{"id":64896,"date":"2025-09-30T15:32:52","date_gmt":"2025-09-30T07:32:52","guid":{"rendered":"https:\/\/swarma.org\/?p=64896"},"modified":"2025-09-30T15:32:52","modified_gmt":"2025-09-30T07:32:52","slug":"nature%e5%ad%90%e5%88%8a%ef%bc%9a%e9%9d%9e%e7%ba%bf%e6%80%a7%e5%8a%a8%e5%8a%9b%e5%ad%a6%e6%9c%80%e6%96%b0%e8%ae%ba%e6%96%87%e5%90%88%e9%9b%86","status":"publish","type":"post","link":"https:\/\/swarma.org\/?p=64896","title":{"rendered":"Nature\u5b50\u520a\uff1a\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u6700\u65b0\u8bba\u6587\u5408\u96c6"},"content":{"rendered":"
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\u8bba\u65871\uff1a\u57fa\u4e8e\u6270\u52a8\u7684<\/span>\u7ec6\u80de\u547d\u8fd0\u51b3\u5b9a\u8fc7\u7a0b\u7684<\/span>\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u63a8\u65ad<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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\u8bba\u6587\u9898\u76ee\uff1aGene regulatory network inference during cell fate decisions by perturbation strategies<\/span><\/span><\/p>\n

\u57fa\u4e8e\u6270\u52a8\u7b56\u7565\u7684\u7ec6\u80de\u547d\u8fd0\u51b3\u5b9a\u8fc7\u7a0b\u4e2d\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\u63a8\u65ad<\/span><\/span><\/p>\n

\u8bba\u6587\u6765\u6e90\uff1a<\/span><\/span>npj Systems Biology and Applications<\/span><\/span><\/em><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41540-025-00504-2<\/span><\/span><\/p>\n

\u4ee3\u7801\u94fe\u63a5\uff1a<\/span><\/span>https:\/\/github.com\/Qing-Hu-gif\/network_inference.git<\/span><\/span>.<\/span><\/span><\/p>\n

\u4e00\u4f5c\u5355\u4f4d\uff1aDepartment of Mathematics, Shanghai University, Shanghai, China<\/span><\/span><\/p>\n


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\u6838\u5fc3\u56fe\uff1a\u56fe 1\u662f\u6270\u52a8\u524dEMT\u7f51\u7edc\uff0c<\/span><\/span>\u7eff\u8272\u7bad\u5934\u548c\u7ea2\u8272\u6761\u5206\u522b\u8868\u793a\u6fc0\u6d3b\u548c\u6291\u5236\u3002\u56fe2\u662f\u5728\u6270\u52a8\u4e0b\u63a8\u65ad\u7684EMT\u7f51\u7edc\u3002<\/span><\/span><\/p>\n


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\u8bba\u65871\uff1a<\/span>\u7ec6\u80de\u7f51\u7edc\u4e2d\u5c40\u90e8\u62d3\u6251\u7ed3\u6784\u3001\u5168\u5c40\u52a8\u529b\u5b66\u4e0e\u5206\u5c94\u7684\u666e\u9002\u5173\u7cfb<\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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\u8bba\u6587\u9898\u76ee\uff1aGeneral relationship of local topologies, global dynamics, and bifurcation in cellular networks<\/span><\/span><\/p>\n

\u7ec6\u80de\u7f51\u7edc\u4e2d\u5c40\u90e8\u62d3\u6251\u7ed3\u6784\u3001\u5168\u5c40\u52a8\u529b\u5b66\u4e0e\u5206\u5c94\u7684\u666e\u9002\u5173\u7cfb<\/span><\/span><\/p>\n

\u8bba\u6587\u6765\u6e90\uff1a<\/span><\/span>npj Systems Biology and Applications<\/span><\/span><\/em><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41540-024-00470-1<\/span><\/span><\/p>\n

\u4e00\u4f5c\u5355\u4f4d\uff1a<\/span><\/span><\/p>\n

These authors contributed equally: Qing Hu, Ruoyu Tang.<\/span><\/span><\/p>\n

Department of Mathematics, Shanghai University, Shanghai, 200444, China<\/span><\/span><\/p>\n


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\u6458\u8981\uff1a<\/span>\u6b64\u7814\u7a76\u4ece\u7ec6\u80de\u7f51\u7edc\u901a\u8fc7\u6574\u5408\u8c03\u63a7\u8def\u5f84\u4e0e\u53cd\u9988\u56de\u8def\u7b49\u5c40\u90e8\u7ed3\u6784\u4e2d\u7684\u590d\u6742\u4fe1\u606f\u6765\u5b9e\u73b0\u5176\u529f\u80fd\u3002\u7136\u800c\uff0c\u5c40\u90e8\u62d3\u6251\u7ed3\u6784\u5982\u4f55\u51b3\u5b9a\u5168\u5c40\u7f51\u7edc\u52a8\u529b\u5b66\u5e76\u8bf1\u53d1\u5206\u5c94\u7684\u5177\u4f53\u673a\u5236\u5c1a\u672a\u660e\u786e\u3002\u7834\u89e3\u8fd9\u4e00\u6574\u5408\u673a\u5236\u7684\u5173\u952e\u5728\u4e8e\u8bc6\u522b\u4fe1\u606f\u6d41\u8fd0\u884c\u7684\u57fa\u672c\u539f\u7406\u3002\u672c\u7814\u7a76\u5f00\u53d1\u4e86\u7d2f\u79ef\u7ebf\u6027\u5316\u903c\u8fd1\uff08CLA\uff09\u7b97\u6cd5\u4ee5\u89e3\u51b3\u8be5\u95ee\u9898\u3002\u57fa\u4e8e\u6270\u52a8\u5206\u6790\u4e0e\u7f51\u7edc\u5206\u89e3\u7406\u8bba\uff0c\u6211\u4eec\u4ece\u6570\u5b66\u4e0a\u8bc1\u660e\u4e86\u6270\u52a8\u5982\u4f55\u901a\u8fc7\u6240\u6709\u8c03\u63a7\u8def\u5f84\u7684\u6574\u5408\u5f71\u54cd\u5e73\u8861\u6001\u53d8\u5316\uff0c\u4ee5\u53ca\u5e73\u8861\u6001\u7684\u7a33\u5b9a\u6027\u5982\u4f55\u7531\u4e0d\u540c\u53cd\u9988\u56de\u8def\u51b3\u5b9a\u3002\u9009\u53d6\u53cc\u7a33\u6001\u4e09\u53d8\u91cf\u7cfb\u7edf\u548c\u66f4\u590d\u6742\u7684\u4e0a\u76ae-\u95f4\u8d28\u8f6c\u5316\uff08EMT\uff09\u7f51\u7edc\u4f5c\u4e3a\u9a8c\u8bc1\u6848\u4f8b\uff0c\u7ed3\u679c\u8868\u660e\u8be5\u65b9\u6cd5\u80fd\u6709\u6548\u63ed\u793a\u5c40\u90e8\u62d3\u6251\u7ed3\u6784\u4e0e\u5168\u5c40\u52a8\u529b\u5b66\u7684\u5173\u7cfb\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u7406\u89e3\u7ec6\u80de\u7f51\u7edc\u4fe1\u606f\u6d41\u5960\u5b9a\u4e86\u575a\u5b9e\u57fa\u7840\uff0c\u51f8\u663e\u4e86\u5c40\u90e8\u62d3\u6251\u7ed3\u6784\u5728\u51b3\u5b9a\u5168\u5c40\u52a8\u529b\u5b66\u548c\u5206\u5c94\u73b0\u8c61\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u3002\u672c\u7814\u7a76\u4e3a\u63a2\u7d22\u6270\u52a8\u6761\u4ef6\u4e0b\u7ec6\u80de\u7f51\u7edc\u5c40\u90e8\u62d3\u6251\u4e0e\u5168\u5c40\u52a8\u529b\u5b66\u4e4b\u95f4\u7684\u666e\u9002\u5173\u7cfb\u63d0\u4f9b\u4e86\u65b0\u6846\u67b6\u3002<\/span><\/p>\n


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\u6838\u5fc3\u56fe\uff1a\u56fe 1\u7531 TCF-1\u3001PU.1 \u548c GATA3 \u6784\u6210\u7684\u8c03\u63a7\u7f51\u7edc\u3002 \u7bad\u5934\u4ee3\u8868\u6fc0\u6d3b\u4f5c\u7528\uff0c\u77ed\u6a2a\u7ebf\u4ee3\u8868\u6291\u5236\u4f5c\u7528\u3002<\/span><\/span><\/span><\/p>\n

\u56fe 2\u662f\u4e09\u53d8\u91cf\u6a21\u578b\u7684\u5206\u5c94\u56fe\u3002 TCF-1 (A)\u3001PU.1 (B) \u548c GATA3 (C) \u7684\u8868\u8fbe\u6c34\u5e73\u968f\u53c2\u6570 <\/span><\/span>k<\/span><\/span><\/em>0<\/span><\/span>T<\/span><\/span><\/em><\/span>\u53d8\u5316\u7684\u51fd\u6570\u5173\u7cfb\u3002\u5b9e\u7ebf\u5e73\u8861\u66f2\u7ebf\u548c\u5e26\u5706\u70b9\u7684\u5e73\u8861\u66f2\u7ebf\u5206\u522b\u7531\u5e38\u5fae\u5206\u65b9\u7a0b\u548c\u7d2f\u79ef\u7ebf\u6027\u5316\u8fd1\u4f3c\u7b97\u6cd5\u5f97\u51fa\u3002\u7d2b\u8272\uff08\u6216\u6df1\u8272\uff09\u548c\u84dd\u8272\uff08\u6216\u6d45\u8272\uff09\u66f2\u7ebf\u5206\u522b\u8868\u793a\u7a33\u5b9a\u548c\u4e0d\u7a33\u5b9a\u5e73\u8861\u70b9\u3002<\/span><\/span><\/span><\/p>\n


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\u8bba\u65872\uff1a<\/span>\u6e20\u5316\u4f5c\u7528\u964d\u4f4e\u751f\u7269\u7f51\u7edc\u4e2d\u8c03\u63a7\u7684\u975e\u7ebf\u6027<\/span><\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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\u8bba\u6587\u9898\u76ee\uff1aCanalization reduces the nonlinearity of regulation in biological networks<\/span><\/span><\/p>\n

\u6e20\u5316\u4f5c\u7528\u964d\u4f4e\u751f\u7269\u7f51\u7edc\u4e2d\u8c03\u63a7\u7684\u975e\u7ebf\u6027<\/span><\/span><\/p>\n

\u8bba\u6587\u6765\u6e90\uff1a<\/span><\/span>npj Systems Biology and Applications<\/span><\/span><\/em><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41540-024-00392-y<\/span><\/span><\/p>\n

\u4ee3\u7801\u94fe\u63a5\uff1aOriginal code to compute the approximability of Boolean networks, published along with(22), is available at <\/span><\/span>https:\/\/gitlab.com\/smanicka\/boolion<\/span><\/span>. Code to analyze the 110 investigated published, expert-curated Boolean biological network models, as well as the Python library canalizing_function_toolbox, published along with(2), is available at <\/span><\/span>https:\/\/github.com\/ckadelka\/DesignPrinciplesGeneNetworks<\/span><\/span>. New code underlying the analyses described in this paper is available at <\/span><\/span>https:\/\/github.com\/ckadelka\/ApproximabilityBooleanNetworks<\/span><\/span>.<\/span><\/span><\/p>\n

\u4e00\u4f5c\u5355\u4f4d\uff1aDepartment of Mathematics, Iowa State University, 411 Morrill Rd, Ames, 50011, IA, USA<\/span><\/span><\/p>\n


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\u6458\u8981\uff1a<\/span>\u751f\u7269\u7f51\u7edc\uff08\u5982\u57fa\u56e0\u8c03\u63a7\u7f51\u7edc\uff09\u5177\u5907\u4f18\u8d8a\u7279\u6027\uff0c\u5176\u9c81\u68d2\u6027\u4e0e\u53ef\u63a7\u6027\u5747\u4f18\u4e8e\u968f\u673a\u7f51\u7edc\u3002\u8fd9\u4e00\u73b0\u8c61\u4fc3\u4f7f\u7814\u7a76\u8005\u63a2\u7d22\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u878d\u5165\u751f\u7269\u7f51\u7edc\u7684\u7ed3\u6784\u4e0e\u52a8\u529b\u5b66\u7279\u5f81\u3002\u8fd1\u671f\u9488\u5bf9\u5df2\u53d1\u8868\u7684\u3001\u7ecf\u4e13\u5bb6\u6574\u7406\u7684\u5e03\u5c14\u578b\u751f\u7269\u7f51\u7edc\u6a21\u578b\u7684\u835f\u8403\u5206\u6790\uff0c\u63ed\u793a\u4e86\u82e5\u5e72\u6b64\u7c7b\u7279\u5f81\uff08\u5e38\u88ab\u79f0\u4e3a \u201c\u8bbe\u8ba1\u539f\u5219\u201d\uff09\u3002\u5176\u4e2d\u5c24\u4e3a\u5173\u952e\u7684\u7279\u5f81\u5305\u62ec\uff1a\u751f\u7269\u7f51\u7edc\u4e2d\u7279\u5b9a\u91cd\u590d\u51fa\u73b0\u7684\u7f51\u7edc\u57fa\u5e8f\uff08network motifs\uff09\u66f4\u4e3a\u5bcc\u96c6\uff1b\u5176\u52a8\u6001\u66f4\u65b0\u89c4\u5219\u6bd4\u9884\u671f\u66f4\u5177\u5197\u4f59\u6027\u3001\u504f\u5411\u6027\u4e0e\u6e20\u5316\u6027\uff1b\u4e14\u76f8\u8f83\u4e8e\u53ef\u6bd4\u968f\u673a\u7f51\u7edc\uff0c\u751f\u7269\u7f51\u7edc\u7684\u52a8\u529b\u5b66\u66f4\u6613\u901a\u8fc7\u7ebf\u6027\u53ca\u4f4e\u9636\u8fd1\u4f3c\u65b9\u6cd5\u63cf\u8ff0\u3002\u7531\u4e8e\u8fd9\u4e9b\u7279\u5f81\u5927\u591a\u76f8\u4e92\u5173\u8054\uff0c\u5398\u6e05\u5176\u95f4\u7684\u56e0\u679c\u5173\u7cfb\u81f3\u5173\u91cd\u8981 \u2014\u2014 \u5373\u660e\u786e\u54ea\u4e9b\u7279\u5f81\u662f\u8fdb\u5316\u4e3b\u52a8\u9009\u62e9\u7684\u7ed3\u679c\uff0c\u8fdb\u800c\u771f\u6b63\u6784\u6210 \u201c\u8fdb\u5316\u8bbe\u8ba1\u539f\u5219\u201d\u3002\u672c\u7814\u7a76\u901a\u8fc7\u5c06\u5df2\u53d1\u8868\u7684\u5e03\u5c14\u578b\u751f\u7269\u7f51\u7edc\u6a21\u578b\u4e0e\u4e0d\u540c\u96c6\u5408\u7684\u96f6\u6a21\u578b\uff08null models\uff09\u8fdb\u884c\u5bf9\u6bd4\uff0c\u53d1\u73b0\u751f\u7269\u7f51\u7edc\u4e2d\u6e20\u5316\u4f5c\u7528\uff08canalization\uff09\u7684\u4e30\u5ea6\u51e0\u4e4e\u53ef\u5b8c\u5168\u89e3\u91ca\u5176\u8fd1\u671f\u88ab\u63d0\u51fa\u7684 \u201c\u9ad8\u53ef\u8fd1\u4f3c\u6027\u201d \u7279\u5f81\u3002\u6b64\u5916\uff0c\u5bf9\u968f\u673a N-K \u8003\u592b\u66fc\u6a21\u578b\uff08N-K Kauffman models\uff09\u7684\u5206\u6790\u8868\u660e\uff0c\u7f51\u7edc\u7684\u53ef\u8fd1\u4f3c\u6027\u4e0e\u5176\u52a8\u529b\u5b66\u9c81\u68d2\u6027\u5b58\u5728\u5f3a\u76f8\u5173\u6027\u3002<\/span><\/p>\n


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\u6838\u5fc3\u56fe\uff1a\u6e20\u9053\u5316\u73b0\u8c61\u89e3\u91ca\u751f\u7269\u7f51\u7edc\u7684\u9ad8\u53ef\u903c\u8fd1\u6027\u3002\u672c\u56fe\u5c55\u793a\u4e86\u751f\u7269\u7f51\u7edc\uff08\u6a59\u8272\uff09\u4e0e\u4e09\u79cd\u5339\u914d\u751f\u7269\u7f51\u7edc\u4e0d\u540c\u7279\u5f81\uff08\u504f\u5dee\u503c\u548c\/\u6216\u6e20\u9053\u5316\u6df1\u5ea6\uff09\u7684\u968f\u673a\u96f6\u6a21\u578b\u7f51\u7edc\uff08\u84dd\u8272\u7cfb\uff09\u7684\u5e73\u5747\u903c\u8fd1\u8bef\u5dee\u5206\u5e03\u3002\u6bcf\u4e2a\u7bb1\u5f62\u56fe\u663e\u793a\u56db\u5206\u4f4d\u8ddd\uff0c\u987b\u7ebf\u5ef6\u4f38\u81f3\u7bb1\u4f531.5\u500d\u56db\u5206\u4f4d\u8ddd\u5185\u7684\u6781\u503c\uff0c\u7bb1\u5185\u6a2a\u7ebf\u8868\u793a\u4e2d\u4f4d\u6570\u3002\u5bf9\u4e8e\u56fa\u5b9a\u903c\u8fd1\u9636\u6570\uff081-3\u9636\uff0cx\u8f74\uff09\uff0c\u91c7\u7528\u53cc\u5c3e\u5a01\u5c14\u79d1\u514b\u68ee\u7b26\u53f7\u79e9\u68c0\u9a8c\u8bc4\u4f30\u751f\u7269\u7f51\u7edc\u4e0e\u968f\u673a\u7f51\u7edc\u7684\u5e73\u5747\u7edd\u5bf9\u8bef\u5dee\u5206\u5e03\u5dee\u5f02\u3002\u6240\u6709\u751f\u7269\u7f51\u7edc\u53ca\u5176\u968f\u673a\u96f6\u6a21\u578b\u7684\u5e73\u5747\u7edd\u5bf9\u8bef\u5dee\u6563\u70b9\u56fe\u8be6\u89c1\u56fe2\u3002<\/span><\/span><\/p>\n


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\u8bba\u65873\uff1a\u7f51\u7edc\u62d3\u6251\u7ed3\u6784\u4e0e\u76f8\u4e92\u4f5c\u7528\u903b\u8f91\u51b3\u5b9a\u5176\u652f\u6301\u7684\u72b6\u6001<\/span><\/span><\/strong><\/span><\/strong><\/strong><\/p>\n<\/section>\n

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\u8bba\u6587\u9898\u76ee\uff1aNetwork topology and interaction logic determine states it supports<\/span><\/span><\/p>\n

\u7f51\u7edc\u62d3\u6251\u7ed3\u6784\u4e0e\u76f8\u4e92\u4f5c\u7528\u903b\u8f91\u51b3\u5b9a\u5176\u652f\u6301\u7684\u72b6\u6001<\/span><\/span><\/section>\n

\u8bba\u6587\u6765\u6e90\uff1a<\/span><\/span>npj Systems Biology and Applications<\/span><\/span><\/em><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s41540-024-00423-8<\/span><\/span><\/p>\n

\u4e00\u4f5c\u5355\u4f4d\uff1aDepartment of Mathematical Sciences, Montana State University, Bozeman, MT, USA<\/span><\/span><\/p>\n


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\u6458\u8981\uff1a<\/span>\u5728\u672c\u6587\u732e\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u603b\u7ed3\u4e86\u5f53\u524d\u5728 \u201c\u63cf\u8ff0\u7f51\u7edc\u6240\u652f\u6301\u7684\u52a8\u529b\u5b66\u8303\u56f4\u201d \u8fd9\u4e00\u95ee\u9898\u4e0a\u7684\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\u3002\u65e8\u5728\u9610\u8ff0\u8c03\u63a7\u7f51\u7edc\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u5c55\u73b0\u4e0d\u540c\u8868\u578b\u7684\u80fd\u529b\u7684\u6700\u65b0\u8fdb\u5c55\u3002\u6211\u4eec\u4ecb\u7ecd\u4e00\u79cd\u66ff\u4ee3\u5206\u6790\u65b9\u6cd5 \u2014\u2014 \u8c03\u63a7\u7f51\u7edc\u52a8\u6001\u7279\u5f81\u751f\u6210\u65b9\u6cd5\uff08Dynamic Signatures Generated by Regulatory Networks, DSGRN\uff09[3,5,10]\u3002\u8be5\u65b9\u6cd5\u4e3a\u7f51\u7edc\u5173\u8054\u4e86\u4e00\u4e2a\u5e38\u5fae\u5206\u65b9\u7a0b\uff08ODE\uff09\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u5305\u542b\u4e0e\u7f51\u7edc\u7ed3\u6784\u4e00\u81f4\u7684\u5206\u6bb5\u5e38\u503c\u5355\u8c03\u975e\u7ebf\u6027\u9879\u3002\u7531\u4e8e\u8fd9\u4e9b\u975e\u7ebf\u6027\u9879\u4ec5\u53d6\u6709\u9650\u4e2a\u503c\uff0c\u76f8\u8f83\u4e8e\u4e00\u822c\u5e38\u5fae\u5206\u65b9\u7a0b\u6a21\u578b\uff0c\u8be5\u65b9\u6cd5\u5b58\u5728\u4e24\u9879\u5173\u952e\u7b80\u5316\uff1a\u7b2c\u4e00\uff0c\u76f8\u7a7a\u95f4\u4e2d\u7684\u5e38\u5fae\u5206\u65b9\u7a0b\u89e3\u53ef\u901a\u8fc7\u6709\u9650\u72b6\u6001\u8f6c\u79fb\u56fe\uff08state transition graph, STG\uff09\u63cf\u8ff0\uff1b\u7b2c\u4e8c\uff0c\u8fde\u7eed\u53c2\u6570\u7a7a\u95f4\u53ef\u5206\u89e3\u4e3a\u6709\u9650\u4e2a\u533a\u57df\uff0c\u4e14\u540c\u4e00\u533a\u57df\u5185\u6240\u6709\u53c2\u6570\u5bf9\u5e94\u7684\u72b6\u6001\u8f6c\u79fb\u56fe\uff08\u53ca\u5176\u5b9a\u4e49\u7684\u52a8\u529b\u5b66\u884c\u4e3a\uff09\u5b8c\u5168\u4e00\u81f4\u3002\u8fd9\u4e00\u7279\u6027\u5c06 \u201c\u5206\u6790\u5177\u6709\u8fde\u7eed\u76f8\u7a7a\u95f4\u4e0e\u8fde\u7eed\u53c2\u6570\u7a7a\u95f4\u7684\u5e38\u5fae\u5206\u65b9\u7a0b\u7cfb\u7edf\u201d \u8f6c\u5316\u4e3a \u201c\u6709\u9650\u7ec4\u5408\u95ee\u9898\u201d\uff0c\u5927\u5e45\u964d\u4f4e\u4e86\u5206\u6790\u590d\u6742\u5ea6\u3002\u6b64\u5916\uff0c\u8be5\u6a21\u578b\u4e2d\u7684\u5206\u6bb5\u5e38\u503c\u975e\u7ebf\u6027\u9879\u53ef\u6270\u52a8\u4e3a\u5e0c\u5c14\u51fd\u6570\uff08Hill function\uff09\u6a21\u578b\u3001\u659c\u5761\u51fd\u6570\uff08ramp function\uff09\u6a21\u578b\u6216\u5176\u4ed6\u4efb\u610f S \u578b\u975e\u7ebf\u6027\u6a21\u578b\uff0c\u4e14\u7406\u8bba\u7814\u7a76\u5df2\u8bc1\u5b9e\uff1a\u5bf9\u8be5\u7ec4\u5408\u52a8\u529b\u5b66\u7684\u5206\u6790\u7ed3\u679c\uff0c\u5bf9\u5176\u90bb\u8fd1\u7684\u8fde\u7eed\u6a21\u578b\u540c\u6837\u6709\u6548 [11]\u3002<\/span><\/p>\n


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\u6838\u5fc3\u56fe\uff1a\u5207\u6362\u4e09\u5143\u7ec4\u7f51\u7edc\u5206\u6790\u3002\uff08a \uff09\u5207\u6362\u4e09\u5143\u7ec4\u7f51\u7edc\uff08 b \uff09\u53ef\u80fd\u7684\u66f4\u65b0\u5e03\u5c14\u51fd\u6570\u96c6  \uff08c\uff09\u6240\u6709 MBF \u7684\u504f\u5e8f\u96c6\uff0c\u76f8\u90bb\u51fd\u6570\u6070\u597d\u76f8\u5dee\u4e00\u4e2a\u503c\u3002<\/span>
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\u8bba\u6587\u9898\u76ee\uff1aReconstructing Kinetic Models for Dynamical Studies of Metabolism using Generative Adversarial Networks<\/span><\/span><\/p>\n

\u57fa\u4e8e\u751f\u6210\u5bf9\u6297\u7f51\u7edc\u7684\u4ee3\u8c22\u52a8\u529b\u5b66\u6a21\u578b\u91cd\u6784\u4e0e\u52a8\u6001\u7814\u7a76<\/span><\/span><\/p>\n

\u8bba\u6587\u6765\u6e90\uff1a<\/span><\/span>Nature Machine Intelligence<\/span><\/span><\/em><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s42256-022-00519-y<\/span><\/span><\/p>\n

\u4ee3\u7801\u94fe\u63a5\uff1aA TensorFlow implementation of the REKINDLE workflow is publicly available at <\/span><\/span>https:\/\/github.com\/EPFL-LCSB\/rekindle<\/span><\/span> and <\/span><\/span>https:\/\/gitlab.com\/EPFL-LCSB\/rekindle<\/span><\/span> (ref. (55)). The ORACLE framework is implemented in the SKiMpy (Symbolic Kinetic Models in Python)(35) toolbox, available at <\/span><\/span>https:\/\/github.com\/EPFL-LCSB\/skimpy<\/span><\/span>.<\/span><\/span><\/p>\n

\u4e00\u4f5c\u5355\u4f4d\uff1aLaboratory of Computational Systems Biology (LCSB), Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland<\/span><\/span><\/p>\n


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\u6458\u8981\uff1a<\/span>\u4ee3\u8c22\u52a8\u529b\u5b66\u6a21\u578b\u901a\u8fc7\u673a\u7406\u5173\u7cfb\u5c06\u4ee3\u8c22\u901a\u91cf\u3001\u4ee3\u8c22\u7269\u6d53\u5ea6\u4e0e\u9176\u6c34\u5e73\u5173\u8054\u8d77\u6765\uff0c\u662f\u7406\u89e3\u3001\u9884\u6d4b\u53ca\u4f18\u5316\u751f\u547d\u4f53\u884c\u4e3a\u7684\u6838\u5fc3\u5de5\u5177\u3002\u7136\u800c\uff0c\u7531\u4e8e\u52a8\u529b\u5b66\u6570\u636e\u7684\u7f3a\u5931\uff0c\u4f20\u7edf\u52a8\u529b\u5b66\u5efa\u6a21\u5f80\u5f80\u53ea\u80fd\u5f97\u5230\u5c11\u91cf\u7b26\u5408\u9884\u671f\u52a8\u529b\u5b66\u7279\u6027\u7684\u6a21\u578b\uff0c\u751a\u81f3\u65e0\u6cd5\u5f97\u5230\u6709\u6548\u6a21\u578b\uff0c\u8fd9\u5bfc\u81f4\u5206\u6790\u7ed3\u679c\u53ef\u9760\u6027\u4e0d\u8db3\u4e14\u8ba1\u7b97\u6548\u7387\u4f4e\u4e0b\u3002\u672c\u7814\u7a76\u63d0\u51fa\u4e00\u79cd\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u6846\u67b6 \u2014\u2014REKINDLE\uff08Reconstruction of Kinetic Models using Deep Learning\uff0c\u5373 \u201c\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u52a8\u529b\u5b66\u6a21\u578b\u91cd\u6784\u201d\uff09\uff0c\u8be5\u6846\u67b6\u53ef\u9ad8\u6548\u751f\u6210\u52a8\u529b\u5b66\u7279\u6027\u4e0e\u7ec6\u80de\u4e2d\u89c2\u6d4b\u7ed3\u679c\u5339\u914d\u7684\u4ee3\u8c22\u52a8\u529b\u5b66\u6a21\u578b\u3002\u7814\u7a76\u5c55\u793a\u4e86 REKINDLE \u7684\u6838\u5fc3\u80fd\u529b\uff1a\u4ec5\u9700\u5c11\u91cf\u6570\u636e\uff0c\u4e14\u5728\u663e\u8457\u964d\u4f4e\u8ba1\u7b97\u9700\u6c42\u7684\u524d\u63d0\u4e0b\uff0c\u5373\u53ef\u5b9e\u73b0\u5bf9\u4ee3\u8c22\u751f\u7406\u72b6\u6001\u7684\u5206\u6790\u4e0e\u63a2\u7d22\u3002\u7ed3\u679c\u8868\u660e\uff0c\u6570\u636e\u9a71\u52a8\u7684\u795e\u7ecf\u7f51\u7edc\u80fd\u591f\u5438\u6536\u4ee3\u8c22\u7f51\u7edc\u9690\u542b\u7684\u52a8\u529b\u5b66\u77e5\u8bc6\u4e0e\u7ed3\u6784\uff0c\u751f\u6210\u5177\u6709\u5b9a\u5236\u5316\u7279\u6027\u548c\u7edf\u8ba1\u591a\u6837\u6027\u7684\u52a8\u529b\u5b66\u6a21\u578b\u3002\u7814\u7a76\u56e2\u961f\u9884\u671f\uff0c\u8be5\u6846\u67b6\u5c06\u6df1\u5316\u5bf9\u4ee3\u8c22\u8fc7\u7a0b\u7684\u7406\u89e3\uff0c\u5e76\u63a8\u52a8\u751f\u7269\u6280\u672f\u4e0e\u5065\u5eb7\u9886\u57df\u7684\u672a\u6765\u7814\u7a76\u8fdb\u7a0b\u3002<\/span><\/p>\n


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\u6838\u5fc3\u56fe\uff1aREKINDLE \u6846\u67b6\u6d41\u7a0b\u4e0e\u5e94\u7528\u89e3\u6790\u3002a\u4e2d\uff0c\u9996\u5148\u901a\u8fc7\u9884\u8bbe\u6761\u4ef6\uff08\u8d34\u5408\u5b9e\u9a8c\u6570\u636e\u3001\u5177\u5907\u5408\u7406\u52a8\u529b\u5b66\u7279\u6027\uff09\u7b5b\u9009\u5e76\u5206\u7c7b\u521d\u59cb\u52a8\u529b\u5b66\u53c2\u6570\u96c6\uff0c\u63a5\u7740\u5229\u7528\u751f\u6210\u5bf9\u6297\u7f51\u7edc\uff08GANs\uff09\u5b66\u4e60\u5e26\u6807\u7b7e\u53c2\u6570\u7684\u5206\u5e03\u89c4\u5f8b\uff0c\u518d\u7531\u8bad\u7ec3\u540e\u7684\u751f\u6210\u5668\u751f\u6210\u65b0\u5408\u89c4\u53c2\u6570\uff0c\u6700\u540e\u901a\u8fc7\u7edf\u8ba1\u68c0\u9a8c\u4e0e\u9a8c\u8bc1\u786e\u4fdd\u53c2\u6570\u6709\u6548\u6027\uff1bb\u4e2d\uff0c\u4e00\u65b9\u9762\u53ef\u501f\u52a9 GANs \u4e60\u5f97\u7684\u751f\u7406\u4e0e\u7ed3\u6784\u77e5\u8bc6\uff0c\u901a\u8fc7\u8fc1\u79fb\u5b66\u4e60\u5728\u6570\u636e\u6709\u9650\u65f6\u5916\u63a8\u81f3\u5176\u4ed6\u751f\u7406\u72b6\u6001\uff0c\u53e6\u4e00\u65b9\u9762\u751f\u6210\u7684\u53c2\u6570\u96c6\u652f\u6301\u5927\u89c4\u6a21\u9ad8\u9636\u7edf\u8ba1\u5206\u6790\uff0c\u52a9\u529b\u63ed\u793a\u4ee3\u8c22\u8868\u578b\u80cc\u540e\u7684\u8c03\u63a7\u673a\u5236\uff0c\u56fe\u4e2d Km,1 \u548c Km,2 \u4e3a\u4efb\u610f\u52a8\u529b\u5b66\u53c2\u6570\uff08\u5982\u7c73\u6c0f\u5e38\u6570\uff09\u7684\u793a\u4f8b\u3002<\/span><\/span>
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\u8bba\u6587\u9898\u76ee\uff1aThe physical frailty syndrome as a transition from homeostatic symphony to cacophony<\/span><\/span><\/p>\n

\u8eaf\u4f53\u8870\u5f31\u7efc\u5408\u5f81\uff1a\u4ece\u5185\u73af\u5883\u7a33\u6001\u534f\u594f\u5230\u673a\u80fd\u7d0a\u4e71\u7684\u8f6c\u5316\u8fc7\u7a0b<\/span><\/span><\/p>\n

\u8bba\u6587\u6765\u6e90\uff1a<\/span><\/span>Nature Aging<\/span><\/span><\/em><\/p>\n

\u8bba\u6587\u94fe\u63a5\uff1ahttps:\/\/www.nature.com\/articles\/s43587-020-00017-z<\/span><\/span><\/p>\n

\u4e00\u4f5c\u5355\u4f4d\uff1aColumbia University Mailman School of Public Health, New York, NY, USA<\/span><\/span><\/p>\n


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\u6458\u8981<\/span>\uff1a\u8870\u8001\u8fc7\u7a0b\u4e2d\u7684\u8106\u5f31\u6027\uff08Frailty\uff09\u6307\u673a\u4f53\u50a8\u5907\u80fd\u529b\u4e0b\u964d\uff0c\u5728\u9762\u4e34\u5e94\u6fc0\u56e0\u7d20\u65f6\u53d1\u751f\u4e0d\u826f\u7ed3\u5c40\u7684\u98ce\u9669\u663e\u8457\u5347\u9ad8\u7684\u72b6\u6001\u3002\u672c\u89c2\u70b9\u6587\u7ae0\u7efc\u5408\u4e86\u4e0e\u8870\u8001\u76f8\u5173\u7684\u75c5\u7406\u751f\u7406\u5b66\u8bc1\u636e\uff0c\u9610\u660e\u4e86\u8eab\u4f53\u8106\u5f31\u6027\uff08physical frailty\uff09\u4f5c\u4e3a\u4e00\u79cd\u4e34\u5e8a\u7efc\u5408\u5f81\u8868\u578b\u7684\u6838\u5fc3\u673a\u5236 \u2014\u2014 \u8be5\u8868\u578b\u6709\u522b\u4e8e\u57fa\u4e8e \u201c\u7d2f\u79ef\u7f3a\u9677\u201d \u7684\u8106\u5f31\u6027\u6307\u6570\uff08frailty index\uff09\u3002\u7814\u7a76\u91cd\u70b9\u6574\u5408\u4e86\u591a\u65b9\u9762\u7684\u4e00\u81f4\u6027\u8bc1\u636e\uff0c\u63d0\u51fa \u201c\u8eab\u4f53\u8106\u5f31\u6027\u662f\u4e00\u79cd\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u72ec\u7acb\u4e8e\u6162\u6027\u75be\u75c5\u7684\u72b6\u6001\u201d\uff1a\u5f53\u591a\u4e2a\u76f8\u4e92\u5173\u8054\u7684\u751f\u7406\u4e0e\u751f\u7269\u7cfb\u7edf\uff08\u5982\u4ee3\u8c22\u3001\u514d\u75ab\u3001\u795e\u7ecf\u5185\u5206\u6ccc\u7cfb\u7edf\uff09\u7684\u8c03\u8282\u5931\u8861\u7a81\u7834\u4e34\u754c\u529f\u80fd\u969c\u788d\u9608\u503c\uff0c\u5bfc\u81f4\u5185\u7a33\u6001\uff08homeostasis\uff09\u4e25\u91cd\u53d7\u635f\u65f6\uff0c\u8eab\u4f53\u8106\u5f31\u6027\u4fbf\u4f1a\u663e\u73b0\u3002\u6587\u7ae0\u8fdb\u4e00\u6b65\u9610\u91ca\uff0c\u8106\u5f31\u6027\u80cc\u540e\u7684\u751f\u7406\u673a\u5236\u672c\u8d28\u4e0a\u662f\u4e00\u4e2a \u201c\u4e25\u91cd\u5931\u8c03\u7684\u590d\u6742\u52a8\u529b\u7cfb\u7edf\u201d\u3002\u8fd9\u4e00\u6982\u5ff5\u6846\u67b6\u610f\u5473\u7740\uff0c\u76f8\u8f83\u4e8e\u4ec5\u9488\u5bf9\u5355\u4e00\u7cfb\u7edf\u8fdb\u884c\u4fee\u590d\u7684\u5e72\u9884\u624b\u6bb5\uff0c\u5177\u6709\u591a\u7cfb\u7edf\u8c03\u8282\u6548\u5e94\u7684\u5e72\u9884\u63aa\u65bd\uff08\u5982\u4f53\u80b2\u953b\u70bc\uff09\u5728\u6539\u5584\u8106\u5f31\u6027\u65b9\u9762\u66f4\u5177\u6f5c\u529b\u3002\u6700\u540e\uff0c\u7814\u7a76\u63a2\u8ba8\u4e86\u8be5\u6846\u67b6\u5982\u4f55\u63a8\u52a8\u672a\u6765\u7814\u7a76 \u2014\u2014 \u901a\u8fc7\u6df1\u5316\u5bf9\u8106\u5f31\u6027\u7684\u7406\u89e3\uff0c\u4f18\u5316\u5176\u9884\u9632\u4e0e\u6cbb\u7597\u7b56\u7565\uff0c\u8fdb\u800c\u6709\u671b\u7ef4\u62a4\u8001\u5e74\u4eba\u7fa4\u7684\u5065\u5eb7\u72b6\u6001\u4e0e\u673a\u4f53\u97e7\u6027\uff08resilience\uff09\u3002<\/span><\/p>\n


<\/span><\/p>\n

<\/section>\n

\u6838\u5fc3\u56fe\uff1a\u672c\u793a\u610f\u56fe\u6784\u5efa\u4e86\u751f\u7406\u5931\u8c03\u4e0e\u8eab\u4f53\u865a\u5f31\u7684\u591a\u5c3a\u5ea6\u5c42\u7ea7\u5173\u7cfb\uff1a\u9876\u5c42\u7684\u4e34\u5e8a\u865a\u5f31\u7efc\u5408\u5f81\u662f\u5fae\u89c2\u673a\u5236\u6d8c\u73b0\u7684\u5b8f\u89c2\u8868\u73b0\uff0c\u5176\u4e0b\u7531\u4e09\u5927\u6838\u5fc3\u751f\u7406\u6a21\u5757\uff08\u91d1\u5708\uff09\u652f\u6491\uff0c\u6bcf\u4e2a\u6a21\u5757\u5305\u542b\u82e5\u5e72\u5b50\u7cfb\u7edf\uff08\u6a59\u692d\u5706\uff09\uff1b\u6700\u5e95\u5c42\u7684\u7ec6\u80de\u5206\u5b50\u5c3a\u5ea6\u5e94\u6fc0\u6e90\uff08\u7d2b\u692d\u5706\uff09\u9a71\u52a8\u4e0a\u5c42\u751f\u7406\u6a21\u5757\u5931\u8c03\uff0c\u8fd9\u4e9b\u8de8\u5c3a\u5ea6\u7ec4\u4ef6\u901a\u8fc7\u76f8\u4e92\u4f5c\u7528\u5f62\u6210\u805a\u5408\u6027\u5931\u8c03\u751f\u7406\u7c7b\u578b\uff08\u6df1\u6a59\u692d\u5706\uff09\uff0c\u6700\u7ec8\u5173\u8054\u9876\u5c42\u7684\u865a\u5f31\u8868\u578b\u53ca\u76f8\u5173\u8106\u5f31\u6027\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n


<\/span><\/strong><\/span><\/strong><\/section>\n
\n
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\u62a5\u540d\u8bfb\u4e66\u4f1a\uff1a\u300c\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u4e0e\u6df7\u6c8c\u300d<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u96c6\u667a\u4ff1\u4e50\u90e8\u8054\u5408\u5317\u4eac\u5e08\u8303\u5927\u5b66\u5f20\u6c5f\u79d1\u7814\u7ec4\u8054\u548c\u5357\u4fe1\u5927\u674e\u6625\u5f6a\u79d1\u7814\u7ec4\u5e08\u751f\u5171\u540c\u53d1\u8d77<\/span>\u300c\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u4e0e\u6df7\u6c8c\u300d\u8bfb\u4e66\u4f1a<\/span><\/a>\uff0c\u7531\u5e08\u751f\u5171\u540c\u9886\u8bfb\u300a\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u4e0e\u6df7\u6c8c\u300b\uff0c\u4ee5\u5206\u7ae0\u8282\u7cbe\u8bfb\u7684\u65b9\u5f0f\uff0c\u5e26\u9886\u5927\u5bb6\u7cfb\u7edf\u5b66\u4e60\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u7684\u57fa\u672c\u7406\u8bba\u4e0e\u5178\u578b\u6a21\u578b\uff0c\u7ed3\u5408\u6d1b\u4f26\u5179\u7cfb\u7edf\u3001Kuramoto\u6a21\u578b\u7b49\u7ecf\u5178\u6848\u4f8b\uff0c\u6df1\u5165\u63a2\u8ba8\u6df7\u6c8c\u7684\u8d77\u6e90\u3001\u5206\u5f62\u4e0e\u5947\u5f02\u5438\u5f15\u5b50\u7b49\u524d\u6cbf\u95ee\u9898\u3002<\/span><\/span><\/p>\n

\u672c\u8bfb\u4e66\u4f1a\u4e0d\u4ec5\u8bfb\u4e66\uff0c\u8fd8\u4f1a\u7cfb\u7edf\u5316\u5730\u68b3\u7406\u672c\u4e66\u4e2d\u7684\u91cd\u8981\u6982\u5ff5\uff0c\u5e76\u6574\u7406\u4e3a\u767e\u79d1\u8bcd\u6761\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u8bfb\u5b8c\u672c\u4e66\uff0c\u6211\u4eec\u4f1a\u68b3\u7406\u51fa\u4e00\u5957\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u4e0e\u6df7\u6c8c\u76f8\u5173\u7684\u767e\u79d1\u8bcd\u6761\uff0c\u8fd9\u624d\u662f\u91cd\u70b9\u3002<\/span><\/span><\/p>\n

\u6211\u4eec\u4e5f\u4f1a\u901a\u8fc7\u68b3\u7406\u8bcd\u6761\u7684\u65b9\u5f0f\uff0c\u8ba9\u5b66\u5458\u7ec4\u6210\u5b66\u4e60\u5c0f\u7ec4\u8fdb\u884c\u6bd4\u8d5b\uff0c\u6700\u7ec8\u4f1a\u8bc4\u51fa\u4f18\u79c0\u5b66\u4e60\u5c0f\u7ec4\u83b7\u5f97\u590d\u6742\u79d1\u5b66\u77e5\u8bc6\u5361\u3001\u6c6a\u5c0f\u5e06\u7b7e\u540d\u7684\u300a\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u4e0e\u6df7\u6c8c\u300b\u3001\u5f20\u6c5f\u7b7e\u540d\u7684\u300a\u89c4\u6a21\u6cd5\u5219\u300b\u3001\u4ee5\u53ca\u8bd1\u8005\u7b7e\u540d\u7684\u300a\u590d\u6742-\u8bde\u751f\u4e8e\u6df7\u6c8c\u4e0e\u79e9\u5e8f\u8fb9\u7f18\u7684\u79d1\u5b66\u300b\u4ee5\u53ca\u7279\u8272\u96c6\u667a\u6587\u5316\u886b\uff01<\/span><\/span><\/p>\n

\"\u56fe\u7247\"<\/section>\n
\n
\u8be6\u60c5\u8bf7\u89c1\uff1a<\/span>\u771f\u6b63\u7684\u8bfb\u201c\u4e66\u201d\u4f1a\u6765\u4e86\u2014\u2014\u5f20\u6c5f\u3001\u674e\u6625\u5f6a\u9080\u4f60\u4e00\u8d77\u8bfb\u300a\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u4e0e\u6df7\u6c8c\u300b<\/a><\/span><\/span><\/section>\n

<\/span><\/span><\/section>\n<\/section>\n

<\/span><\/span><\/strong><\/strong><\/strong><\/section>\n
\u63a8\u8350\u9605\u8bfb<\/span><\/span><\/strong><\/strong><\/strong><\/section>\n
<\/strong><\/section>\n
1. PRL\u901f\u9012\uff1a\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u7cfb\u7edf\u4e2d\u7684\u9690\u85cf\u591a\u7a33\u6001<\/span><\/a><\/span><\/strong>
<\/span><\/strong><\/span><\/section>\n
2. PRL\u901f\u9012\uff1a\u8c03\u8282\u751f\u7269\u632f\u8361\uff0c\u5229\u7528\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u89e3\u8026\u9891\u7387\u548c\u632f\u5e45\u7684\u666e\u9002\u6027\u7406\u8bba<\/span><\/a><\/span><\/strong>
<\/span><\/strong><\/span><\/section>\n
3. \u8d1d\u53f6\u65afX\u975e\u7ebf\u6027\u2014\u2014\u57fa\u4e8e\u52a8\u6001\u56e0\u679c\u7684\u590d\u6742\u7cfb\u7edf\u81ea\u52a8\u5efa\u6a21\u65b9\u6cd5<\/span><\/a><\/span><\/strong><\/section>\n
<\/strong><\/section>\n
4. <\/span>\u6d8c\u73b0\u52a8\u529b\u5b66\u5982\u4f55\u7528\u6765\u5206\u6790\u590d\u6742\u7cfb\u7edf\uff1f | \u65b0\u8bfe\u4e0a\u7ebf<\/span><\/a><\/span><\/strong><\/span>
<\/span><\/strong><\/strong><\/span><\/section>\n
<\/strong>5. <\/span><\/strong>\u96c6\u667a\u5b66\u56ed\u7cbe\u54c1\u8bfe\u7a0b\u514d\u8d39\u5f00\u653e\uff0c\u89e3\u9501\u7cfb\u7edf\u79d1\u5b66\u4e0e AI \u65b0\u4e16\u754c<\/span><\/a><\/span><\/strong><\/section>\n

6. \u9ad8\u8003\u5206\u6570\u53ea\u662f\u5f20\u5165\u573a\u5238\uff0c\u4f60\u7684\u79d1\u7814\u5192\u9669\u5728\u8fd9\u91cc\u542f\u822a\uff01<\/span><\/a><\/span><\/strong><\/p>\n

7. <\/span><\/span><\/strong><\/strong><\/span>\u91cd\u6574\u5316\u7fa4\u4e0e\u975e\u7ebf\u6027\u7269\u7406\uff0c\u5bfb\u627e\u590d\u6742\u7cfb\u7edf\u8de8\u5c3a\u5ea6\u7684\u5206\u6790\u65b9\u6cd5\u4e28\u65b0\u8bfe\u53d1\u5e03<\/a><\/span><\/strong><\/strong><\/strong><\/strong><\/span><\/p>\n


<\/span><\/p>\n

<\/section>\n


<\/span><\/span><\/p>\n

\u70b9\u51fb\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u62a5\u540d\u8bfb\u4e66\u4f1a<\/span><\/span><\/section>\n<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc\u8bed \u975e\u7ebf\u6027\u52a8\u529b\u5b66\u4ece\u6e4d\u6d41\u5230\u9e1f\u7fa4\uff0c\u4ece\u6606\u866b\u7206\u53d1\u5230\u57fa\u56e0\u8c03\u63a7\uff0c\u975e\u7ebf\u6027\u52a8\u529b\u5b66\u4e3a\u6211\u4eec\u63ed\u793a\u4e86\u81ea\u7136\u4e0e\u4eba\u5de5\u7cfb\u7edf\u4e2d\u6700\u4e30\u5bcc\u800c\u53c8\u6700\u96be\u4ee5\u6349\u6478\u7684\u89c4\u5f8b\u3002\u5728\u7ebf\u6027\u65b9\u6cd5\u96be\u4ee5\u5e94\u5bf9\u7684\u79d1\u5b66\u4e0e\u6280\u672f\u524d\u6cbf\uff0c\u975e\u7ebf\u6027\u52a8\u529b\u7cfb\u7edf\u4e0e\u6df7\u6c8c\u7406\u8bba\u4e3a\u7406\u89e3\u590d\u6742\u73b0\u8c61\u63d0\u4f9b\u4e86\u5168\u65b0\u7684\u89c6\u89d2\u3002\u5b83\u4e0d\u4ec5\u80fd\u7cbe\u786e\u523b\u753b\u6f14\u5316\u52a8\u529b\u5b66\u7684\u5185\u5728\u673a\u5236\uff0c\u8fd8\u80fd\u5e2e\u52a9\u6211\u4eec\u9884\u6d4b\u7cfb\u7edf\u7684\u672a\u6765\u884c\u4e3a\uff0c\u63a2\u7d22\u56e0\u679c\u6d8c\u73b0\u80cc\u540e…<\/p>\n","protected":false},"author":0,"featured_media":64875,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"special":[],"_links":{"self":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/64896"}],"collection":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=64896"}],"version-history":[{"count":0,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/posts\/64896\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=\/wp\/v2\/media\/64875"}],"wp:attachment":[{"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=64896"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=64896"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=64896"},{"taxonomy":"special","embeddable":true,"href":"https:\/\/swarma.org\/index.php?rest_route=%2Fwp%2Fv2%2Fspecial&post=64896"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}