4\u7684\u5feb\u901f\u53cd\u9988\u5faa\u73af\u3002[37]<\/span><\/span><\/p>\n

          \u4e0e\u4e4b\u547c\u5e94\uff0cValence Labs<\/span>\uff08Recursion\u65d7\u4e0b\uff09<\/span>\u57282025\u5e745\u6708\u63d0\u51fa\u201c<\/span><\/span>\u9884\u6d4b\u2013\u89e3\u91ca\u2013\u53d1\u73b0<\/span><\/span><\/strong>\u201d<\/span>\uff08Predict\u2013Explain\u2013Discover, P\u2013E\u2013D\uff09<\/span>\u7684\u865a\u62df\u7ec6\u80de\u6846\u67b6\uff0c\u63d0\u51fa\u5bf9\u51c6\u836f\u7269\u53d1\u73b0\u7684\u53ef\u7528\u9884\u6d4b\u5668\u4e0e\u201c\u5b9e\u9a8c\u5728\u73af\u201d\u5de5\u4f5c\u6d41[38]\u3002Recursion\u662f\u4f4d\u4e8e\u7f8e\u56fd\u72b9\u4ed6\u5dde\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u662fAI for Drug\u7684\u9886\u5148\u516c\u53f8\u4e4b\u4e00\u3002Valence Labs\u80cc\u9760 Recursion\u7684 BioHive-2 \u8d85\u7b97<\/span>\uff08\u4e0eNVIDIA\u5408\u4f5c\uff09<\/span>\u4e0e >60 PB \u591a\u6a21\u6001\u5e72\u9884\u6570\u636e\uff0c\u5728\u7b97\u529b\u4e0e\u6570\u636e\u4e0a\u90fd\u8fdc\u8d85\u5927\u591a\u6570\u5b66\u672f\u673a\u6784\u4e0e\u7ade\u4e89\u4f01\u4e1a\u3002<\/span><\/span><\/span><\/p>\n

          Valence Labs\u5728\u6587\u7ae0\u4e2d\u5f3a\u8c03\uff0c\u865a\u62df\u7ec6\u80de\u4e0d\u4ec5\u8981\u5177\u5907\u9ad8\u8d28\u91cf\u7684\u54cd\u5e94\u9884\u6d4b<\/span>\uff08Predict\uff09<\/span>\uff0c\u66f4\u9700\u8981\u901a\u8fc7\u77e5\u8bc6\u56fe\u8c31\u3001\u751f\u7269\u7269\u7406\u4e0e\u7ed3\u6784\u4fe1\u606f\u5c06\u9884\u6d4b\u53ef\u89e3\u91ca\u5316<\/span>\uff08Explain\uff09<\/span>\uff0c\u5e76\u5728\u201c\u5b9e\u9a8c\u5728\u73af<\/span>\uff08lab-in-the-loop\uff09<\/span>\u201d\u7684\u95ed\u73af\u8fed\u4ee3\u8fc7\u7a0b\u4e2d\u4e3b\u52a8\u63a2\u7d22\u3001\u68c0\u9a8c\u3001\u5e76\u53d1\u73b0\u65b0\u578b\u751f\u7269\u673a\u5236\u6216\u836f\u7269\u9776\u6807<\/span>\uff08Discover\uff09<\/span>\u3002Valence Labs\u63d0\u51fa\u4e86\u4e00\u5957\u865a\u62df\u7ec6\u80de\u6027\u80fd\u7684\u5206\u7ea7\u91cc\u7a0b\u7891<\/span>\uff08VC-levels\uff09<\/span>\u4e0e\u8bc4\u6d4b\u6807\u51c6\uff0c\u5e76\u4ee5\u6b64\u5b9a\u4e49\u672a\u6765\u865a\u62df\u7ec6\u80de\u6280\u672f\u7684\u6f14\u8fdb\u65b9\u5411\u548c\u751f\u7269\u5b66\u843d\u5730\u7684\u5177\u4f53\u8def\u5f84\u3002<\/span><\/span><\/p>\n

          <\/section>\n

          \u56fe5\uff1a\u865a\u62df\u7ec6\u80de\u7684\u9884\u6d4b-\u89e3\u91ca-\u53d1\u73b0\u67b6\u6784[38]\u3002\u865a\u62df\u7ec6\u80de\uff08Virtual Cell\uff09\u6280\u672f\u5728\u73b0\u4ee3\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u4e09\u5927\u6838\u5fc3\u80fd\u529b\uff1aPredict\uff08\u9884\u6d4b\uff09\u3001Explain\uff08\u89e3\u91ca\uff09\u4e0e Discover\uff08\u53d1\u73b0\uff09\u3002\u9996\u5148\uff0c\u865a\u62df\u7ec6\u80de\u5e94\u5177\u5907\u9884\u6d4b\u529f\u80fd\uff1a\u80fd\u591f\u63a8\u65ad\u4e0d\u540c\u7ec6\u80de\u73af\u5883\u548c\u5b9e\u9a8c\u6761\u4ef6\u4e0b\uff0c\u7ec6\u80de\u5728\u8868\u578b\u7ec4\u3001\u8f6c\u5f55\u7ec4\u3001\u86cb\u767d\u7ec4\u3001\u4ee3\u8c22\u7ec4\u7b49\u591a\u6a21\u6001\u6570\u636e\u4e2d\u7684\u54cd\u5e94\u53d8\u5316\u3002\u63a5\u7740\uff0c\u5b83\u5fc5\u987b\u63d0\u4f9b\u673a\u5236\u6027\u89e3\u91ca\uff1a\u8fd0\u7528\u56e0\u679c\u5b66\u4e60\u3001\u7ed3\u6784\u9884\u6d4b\u4e0e\u5206\u5b50\u52a8\u529b\u5b66\u7b49\u6280\u672f\u63ed\u793a\u6270\u52a8\u5982\u4f55\u4fee\u6539\u5173\u952e\u751f\u7269\u5206\u5b50\u4e92\u4f5c\uff0c\u4ece\u800c\u89e3\u91ca\u9884\u6d4b\u80cc\u540e\u7684\u56e0\u679c\u673a\u5236\u3002\u6700\u540e\uff0c\u901a\u8fc7\u805a\u7126\u673a\u5236\u7406\u89e3\uff0c\u865a\u62df\u7ec6\u80de\u53ef\u4ee5\u751f\u6210\u5e76\u9ad8\u6548\u7b5b\u9009\u5927\u91cf\u5019\u9009\u5047\u8bbe\uff08\u5982\u836f\u7269\u5e72\u9884\u6216\u9776\u70b9\u8c03\u63a7\u65b9\u6848\uff09\uff0c\u5728\u8fdb\u5165\u6602\u8d35\u7684\u4e34\u5e8a\u8bd5\u9a8c\u524d\u53d1\u73b0\u65b0\u7684\u751f\u7269\u5b66\u89c4\u5f8b\u3002\u8be5\u601d\u8def\u63d0\u51fa\u4e86\u4e00\u79cd\u4ece\u6574\u4f53\u7ec6\u80de\u72b6\u6001\u800c\u975e\u5355\u4e00\u5206\u5b50\u9776\u70b9\u8fdb\u884c\u7406\u6027\u836f\u7269\u8bbe\u8ba1\u7684\u73b0\u4ee3\u8303\u5f0f\u3002<\/span><\/span><\/p>\n

          \u6a21\u578b\u4e0e\u5b9e\u9a8c\u7684\u534f\u540c\u95ed\u73af\u7684\u601d\u8def\uff0c\u540c\u6837\u5f15\u53d1\u4e86\u4ea7\u4e1a\u754c\u7684\u5173\u6ce8\u3002ARK Invest\u57282025\u5e74\u53d1\u5e03\u7684\u300aBig Ideas\u300b\u5e74\u5ea6\u62a5\u544a\u4e2d\u660e\u786e\u6307\u51fa\uff0c\u865a\u62df\u7ec6\u80de\u7684\u95ed\u73af\u5b66\u4e60\u6a21\u5f0f\u5927\u5e45\u5ea6\u964d\u4f4e\u4e86\u5355\u7ec6\u80de\u7ec4\u5b66\u6570\u636e\u751f\u6210\u4e0e\u9a8c\u8bc1\u6210\u672c\uff0c\u5c06\u9a71\u52a8\u751f\u7269\u5236\u836f\u4ea7\u4e1a\u8d70\u5411\u4ee5\u6570\u636e\u4e0e\u6a21\u578b\u9a71\u52a8\u4e3a\u4e3b\u5bfc\u7684\u7814\u53d1\u6a21\u5f0f\uff0c\u9884\u8ba1\u52302028\u5e74\uff0c\u8fd9\u79cd\u6a21\u5f0f\u5c06\u4f7f\u6bcf\u4e2a\u7ec6\u80de\u5b9e\u9a8c\u7684\u5355\u5143\u6210\u672c\u4e0b\u964d\u81f3\u5f53\u524d\u7684\u7ea61\/120\uff0c\u5f62\u6210\u5de8\u5927\u7684\u4ea7\u4e1a\u53d8\u9769\u6548\u5e94[39]\u3002<\/span><\/span><\/p>\n

          \u76ee\u524d\uff0c\u4e00\u4e9b\u524d\u6cbf\u7814\u7a76\u5df2\u7ecf\u5728\u5c40\u90e8\u573a\u666f\u4e2d\u521d\u6b65\u9a8c\u8bc1\u4e86\u201c\u6570\u636e-\u6a21\u578b-\u5b9e\u9a8c\u201d\u95ed\u73af\u7684\u53ef\u884c\u6027\u3002\u4f8b\u5982\uff0c\u5fb7\u56fd\u6155\u5c3c\u9ed1\u5de5\u4e1a\u5927\u5b66\u4e0eHelmholtz\u4e2d\u5fc3\u7684CPA<\/span>\uff08Compositional Perturbation Autoencoder\uff09<\/span>\u6a21\u578b\uff0c\u80fd\u591f\u901a\u8fc7\u6a21\u578b\u9884\u6d4b\u672a\u89c1\u836f\u7269\u7ec4\u5408\u7684\u5355\u7ec6\u80de\u6270\u52a8\u54cd\u5e94\uff0c\u518d\u901a\u8fc7\u524d\u77bb\u6027\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u4e0e\u6570\u636e\u91c7\u96c6\u8fdb\u884c\u9a8c\u8bc1\uff0c\u4ece\u800c\u5b9e\u8bc1\u4e86\u6a21\u578b\u9884\u6d4b\u5728\u95ed\u73af\u4e2d\u7684\u8fed\u4ee3\u63d0\u5347[40]\u3002<\/span><\/span><\/p>\n

          \u6a21\u578b\u9a71\u52a8\u5b9e\u9a8c-\u5b9e\u9a8c\u53cd\u54fa\u6a21\u578b\u7684\u6570\u636e\u95ed\u73af\uff0c\u6b63\u5728AIVC\u9886\u57df\u6210\u4e3a\u5171\u8bc6\u3002\u968f\u7740Arc Institute\u4e3b\u5bfc\u7684\u5e74\u5ea6\u865a\u62df\u7ec6\u80de\u6311\u6218\u8d5b\u9010\u5e74\u5c55\u5f00\uff0c\u4e00\u4e2a\u89c4\u6a21\u5316\u3001\u793e\u533a\u5316\u7684\u6570\u636e\u4e0e\u8bc4\u6d4b\u95ed\u73af\u6b63\u5728\u9010\u6e10\u6784\u5efa\u8d77\u6765\uff0c\u4ee5\u6301\u7eed\u53cd\u9988\u7684\u5f62\u5f0f\u63a8\u52a8\u6a21\u578b\u8fed\u4ee3\u548c\u6570\u636e\u57fa\u7840\u7684\u6f14\u8fdb\u3002<\/span><\/span><\/p>\n


          <\/span><\/h2>\n

          \n
          \n
          \n
          \n
          \n

          <\/span><\/section>\n

          <\/span><\/section>\n
          \n
          <\/section>\n<\/section>\n<\/section>\n
          \n

          6. \u7ed3\u8bed\uff1a\u8fc8\u5411\u865a\u62df\u7ec6\u80de\u7684\u56fe\u7075\u6d4b\u8bd5<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

          \n

          <\/span><\/section>\n

          <\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


          <\/span><\/p>\n

          Arc\u6311\u6218\u8d5b\u53ea\u662f\u8d77\u70b9\u3002<\/span><\/span>\u5728\u5168\u7403\u8303\u56f4\u5185\uff0cAIVC\u76f8\u5173\u7684\u7ade\u8d5b\u548c\u57fa\u51c6\u6b63\u9010\u6b65\u6d8c\u73b0<\/span><\/span><\/strong>\u3002\u65e9\u5728Arc\u4e4b\u524d\uff0cCZI\u8d44\u52a9\u7684\u5f00\u653e\u5408\u4f5c\u9879\u76ee\u5df2\u5728NeurIPS\u5927\u4f1a\u4e0a\u4e3e\u529e\u4e86\u201c<\/span><\/span>\u5355\u7ec6\u80de\u5206\u6790\u516c\u5f00\u95ee\u9898<\/span><\/span><\/strong>\u201d\u7ade\u8d5b\u7cfb\u5217[41]\u3002\u8fd9\u4e9b\u7ade\u8d5b\u7531\u6b27\u6d32\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76\u8005\uff08\u5982Helmholtz\u4e2d\u5fc3\u7684Fabian Theis\u7b49\uff09\u7ec4\u7ec7\uff0c\u5df2\u8fde\u7eed\u4e3e\u529e\u4e09\u5c4a\uff0c\u5f62\u6210\u4e86<\/span><\/span>Open Problems<\/span><\/span><\/strong>\u7cfb\u5217\u57fa\u51c6\u3002\u5b83\u4eec\u4e3aAIVC\u9886\u57df\u63d0\u4f9b\u4e86\u5b9d\u8d35\u7684<\/span><\/span>\u516c\u5f00\u6570\u636e<\/span><\/span><\/strong>\u548c<\/span><\/span>\u8bc4\u6d4b\u6846\u67b6\u3002<\/span><\/span><\/strong><\/span><\/p>\n

          \u7136\u800c\uff0c\u5f53\u524dAIVC\u9886\u57df\u7684\u8fdb\u5c55\u4ecd\u4ee5<\/span><\/span>\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u6570\u636e<\/span><\/span><\/strong>\u4e3a\u4e3b\u8981\u652f\u6491\u3002\u4e0b\u4e00\u9636\u6bb5\u7684\u91cd\u8981\u65b9\u5411\u662f\u62d3\u5c55\u5230\u66f4\u4e30\u5bcc\u7684<\/span><\/span>\u591a\u6a21\u6001\u5e72\u9884\u6570\u636e<\/span><\/span><\/strong>\u3002\u8bf8\u5982\u5355\u7ec6\u80de\u6270\u52a8\u86cb\u767d\u7ec4\u5b66<\/span>\uff08Perturb-CITE-seq\uff09<\/span>\u3001\u67d3\u8272\u8d28\u53ef\u53ca\u6027\u8c31<\/span>\uff08Perturb-ATAC-seq\uff09<\/span>\u4e0e\u9ad8\u5185\u6db5\u7ec6\u80de\u6210\u50cf\u8868\u578b\u6570\u636e<\/span>\uff08\u5982Recursion Pharmaceuticals\u516c\u53f8\u6b63\u5728\u89c4\u6a21\u5316\u4ea7\u751f\u768460PB\u591a\u6a21\u6001\u6570\u636e\u96c6\uff09<\/span>\u7b49\uff0c\u90fd\u53ef\u80fd\u878d\u5165\u65b0\u7684AIVC\u57fa\u51c6\u6570\u636e\u4e2d\u3002Arc Institute \u9ad8\u7ea7\u79d1\u5b66\u5bb6Nianzhen Li\u900f\u9732\uff0c\u672a\u6765\u8ba1\u5212\u5c06\u5927\u89c4\u6a21 CRISPR \u5e72\u6270\u4e0e\u539f\u4f4d<\/span>\uff08in situ\uff09<\/span>\u8bfb\u51fa\u7ed3\u5408\uff0c\u5b9e\u73b0\u8f6c\u5f55\u7ec4\u3001\u86cb\u767d\u4e0e\u9ad8\u901a\u91cf\u6210\u50cf\u6570\u636e\u7684\u7edf\u4e00\u91c7\u96c6\u3002\u8fd9\u4e9b\u65b0\u6a21\u6001\u7684\u5f15\u5165\u548c\u6574\u5408\uff0c\u5c06\u8fdb\u4e00\u6b65\u589e\u5f3a\u865a\u62df\u7ec6\u80de\u6a21\u578b\u7684\u673a\u5236\u7406\u89e3\u4e0e\u9884\u6d4b\u80fd\u529b[42]\u3002<\/span><\/span><\/span><\/p>\n

          \u9664\u6570\u636e\u6a21\u6001\u6269\u5c55\u5916\uff0c\u53e6\u4e00\u4e2a\u5173\u952e\u65b9\u5411\u662f<\/span><\/span>\u7ec4\u5408\u6270\u52a8\u4e0e\u52a8\u6001\u8f68\u8ff9<\/span><\/span><\/strong>\u3002\u771f\u5b9e\u7684\u751f\u7269\u7ec6\u80de\u901a\u5e38\u5904\u4e8e\u591a\u91cd\u6270\u52a8<\/span>\uff08\u57fa\u56e0\u7ec4\u5408\u3001\u836f\u7269\u8054\u7528\uff09<\/span>\u548c\u52a8\u6001\u6f14\u53d8\u8fc7\u7a0b\u4e2d\uff0c\u73b0\u9636\u6bb5\u7684\u5355\u4e00\u6270\u52a8\u3001\u9759\u6001\u201c\u5feb\u7167\u201d\u8fdc\u4e0d\u8db3\u4ee5\u63cf\u8ff0\u771f\u5b9e\u7ec6\u80de\u3002Arc\u673a\u5668\u5b66\u4e60\u7ec4\u8d1f\u8d23\u4ebaYusuf Roohani\u76f4\u8a00\uff0c\u672a\u6765Arc\u7ade\u8d5b\u53ef\u80fd\u4f1a\u63a2\u7d22\u7ec4\u5408\u6270\u52a8\u7b49\u96be\u800c\u9ad8\u4ef7\u503c\u7684\u6570\u636e\u96c6[43]\u3002\u7ec4\u5408\u6270\u52a8\u548c\u65f6\u95f4\u5e8f\u5217\u6270\u52a8\u7b49\u6570\u636e\uff0c\u5c06\u652f\u6301\u6a21\u578b\u66f4\u63a5\u8fd1\u7ec6\u80de\u771f\u5b9e\u52a8\u6001\u8fc7\u7a0b\uff0c\u4ece\u76f8\u5173\u9884\u6d4b\u8d70\u5411\u56e0\u679c\u673a\u5236\u89e3\u6790\uff0c\u63a8\u52a8\u4ece\u201c\u9759\u6001\u865a\u62df\u7ec6\u80de\u201d\u5411\u201c\u52a8\u6001\u865a\u62df\u7ec6\u80de\u201d\u8f6c\u578b\u3002  \u7ad9\u5728\u8fdc\u666f\u6765\u770b\uff0c\u865a\u62df\u7ec6\u80de\u7814\u7a76\u7684\u6700\u7ec8\u76ee\u6807\u662f\u8d85\u8d8a\u9884\u6d4b\u672c\u8eab\uff0c\u901a\u8fc7\u6a21\u578b\u53cd\u8fc7\u6765\u63ed\u793a\u751f\u7269\u7cfb\u7edf\u7684\u56e0\u679c\u673a\u5236\u3002\u5f53\u865a\u62df\u7ec6\u80de\u6a21\u578b\u5bf9\u5404\u79cd\u6270\u52a8\u7684\u54cd\u5e94\u9884\u6d4b\u8db3\u591f\u7cbe\u51c6\uff0c\u6211\u4eec\u5c31\u80fd\u501f\u52a9\u53cd\u4e8b\u5b9e\u5b9e\u9a8c\u3001\u4e3b\u52a8\u5b66\u4e60\u7b49\u95ed\u73af\u65b9\u6cd5\u63a8\u65ad\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u4e2d\u7684\u5173\u952e\u56e0\u679c\u5173\u7cfb\uff0c\u4ece\u800c\u5b9e\u73b0\u6a21\u578b\u2014\u5b9e\u9a8c\u2014\u6570\u636e\u7684\u95ed\u73af\u3002\u8fd9\u79cd\u95ed\u73af\u5b66\u4e60\u8303\u5f0f\u6b63\u5f97\u5230CZI\u3001Valence Labs\u3001Arc Institute\u548c\u4f17\u591a\u524d\u6cbf\u5b66\u672f\u56e2\u961f\u7684\u4e00\u81f4\u8ba4\u53ef\u3002\u5728\u4e00\u4e9b\u6a21\u5f0f\u751f\u7269\u4e2d\uff0c\u8fd9\u79cd\u95ed\u73af\u53ef\u80fd\u7387\u5148\u5b9e\u73b0\u3002\u4f8b\u5982\u5bf9\u4e8e\u9175\u6bcd\u83cc\uff0c\u76ee\u524d\u5df2\u7ecf\u5177\u5907\u8db3\u591f\u7684\u591a\u6a21\u6001\u6570\u636e\u3001\u660e\u786e\u7684\u751f\u7269\u5b66\u77e5\u8bc6\u6846\u67b6\u548c\u5feb\u901f\u8fed\u4ee3\u7684\u5b9e\u9a8c\u624b\u6bb5\uff0c\u8fd9\u4e3a\u7387\u5148\u8dd1\u901a\u771f\u6b63\u610f\u4e49\u4e0a\u7684\u201c\u865a\u62df\u7ec6\u80de\u56fe\u7075\u6d4b\u8bd5\u201d\u63d0\u4f9b\u4e86\u7406\u60f3\u7684\u5b9e\u9a8c\u751f\u6001\u73af\u5883[37]\u3002<\/span><\/span><\/span><\/p>\n

          \u4ece\u56fe\u7075\u7684\u201c\u6a21\u4eff\u6e38\u620f\u201d\u5230\u201c\u865a\u62df\u7ec6\u80de\u7684\u56fe\u7075\u6d4b\u8bd5\u201d<\/span><\/span><\/strong>\uff0c\u4e00\u8def\u63a2\u7d22\u662f\u66f2\u6298\u56de\u73af\u7684\uff1a\u859b\u5b9a\u8c14\u7528\u201c\u975e\u5468\u671f\u6676\u4f53\u201d\u53bb\u8ffd\u95ee\u9057\u4f20\u4fe1\u606f\u7684\u7269\u7406\u5f62\u6001\uff0c\u51af\u00b7\u8bfa\u4f9d\u66fc\u4ee5\u201c\u81ea\u590d\u5236\u81ea\u52a8\u673a\u201d\u5728\u903b\u8f91\u4e0a\u5b9a\u4e49\u751f\u547d\u81ea\u590d\u5236\u7684\u6700\u5c0f\u5355\u5143\uff0c\u7ea6\u7ff0\u00b7\u5eb7\u5a01\u5728\u6781\u7b80\u89c4\u5219\u4e16\u754c\u4e2d\u5448\u73b0\u751f\u547d\u7684\u53ef\u8ba1\u7b97\u6027\u2014\u2014\u8fd9\u4e9b\u601d\u60f3\u6b63\u6c47\u805a\u5230\u6d77\u91cf\u751f\u7269\u6570\u636e\u4e2d\uff0c\u7b49\u5f85AI\u91cd\u65b0\u8be0\u91ca\u73b0\u4ee3\u7248\u7684\u7c73\u52d2-\u5c24\u91cc\u4e4b\u95ee\uff1a\u5982\u679c\u518d\u7ed9\u7ec6\u80de\u4e00\u9053\u201c\u95ea\u7535\u201d\uff0c\u5b83\u5c06\u5982\u4f55\u5b9e\u73b0\u751f\u547d\u7684\u8dc3\u8fc1\uff1f\u5728\u53cd\u4e8b\u5b9e\u5b9e\u9a8c\u548c\u4e3b\u52a8\u5b66\u4e60\u7684\u9a71\u52a8\u4e0b\uff0cAIVC\u7684\u6301\u7eed\u8fed\u4ee3\uff0c\u4f1a\u50ac\u751f\u51fa\u66f4\u6df1\u523b\u7684\u79d1\u5b66\u95ee\u9898\u548c\u66f4\u7cbe\u786e\u7684\u53c2\u8003\u7b54\u6848\uff0c\u8ba9\u5efa\u6a21\u8d8a\u6765\u8d8a\u903c\u771f\uff0c\u76f4\u81f3ALife\u5b9e\u73b0\u3002<\/span><\/span><\/span><\/p>\n

          \u751f\u547d\u7684\u8c1c\u9898\u4f55\u5176\u9ad8\u6df1\uff0c\u671f\u5f85Arc\u865a\u62df\u7ec6\u80de\u6311\u6218\u8d5b\u6210\u4e3a\u8fd9\u573a\u6f2b\u957f\u6500\u767b\u4e4b\u65c5\u7684\u65b0\u57fa\u77f3\u3002<\/span><\/span><\/p>\n


          <\/span><\/p>\n


          <\/span><\/h2>\n
          \n
          \n
          \n
          \n
          \n
          \n
          \n

          \u53c2\u8003\u8d44\u6599<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \n
          \n


          <\/span><\/p>\n

          [1] Arc Institute \u53d1\u8d77 Virtual Cell Challenge\uff08GEN\uff09https:\/\/www.genengnews.com\/topics\/artificial-intelligence\/arc-institute-launches-virtual-cell-challenge-to-accelerate-ai-model-development\/<\/span><\/span><\/span><\/p>\n

          [2] Patrick Hsu \u8bc4\u8bba\uff08EurekAlert\uff09https:\/\/www.eurekalert.org\/news-releases\/1089091<\/span><\/span><\/p>\n

          [3] \u300aCell\u300b\u8bc4\u8bba\uff1aVirtual Cell Challenge: Toward a Turing test for the virtual cellhttps:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(25)00675-0<\/span><\/span><\/p>\n

          [4] Arc \u865a\u62df\u7ec6\u80de\u56fe\u8c31 Atlas \u53d1\u5e03<\/span><\/span><\/p>\n

          https:\/\/arcinstitute.org\/news\/arc-virtual-cell-atlas-launch<\/span><\/span><\/p>\n

          [5] Tahoe-100M \u836f\u7269\u6270\u52a8\u6570\u636e\u96c6\u53d1\u5e03https:\/\/www.tahoebio.ai\/news\/open-sourcing-tahoe-100m<\/span><\/span><\/p>\n

          [6] scBaseCount \u6570\u636e\u96c6\u62a5\u544a<\/span><\/span><\/p>\n

          https:\/\/www.biorxiv.org\/content\/10.1101\/2025.02.27.640494v2<\/span><\/span><\/p>\n

          [7] \u865a\u62df\u7ec6\u80de\u6311\u6218\u8d5b\u6570\u636e\u96c6\u8be6\u60c5https:\/\/virtualcellchallenge.org\/datasets<\/span><\/span><\/p>\n

          [8] Arc \u6570\u636e\u751f\u6210\u5e73\u53f0\u4ecb\u7ecdhttps:\/\/arcinstitute.org\/news\/arc-10x-ultima<\/span><\/span><\/p>\n

          [9] \u865a\u62df\u7ec6\u80de\u6311\u6218\u8d5b\u8bc4\u6d4b\u6307\u6807\u8bf4\u660ehttps:\/\/virtualcellchallenge.org\/evaluation<\/span><\/span><\/p>\n

          [10] \u5386\u5e74CASP<\/span><\/span><\/p>\n

          https:\/\/predictioncenter.org<\/span><\/span><\/p>\n

          [11] DeepMind \u535a\u5ba2\uff1aAlphaFold\u2014\u2014\u751f\u7269\u5b6650\u5e74\u96be\u9898\u7684\u89e3\u51b3\u65b9\u6848https:\/\/deepmind.google\/discover\/blog\/alphafold-a-solution-to-a-50-year-old-grand-challenge-in-biology<\/span><\/span><\/p>\n

          [12] Tabula Sapiens \u9879\u76ee\u5b98\u7f51https:\/\/tabula-sapiens.sf.czbiohub.org\/<\/span><\/span><\/p>\n

          [13] CZI\u7684Virtual Cells\u4e3b\u9875https:\/\/chanzuckerberg.com\/science\/technology\/virtual-cells<\/span><\/span><\/p>\n

          [14] \u300aCell\u300b\u8bc4\u8bba\uff1aHow to build the virtual cell with artificial intelligence: Priorities and opportunitieshttps:\/\/www.cell.com\/cell\/pdf\/S0092-8674(24)01332-1.pdf<\/span><\/span><\/p>\n

          [15] CMap \u9879\u76ee\u5b98\u7f51https:\/\/www.broadinstitute.org\/connectivity-map-cmap<\/span><\/span><\/p>\n

          [16] \u300aCell\u300b\u7ecf\u5178\u8bba\u6587\uff1aPerturb-seq \u65b9\u6cd5\u63d0\u51fa<\/span><\/span><\/p>\n

          https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867416316105<\/span><\/span><\/p>\n

          [17] \u300aNature Biotechnology\u300b\u8bba\u6587\uff1aReplogle \u7b49\u4eba Perturb-seq \u5927\u89c4\u6a21\u5b9e\u9a8chttps:\/\/www.nature.com\/articles\/s41587-022-01302-5<\/span><\/span><\/p>\n

          [18] \u300aNature Genetics\u300b\u8bba\u6587\uff1aNadig \u7b49\u4eba 2025 Perturb-seq \u7814\u7a76https:\/\/www.nature.com\/articles\/s41588-025-02169-3<\/span><\/span><\/p>\n

          [19] Xaira Therapeutics \u53d1\u5e03\u6700\u5927\u89c4\u6a21 Perturb-seq \u6570\u636e\u96c6https:\/\/www.genengnews.com\/topics\/artificial-intelligence\/xaira-therapeutics-releases-largest-perturb-seq-dataset-to-power-the-virtual-cell<\/span><\/span><\/p>\n

          [20] \u300aScience\u300b\u8bba\u6587\uff1aSci-Plexhttps:\/\/science.sciencemag.org\/content\/367\/6473\/45<\/span><\/span><\/p>\n

          [21] Parse Biosciences \u516c\u53f8\u5b98\u7f51\uff1aPBMC \u836f\u7269\u6270\u52a8\u6570\u636e\u96c6https:\/\/www.parsebiosciences.com\/datasets<\/span><\/span><\/p>\n

          [22] STATE \u6a21\u578b\u62a5\u544ahttps:\/\/biorxiv.org\/cgi\/content\/short\/2025.06.26.661135<\/span><\/span><\/p>\n

          [23] Arc Institute \u5b98\u7f51https:\/\/arcinstitute.org<\/span><\/span><\/p>\n

          [24] Arc \u65b0\u95fb\uff1aAI can now model and design the genetic code for all domains of life with Evo 2<\/span><\/span><\/p>\n

          https:\/\/arcinstitute.org\/news\/evo2<\/span><\/span><\/p>\n

          [25] Broad Institute \u5b98\u7f51https:\/\/www.broadinstitute.org<\/span><\/span><\/p>\n

          [26] \u300aNature Methods\u300b\uff1aBroad Institute \u53d1\u5e03\u7684\u5168\u57fa\u56e0\u7ec4\u5c3a\u5ea6\u7ec6\u80de\u5f62\u6001\u5b66\u56fe\u8c31https:\/\/www.nature.com\/articles\/s41592-025-02753-9<\/span><\/span><\/p>\n

          [27] CZI \u865a\u62df\u7ec6\u80de\u4e0e\u5f00\u653e\u6a21\u578b\u5e73\u53f0https:\/\/virtualcellmodels.cziscience.com\/<\/span><\/span><\/p>\n

          [28] CZI\uff1a\u5341\u4ebf\u7ec6\u80de\u8ba1\u5212\u4e0e\u6570\u636e\u96c6https:\/\/chanzuckerberg.com\/newsroom\/czi-datasets-gen-stat-coverage<\/span><\/span><\/p>\n

          [29] Insitro \u5b98\u7f51https:\/\/www.insitro.com\/<\/span><\/span><\/p>\n

          [30] Recursion \u5b98\u7f51https:\/\/www.recursion.com\/<\/span><\/span><\/p>\n

          [31] NVIDIA \u535a\u5ba2\uff1aRecursion \u8d85\u7ea7\u8ba1\u7b97\u4e0e\u836f\u7269\u53d1\u73b0https:\/\/blogs.nvidia.com\/blog\/drug-discovery-recursion-supercomputer\/<\/span><\/span><\/p>\n

          [32] Cellarity \u5b98\u7f51https:\/\/cellarity.com\/<\/span><\/span><\/p>\n

          [33] Tahoe Therapeutics \u65b0\u95fb\uff1a\u878d\u8d443000\u4e07\u7f8e\u5143\u6269\u5c55\u81f310\u4ebf\u5355\u7ec6\u80dehttps:\/\/www.tahoebio.ai\/news\/tahoe-therapeutics-raises-30m<\/span><\/span><\/p>\n

          [34] Isomorphic Labs \u516c\u53f8\u5b98\u7f51https:\/\/www.isomorphiclabs.com\/<\/span><\/span><\/p>\n

          [35] \u300aNature\u300b\u8bc4\u8bba\uff1aCan AI build a virtual cell? Scientists race to model life\u2019s smallest unithttps:\/\/www.nature.com\/articles\/d41586-025-02011-0<\/span><\/span><\/p>\n

          [36] Arc \u65b0\u95fb\uff1aVirtual Cell Model \u2013 STATEhttps:\/\/arcinstitute.org\/news\/virtual-cell-model-state<\/span><\/span><\/p>\n

          [37] \u300aCell Research\u300b\u8bc4\u8bba\uff1aGrow AI virtual cells: three data pillars and closed-loop learninghttps:\/\/www.nature.com\/articles\/s41422-025-01101-y<\/span><\/span><\/p>\n

          [38] Virtual Cells: Predict, Explain, Discover\uff08Valence Labs\/Recursion\uff09https:\/\/arxiv.org\/abs\/2505.14613<\/span><\/span><\/p>\n

          [39] ARK Invest \u62a5\u544a\uff1aBig Ideas 2025https:\/\/www.nikkoam.com.hk\/files\/sp\/ark\/pdf\/2502_ark_big_ideas.pdf<\/span><\/span><\/p>\n

          [40] CPA \u6a21\u578b\u95ed\u73af\u9a8c\u8bc1https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10258562\/<\/span><\/span><\/p>\n

          [41] NeurIPS 2023 Competition\uff1aOpen Problems in Single-Cell Analysishttps:\/\/neurips.cc\/virtual\/2023\/competition\/66586<\/span><\/span><\/p>\n

          [42] Arc Institute Nianzhen Li\u5173\u4e8e\u5f00\u53d1\u865a\u62df\u7ec6\u80de\u5b9e\u9a8c\u5e73\u53f0\u7684\u5206\u4eab<\/span><\/span><\/p>\n

          https:\/\/arcinstitute.org\/news\/nianzhen-li-virtual-cell-experimental-platform<\/span><\/span><\/p>\n

          [43] Arc Institute Yusuf Roohani \u5173\u4e8e\u865a\u62df\u7ec6\u80de\u67b6\u6784\u8bbe\u8ba1\u7684\u5206\u4eabhttps:\/\/arcinstitute.org\/news\/yusuf-roohani-virtual-cell-architecture<\/span><\/span><\/span><\/p>\n


          <\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n

          \u53c2\u8003\u6587\u732e\u53ef<\/span>\u4e0a\u4e0b\u6ed1\u52a8<\/span><\/strong>\u67e5\u770b<\/span><\/p>\n<\/section>\n<\/section>\n

          \n

          <\/span><\/section>\n
          \n

          <\/span><\/span><\/strong><\/span><\/section>\n
          \n
          \n
          \n
          \n

          \u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a<\/span><\/strong><\/p>\n

          \u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/span><\/strong>
          <\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


          <\/span><\/section>\n

          \u5728\u751f\u7269\u5b66\u4e2d\u5fc3\u6cd5\u5219\u7684\u8d77\u70b9\uff0c\u57fa\u56e0\u4f5c\u4e3a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u9057\u4f20\u4fe1\u606f\u8f7d\u4f53\uff0c\u5728\u751f\u547d\u5468\u671f\u5185\u7a33\u5b9a\u5b58\u5728\uff1b\u800c\u4f4d\u4e8e\u4e2d\u5fc3\u6cd5\u5219\u672b\u7aef\u7684\u86cb\u767d\u8d28\uff0c\u5176\u7ec4\u7ec7\u6784\u6210\u548c\u65f6\u7a7a\u53d8\u5316\u7684\u590d\u6742\u6027\u5448\u6307\u6570\u5f0f\u589e\u957f\u3002\u968f\u7740\u5206\u5b50\u751f\u7269\u5b66\u6570\u5341\u5e74\u6765\u7684\u7a81\u98de\u731b\u8fdb\uff0c\u5c24\u5176\u662f\u751f\u547d\u7ec4\u5b66\uff08\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7b49\u7684\u96c6\u5408\uff09\u7b49\u9886\u57df\u7684\u65e5\u65b0\u6708\u5f02\uff0c\u5f53\u4ee3\u751f\u547d\u79d1\u5b66\u4e34\u8fd1\u7206\u53d1\u7684\u8fb9\u7f18\u3002\u5982\u6b64\u6d77\u91cf\u7684\u6570\u636e\u5982\u4f55\u5e2e\u52a9\u6211\u4eec\u63ed\u793a\u5b87\u5b99\u4e2d\u6700\u590d\u6742\u7684\u7269\u8d28\u7cfb\u7edf\u2014\u2014\u201c\u4eba\u4f53\u201d\u7684\u6784\u6210\u539f\u7406\u548c\u8bbe\u8ba1\u539f\u7406\uff1f\u9610\u91ca\u4eba\u7c7b\u53d1\u80b2\u3001\u8870\u8001\u548c\u91cd\u5927\u75be\u75c5\u7684\u53d1\u751f\u673a\u5236\uff1f<\/span><\/span><\/p>\n


          <\/span><\/span><\/p>\n

          \u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u7406\u5b66\u9662\u53ca\u4ea4\u53c9\u79d1\u5b66\u4e2d\u5fc3\u8bb2\u5e2d\u6559\u6388\u6c64\u96f7\u7ff0\uff0c\u56fd\u5bb6\u86cb\u767d\u8d28\u79d1\u5b66<\/span><\/span>\u4e2d\u5fc3\uff08\u5317\u4eac\uff09\u526f\u7814\u7a76\u5458\u5e38\u4e58\u3001\u674e\u6768\uff0c\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\u52a9\u7406\u6559\u6388\u5510\u4e7e\u5143\uff0c\u5317\u4eac\u5927\u5b66\u524d\u6cbf\u4ea4\u53c9\u5b66\u79d1\u7814\u7a76\u9662\u7814\u7a76\u5458\u6797\u4e00\u701a\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5206\u5b50\u7ec6\u80de\u79d1\u5b66\u5353\u8d8a\u521b\u65b0\u4e2d\u5fc3\u535a\u58eb\u540e\u5510\u8bd7\u5a55\uff0c\u5171\u540c\u53d1\u8d77<\/span><\/span>\u300c\u751f\u547d\u590d\u6742\u6027\uff1a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406\u300d\u8bfb\u4e66\u4f1a<\/a><\/span>\uff0c\u4ece\u5fae\u89c2\u7ec6\u80de\u5c3a\u5ea6\u3001\u4ecb\u89c2\u7ec4\u7ec7\u5668\u5b98\u5c3a\u5ea6\u5230\u5b8f\u89c2\u4eba\u4f53\u5c3a\u5ea6\uff0c\u68b3\u7406\u751f\u547d\u79d1\u5b66\u9886\u57df\u4e2d\u7684\u91cd\u8981\u95ee\u9898\u53ca\u91cd\u8981\u6570\u636e\uff0c\u7531\u751f\u7269\u5b66\u5bb6\u63d0\u95ee\uff0c\u5e0c\u671b\u4fc3\u8fdb\u7edf\u8ba1\u7269\u7406\u3001\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u7814\u7a76\u8005\u548c\u751f\u547d\u79d1\u5b66\u7814\u7a76\u8005\u4e4b\u95f4\u7684\u6df1\u5ea6\u4ea4\u6d41\uff0c\u5efa\u7acb\u8de8\u5b66\u79d1\u5408\u4f5c\u5173\u7cfb\uff0c\u6fc0\u53d1\u65b0\u7684\u7814\u7a76\u601d\u8def\u548c\u5408\u4f5c\u9879\u76ee\u3002\u8bfb\u4e66\u4f1a\u76ee\u524d\u5171\u8fdb\u884c10\u671f\uff0c\u73b0\u5728\u62a5\u540d\u53c2\u4e0e\u8bfb\u4e66\u4f1a\u53ef\u4ee5\u52a0\u5165\u8bfb\u4e66\u4f1a\u793e\u7fa4\uff0c\u89c2\u770b\u89c6\u9891\u56de\u653e\uff0c\u89e3\u9501\u5b8c\u6574\u8bfb\u4e66\u4f1a\u6743\u9650\u3002<\/span><\/span><\/p>\n


          <\/span><\/span><\/section>\n
          \"\u56fe\u7247\"<\/span><\/a><\/span><\/strong><\/span><\/section>\n

          <\/span><\/span><\/section>\n
          \u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/span><\/section>\n
          \u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a\u4ece\u5fae\u89c2\u5230\u5b8f\u89c2\uff0c\u591a\u5c3a\u5ea6\u89c6\u89d2\u63a2\u7d22\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/a><\/span><\/span>
          <\/span><\/section>\n


          <\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


          <\/span><\/p>\n

          \u63a8\u8350\u9605\u8bfb<\/span><\/span><\/strong><\/strong><\/strong><\/section>\n
          <\/strong><\/section>\n
          1. \u6253\u5f00AI\u9ed1\u7bb1\uff1a\u5982\u4f55\u7528\u5f52\u56e0\u56fe\u7ed8\u5236\u5927\u8bed\u8a00\u6a21\u578b\u7684\u8111\u56de\u8def\uff1f<\/span><\/a><\/span><\/strong>
          <\/span><\/strong><\/span><\/section>\n
          2. \u4ece\u5f52\u56e0\u56fe\u5230 AI \u7684\u201c\u751f\u7269\u5b66\u201d\uff1a\u63a2\u7d22\u5927\u8bed\u8a00\u6a21\u578b\u7684\u5185\u90e8\u673a\u5236\u300c\u4e0a\u300d<\/span><\/a><\/span><\/strong>
          <\/span><\/strong><\/span><\/section>\n
          3. \u4ece\u5f52\u56e0\u56fe\u5230 AI \u7684\u201c\u751f\u7269\u5b66\u201d\uff1a\u63a2\u7d22 Claude3.5 Haiku \u7684\u5185\u90e8\u673a\u5236\u300c\u4e2d\u300d<\/span><\/a><\/span><\/strong><\/section>\n
          <\/strong><\/section>\n
          4. <\/span>\u6d8c\u73b0\u52a8\u529b\u5b66\u5982\u4f55\u7528\u6765\u5206\u6790\u590d\u6742\u7cfb\u7edf\uff1f | \u65b0\u8bfe\u4e0a\u7ebf<\/span><\/a><\/span><\/strong><\/span>
          <\/span><\/strong><\/strong><\/span><\/section>\n
          <\/strong>5. <\/span><\/strong>\u96c6\u667a\u5b66\u56ed\u7cbe\u54c1\u8bfe\u7a0b\u514d\u8d39\u5f00\u653e\uff0c\u89e3\u9501\u7cfb\u7edf\u79d1\u5b66\u4e0e AI \u65b0\u4e16\u754c<\/span><\/a><\/span><\/strong><\/section>\n

          6. \u9ad8\u8003\u5206\u6570\u53ea\u662f\u5f20\u5165\u573a\u5238\uff0c\u4f60\u7684\u79d1\u7814\u5192\u9669\u5728\u8fd9\u91cc\u542f\u822a\uff01<\/span><\/a><\/span><\/strong><\/p>\n

          7. <\/span><\/span><\/strong><\/strong><\/span>\u7cfb\u7edf\u79d1\u5b66\u524d\u6cbf\u5341\u8bb2\uff1a\u7406\u89e3\u81ea\u7136\u3001\u751f\u547d\u4e0e\u793e\u4f1a\u7684\u590d\u6742\u6027<\/span><\/a><\/span><\/strong><\/strong><\/span><\/p>\n


          <\/span><\/p>\n


          <\/span><\/span><\/p>\n

          \u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/span><\/span><\/section>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

          \u5bfc\u8bed AI\u865a\u62df\u7ec6\u80de\uff08AIVC\uff09\u65e8\u5728\u501f\u52a9\u6d77\u91cf\u751f\u7269\u6570\u636e\u4e0eAI\u6a21\u578b\uff0c\u7cbe\u786e\u6a21\u62df\u7ec6\u80de\u5728\u5404\u79cd\u57fa\u56e0\u6216\u836f\u7269\u6270\u52a8\u4e0b\u7684\u54cd\u5e94\u72b6\u6001\u3002\u6700\u8fd1\u4e24\u5e74\uff0cAIVC\u6b63\u5feb\u901f\u6e17\u900f\u5230\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u836f\u7814\u53d1\u9886\u57df\uff0c\u4f46\u4ecd\u9762\u4e34\u6570\u636e\u7c7b\u578b\u7e41\u6742\u3001\u6a21\u578b\u96be\u4ee5\u6cdb\u5316\u3001\u7f3a\u4e4f\u7edf\u4e00\u6807\u51c6\u7b49\u5236\u7ea6\u30022025\u5e746\u6708\uff0cArc Institute\u53d1\u8d77\u9996\u5c4a\u201c\u865a\u62df\u7ec6\u80de\u6311\u6218\u8d5b\u201d\uff0c\u901a\u8fc7\u6784\u5efa\u7edf\u4e00…<\/p>\n","protected":false},"author":0,"featured_media":63740,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/63753"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=63753"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/63753\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/63740"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=63753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=63753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=63753"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=63753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}