{"id":63992,"date":"2025-08-30T19:15:23","date_gmt":"2025-08-30T11:15:23","guid":{"rendered":"https:\/\/swarma.org\/?p=63992"},"modified":"2025-08-30T19:15:23","modified_gmt":"2025-08-30T11:15:23","slug":"ai%e9%a9%b1%e5%8a%a8%e7%9a%84%e8%9b%8b%e7%99%bd%e8%b4%a8%e7%a0%94%e7%a9%b6%e9%97%ad%e7%8e%af%ef%bc%9a%e7%bb%93%e6%9e%84%e3%80%81%e5%8a%9f%e8%83%bd%e3%80%81%e8%ae%be%e8%ae%a1%e7%9a%84%e8%9e%8d%e5%90%88","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=63992","title":{"rendered":"AI\u9a71\u52a8\u7684\u86cb\u767d\u8d28\u7814\u7a76\u95ed\u73af\uff1a\u7ed3\u6784\u3001\u529f\u80fd\u3001\u8bbe\u8ba1\u7684\u878d\u5408\u8fdb\u5c55"},"content":{"rendered":"
\n
\n
\n
\n
\n
\n
\n
\n
\n
<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n

<\/span><\/section>\n<\/section>\n
\n
\n

\u5bfc\u8bed<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

<\/strong>\u86cb\u767d\u8d28\u7814\u7a76\u6b63\u5904\u4e8e\u4e00\u573a\u7531AI\u9a71\u52a8\u7684\u6df1\u523b\u53d8\u9769\u4e4b\u4e2d\u3002\u4ece\u7ed3\u6784\u9884\u6d4b\u3001\u529f\u80fd\u89e3\u6790\u5230\u4ece\u5934\u8bbe\u8ba1\uff0cAI\u5de5\u5177\u7684\u5e7f\u6cdb\u5e94\u7528\u663e\u8457\u62d3\u5c55\u4e86\u86cb\u767d\u8d28\u79d1\u5b66\u63a2\u7d22\u7684\u6df1\u5ea6\u4e0e\u5e7f\u5ea6\u3002\u4ee5AlphaFold\u4e3a\u4ee3\u8868\u7684\u524d\u6cbf\u6a21\u578b\u5f00\u521b\u4e86\u86cb\u767d\u8d28\u7814\u7a76\u7684\u65b0\u8303\u5f0f\uff0c\u800c\u56fd\u5185\u4f17\u591a\u56e2\u961f\u7684\u8fc5\u901f\u5d1b\u8d77\u5219\u8fdb\u4e00\u6b65\u63a8\u52a8\u4e86\u6570\u636e-\u6a21\u578b-\u5b9e\u9a8c\u95ed\u73af\u7684\u9ad8\u6548\u5f62\u6210\u3002<\/span><\/span><\/strong><\/p>\n


<\/span><\/span><\/strong><\/p>\n

\u5728\u8fd1\u671f\u7684\u300cAI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b\u5b66\u7814\u8ba8\u4f1a\u300d<\/a>\u4e2d\uff0c\u86cb\u767d\u8d28\u7814\u7a76\u6b63\u662f\u5206\u5b50\u5c3a\u5ea6\u4e0a\u6700\u5177\u6d3b\u529b\u7684\u65b9\u5411\u4e4b\u4e00\u3002\u672c\u6587\u5c06\u805a\u7126AI\u5728\u86cb\u767d\u8d28\u9886\u57df\u7684\u524d\u6cbf\u8fdb\u5c55\u4e0e\u4ee3\u8868\u6027\u6210\u679c\uff0c\u6df1\u5165\u63a2\u8ba8\u5168\u7403\u7279\u522b\u662f\u56fd\u5185\u56e2\u961f\u7684\u521b\u65b0\u7a81\u7834\uff0c\u5c55\u671b\u8ba1\u7b97\u533b\u5b66\u65f6\u4ee3\u86cb\u767d\u8d28\u7814\u7a76\u7684\u672a\u6765\u8def\u5f84\u4e0e\u5e94\u7528\u524d\u666f\u3002<\/span><\/span><\/strong><\/p>\n


<\/span><\/p>\n

\u5173\u952e\u8bcd\uff1a\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\uff0c\u529f\u80fd\u89e3\u6790\uff0c\u4ece\u5934\u8bbe\u8ba1\uff0c\u751f\u6210\u5f0fAI\uff0c\u5206\u5b50\u4e92\u4f5c\u5efa\u6a21\uff0c\u5b9a\u5411\u8fdb\u5316\u6a21\u578b<\/span><\/strong><\/strong><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\"\u56fe\u7247\"<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u90ed\u745e\u4e1c\u4e28\u4f5c\u8005<\/span><\/span>
<\/span><\/p>\n

\u5218\u57f9\u6e90\u4e28\u7f16\u8f91<\/span><\/span><\/p>\n


<\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u86cb\u767d\u8d28\u662f\u751f\u547d\u6d3b\u52a8\u4e2d\u7684\u201c\u57fa\u5c42\u6253\u5de5\u4eba\u201d\u3002\u4eceDNA\u8fd9\u4e2a\u201c\u5927\u9886\u5bfc\u201d\u90a3\u91cc\u9886\u5230\u4efb\u52a1\u540e\uff0c\u518d\u7ecf\u8fc7RNA\u8fd9\u4e00\u201c\u4e2d\u5c42\u201d\u7684\u8f6c\u5f55\u3001\u7ffb\u8bd1\u548c\u4fee\u9970\uff0c\u6700\u7ec8\u6240\u6709\u5177\u4f53\u7684\u5de5\u4f5c\u90fd\u8981\u9760\u86cb\u767d\u8d28\u6765\u5b8c\u6210\u3002\u5728\u5de8\u5927\u538b\u529b\u4e0b\uff0c\u86cb\u767d\u8d28\u4e5f\u4e0d\u5f97\u4e0d\u201c\u5377\u8d77\u6765\u201d\uff1a\u5373\u4f7f\u662f\u76f8\u540c\u6c28\u57fa\u9178\u5e8f\u5217\u7684\u86cb\u767d\u8d28\uff0c\u4e5f\u53ef\u80fd\u5448\u73b0\u4e0d\u540c\u7684\u7ed3\u6784\uff0c\u5e76\u4e0e\u5176\u4ed6\u86cb\u767d\u6216RNA\u4e92\u4f5c\u3002\u800c\u4e00\u65e6\u86cb\u767d\u8d28\u201c\u7f62\u5de5\u201d\uff0c\u6211\u4eec\u7684\u5065\u5eb7\u4e5f\u4f1a\u968f\u4e4b\u53d7\u5230\u5a01\u80c1\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u5c31\u50cf\u6253\u5de5\u4eba\u603b\u6709\u5404\u79cd\u201c\u6478\u9c7c\u6280\u5de7\u201d\uff0c\u86cb\u767d\u8d28\u7684\u6d3b\u52a8\u65b9\u5f0f\u4e5f\u5e76\u975e\u7b80\u5355\u56fa\u5b9a\u3002\u4ee5\u5f80\u7814\u7a76\u8005\u53ea\u80fd\u7528\u51b7\u51bb\u7535\u955c\u7b49\u6602\u8d35\u4e14\u5468\u671f\u957f\u7684\u5b9e\u9a8c\u624b\u6bb5\uff0c\u4e00\u70b9\u70b9\u79ef\u7d2f\u5bf9\u86cb\u767d\u8d28\u7684\u4e86\u89e3\uff0c\u800cAI\u7684\u51fa\u73b0\u5219\u4e3a\u86cb\u767d\u8d28\u7814\u7a76\u6309\u4e0b\u4e86\u52a0\u901f\u952e\u3002\u672c\u6587\u5c06\u4ece\u7ed3\u6784\u89e3\u6790\u3001\u529f\u80fd\u9884\u6d4b\u518d\u5230\u86cb\u767d\u8bbe\u8ba1\uff0c<\/span><\/span><\/span>\u68b3\u7406AI\u9a71\u52a8<\/span><\/span><\/span>\u86cb\u767d\u8d28<\/span><\/span><\/span>\u7814\u7a76\u7684<\/span><\/span><\/span>\u524d\u6cbf\u8fdb\u5c55\uff0c<\/span><\/span><\/span>\u5e76\u5173\u6ce8\u56fd\u5185\u56e2\u961f\u7684\u4ee3\u8868\u6027\u5de5\u4f5c<\/span><\/span><\/span>\u3002<\/span><\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\n
\n
\n
\n
\n

<\/span><\/section>\n

<\/span><\/section>\n
\n
<\/section>\n<\/section>\n<\/section>\n
\n

1. \u4eceAlphaFold<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n

\u5230\u767e\u82b1\u9f50\u653e\u7684\u56fd\u4ea7\u7ed3\u6784\u9884\u6d4b\u6a21\u578b<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/span><\/span><\/p>\n

2024\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u6388\u4e88\u4e86\u5f00\u53d1AlphaFold\u7684John Jumper\u548cDemis Hassabis\uff0c\u4ee5\u53ca\u86cb\u767d\u8d28\u8bbe\u8ba1\u9886\u57df\u7684\u5148\u9a71David Baker\u3002\u5728\u4ee5AlphaFold\u4e3a\u4ee3\u8868\u7684\u7ed3\u6784\u9884\u6d4b\u6a21\u578b\u51fa\u73b0\u4e4b\u524d\uff0c\u5168\u7403\u7ed3\u6784\u751f\u7269\u5b66\u754c\u901a\u8fc7\u5b9e\u9a8c\u624b\u6bb5\u9a8c\u8bc1\u7684\u86cb\u767d\u8d28\u7ed3\u6784<\/span>\uff08\u8bb0\u5f55\u5728\u86cb\u767d\u8d28\u6570\u636e\u5e93PDB\u4e2d\uff0c\u622a\u81f32024\u5e747\u670821\u65e5\uff09<\/span>\u4e0d\u8db324\u4e07\u4e2a\uff1b\u800cAlphaFold\u6570\u636e\u5e93<\/span>\uff08AlphaFold Database\uff0cAFDB\uff09<\/span>\u63d0\u4f9b\u4e86\u6db5\u76d6\u4ece\u7ec6\u83cc\u5230\u4eba\u7c7b\u7b49\u591a\u4e2a\u7269\u79cd\u7684\u8d85\u8fc72\u4ebf\u4e2a\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u6570\u636e\uff0c\u4ec5\u4ece\u8fd9\u4e00\u6570\u91cf\u5bf9\u6bd4\u5c31\u80fd\u770b\u5230AlphaFold\u7684\u9769\u547d\u6027\u6240\u5728\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

2024 \u5e74\u63a8\u51fa\u7684 AlphaFold 3[1]\uff0c\u4e8e 2024 \u5e74 11 \u6708\u5bf9\u5b66\u672f\u7528\u9014\u5f00\u653e\u4e86\u4ee3\u7801\u4e0e\u6743\u91cd<\/span>\uff08\u975e\u5546\u7528\u8bb8\u53ef\uff0c\u975e\u5b8c\u5168\u5f00\u6e90\uff09<\/span>\uff0c\u5e76\u63d0\u4f9b AlphaFold Server \u5728\u7ebf\u4f7f\u7528\u3002<\/span><\/span><\/span>\u5176\u91c7\u53d6\u4e86\u6269\u6563\u6a21\u578b\uff0c\u80fd\u505a\u5230\u4e0d\u4ec5\u4ec5\u9884\u6d4b\u86cb\u767d\u8d28\u5728\u81ea\u7136\u72b6\u6001\u4e0b\u7684\u9759\u6001\u7ed3\u6784\uff0c\u8fd8\u80fd\u591f\u9884\u6d4b\u5305\u62ecRNA\uff0c\u5c0f\u5206\u5b50<\/span>\uff08\u4f8b\u5982<\/span><\/span><\/span>\u86cb\u767d\u8d28-\u914d\u4f53\u7ed3\u5408\u3001\u6297\u539f-\u6297\u4f53\u590d\u5408\u7269<\/span><\/span><\/span>\uff09<\/span>\u7684\u7ed3\u6784\uff0c\u6807\u5fd7\u7740<\/span><\/span><\/span>AI\u9a71\u52a8\u7684\u7ed3\u6784\u9884\u6d4b\u4ece\u5355\u4e00\u86cb\u767d\u8d28\u5411\u591a\u5206\u5b50\u4e92\u4f5c\u7f51\u7edc\u7684\u8303\u5f0f\u8f6c\u53d8<\/span><\/span><\/span>\uff0c\u8fd9\u4e5f\u610f\u5473\u7740\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u5c06\u66f4\u4e3a\u5b9e\u7528\u3002<\/span><\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/span><\/p>\n

\u7528\u4e00\u4e2a\u5f62\u8c61\u7684\u6bd4\u55bb\u8bf4\u660eAlphaFold2\u5230AlphaFold3\u7684\u8fdb\u6b65\uff1aAlphaFold2\u76f8\u5f53\u4e8e\u4e3a\u86cb\u767d\u8d28\u62cd\u6444\u4e86\u4e00\u5f20\u201c\u8bc1\u4ef6\u7167\u201d\uff0c\u4f46\u86cb\u767d\u8d28\u771f\u6b63\u5de5\u4f5c\u65f6\u8fd8\u9700\u8981\u4e0e\u5176\u4ed6\u5206\u5b50\u534f\u540c\u914d\u5408\uff0c\u800cAlphaFold3\u5219\u80fd\u9884\u6d4b\u86cb\u767d\u8d28\u5de5\u4f5c\u65f6\u4e0e\u5176\u4ed6\u201c\u540c\u4e8b\u201d\u7684\u201c\u5408\u5f71\u201d\u3002\u4e0d\u8fc7\uff0c\u86cb\u767d\u8d28\u5728\u7ec6\u80de\u4e2d\u59cb\u7ec8\u5904\u4e8e\u52a8\u6001\u7684\u53d8\u5316\u4e4b\u4e2d\uff0c\u836f\u7269\u5206\u5b50\u80fd\u5426\u4e0e\u7279\u5b9a\u86cb\u767d\u7ed3\u5408\uff0c\u5f80\u5f80\u53d6\u51b3\u4e8e\u80fd\u5426\u6355\u6349\u86cb\u767d\u8d28\u67d0\u4e2a\u7a0d\u7eb5\u5373\u901d\u7684\u52a8\u6001\u6784\u8c61\uff0c\u8fd9\u5c31\u8981\u6c42\u8fdb\u4e00\u6b65\u4e3a\u86cb\u767d\u8d28\u62cd\u6444\u201c\u89c6\u9891\u201d\uff0c\u800c\u8fd9\u6b63\u662f\u63a5\u4e0b\u6765\u4ecb\u7ecd\u7684\u56fd\u4ea7\u9884\u6d4b\u6a21\u578b\u7684\u7814\u7a76\u91cd\u70b9\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u5728\u7ed3\u6784\u9884\u6d4b\u9886\u57df\uff0c\u591a\u4e2a\u56fd\u5185\u56e2\u961f<\/span><\/span><\/span>\u7ade\u76f8\u8ffd\u8d76<\/span><\/span><\/span>\u30022025\u5e743\u6708\uff0c\u5317\u4eac\u667a\u6e90\u4eba\u5de5\u667a\u80fd\u7814\u7a76\u9662\u63a8\u51fa\u4e86\u65b0\u4e00\u4ee3\u7684OpenComplex-2<\/span><\/span><\/span> [2]<\/span><\/span><\/span>\uff0c\u5176\u524d\u4f5c\u66fe\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u6743\u5a01\u7ade\u8d5bCAMEO\u4e2d\u7a33\u5b9a\u53d6\u5f97\u9886\u5148\u6210\u7ee9\u3002\u65b0\u4e00\u4ee3\u7684OpenComplex-2\u5728\u529f\u80fd\u4e0a\u6db5\u76d6\u4e86\u5355\u4f53\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u3001\u590d\u5408\u7269\u5efa\u6a21<\/span>\uff08\u591a\u94fe\u590d\u5408\u7269\u7ed3\u6784\u9884\u6d4b\uff09<\/span>\u3001\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528<\/span>\uff08RNA\u53ca\u86cb\u767d\u8d28-RNA\u590d\u5408\u7269\uff09<\/span>\u9884\u6d4b\u4ee5\u53ca\u67d4\u6027\u5bf9\u63a5\uff0c\u80fd\u5728\u539f\u5b50\u5206\u8fa8\u7387\u5c42\u9762\u6355\u6349\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u53ca\u5176\u5e73\u8861\u6784\u8c61\u3002\u6b64\u5916\uff0cOpenComplex-2\u7684\u8ba1\u7b97\u6548\u7387\u76f8\u6bd4AlphaFold\u66f4\u9ad8\uff0c\u6240\u9700\u7684\u8ba1\u7b97\u8d44\u6e90\u4e5f\u66f4\u5c11\u3002<\/span><\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe1\uff1aOpenComplex\u6a21\u578b\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u6743\u5a01\u7ade\u8d5bCAMEO\u4e2d\u7684\u6210\u7ee9<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u767e\u5ea6\u98de\u6868\u56e2\u961f\u4e8e2025\u5e747\u6708\u63d0\u51fa\u4e86HelixFold-S1[3]\uff0c\u501f\u9274\u4e86\u5927\u8bed\u8a00\u6a21\u578b\u9886\u57df\u7684test-time scaling\u7b56\u7565\uff0c\u91c7\u7528\u4e86\u4e00\u79cd\u57fa\u4e8e\u63a5\u89e6\u611f\u77e5\u7684\u91c7\u6837\u65b9\u6cd5\uff0c\u80fd\u591f\u6709\u6548\u9884\u6d4b\u4e24\u4e2a\u86cb\u767d\u8d28\u5206\u5b50\u5982\u4f55\u7ed3\u5408\u3002\u5177\u4f53\u800c\u8a00\uff0cHelixFold-S1\u4f1a\u9996\u5148\u9884\u6d4b\u4e24\u4e2a\u86cb\u767d\u8d28\u53ef\u80fd\u5728\u54ea\u4e2a\u533a\u57df\u3001\u4ee5\u4f55\u79cd\u65b9\u5f0f\u7ed3\u5408\uff0c\u968f\u540e\u518d\u4f18\u5148\u63a2\u7d22\u5177\u6709\u9ad8\u7ed3\u5408\u6f5c\u529b\u7684\u533a\u57df\uff0c\u901a\u8fc7\u201c\u5148\u9501\u5b9a\u76ee\u6807\uff0c\u518d\u7cbe\u51c6\u5efa\u6a21\u201d\u7684\u65b9\u5f0f\uff0c\u6709\u6548\u5f15\u5bfc\u4e86\u7ed3\u6784\u751f\u6210\u8fc7\u7a0b\uff0c\u663e\u8457\u63d0\u9ad8\u4e86\u590d\u6742\u573a\u666f\u4e0b\u9884\u6d4b\u7684\u51c6\u786e\u7387\u548c\u6548\u7387\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe2\uff1aHelixFold-S1\uff08HF-S1\uff09\u6a21\u578b\u76f8\u6bd4\u6b64\u524d\u7684HF3\u53ca\u5176\u4ed6\u6a21\u578b\uff0c\u5728\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u5bf9\u63a5\u8d28\u91cf\u8bc4\u4f30\u6307\u6807DockQ\u4e0a\u7684\u8868\u73b0<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u5357\u5f00\u5927\u5b66\u7edf\u8ba1\u4e0e\u6570\u636e\u79d1\u5b66\u5b66\u9662\u90d1\u4f1f\u6559\u6388\u56e2\u961f\u4e0e\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5408\u4f5c\uff0c\u4e8e2025\u5e74\u5728<\/span>Nature Biotechnology <\/span>\u53d1\u8868\u4e86D-I-TASSER\u6a21\u578b[4]\u3002\u8be5\u6a21\u578b\u878d\u5408\u4e86\u6df1\u5ea6\u5b66\u4e60\u4e0e\u7edf\u8ba1\u7269\u7406\u80fd\u91cf\u51fd\u6570\u529b\u573a\uff0c\u80fd\u591f\u5728\u539f\u5b50\u7ea7\u7cbe\u5ea6\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u86cb\u767d\u8d28\u7ed3\u6784\u57df<\/span>\uff08Domain\uff09<\/span>\u662f\u590d\u6742\u86cb\u767d\u8d28\u4e09\u7ea7\u7ed3\u6784\u4e2d\u7684\u57fa\u672c\u6298\u53e0\u548c\u529f\u80fd\u5355\u5143\uff0c\u5927\u7ea660%\u7684\u539f\u6838\u751f\u7269\u86cb\u767d\u8d28\u548c80%\u7684\u771f\u6838\u751f\u7269\u86cb\u767d\u8d28\u90fd\u7531\u591a\u4e2a\u7ed3\u6784\u57df<\/span>\uff08Multi-domain\uff09<\/span>\u7ec4\u6210\uff0c\u5e76\u4e14\u4f9d\u8d56\u7ed3\u6784\u57df\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u6765\u5b9e\u73b0\u66f4\u590d\u6742\u7684\u751f\u7269\u5b66\u529f\u80fd\u3002\u76ee\u524d\u5927\u90e8\u5206\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u5de5\u5177\u53ea\u805a\u7126\u4e8e\u5355\u4e2a\u7ed3\u6784\u57df\uff0c\u8fd9\u76f8\u5f53\u4e8e\u53ea\u80fd\u7ed9\u86cb\u767d\u8d28\u62cd\u6444\u201c\u534a\u8eab\u7167\u201d\uff0c\u800cD-I-TASSER\u5219\u80fd\u591f\u6355\u6349\u5b8c\u6574\u86cb\u767d\u8d28\u7684\u5168\u57df\u7ed3\u6784\uff0c\u5982\u540c\u62cd\u6444\u201c\u5168\u8eab\u7167\u201d\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe3\uff1a\u4e00\u4e2a\u542b\u6709\u591a\u4e2a\u7ed3\u6784\u57df\uff08\u51713\u4e2a\u7ed3\u6784\u57df\uff09\u7684\u86cb\u767d\u8d28\u5355\u4f53\u793a\u610f\u56fe\uff0c\u4e0d\u540c\u7ed3\u6784\u57df\u4ee5\u4e0d\u540c\u989c\u8272\u6807\u8bb0<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

TCR<\/span>\uff08T\u7ec6\u80de\u53d7\u4f53\uff09<\/span>\u662f\u514d\u75ab\u7ec6\u80deT\u7ec6\u80de\u7528\u4e8e\u6297\u539f\u8bc6\u522b\u548c\u514d\u75ab\u5e94\u7b54\u7684\u91cd\u8981\u53d7\u4f53\uff0c\u76f8\u5f53\u4e8e\u514d\u75ab\u7cfb\u7edf\u7684\u201c\u654c\u6211\u8bc6\u522b\u201d\u673a\u5236\u3002\u5408\u7406\u5730\u8bbe\u8ba1TCR\u7684\u4eb2\u548c\u529b\uff0c\u5bf9\u4e8e\u75ab\u82d7\u5f00\u53d1\u3001\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u548c\u764c\u75c7\u6cbb\u7597\u81f3\u5173\u91cd\u8981\u3002\u817e\u8bafAI Lab\u3001\u6e05\u534e\u5927\u5b66\u6df1\u5733\u56fd\u9645\u7814\u7a76\u751f\u9662\u548c\u83ab\u7eb3\u4ec0\u5927\u5b66\u5408\u4f5c\u63a8\u51fa\u4e86tFold-TCR\u6a21\u578b[5]\u3002\u4e0e\u73b0\u6709\u65b9\u6cd5<\/span>\uff08\u5305\u62ecAlphaFold 3\uff09<\/span>\u76f8\u6bd4\uff0ctFold-TCR\u5728\u9884\u6d4bTCR\u76f8\u5173\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u65f6\uff0c\u5728DockQ\u6307\u6807\u4e0b\u9884\u6d4b\u6210\u529f\u7387\u63d0\u9ad8\u4e86\u7ea630.7%\uff0c\u8ba1\u7b97\u901f\u5ea6\u4e5f\u63d0\u5347\u4e86\u8d85\u8fc725\u500d\u3002\u8fd9\u79cd\u6539\u8fdb\u5c06\u6709\u671b\u52a0\u901f\u514d\u75ab\u6cbb\u7597\u4e2d\u5bf9\u6709\u6548\u6297\u4f53\u7684\u7b5b\u9009\u8fc7\u7a0b\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\n
\n
\n
\n
\n

<\/span><\/section>\n

<\/span><\/section>\n
\n
<\/section>\n<\/section>\n<\/section>\n
\n

2. \u4ece\u7ed3\u6784\u9884\u6d4b\u5230\u529f\u80fd\u89e3\u6790<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/span><\/span><\/p>\n

\u5982\u679c\u8bf4\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u662f\u5728\u63cf\u8ff0\u86cb\u767d\u8d28\u7684\u72b6\u6001\uff0c\u90a3\u4e48\u751f\u7269\u5b66\u7814\u7a76\u8005\u6700\u7ec8\u5173\u5fc3\u7684\uff0c\u662f\u4e00\u4e2a\u7279\u5b9a\u86cb\u767d\u8d28\u80fd\u591f\u5b8c\u6210\u54ea\u4e9b\u529f\u80fd\u3002\u86cb\u767d\u8d28\u529f\u80fd\u9884\u6d4b\u7684\u5b9e\u8d28\u5728\u4e8e\u51c6\u786e\u5224\u5b9a\u672a\u77e5\u529f\u80fd\u86cb\u767d\u8d28\u4e0e\u5df2\u77e5\u529f\u80fd\u86cb\u767d\u8d28\u5728\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u529f\u80fd\u7b49\u65b9\u9762\u7684\u76f8\u4f3c\u7a0b\u5ea6\u3002\u76ee\u524d\u6700\u5e38\u7528\u7684\u529f\u80fd\u63cf\u8ff0\u65b9\u5f0f\u79f0\u4e3a\u57fa\u56e0\u672c\u4f53<\/span>\uff08Gene Ontology, GO\uff09<\/span>\uff0c\u5305\u542b\u4e86\u6570\u4e07\u4e2a\u672f\u8bed\uff0c\u6db5\u76d6\u86cb\u767d\u8d28\u5728\u7ec6\u80de\u548c\u751f\u7269\u4f53\u5185\u7684\u5404\u79cd\u529f\u80fd\u4e0e\u4f4d\u7f6e\u3002\u968f\u7740\u9ad8\u901a\u91cf\u6d4b\u5e8f\u6280\u672f\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u5df2\u77e5\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u91cf\u8fc5\u901f\u589e\u52a0\uff0c\u4f46\u76ee\u524d\u4ec5\u4e0d\u52301%\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u901a\u8fc7GO\u5206\u6790\u8fdb\u884c\u4e86\u529f\u80fd\u6ce8\u91ca\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u86cb\u767d\u8d28\u529f\u80fd\u9884\u6d4b\u65b9\u6cd5\u4e3b\u8981\u53ef\u5206\u4e3a\u4e24\u7c7b\uff0c\u5206\u522b\u662f\u57fa\u4e8e\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u65b9\u6cd5\u4e0e\u57fa\u4e8e\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u65b9\u6cd5\u3002\u7b2c\u4e00\u7c7b\u65b9\u6cd5\u7684\u4ee3\u8868\u662fDeepGO-SE<\/span><\/span><\/span><\/span>[6]\uff0c\u8be5\u65b9\u6cd5\u901a\u8fc7\u8fd1\u4f3c\u8bed\u4e49\u8574\u542b\u6765\u589e\u5f3a\u6a21\u578b\u7684\u9884\u6d4b\u80fd\u529b\u3002\u5177\u4f53\u800c\u8a00\uff0cDeepGO-SE\u9996\u5148\u5f15\u5165\u9690\u7a7a\u95f4\uff0c\u4f7f\u86cb\u767d\u8d28\u7684\u5d4c\u5165\u8868\u5f81\u80fd\u591f\u6355\u6349\u5e8f\u5217\u76f8\u4f3c\u6027\u4e4b\u5916\u7684\u66f4\u591a\u7279\u5f81\uff0c\u7136\u540e\u518d\u901a\u8fc7\u8bed\u4e49\u7684\u903b\u8f91\u5173\u7cfb\uff0c\u63a8\u5bfc\u51fa\u5f85\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u529f\u80fd\u9884\u6d4b\u7ed3\u679c\u3002\u8be5\u65b9\u6cd5\u5728\u86cb\u767d\u8d28\u529f\u80fd\u9884\u6d4b\u7684\u51c6\u786e\u6027\u4e0a\u76f8\u6bd4\u4f20\u7edf\u57fa\u7ebf\u65b9\u6cd5\u6709\u663e\u8457\u63d0\u5347\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe4\uff1aDeepGO-SE\u7684\u6570\u636e\u5904\u7406\u6d41\u7a0b\u56fe<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u4e2d\u5c71\u5927\u5b66\u674e\u654f\u6559\u6388\u56e2\u961f\u4e8e25\u5e741\u6708\u5728Nature Communications\u4e0a\u53d1\u8868\u7684DPFunc<\/span><\/span><\/span>[7]<\/span><\/span><\/span>\u662f\u57fa\u4e8e\u7ed3\u6784\u8fdb\u884c\u86cb\u767d\u529f\u80fd\u9884\u6d4b\u7684\u5de5\u5177\u3002\u8be5\u65b9\u6cd5\u4f7f\u7528\u6df1\u5ea6\u5b66\u4e60\uff0c\u901a\u8fc7\u5f15\u5165\u7ed3\u6784\u57df\u5f15\u5bfc\uff0c\u663e\u8457\u63d0\u5347\u4e86\u86cb\u767d\u8d28\u529f\u80fd\u9884\u6d4b\u7684\u51c6\u786e\u6027\u548c\u53ef\u89e3\u91ca\u6027\u3002\u76f8\u6bd4\u4e8e\u57fa\u4e8e\u5e8f\u5217\u76f8\u4f3c\u6027\u7684\u65b9\u6cd5\uff0c\u57fa\u4e8e\u7ed3\u6784\u7684\u9884\u6d4b\u65b9\u6cd5DPFunc\u5728\u9884\u6d4b\u7f55\u89c1\u529f\u80fd\u3001\u7279\u5b9a\u529f\u80fd\u4ee5\u53ca\u4f4e\u5e8f\u5217\u76f8\u4f3c\u6027\u86cb\u767d\u8d28\u65b9\u9762\u8868\u73b0\u4f18\u5f02\uff0c\u5c24\u5176\u5728\u7ed3\u6784\u57df\u4fe1\u606f\u7684\u6307\u5bfc\u4e0b\uff0c\u663e\u8457\u63d0\u5347\u4e86\u9884\u6d4b\u51c6\u786e\u6027\u3002<\/span><\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe5\uff1aDPFunc\u7684\u6a21\u578b\u67b6\u6784\uff0c\u5305\u62ec\u6b8b\u57fa\u7ea7\u7279\u5f81\u5b66\u4e60\u6a21\u5757\u548c\u86cb\u767d\u8d28\u529f\u80fd\u9884\u6d4b\u6a21\u5757<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u90a3\u4e48\uff0c\u6709\u6ca1\u6709\u4e00\u79cd\u65b9\u6cd5\u80fd\u591f\u540c\u65f6\u5229\u7528\u5e8f\u5217\u76f8\u4f3c\u6027\u548c\u7ed3\u6784\u4fe1\u606f\u6765\u9884\u6d4b\u86cb\u767d\u8d28\u529f\u80fd\u5462\uff1f\u6709\u7684\uff0c\u8fd9\u5c31\u662fProt2Text-V2[8]\u6a21\u578b\u3002Prot2Text-V2\u5c06\u56fe\u795e\u7ecf\u7f51\u7edc<\/span>\uff08Graph Neural Network, GNN\uff09<\/span>\u4e0e\u5927\u578b\u8bed\u8a00\u6a21\u578b<\/span>\uff08Large Language Model, LLM\uff09<\/span>\u878d\u5408\u5230\u540c\u4e00\u4e2a\u7f16\u7801\u5668-\u89e3\u7801\u5668\u6846\u67b6\u4e2d\uff0c\u6709\u6548\u6574\u5408\u4e86\u5305\u62ec\u86cb\u767d\u8d28\u5e8f\u5217\u3001\u7ed3\u6784\u548c\u6587\u672c\u6ce8\u91ca\u5728\u5185\u7684\u591a\u79cd\u6570\u636e\uff0c\u4ee5\u81ea\u7531\u6587\u672c\u5f62\u5f0f\u8f93\u51fa\u86cb\u767d\u8d28\u529f\u80fd\u9884\u6d4b\u7ed3\u679c\uff0c\u8d85\u8d8a\u4e86\u4f20\u7edf\u4e8c\u5206\u7c7b\u6216\u591a\u5206\u7c7b\u7684\u5c40\u9650\u3002Prot2Text-V2\u751f\u6210\u7684\u9884\u6d4b\u7ed3\u679c\uff0c\u4e0d\u518d\u662f\u7c7b\u4f3cGO\u672f\u8bed\u90a3\u6837\u7ed3\u6784\u5316\u4f46\u96be\u4ee5\u7406\u89e3\u7684\u4ee3\u7801\uff0c\u800c\u662f\u66f4\u52a0\u76f4\u89c2\u6613\u61c2\u7684\u81ea\u7136\u8bed\u8a00\u63cf\u8ff0\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe6\uff1aProt2Text-V2\u7684\u5904\u7406\u6d41\u7a0b\u793a\u610f\u56fe<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\n
\n
\n
\n
\n

<\/span><\/section>\n

<\/span><\/section>\n
\n
<\/section>\n<\/section>\n<\/section>\n
\n

3. \u4ece\u529f\u80fd\u9884\u6d4b\u5230\u86cb\u767d\u8bbe\u8ba1<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/span><\/span><\/p>\n

\u5c06\u751f\u547d\u8fc7\u7a0b\u8f6c\u5316\u4e3a\u4e00\u79cd\u5de5\u7a0b\u6d3b\u52a8\uff0c\u4f7f\u7814\u7a76\u8005\u80fd\u591f\u50cf\u5b9a\u5236\u4e50\u9ad8\u79ef\u6728\u90a3\u6837\uff0c\u6709\u8ba1\u5212\u5730\u5bf9\u86cb\u767d\u8d28\u9aa8\u67b6\u53ca\u529f\u80fd\u8fdb\u884c\u201c\u4ece\u5934<\/span>\uff08de novo\uff09<\/span>\u201d\u8bbe\u8ba1\uff0c\u662f\u86cb\u767d\u8d28\u7814\u7a76\u7684\u7ec8\u6781\u76ee\u6807\u3002\u5929\u7136\u86cb\u767d\u8d28\u53ea\u5360\u6709\u6548\u86cb\u767d\u8d28\u5e8f\u5217\u7a7a\u95f4\u7684\u4e00\u5c0f\u90e8\u5206\uff0c\u201c\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u201d\u80fd\u591f\u8df3\u8131\u81ea\u7136\u8fdb\u5316\u7684\u9650\u5236\uff0c\u4ece\u96f6\u5f00\u59cb\u62d3\u5c55\u86cb\u767d\u8d28\u7ed3\u6784\u3001\u5e8f\u5217\u548c\u529f\u80fd\u7684\u53ef\u80fd\u6027\u7a7a\u95f4\uff0c\u521b\u9020\u51fa\u81ea\u7136\u754c\u4e0d\u5b58\u5728\u7684\u65b0\u578b\u86cb\u767d\u8d28\u3002\u7ecf\u8fc7\u8bbe\u8ba1\u7684\u86cb\u767d\u8d28\uff0c\u5176\u5b9a\u91cf\u6027\u8d28<\/span>\uff08\u5982\u901f\u7387\u3001\u4eb2\u548c\u529b\u7b49\uff09<\/span>\u53ef\u8c03\u3001\u53ef\u88ab\u4efb\u610f\u8f93\u5165\u63a7\u5236\u4e14\u5177\u6709\u6a21\u5757\u5316\u7279\u6027\uff0c\u4f7f\u4e0d\u540c\u86cb\u767d\u8d28\u5143\u4ef6\u80fd\u591f\u7ec4\u5408\u5728\u4e00\u8d77\u5b9e\u73b0\u591a\u6837\u5316\u7684\u8f93\u5165\/\u8f93\u51fa\u529f\u80fd\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe7\uff1a\u86cb\u767d\u8d28\u4ece\u5934\u8bbe\u8ba1\u7684\u4f18\u52bf\uff0c\u6765\u6e90\u4e8e\u6587\u732e[9]<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u86cb\u767d\u8d28\u8bbe\u8ba1\u5728\u836f\u7269\u7814\u53d1\u3001\u7eff\u8272\u5236\u9020\u3001\u98df\u54c1\u5b89\u5168\u7b49\u9886\u57df\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u6f5c\u529b\u30022024\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5f97\u4e3bDavid Baker\u56e0\u5176\u5728\u86cb\u767d\u8d28\u8bbe\u8ba1\u9886\u57df\u7684\u5f00\u521b\u6027\u7814\u7a76\u800c\u83b7\u5956\u3002\u4ed6\u63d0\u51fa\u7684RFdiffusion\u65b9\u6cd5[13]\uff0c\u80fd\u591f\u4ece\u5934\u8bbe\u8ba1\u5e76\u751f\u6210\u81ea\u7136\u754c\u4e2d\u4e0d\u5b58\u5728\u7684\u5168\u65b0\u86cb\u767d\u8d28\uff0c\u4f8b\u5982\uff0c\u4ed6\u7684\u56e2\u961f\u5229\u7528\u8be5\u65b9\u6cd5\u8bbe\u8ba1\u7684\u86cb\u767d\u8d28\uff0c\u5df2\u6210\u529f\u4e2d\u548c\u591a\u79cd\u86c7\u6bd2\u4e2d\u7684\u795e\u7ecf\u6bd2\u7d20\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u86cb\u767d\u8d28\u4e2d\u4fe1\u606f\u7684\u6d41\u52a8\u901a\u5e38\u662f\u4ece\u5e8f\u5217\u5230\u7ed3\u6784\u518d\u5230\u529f\u80fd\uff0c\u6bcf\u4e00\u6b65\u7684\u786e\u5b9a\u90fd\u57fa\u4e8e\u524d\u4e00\u6b65\u4fe1\u606f\u7684\u9a71\u52a8\u3002\u86cb\u767d\u8d28\u8bbe\u8ba1\u5219\u5efa\u7acb\u5728\u53cd\u8f6c\u8fd9\u4e00\u8fc7\u7a0b\u7684\u57fa\u7840\u4e0a\uff1a\u5148\u6307\u5b9a\u76ee\u6807\u529f\u80fd\uff0c\u518d\u8bbe\u8ba1\u80fd\u591f\u5b9e\u73b0\u8be5\u529f\u80fd\u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u6700\u7ec8\u627e\u5230\u80fd\u6298\u53e0\u4e3a\u8be5\u7ed3\u6784\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe8\uff1a\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u57fa\u672c\u6d41\u7a0b\u793a\u610f\u56fe\uff0c\u6765\u6e90\u4e8e\u6587\u732e[10]<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u76ee\u524dAI\u5728\u86cb\u767d\u8d28\u8bbe\u8ba1\u4e2d\u7684\u5e94\u7528\u53ef\u5206\u4e3a\u4e24\u7c7b\u3002\u7b2c\u4e00\u7c7b\u65b9\u6cd5\u7c7b\u4f3c\u7528\u201c\u6307\u7eb9\u201d\u5339\u914d\u201c\u9501\u5b54\u201d\uff1aAI\u7b97\u6cd5\u5c06\u86cb\u767d\u8d28\u7ed3\u6784\u8f6c\u5316\u4e3a\u5e26\u7535\u6027\u8d28\u7684\u201c\u51f9\u51f8\u5bc6\u7801\u201d<\/span>\uff08\u5982\u6b63\u7535\u8377\u51f9\u69fd\uff09<\/span>\uff0c\u518d\u5339\u914d\u5177\u6709\u4e92\u8865\u7535\u8377\u548c\u7ed3\u6784\u7684\u5c0f\u5206\u5b50<\/span>\uff08\u5982\u5e26\u8d1f\u7535\u8377\u7684\u51f8\u8d77\uff09<\/span>\u3002\u4f8b\u5982\uff0c\u8bbe\u8ba1\u65b0\u51a0\u75c5\u6bd2\u523a\u7a81\u86cb\u767d\u6291\u5236\u5242\u65f6\uff0cAI\u7b97\u6cd5\u53ef\u76f4\u63a5\u9884\u6d4b\u51fa\u80fd\u591f\u7cbe\u51c6\u5d4c\u5408\u75c5\u6bd2\u8868\u9762\u7684\u5206\u5b50\u5f62\u72b6\u3002\u8fd9\u7c7b\u65b9\u6cd5\u80fd\u591f\u53d1\u73b0\u4eba\u7c7b\u7814\u7a76\u8005\u96be\u4ee5\u5bdf\u89c9\u7684\u590d\u6742\u6a21\u5f0f\uff0c\u4f46\u5176\u51b3\u7b56\u8fc7\u7a0b\u8f83\u4e3a\u201c\u9ed1\u7bb1\u201d\uff0c\u96be\u4ee5\u76f4\u89c2\u89e3\u91ca\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe9\uff1a\u86cb\u767d\u8d28\u529f\u80fd\u8bbe\u8ba1\u793a\u610f\u56fe\uff0c\u6765\u6e90\u4e8e\u6587\u732e[9]\u3002(B\u548cC) \u5c55\u793a\u8bbe\u8ba1\u4e0e\u5c0f\u5206\u5b50\u7ed3\u5408\u7684\u86cb\u767d\u8d28\uff0c\u7ecf\u5178\u8bbe\u8ba1\u65b9\u6cd5\uff08B\uff09\u5c06\u76ee\u6807\u7ed3\u5408\u4f4d\u70b9\u5d4c\u5165\u5df2\u5b58\u5728\u7684\u86cb\u767d\u9aa8\u67b6\u4e2d\uff0c\u800c\u57fa\u4e8e\u4eba\u5de5\u667a\u80fd\u7684\u65b9\u6cd5\uff08C\uff09\u5219\u56f4\u7ed5\u76ee\u6807\u7ed3\u5408\u4f4d\u70b9\u751f\u6210\u65b0\u7684\u86cb\u767d\u8d28\u9aa8\u67b6\u3002(D\u2013F) \u5c55\u793a\u8bbe\u8ba1\u4e0e\u76ee\u6807\u86cb\u767d\uff08\u84dd\u8272\u5f62\u72b6\uff09\u7ed3\u5408\u7684\u86cb\u767d\u8d28\uff0c\u6df1\u7ea2\u8272\u533a\u57df\u4e3a\u901a\u8fc7\u5e8f\u5217\u4f18\u5316\u8bbe\u8ba1\u7684\u533a\u57df\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u7b2c\u4e8c\u7c7b\u65b9\u6cd5\u662f\u57fa\u4e8e\u751f\u6210\u5f0fAI\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u3002\u8fd9\u7c7b\u65b9\u6cd5\u4f7fAI\u901a\u8fc7\u6d77\u91cf\u5b66\u4e60\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u6570\u636e\uff0c\u201c\u8111\u8865\u201d\u51fa\u5168\u65b0\u7684\u529f\u80fd\u6a21\u5757\u3002\u6bd4\u5982\u8f93\u5165\u4e00\u4e2a\u529f\u80fd\u9700\u6c42\u201c\u80fd\u591f\u7ed3\u5408\u94c1\u79bb\u5b50\u7684\u86cb\u767d\u8d28\u201d\uff0cAI\u5373\u53ef\u81ea\u52a8\u751f\u6210\u5019\u9009\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u3002\u8fd9\u7c7b\u65b9\u6cd5\u7684\u4ee3\u8868\u4e4b\u4e00\u662fProGen[11]\uff0c\u8be5\u65b9\u6cd5\u501f\u9274\u4e86ChatGPT\u7684\u8bad\u7ec3\u601d\u8def\uff0c\u4e0d\u4ec5\u8f93\u5165\u5df2\u77e5\u86cb\u767d\u8d28\u7684\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u540c\u65f6\u8fd8\u8f93\u5165\u76f8\u5e94\u7684\u529f\u80fd\u63a7\u5236\u6807\u7b7e\u3002ProGen\u80fd\u591f\u6279\u91cf\u751f\u6210\u5177\u6709\u6f5c\u5728\u7279\u5b9a\u529f\u80fd\u7684\u65b0\u86cb\u767d\u8d28\u5e8f\u5217\uff1b\u5c3d\u7ba1\u8fd9\u4e9b\u5e8f\u5217\u4e0e\u5929\u7136\u86cb\u767d\u8d28\u5e8f\u5217\u6709\u8f83\u5927\u5dee\u5f02\uff0c\u4f46\u5176\u529f\u80fd\u5374\u80fd\u8fbe\u5230\u751a\u81f3\u8d85\u8fc7\u5929\u7136\u86cb\u767d\u8d28\u7684\u6c34\u5e73\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe10\uff1aProGen\u6a21\u578b\u7684\u8f93\u5165\u3001\u8f93\u51fa\u53ca\u5904\u7406\u6d41\u7a0b\u793a\u610f\u56fe<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u9664\u4e86\u4e0a\u8ff0\u201c\u4ece\u5934\u8bbe\u8ba1\u201d\u65b9\u6cd5\u4e4b\u5916\uff0c\u8fd8\u6709\u4e00\u79cd\u4ece\u73b0\u6709\u86cb\u767d\u8d28\u51fa\u53d1\u7684\u8bbe\u8ba1\u65b9\u6cd5\u3002\u8fd9\u7c7b\u65b9\u6cd5\u6839\u636e\u7ed9\u5b9a\u7684\u76ee\u6807\u529f\u80fd\uff0c\u63d0\u51fa\u9700\u8981\u8c03\u6574\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u4f4d\u7f6e\u4e0e\u7a81\u53d8\u5efa\u8bae\u3002\u6761\u4ef6\u751f\u6210\u6a21\u578b<\/span>\uff08\u5982DeepDirect[12]\uff09<\/span>\u4fbf\u5c5e\u4e8e\u8fd9\u4e00\u7c7b\u578b\uff0c\u53ef\u4ee5\u9488\u5bf9\u7279\u5b9a\u9700\u6c42<\/span>\uff08\u5982\u63d0\u9ad8\u7ed3\u5408\u4eb2\u548c\u529b\u6216\u70ed\u7a33\u5b9a\u6027\uff09<\/span>\u5b9a\u5236\u86cb\u767d\u8d28\u3002DeepDirect\u5229\u7528\u5bf9\u6297\u5b66\u4e60\u751f\u6210\u7a81\u53d8\uff0c\u663e\u8457\u63d0\u5347\u86cb\u767d\u8d28\u4e0e\u76ee\u6807\u5206\u5b50\u4e4b\u95f4\u7684\u4eb2\u548c\u529b\u53d8\u5316\u65b9\u5411\u3002\u5176\u8f93\u5165\u5305\u62ec\u86cb\u767d\u8d28\u6c28\u57fa\u9178\u5e8f\u5217\u3001\u86cb\u767d\u8d28\u7ed3\u6784\/\u8f85\u52a9\u6570\u636e\u548c\u76f8\u5173\u7684\u566a\u58f0\u4fe1\u606f<\/span>\uff08\u5982\u56fe11a\u6240\u793a\uff09<\/span>\u3002\u7a81\u53d8\u751f\u6210\u5668\u53ef\u4ea7\u751f\u6f5c\u5728\u7684\u7a81\u53d8\u4f4d\u70b9\uff0c\u5e76\u7ed3\u5408\u86cb\u767d\u8d28\u7ed3\u6784\u7279\u5f81\uff0c\u901a\u8fc7\u5bf9\u6297\u5b66\u4e60\u673a\u5236\u7b5b\u9009\u7a81\u53d8\u86cb\u767d<\/span>\uff08\u5982\u56fe11b\u6240\u793a\uff09<\/span>\uff0c\u5f15\u5bfc\u4eb2\u548c\u529b\u5411\u9884\u671f\u65b9\u5411\u53d8\u5316<\/span>\uff08\u5982\u56fe11c\u6240\u793a\uff09<\/span>\u3002DeepDirect\u4e0d\u4ec5\u9002\u7528\u4e8e\u86cb\u767d\u8d28\u8bbe\u8ba1\uff0c\u4e5f\u80fd\u7528\u4e8e\u7406\u89e3\u75be\u75c5\u8fdb\u5316\u673a\u5236\u4e0e\u86cb\u767d\u8d28\u52a8\u529b\u5b66\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe11\uff1aDeepDirect\u7a81\u53d8\u751f\u6210\u5668\u5de5\u4f5c\u539f\u7406\u793a\u610f\u56fe<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

EVOLVEpro[14]\u4e0eDeepDirect\u7c7b\u4f3c\uff0c\u540c\u5c5e\u4e8e\u5b9a\u5411\u8fdb\u5316\u6846\u67b6\u6a21\u578b\u3002\u4e0d\u540c\u4e4b\u5904\u5728\u4e8e\uff0cEVOLVEpro\u7ed3\u5408\u4e86\u86cb\u767d\u8d28\u8bed\u8a00\u6a21\u578b\u548c\u5c11\u6837\u672c\u4e3b\u52a8\u5b66\u4e60\uff0c\u5c06\u86cb\u767d\u8d28\u5e8f\u5217\u7f16\u7801\u81f3\u8fde\u7eed\u7684\u6f5c\u5728\u7a7a\u95f4\u4e2d\uff0c\u4ee5\u63d0\u9ad8\u6d3b\u6027\u4f18\u5316\u6548\u7387\uff1b\u968f\u540e\u5229\u7528\u9876\u5c42\u56de\u5f52\u6a21\u578b\uff0c\u4ece\u5c11\u91cf\u5b9e\u9a8c\u6570\u636e\u4e2d\u5b66\u4e60\u6f5c\u5728\u7a7a\u95f4\u4e0e\u86cb\u767d\u8d28\u6d3b\u6027\u4e4b\u95f4\u7684\u6620\u5c04\u5173\u7cfb\u3002EVOLVEpro\u901a\u8fc7\u591a\u8f6e\u4e3b\u52a8\u5b66\u4e60\u8fed\u4ee3\uff0c\u6bcf\u8f6e\u6839\u636e\u6a21\u578b\u9884\u6d4b\u7684\u6d3b\u6027\u5bf9\u5e8f\u5217\u8fdb\u884c\u6392\u540d\uff0c\u6311\u9009\u6392\u540d\u9760\u524d\u7684\u5e8f\u5217\u8fdb\u884c\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u5e76\u5faa\u73af\u8fed\u4ee3\uff0c\u76f4\u81f3\u8fbe\u5230\u9884\u5b9a\u76ee\u6807\u3002\u8fd9\u76f8\u5f53\u4e8e\u5728\u6570\u5b57\u73af\u5883\u4e2d\u52a0\u901f\u86cb\u767d\u8d28\u5728\u7279\u5b9a\u529f\u80fd\u65b9\u5411\u4e0a\u7684\u8fdb\u5316\uff0c\u4f7f\u7814\u7a76\u4eba\u5458\u80fd\u591f\u5feb\u901f\u4ece\u73b0\u6709\u86cb\u767d\u51fa\u53d1\uff0c\u4f18\u5316\u5176\u591a\u79cd\u6d3b\u6027\u3002\u5728\u6297\u4f53\u8bbe\u8ba1\u5e94\u7528\u4e2d\uff0cEVOLVEpro\u8fd8\u80fd\u540c\u65f6\u8003\u8651\u591a\u4e2a\u8bbe\u8ba1\u9700\u6c42\uff0c\u5e76\u8d4b\u4e88\u4e0d\u540c\u6743\u91cd<\/span>\uff08\u5982\u4eb2\u548c\u529b\u6743\u91cd\u8bbe\u4e3a\u8868\u8fbe\u6c34\u5e73\u7684\u56db\u500d\uff09<\/span>\u3002\u901a\u8fc7\u591a\u76ee\u6807\u4f18\u5316\uff0cEVOLVEpro\u4f18\u5148\u9009\u51fa\u66f4\u9ad8\u4eb2\u548c\u529b\u7684\u5019\u9009\u86cb\u767d\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

<\/span><\/span><\/p>\n

\u56fe12\uff1aEVOLVEpro\u6a21\u578b\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u6d41\u7a0b\u56fe<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u9762\u5bf9\u4f17\u591a\u86cb\u767d\u8d28\u8bbe\u8ba1\u5de5\u5177\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u6d2a\u4eae<\/span><\/span><\/span>\u56e2\u961f<\/span><\/span><\/span>\u5f00\u53d1\u4e86VenusFactory\u5e73\u53f0[15]\uff0c\u96c6\u6210\u4e86\u8d85\u8fc740\u4e2a\u524d\u6cbf\u86cb\u767d\u8d28\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff0c\u53ef\u5728\u672c\u5730\u542f\u52a8Web\u670d\u52a1\u5feb\u901f\u8c03\u7528\u3002VenusFactory\u76f4\u63a5\u8fde\u63a5\u4e86RCSB PDB\u3001UniProt\u3001InterPro\u7b49\u4e3b\u6d41\u516c\u5f00\u6570\u636e\u5e93\uff0c\u5e76\u901a\u8fc7\u591a\u7ebf\u7a0b\u9ad8\u901f\u4e0b\u8f7d\uff0c\u6781\u5927\u63d0\u9ad8\u4e86\u6570\u636e\u68c0\u7d22\u6548\u7387\u3002\u8be5\u5e73\u53f0\u63d0\u4f9b\u5728\u7ebf\u670d\u52a1\uff0c\u6709\u6548\u964d\u4f4e\u4e86\u86cb\u767d\u8d28\u8bbe\u8ba1\u5de5\u5177\u7684\u4f7f\u7528\u95e8\u69db\u3002<\/span><\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\n
\n

<\/span><\/section>\n

<\/span><\/section>\n
\n
<\/section>\n<\/section>\n<\/section>\n
\n

4. \u5c0f\u7ed3\uff1aAI\u9a71\u52a8\u7684\u86cb\u767d\u8d28\u7814\u7a76\u95ed\u73af<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

\n

<\/span><\/section>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/h3>\n


<\/span><\/p>\n

\u672c\u6587\u7684\u884c\u6587\u903b\u8f91\u56f4\u7ed5\u201c\u63d0\u51fa\u5047\u8bbe\u2014\u5b9e\u9a8c\u9a8c\u8bc1\u2014\u6a21\u578b\u4f18\u5316\u201d\u7684AI\u9a71\u52a8\u95ed\u73af\u5c55\u5f00\u3002\u5728\u836f\u7269\u7814\u53d1\u7b49\u5e94\u7528\u8fc7\u7a0b\u4e2d\uff0c\u7531\u4e8e\u6f5c\u5728\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u91cf\u5de8\u5927\uff0c\u4e14\u86cb\u767d\u8d28\u5e8f\u5217\u7a0d\u5fae\u6539\u53d8\uff0c\u5176\u7ed3\u6784\u5f80\u5f80\u4f1a\u53d1\u751f\u663e\u8457\u53d8\u5316\uff0c\u7814\u7a76\u8005\u65e0\u6cd5\u901a\u8fc7\u5b9e\u9a8c\u624b\u6bb5\u7a77\u4e3e\u6240\u6709\u53ef\u80fd\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u8005\u8981\u4e48\u6839\u636e\u9884\u671f\u529f\u80fd\uff0c\u901a\u8fc7\u5b9a\u5411\u8fdb\u5316\u4ece\u5df2\u6709\u5e8f\u5217\u9010\u6b65\u4f18\u5316\u83b7\u5f97\u76ee\u6807\u86cb\u767d\u8d28\uff0c\u8981\u4e48\u4f7f\u7528\u7aef\u5230\u7aef\u7684\u6a21\u578b\uff0c\u4ece\u5934\u8bbe\u8ba1\u5177\u6709\u7279\u5b9a\u529f\u80fd\u7684\u65b0\u86cb\u767d\u8d28\u3002AI\u5de5\u5177\u8bbe\u8ba1\u51fa\u5019\u9009\u86cb\u767d\u8d28\u540e\uff0c\u5728\u8fdb\u884c\u5b9e\u9a8c\u9a8c\u8bc1\u524d\uff0c\u8fd8\u53ef\u4ee5\u5148\u7528\u7ed3\u6784\u9884\u6d4b\u5de5\u5177\u8fdb\u884c\u521d\u7b5b\uff0c\u518d\u901a\u8fc7\u5b9e\u9a8c\u7ed3\u679c\u8fdb\u4e00\u6b65\u6307\u5bfc\u6a21\u578b\u4f18\u5316\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/span><\/p>\n

\u8fd1\u5e74\u6765\uff0c\u5728\u86cb\u767d\u8d28\u7ec4\u5b66\u4e0e\u4eba\u5de5\u667a\u80fd<\/span>\uff08AI\uff09<\/span>\u6df1\u5ea6\u878d\u5408\u7684\u80cc\u666f\u4e0b\uff0c\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u3001\u529f\u80fd\u89e3\u6790\u4e0e\u4ece\u5934\u8bbe\u8ba1\u9886\u57df\u53d6\u5f97\u4e86\u4e00\u7cfb\u5217\u7a81\u7834\u6027\u8fdb\u5c55\u3002\u672c\u6587\u56de\u987e\u4e86\u8fd1\u51e0\u5e74\u7684\u51e0\u9879\u5173\u952e\u6210\u679c\uff1a\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u65b9\u9762\uff0cAI\u6280\u672f\u52a0\u901f\u4e86\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u5b9e\u9a8c\u89e3\u6790\u8fdb\u7a0b\uff0c\u4e3a\u7f55\u89c1\u86cb\u767d\u8d28\u7684\u529f\u80fd\u89e3\u6790\u63d0\u4f9b\u4e86\u57fa\u7840\u3002\u5728\u86cb\u767d\u8d28\u529f\u80fd\u9884\u6d4b\u65b9\u9762\uff0cAI\u6a21\u578b\u901a\u8fc7\u6574\u5408\u591a\u7ec4\u5b66\u6570\u636e<\/span>\uff08\u5982\u8f6c\u5f55\u7ec4\u3001\u4e92\u4f5c\u7ec4\u3001\u4ee3\u8c22\u901a\u8def\u7b49\uff09<\/span>\u548c\u5e8f\u5217\u7279\u5f81\uff0c\u6709\u6548\u5730\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u4e9a\u7ec6\u80de\u5b9a\u4f4d\u3001\u9176\u6d3b\u6027\u7c7b\u522b\u3001\u7ed3\u5408\u4f4d\u70b9\u4ee5\u53ca\u53c2\u4e0e\u7684\u751f\u7269\u901a\u8def\u3002\u5728\u86cb\u767d\u8d28\u8bbe\u8ba1\u9886\u57df\uff0cAI\u6b63\u4ece\u201c\u7406\u89e3\u201d\u8fc8\u5411\u201c\u521b\u9020\u201d\uff0c\u751f\u6210\u5f0f\u6a21\u578b<\/span>\uff08\u5982\u6269\u6563\u6a21\u578b\u3001\u53d8\u5206\u81ea\u7f16\u7801\u5668VAE\uff09<\/span>\u548c\u7ed3\u6784\u6761\u4ef6\u5316\u5e8f\u5217\u8bbe\u8ba1\u6a21\u578b<\/span>\uff08\u5982ProteinMPNN\uff09<\/span>\u5df2\u6210\u529f\u5e94\u7528\u4e8e\u4ece\u5934\u8bbe\u8ba1\u5177\u6709\u7279\u5b9a\u7ed3\u6784\u548c\u529f\u80fd\u7684\u86cb\u767d\u8d28\u3002<\/span><\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

\u53c2\u8003\u6587\u732e<\/span><\/span><\/span><\/span><\/p>\n

[1] <\/span><\/span><\/span><\/span>Abramson, J., Adler, J., Dunger, J., Evans, R., Green, T., Pritzel, A., Ronneberger, O., Willmore, L., Ballard, A. J., Bambrick, J., Bodenstein, S. W., Evans, D. A., Hung, C., O\u2019Neill, M., Reiman, D., Tunyasuvunakool, K., Wu, Z., \u017demgulyt\u0117, A., Arvaniti, E., . . . Jumper, J. M. (2024). Accurate structure prediction of biomolecular interactions with AlphaFold 3. <\/span><\/span><\/span>Nature<\/span><\/span><\/span>, <\/span><\/span><\/span>630<\/span><\/span><\/span>(8016), 493\u2013500. <\/span><\/span><\/span>https:\/\/doi.org\/10.1038\/s41586-024-07487-w<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

[2] <\/span><\/span><\/span>https:\/\/www.biorxiv.org\/content\/10.1101\/2025.05.01.651643v1<\/span><\/span><\/span><\/span><\/span><\/p>\n

[3] <\/span><\/span><\/span>Liu, L., Liu, Y., Ye, X., Zhang, S., Li, Y., Zhu, K., Xue, Y., Zhang, X., & Fang, X. (2025, July 12). Advancing Structure Prediction of Biomolecular Interaction via Contact-Guided Sampling with HelixFold-S1. arXiv.org. https:\/\/arxiv.org\/abs\/2507.09251<\/span><\/span><\/span><\/span><\/span><\/p>\n

[4] <\/span><\/span><\/span>Zheng, W., Wuyun, Q., Li, Y., Liu, Q., Zhou, X., Peng, C., Zhu, Y., Freddolino, L., & Zhang, Y. (2025). Deep-learning-based single-domain and multidomain protein structure prediction with D-I-TASSER. Nature Biotechnology. https:\/\/doi.org\/10.1038\/s41587-025-02654-4<\/span><\/span><\/span><\/span><\/span><\/p>\n

[5] <\/span><\/span><\/span>https:\/\/www.biorxiv.org\/content\/10.1101\/2024.02.05.578892v1<\/span><\/span><\/span><\/span><\/span><\/p>\n

[6] <\/span><\/span><\/span>Kulmanov, M., Guzm\u00e1n-Vega, F. J., Roggli, P. D., Lane, L., Arold, S. T., & Hoehndorf, R. (2024). Protein function prediction as approximate semantic entailment. <\/span><\/span><\/span>Nature Machine Intelligence<\/span><\/span><\/span>, <\/span><\/span><\/span>6<\/span><\/span><\/span>(2), 220\u2013228. https:\/\/doi.org\/10.1038\/s42256-024-00795-w<\/span><\/span><\/span><\/span><\/span><\/p>\n

[7] <\/span><\/span><\/span>Wang, W., Shuai, Y., Zeng, M., Fan, W., & Li, M. (2025). DPFunc: accurately predicting protein function via deep learning with domain-guided structure information. <\/span><\/span><\/span>Nature Communications<\/span><\/span><\/span>, <\/span><\/span><\/span>16<\/span><\/span><\/span>(1). https:\/\/doi.org\/10.1038\/s41467-024-54816-8<\/span><\/span><\/span><\/span><\/span><\/p>\n

[8] <\/span><\/span><\/span>Fei, X., Chatzianastasis, M., Carneiro, S. A., Abdine, H., Petalidis, L. P., & Vazirgiannis, M. (2025, May 16). <\/span><\/span><\/span>Prot2Text-V2: Protein Function Prediction with Multimodal Contrastive Alignment<\/span><\/span><\/span>. arXiv.org. https:\/\/arxiv.org\/abs\/2505.11194<\/span><\/span><\/span><\/span><\/span><\/p>\n

[9] <\/span><\/span><\/span>https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(23)01402-2<\/span><\/span><\/span><\/span><\/span><\/p>\n

[10] <\/span><\/span><\/span>Chu, A. E., Lu, T., & Huang, P. (2024). Sparks of function by de novo protein design. <\/span><\/span><\/span>Nature Biotechnology<\/span><\/span><\/span>, <\/span><\/span><\/span>42<\/span><\/span><\/span>(2), 203\u2013215. https:\/\/doi.org\/10.1038\/s41587-024-02133-2<\/span><\/span><\/span><\/span><\/span><\/p>\n

[11] <\/span><\/span><\/span>Madani, A., Krause, B., Greene, E. R., Subramanian, S., Mohr, B. P., Holton, J. M., Olmos, J. L., Xiong, C., Sun, Z. Z., Socher, R., Fraser, J. S., & Naik, N. (2023). Large language models generate functional protein sequences across diverse families. <\/span><\/span><\/span>Nature Biotechnology<\/span><\/span><\/span>, <\/span><\/span><\/span>41<\/span><\/span><\/span>(8), 1099\u20131106. https:\/\/doi.org\/10.1038\/s41587-022-01618-2<\/span><\/span><\/span><\/span><\/span><\/p>\n

[12] <\/span><\/span><\/span>Lan, T., Su, S., Ping, P., Hutvagner, G., Liu, T., Pan, Y., & Li, J. (2024). Generating mutants of monotone affinity towards stronger protein complexes through adversarial learning. <\/span><\/span><\/span>Nature Machine Intelligence<\/span><\/span><\/span>, <\/span><\/span><\/span>6<\/span><\/span><\/span>(3), 315\u2013325. https:\/\/doi.org\/10.1038\/s42256-024-00803-z<\/span><\/span><\/span><\/span><\/span><\/p>\n

[13] <\/span><\/span><\/span>Watson, J. L., Juergens, D., Bennett, N. R., Trippe, B. L., Yim, J., Eisenach, H. E., Ahern, W., Borst, A. J., Ragotte, R. J., Milles, L. F., Wicky, B. I. M., Hanikel, N., Pellock, S. J., Courbet, A., Sheffler, W., Wang, J., Venkatesh, P., Sappington, I., Torres, S. V., . . . Baker, D. (2023). De novo design of protein structure and function with RFdiffusion. <\/span><\/span><\/span>Nature<\/span><\/span><\/span>, <\/span><\/span><\/span>620<\/span><\/span><\/span>(7976), 1089\u20131100. https:\/\/doi.org\/10.1038\/s41586-023-06415-8<\/span><\/span><\/span><\/span><\/span><\/p>\n

[14] <\/span><\/span><\/span>Jiang, K., Yan, Z., Di Bernardo, M., Sgrizzi, S. R., Villiger, L., Kayabolen, A., Kim, B., Carscadden, J. K., Hiraizumi, M., Nishimasu, H., Gootenberg, J. S., & Abudayyeh, O. O. (2024). Rapid in silico directed evolution by a protein language model with EVOLVEpro. <\/span><\/span><\/span>Science<\/span><\/span><\/span>. https:\/\/doi.org\/10.1126\/science.adr6006<\/span><\/span><\/span><\/span><\/span><\/p>\n

[15] <\/span><\/span><\/span>Tan, Y., Liu, C., Gao, J., Wu, B., Li, M., Wang, R., Zhang, L., Yu, H., Fan, G., Hong, L., & Zhou, B. (2025, March 19). <\/span><\/span><\/span>VenusFactory: a unified platform for protein engineering data retrieval and language model Fine-Tuning<\/span><\/span><\/span><\/span>. arXiv.org. https:\/\/arxiv.org\/abs\/2503.15438<\/span><\/span><\/span><\/span><\/span><\/p>\n

\n
\n
\n
\n
\n
\n

<\/span><\/section>\n

<\/span><\/span><\/strong><\/span><\/section>\n
\n
\n
\n
\n

\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a<\/span><\/strong><\/p>\n

\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/span><\/strong>
<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/span><\/section>\n

\u5728\u751f\u7269\u5b66\u4e2d\u5fc3\u6cd5\u5219\u7684\u8d77\u70b9\uff0c\u57fa\u56e0\u4f5c\u4e3a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u9057\u4f20\u4fe1\u606f\u8f7d\u4f53\uff0c\u5728\u751f\u547d\u5468\u671f\u5185\u7a33\u5b9a\u5b58\u5728\uff1b\u800c\u4f4d\u4e8e\u4e2d\u5fc3\u6cd5\u5219\u672b\u7aef\u7684\u86cb\u767d\u8d28\uff0c\u5176\u7ec4\u7ec7\u6784\u6210\u548c\u65f6\u7a7a\u53d8\u5316\u7684\u590d\u6742\u6027\u5448\u6307\u6570\u5f0f\u589e\u957f\u3002\u968f\u7740\u5206\u5b50\u751f\u7269\u5b66\u6570\u5341\u5e74\u6765\u7684\u7a81\u98de\u731b\u8fdb\uff0c\u5c24\u5176\u662f\u751f\u547d\u7ec4\u5b66\uff08\u57fa\u56e0\u7ec4\u5b66\u3001\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u4ee3\u8c22\u7ec4\u5b66\u7b49\u7684\u96c6\u5408\uff09\u7b49\u9886\u57df\u7684\u65e5\u65b0\u6708\u5f02\uff0c\u5f53\u4ee3\u751f\u547d\u79d1\u5b66\u4e34\u8fd1\u7206\u53d1\u7684\u8fb9\u7f18\u3002\u5982\u6b64\u6d77\u91cf\u7684\u6570\u636e\u5982\u4f55\u5e2e\u52a9\u6211\u4eec\u63ed\u793a\u5b87\u5b99\u4e2d\u6700\u590d\u6742\u7684\u7269\u8d28\u7cfb\u7edf\u2014\u2014\u201c\u4eba\u4f53\u201d\u7684\u6784\u6210\u539f\u7406\u548c\u8bbe\u8ba1\u539f\u7406\uff1f\u9610\u91ca\u4eba\u7c7b\u53d1\u80b2\u3001\u8870\u8001\u548c\u91cd\u5927\u75be\u75c5\u7684\u53d1\u751f\u673a\u5236\uff1f<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u897f\u6e56\u5927\u5b66\u7406\u5b66\u9662\u53ca\u4ea4\u53c9\u79d1\u5b66\u4e2d\u5fc3\u8bb2\u5e2d\u6559\u6388\u6c64\u96f7\u7ff0\uff0c\u56fd\u5bb6\u86cb\u767d\u8d28\u79d1\u5b66<\/span><\/span>\u4e2d\u5fc3\uff08\u5317\u4eac\uff09\u526f\u7814\u7a76\u5458\u5e38\u4e58\u3001\u674e\u6768\uff0c\u9999\u6e2f\u6d78\u4f1a\u5927\u5b66\u52a9\u7406\u6559\u6388\u5510\u4e7e\u5143\uff0c\u5317\u4eac\u5927\u5b66\u524d\u6cbf\u4ea4\u53c9\u5b66\u79d1\u7814\u7a76\u9662\u7814\u7a76\u5458\u6797\u4e00\u701a\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u5206\u5b50\u7ec6\u80de\u79d1\u5b66\u5353\u8d8a\u521b\u65b0\u4e2d\u5fc3\u535a\u58eb\u540e\u5510\u8bd7\u5a55\uff0c\u5171\u540c\u53d1\u8d77<\/span><\/span>\u300c\u751f\u547d\u590d\u6742\u6027\uff1a\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406\u300d\u8bfb\u4e66\u4f1a<\/a><\/span>\uff0c\u4ece\u5fae\u89c2\u7ec6\u80de\u5c3a\u5ea6\u3001\u4ecb\u89c2\u7ec4\u7ec7\u5668\u5b98\u5c3a\u5ea6\u5230\u5b8f\u89c2\u4eba\u4f53\u5c3a\u5ea6\uff0c\u68b3\u7406\u751f\u547d\u79d1\u5b66\u9886\u57df\u4e2d\u7684\u91cd\u8981\u95ee\u9898\u53ca\u91cd\u8981\u6570\u636e\uff0c\u7531\u751f\u7269\u5b66\u5bb6\u63d0\u95ee\uff0c\u5e0c\u671b\u4fc3\u8fdb\u7edf\u8ba1\u7269\u7406\u3001\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u7814\u7a76\u8005\u548c\u751f\u547d\u79d1\u5b66\u7814\u7a76\u8005\u4e4b\u95f4\u7684\u6df1\u5ea6\u4ea4\u6d41\uff0c\u5efa\u7acb\u8de8\u5b66\u79d1\u5408\u4f5c\u5173\u7cfb\uff0c\u6fc0\u53d1\u65b0\u7684\u7814\u7a76\u601d\u8def\u548c\u5408\u4f5c\u9879\u76ee\u3002\u8bfb\u4e66\u4f1a\u76ee\u524d\u5171\u8fdb\u884c10\u671f\uff0c\u73b0\u5728\u62a5\u540d\u53c2\u4e0e\u8bfb\u4e66\u4f1a\u53ef\u4ee5\u52a0\u5165\u8bfb\u4e66\u4f1a\u793e\u7fa4\uff0c\u89c2\u770b\u89c6\u9891\u56de\u653e\uff0c\u89e3\u9501\u5b8c\u6574\u8bfb\u4e66\u4f1a\u6743\u9650\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/section>\n
\"\u56fe\u7247\"<\/span><\/a><\/span><\/strong><\/span><\/section>\n

<\/span><\/span><\/section>\n
\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span><\/span><\/section>\n
\u751f\u547d\u590d\u6742\u6027\u8bfb\u4e66\u4f1a\uff1a\u4ece\u5fae\u89c2\u5230\u5b8f\u89c2\uff0c\u591a\u5c3a\u5ea6\u89c6\u89d2\u63a2\u7d22\u751f\u547d\u590d\u6742\u7cfb\u7edf\u7684\u6784\u6210\u539f\u7406<\/a><\/span><\/span>
<\/span><\/section>\n


<\/span><\/span><\/p>\n


<\/span><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\u63a8\u8350\u9605\u8bfb<\/span><\/span><\/strong><\/strong><\/strong><\/section>\n
<\/strong><\/section>\n
1. AI+Science\u65b0\u89c6\u91ce\uff1a\u7528\u7269\u7406\u4fe1\u606f\u5f15\u5bfcAlphaFold 2\u9884\u6d4b\u86cb\u767d\u8d28\u52a8\u529b\u5b66<\/span><\/a><\/span><\/strong>
<\/span><\/strong><\/span><\/section>\n
2. \u5df4\u62c9\u5df4\u897f\u65b0\u4f5c\uff1aAI-Bind \u52a9\u529b\u86cb\u767d\u8d28-\u914d\u4f53\u7ed3\u5408\u9884\u6d4b<\/span><\/a><\/span><\/strong>
<\/span><\/strong><\/span><\/section>\n
3. \u80fd\u591f\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u3001\u63a7\u5236\u6838\u805a\u53d8\u7684AI\uff0c\u600e\u6837\u4fc3\u8fdb\u79d1\u5b66\u7406\u89e3\uff1f<\/span><\/a><\/span><\/strong><\/section>\n
<\/strong><\/section>\n
4. <\/span>\u6d8c\u73b0\u52a8\u529b\u5b66\u5982\u4f55\u7528\u6765\u5206\u6790\u590d\u6742\u7cfb\u7edf\uff1f | \u65b0\u8bfe\u4e0a\u7ebf<\/span><\/a><\/span><\/strong><\/span>
<\/span><\/strong><\/strong><\/span><\/section>\n
<\/strong>5. <\/span><\/strong>\u96c6\u667a\u5b66\u56ed\u7cbe\u54c1\u8bfe\u7a0b\u514d\u8d39\u5f00\u653e\uff0c\u89e3\u9501\u7cfb\u7edf\u79d1\u5b66\u4e0e AI \u65b0\u4e16\u754c<\/span><\/a><\/span><\/strong><\/section>\n

6. \u9ad8\u8003\u5206\u6570\u53ea\u662f\u5f20\u5165\u573a\u5238\uff0c\u4f60\u7684\u79d1\u7814\u5192\u9669\u5728\u8fd9\u91cc\u542f\u822a\uff01<\/span><\/a><\/span><\/strong><\/p>\n

7. <\/span><\/span><\/strong><\/strong><\/span>\u7cfb\u7edf\u79d1\u5b66\u524d\u6cbf\u5341\u8bb2\uff1a\u7406\u89e3\u81ea\u7136\u3001\u751f\u547d\u4e0e\u793e\u4f1a\u7684\u590d\u6742\u6027<\/span><\/a><\/span><\/strong><\/strong><\/span><\/p>\n


<\/span><\/p>\n


<\/span><\/span><\/p>\n

\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/span><\/span><\/section>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc\u8bed \u86cb\u767d\u8d28\u7814\u7a76\u6b63\u5904\u4e8e\u4e00\u573a\u7531AI\u9a71\u52a8\u7684\u6df1\u523b\u53d8\u9769\u4e4b\u4e2d\u3002\u4ece\u7ed3\u6784\u9884\u6d4b\u3001\u529f\u80fd\u89e3\u6790\u5230\u4ece\u5934\u8bbe\u8ba1\uff0cAI\u5de5\u5177\u7684\u5e7f\u6cdb\u5e94\u7528\u663e\u8457\u62d3\u5c55\u4e86\u86cb\u767d\u8d28\u79d1\u5b66\u63a2\u7d22\u7684\u6df1\u5ea6\u4e0e\u5e7f\u5ea6\u3002\u4ee5AlphaFold\u4e3a\u4ee3\u8868\u7684\u524d\u6cbf\u6a21\u578b\u5f00\u521b\u4e86\u86cb\u767d\u8d28\u7814\u7a76\u7684\u65b0\u8303\u5f0f\uff0c\u800c\u56fd\u5185\u4f17\u591a\u56e2\u961f\u7684\u8fc5\u901f\u5d1b\u8d77\u5219\u8fdb\u4e00\u6b65\u63a8\u52a8\u4e86\u6570\u636e-\u6a21\u578b-\u5b9e\u9a8c\u95ed\u73af\u7684\u9ad8\u6548\u5f62\u6210\u3002 \u5728\u8fd1\u671f\u7684\u300cAI\u9a71\u52a8\u7684\u8ba1\u7b97\u533b…<\/p>\n","protected":false},"author":0,"featured_media":63973,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/63992"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=63992"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/63992\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/63973"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=63992"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=63992"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=63992"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=63992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}